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2024-04-26 14:38:47, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001040623 1371 bp mRNA linear PRI 01-JUL-2013
DEFINITION Homo sapiens chitinase, acidic (CHIA), transcript variant 3, mRNA.
ACCESSION NM_001040623
VERSION NM_001040623.2 GI:384367979
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1371)
AUTHORS Di Rosa,M., De Gregorio,C., Malaguarnera,G., Tuttobene,M.,
Biazzo,F. and Malaguarnera,L.
TITLE Evaluation of AMCase and CHIT-1 expression in monocyte macrophages
lineage
JOURNAL Mol. Cell. Biochem. 374 (1-2), 73-80 (2013)
PUBMED 23129258
REMARK GeneRIF: results showed that the expression of AMCase and CHIT-1
were differently modulated in monocyte macrophages at different
stage of maturation. The behavior of these two active chitinase
suggests that in the immune response their role is complementary.
REFERENCE 2 (bases 1 to 1371)
AUTHORS Aminuddin,F., Akhabir,L., Stefanowicz,D., Pare,P.D., Connett,J.E.,
Anthonisen,N.R., Fahy,J.V., Seibold,M.A., Burchard,E.G., Eng,C.,
Gulsvik,A., Bakke,P., Cho,M.H., Litonjua,A., Lomas,D.A.,
Anderson,W.H., Beaty,T.H., Crapo,J.D., Silverman,E.K. and
Sandford,A.J.
TITLE Genetic association between human chitinases and lung function in
COPD
JOURNAL Hum. Genet. 131 (7), 1105-1114 (2012)
PUBMED 22200767
REMARK GeneRIF: study demonstrated genetic associations between chitinase
gene variants and lung function level and rate of decline in
chronic obstructive pulmonary disease patients from the Lung Health
Study; also functional effect of the rs3818822 polymorphism on
AMCase levels and activity was demonstrated
REFERENCE 3 (bases 1 to 1371)
AUTHORS Birben,E., Sackesen,C., Kazani,S., Tincer,G., Karaaslan,C.,
Durgunsu,B., Gursel,I., Wechsler,M.E., Israel,E. and Kalayci,O.
TITLE The effects of an insertion in the 5'UTR of the AMCase on gene
expression and pulmonary functions
JOURNAL Respir Med 105 (8), 1160-1169 (2011)
PUBMED 21511453
REMARK GeneRIF: A ten base pair insertion in the second exon in the 5'UTR
region of the AMCase gene may modify the gene expression and thus
may affect the severity of asthma.
REFERENCE 4 (bases 1 to 1371)
AUTHORS Gu,Z., Cao,Z. and Jin,M.
TITLE Expression and role of acidic mammalian chitinase and eotaxin-3 in
chronic rhinosinusitis with nasal polyps
JOURNAL J Otolaryngol Head Neck Surg 40 (1), 64-69 (2011)
PUBMED 21303604
REMARK GeneRIF: AMCase and eotaxin-3 may be important mediators in the
pathogenesis of nasal polyps. The increased AMCase and eotaxin-3
might lead to nasal polyp formation and growth.
REFERENCE 5 (bases 1 to 1371)
AUTHORS Park,S.K., Heo,K.W., Hur,D.Y. and Yang,Y.I.
TITLE Chitinolytic activity in nasal polyps
JOURNAL Am J Rhinol Allergy 25 (1), 12-14 (2011)
PUBMED 21711963
REMARK GeneRIF: increased chitinolytic activity in nasal polyps
REFERENCE 6 (bases 1 to 1371)
AUTHORS Chou,Y.T., Yao,S., Czerwinski,R., Fleming,M., Krykbaev,R., Xuan,D.,
Zhou,H., Brooks,J., Fitz,L., Strand,J., Presman,E., Lin,L.,
Aulabaugh,A. and Huang,X.
TITLE Kinetic characterization of recombinant human acidic mammalian
chitinase
JOURNAL Biochemistry 45 (14), 4444-4454 (2006)
PUBMED 16584180
REMARK GeneRIF: human AMCase has only one pH optimum for k(cat)/K(m)
between pH 4 and 5. Steady state kinetics shows that human AMCase
has 'low' intrinsic transglycosidase activity, which leads to the
observation of apparent substrate inhibition.
REFERENCE 7 (bases 1 to 1371)
AUTHORS Zhu,Z., Zheng,T., Homer,R.J., Kim,Y.K., Chen,N.Y., Cohn,L.,
Hamid,Q. and Elias,J.A.
