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2024-04-20 09:21:40, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001040455 3919 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens SID1 transmembrane family, member 2 (SIDT2), mRNA.
ACCESSION NM_001040455
VERSION NM_001040455.1 GI:94721339
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3919)
AUTHORS Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B,
Yusuf S, Gerstein HC, Engert JC and Anand S.
CONSRTM DREAM investigators
TITLE Variation at the NFATC2 locus increases the risk of
thiazolidinedione-induced edema in the Diabetes REduction
Assessment with ramipril and rosiglitazone Medication (DREAM) study
JOURNAL Diabetes Care 33 (10), 2250-2253 (2010)
PUBMED 20628086
REMARK GeneRIF: Observational study of gene-disease association,
gene-environment interaction, and pharmacogenomic / toxicogenomic.
(HuGE Navigator)
REFERENCE 2 (bases 1 to 3919)
AUTHORS Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt
TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M,
Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ,
Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S,
Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD,
Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE
and Hingorani AD.
CONSRTM ASCOT investigators; NORDIL investigators; BRIGHT Consortium
TITLE Gene-centric association signals for lipids and apolipoproteins
identified via the HumanCVD BeadChip
JOURNAL Am. J. Hum. Genet. 85 (5), 628-642 (2009)
PUBMED 19913121
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 3 (bases 1 to 3919)
AUTHORS Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
TITLE Integral and associated lysosomal membrane proteins
JOURNAL Traffic 8 (12), 1676-1686 (2007)
PUBMED 17897319
REFERENCE 4 (bases 1 to 3919)
AUTHORS Zhang,Z. and Henzel,W.J.
TITLE Signal peptide prediction based on analysis of experimentally
verified cleavage sites
JOURNAL Protein Sci. 13 (10), 2819-2824 (2004)
PUBMED 15340161
REFERENCE 5 (bases 1 to 3919)
AUTHORS Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
TITLE The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins:
a bioinformatics assessment
JOURNAL Genome Res. 13 (10), 2265-2270 (2003)
PUBMED 12975309
REMARK Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AY358442.1 and BX648437.1.
##Evidence-Data-START##
Transcript exon combination :: AY358442.1, AK292501.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-3916 AY358442.1 10-3925
3917-3919 BX648437.1 3015-3017
FEATURES Location/Qualifiers
source 1..3919
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q23.3"
gene 1..3919
/gene="SIDT2"
/gene_synonym="CGI-40"
/note="SID1 transmembrane family, member 2"
/db_xref="GeneID:51092"
/db_xref="HGNC:24272"
exon 1..224
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="alignment:Splign:1.39.8"
CDS 42..2540
/gene="SIDT2"
/gene_synonym="CGI-40"
/codon_start=1
/product="SID1 transmembrane family member 2 precursor"
/protein_id="NP_001035545.1"
/db_xref="GI:94721340"
/db_xref="CCDS:CCDS31682.1"
/db_xref="GeneID:51092"
/db_xref="HGNC:24272"
/translation="