TITLE Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13
pathway activation
JOURNAL Science 304 (5677), 1678-1682 (2004)
PUBMED 15192232
REMARK GeneRIF: expressed in exaggerated quantities in human asthma
REFERENCE 8 (bases 1 to 1371)
AUTHORS Goto,M., Fujimoto,W., Nio,J., Iwanaga,T. and Kawasaki,T.
TITLE Immunohistochemical demonstration of acidic mammalian chitinase in
the mouse salivary gland and gastric mucosa
JOURNAL Arch. Oral Biol. 48 (10), 701-707 (2003)
PUBMED 12971947
REFERENCE 9 (bases 1 to 1371)
AUTHORS Boot,R.G., Blommaart,E.F., Swart,E., Ghauharali-van der Vlugt,K.,
Bijl,N., Moe,C., Place,A. and Aerts,J.M.
TITLE Identification of a novel acidic mammalian chitinase distinct from
chitotriosidase
JOURNAL J. Biol. Chem. 276 (9), 6770-6778 (2001)
PUBMED 11085997
REFERENCE 10 (bases 1 to 1371)
AUTHORS Saito,A., Ozaki,K., Fujiwara,T., Nakamura,Y. and Tanigami,A.
TITLE Isolation and mapping of a human lung-specific gene, TSA1902,
encoding a novel chitinase family member
JOURNAL Gene 239 (2), 325-331 (1999)
PUBMED 10548734
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK290702.1, AB025008.1,
AF290004.1, AY789445.1 and BC036339.1.
On Apr 14, 2012 this sequence version replaced gi:95147543.
Summary: The protein encoded by this gene degrades chitin, which is
found in the cell wall of most fungi as well as in arthropods and
some nematodes. The encoded protein can also stimulate interleukin
13 expression, and variations in this gene can lead to asthma
susceptibility. Several transcript variants encoding a few
different isoforms have been found for this gene. [provided by
RefSeq, Apr 2012].
Transcript Variant: This variant (3) lacks exons in the 5' end of
the coding region compared to variant 4. The resulting isoform (b,
also known as TSA1902-S) is shorter at the N-terminus compared to
isoform a. Variants 3, 6, 8, and 9 all encode the same isoform (b).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
CDS exon combination :: AY789445.1, AB025009.1 [ECO:0000331]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-10 AK290702.1 1-10
11-64 AB025008.1 1-54
65-99 AF290004.1 1-35
100-1070 AY789445.1 2-972
1071-1371 BC036339.1 1052-1352
FEATURES Location/Qualifiers
source 1..1371
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p13.2"
gene 1..1371
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/note="chitinase, acidic"
/db_xref="GeneID:27159"
/db_xref="HGNC:17432"
/db_xref="MIM:606080"
exon 1..99
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
variation 16..18
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="ct"
/db_xref="dbSNP:34698010"
variation 16..17
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="ct"
/db_xref="dbSNP:374234404"
variation 22
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:116488064"
variation 44
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:12026825"
variation 72
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:149411814"
variation 75
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:146385552"
variation 88
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:139768111"
variation 97
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:142723581"
exon 100..192
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
variation 103
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:193167990"
variation 123
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:376415475"
variation 126
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:367796033"
variation 131
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:371120238"
variation 134
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:200693541"
variation 136..137
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="aagcc"
/db_xref="dbSNP:201649523"
variation 137..138
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="agccaatct"
/db_xref="dbSNP:200345479"
variation 138..139
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="gccaatctag"
/db_xref="dbSNP:143789088"
variation 140..141
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="caatctaggc"
/db_xref="dbSNP:375930070"
variation 146
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:374220212"
variation 151
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:201988572"
variation 155
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:17027394"
variation 163
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:376159900"
variation 165
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:200929969"
variation 166
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:373861430"
variation 170
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:368020028"
variation 178
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:371398270"
variation 182
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:200053948"
variation 185
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:375003916"
exon 193..222
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
misc_feature 208..210
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/note="upstream in-frame stop codon"
exon 223..279
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
variation 226
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:368828123"
variation 233
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="c"
/db_xref="dbSNP:143910053"
variation 262
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:147282128"
variation 269
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:3818822"
variation 279
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:201556508"
exon 280..404
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
CDS 283..1230
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/EC_number="3.2.1.14"
/note="isoform b is encoded by transcript variant 3;
acidic mammalian chitinase; lung-specific protein TSA1902"
/codon_start=1
/product="acidic mammalian chitinase isoform b"
/protein_id="NP_001035713.1"
/db_xref="GI:95147544"
/db_xref="CCDS:CCDS58017.1"
/db_xref="GeneID:27159"
/db_xref="HGNC:17432"
/db_xref="MIM:606080"
/translation="
MREAFEQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSSGGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
"
misc_feature <283..960
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/note="The GH18 (glycosyl hydrolase, family 18) type II
chitinases hydrolyze chitin, an abundant polymer of
beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a
major component of the cell wall of fungi and the
exoskeleton of arthropods. Chitinases have...; Region:
GH18_chitinase-like; cl10447"
/db_xref="CDD:209141"
misc_feature <283..894
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/note="Glyco_18 domain; Region: Glyco_18; smart00636"
/db_xref="CDD:197811"
misc_feature 1084..1227
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/note="Chitin-binding domain type 2; Region: ChtBD2;
smart00494"
/db_xref="CDD:197759"
variation 286
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:139158262"
variation 301
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:199860140"
variation 304
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:143586120"
variation 314
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:144679403"
variation 316
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="t"
/db_xref="dbSNP:116430435"
variation 321
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="c"
/db_xref="dbSNP:200617710"
variation 341
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:377181497"
variation 364
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:369860168"
variation 379
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:199874052"
variation 394
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="c"
/db_xref="dbSNP:150563512"
exon 405..528
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
variation 411
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:140904700"
variation 423
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:368843945"
variation 435
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:148384495"
variation 436
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:200134913"
variation 492
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:369614927"
variation 494
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:376497990"
variation 499
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:147103194"
variation 504
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:143960572"
variation 513
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:139759326"
variation 514
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:142137716"
variation 520
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:151297358"
exon 529..714
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
variation 552
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:114510939"
variation 556
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="t"
/db_xref="dbSNP:181434663"
variation 583
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:367730751"
variation 610
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:78293817"
variation 615
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="c"
/db_xref="dbSNP:139093708"
variation 624
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:143107428"
variation 626
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:371506503"
variation 631
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:143732960"
variation 647
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:150309903"
variation 662
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:61748620"
variation 672
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:61748619"
variation 682
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:79500525"
variation 688
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:139420194"
variation 690
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:201390788"
variation 701
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:150840174"
variation 712
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:201266629"
exon 715..834
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
variation 722
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:142736771"
variation 749
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:139812869"
variation 755..756
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="tgcccctcaggaag"
/db_xref="dbSNP:151326722"
variation 757
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:200566957"
variation 759..760
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="cctcaggaagtgcc"
/db_xref="dbSNP:375881947"
variation 773
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="cctcaggaagtgcc"
/db_xref="dbSNP:74706064"
variation 792
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:144546962"
variation 793
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:375947945"
variation 795
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:17027410"
variation 796
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:190772785"
variation 798
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:144182515"
variation 807
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:370020615"
variation 813
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:182916944"
variation 814
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:2275253"
variation 821
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:189146821"
variation 825
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:200092579"
variation 829
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:374270214"
exon 835..976
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
variation 860
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:2275254"
variation 867
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:151038298"
variation 868
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:201691527"
variation 869
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:374315938"
variation 871
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:142800191"
variation 881
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:373985805"
variation 896
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:141843885"
variation 912
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:76395847"
variation 928
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:36011905"
variation 942
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:368203516"
variation 950
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:143969273"
variation 955
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:147768976"