MFALGLPFLVLLVASVESHLGVLGPKNVSQKDAEFERTYVDEVNSELVNIYTFNHTVTRNRTEGVRVSVNVLNKQKGAPLLFVVRQKEAVVSFQVPLILRGMFQRKYLYQKVERTLCQPPTKNESEIQFFYVDVSTLSPVNTTYQLRVSRMDDFVLRTGEQFSFNTTAAQPQYFKYEFPEGVDSVIVKVTSNKAFPCSVISIQDVLCPVYDLDNNVAFIGMYQTMTKKAAITVQRKDFPSNSFYVVVVVKTEDQACGGSLPFYPFAEDEPVDQGHRQKTLSVLVSQAVTSEAYVSGMLFCLGIFLSFYLLTVLLACWENWRQKKKTLLVAIDRACPESGHPRVLADSFPGSSPYEGYNYGSFENVSGSTDGLVDSAGTGDLSYGYQGRSFEPVGTRPRVDSMSSVEEDDYDTLTDIDSDKNVIRTKQYLYVADLARKDKRVLRKKYQIYFWNIATIAVFYALPVVQLVITYQTVVNVTGNQDICYYNFLCAHPLGNLSAFNNILSNLGYILLGLLFLLIILQREINHNRALLRNDLCALECGIPKHFGLFYAMGTALMMEGLLSACYHVCPNYTNFQFDTSFMYMIAGLCMLKLYQKRHPDINASAYSAYACLAIVIFFSVLGVVFGKGNTAFWIVFSIIHIIATLLLSTQLYYMGRWKLDSGIFRRILHVLYTDCIRQCSGPLYVDRMVLLVMGNVINWSLAAYGLIMRPNDFASYLLAIGICNLLLYFAFYIIMKLRSGERIKLIPLLCIVCTSVVWGFALFFFFQGLSTWQKTPAESREHNRDCILLDFFDDHDIWHFLSSIAMFGSFLVLLTLDDDLDTVQRDKIYVF
"
sig_peptide 42..95
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
mat_peptide 96..2537
/gene="SIDT2"
/gene_synonym="CGI-40"
/product="SID1 transmembrane family member 2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8NBJ9.2)"
misc_feature 555..>986
/gene="SIDT2"
/gene_synonym="CGI-40"
/note="dsRNA-gated channel SID-1; Region: SID-1_RNA_chan;
pfam13965"
/db_xref="CDD:206135"
misc_feature 930..992
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8NBJ9.2);
transmembrane region"
misc_feature <1206..2537
/gene="SIDT2"
/gene_synonym="CGI-40"
/note="dsRNA-gated channel SID-1; Region: SID-1_RNA_chan;
pfam13965"
/db_xref="CDD:206135"
misc_feature 1242..1244
/gene="SIDT2"
/gene_synonym="CGI-40"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q8NBJ9.2); phosphorylation site"
misc_feature 1242..1244
/gene="SIDT2"
/gene_synonym="CGI-40"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1248..1250
/gene="SIDT2"
/gene_synonym="CGI-40"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q8NBJ9.2); phosphorylation site"
misc_feature 1248..1250
/gene="SIDT2"
/gene_synonym="CGI-40"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1251..1253
/gene="SIDT2"
/gene_synonym="CGI-40"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q8NBJ9.2); phosphorylation site"
misc_feature 1251..1253
/gene="SIDT2"
/gene_synonym="CGI-40"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1383..1445
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8NBJ9.2);
transmembrane region"
misc_feature 1539..1601
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8NBJ9.2);
transmembrane region"
misc_feature 1680..1742
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8NBJ9.2);
transmembrane region"
misc_feature 1857..1919
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8NBJ9.2);
transmembrane region"
misc_feature 1935..1997
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8NBJ9.2);
transmembrane region"
misc_feature 2106..2168
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8NBJ9.2);
transmembrane region"
misc_feature 2187..2249
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8NBJ9.2);
transmembrane region"
misc_feature 2280..2342
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8NBJ9.2);
transmembrane region"
misc_feature 2430..2492
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8NBJ9.2);
transmembrane region"
exon 225..346
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="alignment:Splign:1.39.8"
exon 347..511
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="alignment:Splign:1.39.8"
exon 512..557
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="alignment:Splign:1.39.8"
exon 558..659
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="alignment:Splign:1.39.8"
exon 660..743
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="alignment:Splign:1.39.8"