variation 960
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:2820092"
variation 961
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:371701062"
variation 964
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:12094378"
exon 977..1330
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
variation 984
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:372590829"
variation 991
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:140459744"
variation 1005
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:199879175"
variation 1014
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:377085074"
variation 1017
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:150421495"
variation 1019
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:145023911"
variation 1020
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="t"
/db_xref="dbSNP:187769579"
variation 1031
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:144623576"
variation 1039
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:199811046"
variation 1040
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:141747675"
variation 1045
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:138227985"
variation 1065
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="c"
/db_xref="dbSNP:376164222"
variation 1071
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:35242709"
variation 1075
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:149869566"
variation 1094
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:2256721"
variation 1107
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="c"
/db_xref="dbSNP:369442393"
variation 1114
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="c"
/db_xref="dbSNP:368010768"
variation 1115
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:143551303"
variation 1117
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:138073907"
variation 1136
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:201456008"
variation 1140
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:368211379"
variation 1176
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:145057685"
variation 1185
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:140461957"
variation 1186
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:142653250"
variation 1225
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:146040153"
variation 1247
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:373720681"
variation 1252
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:139802202"
variation 1264
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:372826781"
variation 1269
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:141163072"
polyA_signal 1306..1311
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
polyA_site 1330
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
ORIGIN
aaagcttcatgaaacctcctcgtctgtgcacgaacaggtggccgactctggagcccaggctgttgctttccagtctggtggtgaatcctccatagtctgaagcctttgtgataaccacagaatcagaacatataaaaagctctgcgggactggtgctgactgcaaccatgacaaagcttattctcctcacaggtcttgtccttatactgaatttgcagctcggaacagccagctgaaaactctcctggccattggaggctggaacttcgggactgccccgaaatgcgtgaagcttttgagcaggaggccaagcagatcaacaagcccaggctgatggtcactgctgcagtagctgctggcatctccaatatccagtctggctatgagatcccccaactgtcacagtacctggactacatccatgtcatgacctacgacctccatggctcctgggagggctacactggagagaacagccccctctacaaatacccgactgacaccggcagcaacgcctacctcaatgtggattatgtcatgaactactggaaggacaatggagcaccagctgagaagctcatcgttggattccctacctatggacacaacttcatcctgagcaacccctccaacactggaattggtgcccccacctctggtgctggtcctgctgggccctatgccaaggagtctgggatctgggcttactacgagatctgtaccttcctgaaaaatggagccactcagggatgggatgcccctcaggaagtgccttatgcctatcagggcaatgtgtgggttggctatgacaacatcaagagcttcgatattaaggctcaatggcttaagcacaacaaatttggaggcgccatggtctgggccattgatctggatgacttcactggcactttctgcaaccagggcaagtttcccctaatctccaccctgaagaaggccctcggcctgcagagtgcaagttgcacggctccagctcagcccattgagccaataactgctgctcccagtggcagcgggaacgggagcgggagtagcagctctggaggcagctcgggaggcagtggattctgtgctgtcagagccaacggcctctaccccgtggcaaataacagaaatgccttctggcactgcgtgaatggagtcacgtaccagcagaactgccaggccgggcttgtcttcgacaccagctgtgattgctgcaactgggcataaacctgacctggtctatattccctagagttccagtctcttttgcttaggacatgttgcccctacctaaagtcctgcaataaaatcagcagtcaaaacatgaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:27159 -> Molecular function: GO:0003796 [lysozyme activity] evidence: NAS
GeneID:27159 -> Molecular function: GO:0004568 [chitinase activity] evidence: IDA
GeneID:27159 -> Molecular function: GO:0004568 [chitinase activity] evidence: NAS
GeneID:27159 -> Molecular function: GO:0008061 [chitin binding] evidence: TAS
GeneID:27159 -> Molecular function: GO:0019900 [kinase binding] evidence: IPI
GeneID:27159 -> Molecular function: GO:0030246 [carbohydrate binding] evidence: NAS
GeneID:27159 -> Biological process: GO:0000272 [polysaccharide catabolic process] evidence: IEA
GeneID:27159 -> Biological process: GO:0001101 [response to acid] evidence: TAS
GeneID:27159 -> Biological process: GO:0002532 [production of molecular mediator involved in inflammatory response] evidence: IDA
GeneID:27159 -> Biological process: GO:0006030 [chitin metabolic process] evidence: NAS
GeneID:27159 -> Biological process: GO:0006032 [chitin catabolic process] evidence: IDA
GeneID:27159 -> Biological process: GO:0006032 [chitin catabolic process] evidence: NAS
GeneID:27159 -> Biological process: GO:0006037 [cell wall chitin metabolic process] evidence: TAS
GeneID:27159 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:27159 -> Biological process: GO:0006955 [immune response] evidence: NAS
GeneID:27159 -> Biological process: GO:0007586 [digestion] evidence: NAS
GeneID:27159 -> Biological process: GO:0009620 [response to fungus] evidence: TAS
GeneID:27159 -> Biological process: GO:0090197 [positive regulation of chemokine secretion] evidence: IDA
GeneID:27159 -> Cellular component: GO:0005615 [extracellular space] evidence: IC
GeneID:27159 -> Cellular component: GO:0005615 [extracellular space] evidence: IDA
GeneID:27159 -> Cellular component: GO:0005737 [cytoplasm] evidence: ISS
GeneID:27159 -> Cellular component: GO:0005737 [cytoplasm] evidence: NAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001035713 -> EC 3.2.1.14
by
@meso_cacase at
DBCLS
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