exon 744..843
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="alignment:Splign:1.39.8"
exon 844..909
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="alignment:Splign:1.39.8"
exon 910..1003
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="alignment:Splign:1.39.8"
exon 1004..1056
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="alignment:Splign:1.39.8"
exon 1057..1128
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="alignment:Splign:1.39.8"
exon 1129..1200
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="alignment:Splign:1.39.8"
exon 1201..1319
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="alignment:Splign:1.39.8"
exon 1320..1393
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="alignment:Splign:1.39.8"
exon 1394..1460
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="alignment:Splign:1.39.8"
exon 1461..1534
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="alignment:Splign:1.39.8"
exon 1535..1658
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="alignment:Splign:1.39.8"
exon 1659..1776
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="alignment:Splign:1.39.8"
exon 1777..1913
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="alignment:Splign:1.39.8"
exon 1914..2022
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="alignment:Splign:1.39.8"
exon 2023..2099
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="alignment:Splign:1.39.8"
exon 2100..2146
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="alignment:Splign:1.39.8"
exon 2147..2252
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="alignment:Splign:1.39.8"
exon 2253..2363
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="alignment:Splign:1.39.8"
exon 2364..2477
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="alignment:Splign:1.39.8"
exon 2478..3919
/gene="SIDT2"
/gene_synonym="CGI-40"
/inference="alignment:Splign:1.39.8"
STS 3623..3800
/gene="SIDT2"
/gene_synonym="CGI-40"
/standard_name="RH18240"
/db_xref="UniSTS:44500"
variation complement(3752)
/gene="SIDT2"
/gene_synonym="CGI-40"
/replace="g"
/replace="t"
/db_xref="dbSNP:11545338"
STS 3760..3875
/gene="SIDT2"
/gene_synonym="CGI-40"
/standard_name="D11S2284E"
/db_xref="UniSTS:151415"
polyA_site 3919
/gene="SIDT2"
/gene_synonym="CGI-40"
ORIGIN
gccgccgccaccaccgctgccactgccgccctgccggggccatgttcgctctgggcttgcccttcttggtgctcttggtggcctcggtcgagagccatctgggggttctggggcccaagaacgtctcgcagaaagacgccgagtttgagcgcacctacgtggacgaggtcaacagcgagctggtcaacatctacaccttcaaccatactgtgacccgcaacaggacagagggcgtgcgtgtgtctgtgaacgtcctgaacaagcagaagggggcgccgttgctgtttgtggtccgccagaaggaggctgtggtgtccttccaggtgcccctaatcctgcgagggatgtttcagcgcaagtacctctaccaaaaagtggaacgaaccctgtgtcagccccccaccaagaatgagtcggagattcagttcttctacgtggatgtgtccaccctgtcaccagtcaacaccacataccagctccgggtcagccgcatggacgattttgtgctcaggactggggagcagttcagcttcaataccacagcagcacagccccagtacttcaagtatgagttccctgaaggcgtggactcggtaattgtcaaggtgacctccaacaaggccttcccctgctcagtcatctccattcaggatgtgctgtgtcctgtctatgacctggacaacaacgtagccttcatcggcatgtaccagacgatgaccaagaaggcggccatcaccgtacagcgcaaagacttccccagcaacagcttttatgtggtggtggtggtgaagaccgaagaccaagcctgcgggggctccctgcctttctaccccttcgcagaagatgaaccggtcgatcaagggcaccgccagaaaaccctgtcagtgctggtgtctcaagcagtcacgtctgaggcatacgtcagtgggatgctcttttgcctgggtatatttctctccttttacctgctgaccgtcctcctggcctgctgggagaactggaggcagaagaagaagaccctgctggtggccattgaccgagcctgcccagaaagcggtcaccctcgagtcctggctgattcttttcctggcagttccccttatgagggttacaactatggctcctttgagaatgtttctggatctaccgatggtctggttgacagcgctggcactggggacctctcttacggttaccagggccgctcctttgaacctgtaggtactcggccccgagtggactccatgagctctgtggaggaggatgactacgacacattgaccgacatcgattccgacaagaatgtcattcgcaccaagcaatacctctatgtggctgacctggcacggaaggacaagcgtgttctgcggaaaaagtaccagatctacttctggaacattgccaccattgctgtcttctatgcccttcctgtggtgcagctggtgatcacctaccagacggtggtgaatgtcacagggaatcaggacatctgctactacaacttcctctgcgcccacccactgggcaatctcagcgccttcaacaacatcctcagcaacctggggtacatcctgctggggctgcttttcctgctcatcatcctgcaacgggagatcaaccacaaccgggccctgctgcgcaatgacctctgtgccctggaatgtgggatccccaaacactttgggcttttctacgccatgggcacagccctgatgatggaggggctgctcagtgcttgctatcatgtgtgccccaactataccaatttccagtttgacacatcgttcatgtacatgatcgccggactctgcatgctgaagctctaccagaagcggcacccggacatcaacgccagcgcctacagtgcctacgcctgcctggccattgtcatcttcttctctgtgctgggcgtggtctttggcaaagggaacacggcgttctggatcgtcttctccatcattcacatcatcgccaccctgctcctcagcacgcagctctattacatgggccggtggaaactggactcggggatcttccgccgcatcctccacgtgctctacacagactgcatccggcagtgcagcgggccgctctacgtggaccgcatggtgctgctggtcatgggcaacgtcatcaactggtcgctggctgcctatgggcttatcatgcgccccaatgatttcgcttcctacttgttggccattggcatctgcaacctgctcctttacttcgccttctacatcatcatgaagctccggagtggggagaggatcaagctcatccccctgctctgcatcgtttgcacctccgtggtctggggcttcgcgctcttcttcttcttccagggactcagcacctggcagaaaacccctgcagagtcgagggagcacaaccgggactgcatcctcctcgacttctttgacgaccacgacatctggcacttcctctcctccatcgccatgttcgggtccttcctggtgttgctgacactggatgacgacctggatactgtgcagcgggacaagatctatgtcttctagcaggagctgggcccttcgcttcacctcaaggggccctgagctcctttgtgtcatagaccggtcactctgtcgtgctgtggggatgagtcccagcaccgctgcccagcactggatggcagcaggacagccaggtctagcttaggcttggcctgggacagccatggggtggcatggaaccttgcagctgccctctgccgaggagcaggcctgctcccctggaacccccagatgttggccaaattgctgctttcttctcagtgttggggccttccatgggcccctgtcctttggctctccatttgtccctttgcaagaggaaggatggaagggacaccctccccatttcatgccttgcattttgcccgtcctcctccccacaatgccccagcctgggacctaaggcctctttttcctcccatactcccactccagggcctagtctggggcctgaatctctgtcctgtatcagggccccagttctctttgggctgtccctggctgccatcactgcccattccagtcagccaggatggatgggggtatgagattttgggggttggccagctggtgccagacttttggtgctaaggcctgcaaggggcctggggcagtgcgtattctcttccctctgacctgtgctcagggctggctctttagcaatgcgctcagcccaatttgagaaccgccttctgattcaagaggctgaattcagaggtcacctcttcatcccatcagctcccagactgatgccagcaccaggactggagggagaagcgcctcaccccttcccttccttctttccaggcccttagtcttgccaaaccccagctggtggcctttcagtgccattgacactgcccaagaatgtccaggggcaaaggagggatgatacagagttcagcccgttctgcctccacagctgtgggcaccccagtgcctaccttagaaaggggcttcaggaagggatgtgctgtttccctctacgtgcccagtcctagcctcgctctaggacccagggctggcttctaagtttccgtccagtcttcaggcaagttctgtgttagtcatgcacacacatacctatgaaaccttggagtttacaaagaattgccccagctctgggcaccctggccaccctggtccttggatccccttcgtcccacctggtccaccccagatgctgaggatgggggagctcaggcggggcctctgctttggggatgggaatgtgtttttctcccaaacttgtttttatagctctgcttgaagggctgggagatgaggtgggtctggatcttttctcagagcgtctccatgctatggttgcatttccgttttctatgaatgaatttgcattcaataaacaaccagactcagtt
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:51092 -> Molecular function: GO:0051033 [RNA transmembrane transporter activity] evidence: IEA
GeneID:51092 -> Biological process: GO:0016246 [RNA interference] evidence: IEA
GeneID:51092 -> Biological process: GO:0033227 [dsRNA transport] evidence: IEA
GeneID:51092 -> Cellular component: GO:0005765 [lysosomal membrane] evidence: IDA
GeneID:51092 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
by
@meso_cacase at
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