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2024-04-20 10:54:32, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001040181 2193 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens claudin domain containing 1 (CLDND1), transcript variant 1, mRNA. ACCESSION NM_001040181 VERSION NM_001040181.1 GI:93588613 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2193) AUTHORS Liu,Y., Sun,W., Zhang,K., Zheng,H., Ma,Y., Lin,D., Zhang,X., Feng,L., Lei,W., Zhang,Z., Guo,S., Han,N., Tong,W., Feng,X., Gao,Y. and Cheng,S. TITLE Identification of genes differentially expressed in human primary lung squamous cell carcinoma JOURNAL Lung Cancer 56 (3), 307-317 (2007) PUBMED 17316888 REMARK GeneRIF: A cDNA library consisting of 220 upregulated genes in tumour tissue was established and named as LSCC. Differential expression was confirmed in five of these genes, including IGFBP5, SQLE, RAP2B, CLDN1, and TBL1XR1. REFERENCE 2 (bases 1 to 2193) AUTHORS Lamesch,P., Li,N., Milstein,S., Fan,C., Hao,T., Szabo,G., Hu,Z., Venkatesan,K., Bethel,G., Martin,P., Rogers,J., Lawlor,S., McLaren,S., Dricot,A., Borick,H., Cusick,M.E., Vandenhaute,J., Dunham,I., Hill,D.E. and Vidal,M. TITLE hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes JOURNAL Genomics 89 (3), 307-315 (2007) PUBMED 17207965 REFERENCE 3 (bases 1 to 2193) AUTHORS Fayein,N.A., Stankoff,B., Auffray,C. and Devignes,M.D. TITLE Characterization of tissue expression and full-length coding sequence of a novel human gene mapping at 3q12.1 and transcribed in oligodendrocytes JOURNAL Gene 289 (1-2), 119-129 (2002) PUBMED 12036590 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB461184.1, AC021660.16, BC013610.1, EB386420.1 and AA811441.1. Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform a. Variants 1, 2, 3, and 6 all encode the same isoform. ##Evidence-Data-START## Transcript exon combination :: AK075367.1, BC022551.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-11 DB461184.1 1-11 12-12 AC021660.16 119164-119164 13-155 DB461184.1 13-155 156-1589 BC013610.1 1-1434 1590-2038 EB386420.1 279-727 2039-2193 AA811441.1 1-155 c FEATURES Location/Qualifiers source 1..2193 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="3" /map="3q12.1" gene 1..2193 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /note="claudin domain containing 1" /db_xref="GeneID:56650" /db_xref="HGNC:1322" exon 1..218 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /inference="alignment:Splign:1.39.8" exon 219..528 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /inference="alignment:Splign:1.39.8" variation 222..223 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /replace="a" /replace="c" /db_xref="dbSNP:11553645" variation 233 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /replace="c" /replace="g" /db_xref="dbSNP:11553648" CDS 237..998 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /note="isoform a is encoded by transcript variant 1; claudin domain containing 1 protein; claudin domain-containing protein 1; membrane protein GENX-3745" /codon_start=1 /product="claudin domain-containing protein 1 isoform a" /protein_id="NP_001035271.1" /db_xref="GI:93588614" /db_xref="CCDS:CCDS2930.1" /db_xref="GeneID:56650" /db_xref="HGNC:1322" /translation="
MDNRFATAFVIACVLSLISTIYMAASIGTDFWYEYRSPVQENSSDLNKSIWDEFISDEADEKTYNDALFRYNGTVGLWRRCITIPKNMHWYSPPERTESFDVVTKCVSFTLTEQFMEKFVDPGNHNSGIDLLRTYLWRCQFLLPFVSLGLMCFGALIGLCACICRSLYPTIATGILHLLAGLCTLGSVSCYVAGIELLHQKLELPDNVSGEFGWSFCLACVSAPLQFMASALFIWAAHTNRKEYTLMKAYRVA
"
misc_feature 249..311
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NY35.1);
transmembrane region"
misc_feature 285..938
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/note="PMP-22/EMP/MP20/Claudin tight junction; Region:
Claudin_2; pfam13903"
/db_xref="CDD:206074"
misc_feature 657..719
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NY35.1);
transmembrane region"
misc_feature 759..821
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NY35.1);
transmembrane region"
misc_feature 882..944
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NY35.1);
transmembrane region"
variation 247
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="g"
/db_xref="dbSNP:11553643"
variation 297
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="t"
/db_xref="dbSNP:11553647"
variation 313
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="c"
/replace="g"
/db_xref="dbSNP:11553642"
variation 337
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="g"
/db_xref="dbSNP:11553639"
variation 415
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="g"
/db_xref="dbSNP:11553646"
variation 482
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="c"
/db_xref="dbSNP:11553650"
exon 529..639
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="alignment:Splign:1.39.8"
exon 640..777
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="alignment:Splign:1.39.8"
variation 731
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="t"
/db_xref="dbSNP:11553641"
variation 734
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="c"
/replace="t"
/db_xref="dbSNP:35994971"
exon 778..2184
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="alignment:Splign:1.39.8"
variation 920
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="g"
/replace="t"
/db_xref="dbSNP:11553649"
STS 980..1070
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/standard_name="D3S2932E"
/db_xref="UniSTS:150916"
variation 1903
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="g"
/db_xref="dbSNP:11553644"
STS 1947..2149
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/standard_name="D3S3109"
/db_xref="UniSTS:80916"
polyA_signal 2151..2156
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
polyA_signal 2157..2162
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
polyA_site 2174
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
polyA_site 2184
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
ORIGIN
tatcgccgcctcagacagctttcagtctgtccctcctacaactcccacaaggcccctcggccccgggccgcggcccggcccggagtgggggcgggcggaggcgcgggagttatggagggggcgggctctgcagggaagtgcgtcagaggaggcgcggggagagtagggtgctgtggtctgagctagagggtgaagctggcggagcaggaggatgggcgagcagtctgaatgccagaatggataaccgttttgctacagcatttgtaattgcttgtgtgcttagcctcatttccaccatctacatggcagcctccattggcacagacttctggtatgaatatcgaagtccagttcaagaaaattccagtgatttgaataaaagcatctgggatgaattcattagtgatgaggcagatgaaaagacttataatgatgcactttttcgatacaatggcacagtgggattgtggagacggtgtatcaccatacccaaaaacatgcattggtatagcccaccagaaaggacagagtcatttgatgtggtcacaaaatgtgtgagtttcacactaactgagcagttcatggagaaatttgttgatcccggaaaccacaatagcgggattgatctccttaggacctatctttggcgttgccagttccttttaccttttgtgagtttaggtttgatgtgctttggggctttgatcggactttgtgcttgcatttgccgaagcttatatcccaccattgccacgggcattctccatctccttgcaggtctgtgtacactgggctcagtaagttgttatgttgctggaattgaactactccaccagaaactagagctccctgacaatgtatccggtgaatttggatggtccttctgcctggcttgtgtctctgctcccttacagttcatggcttctgctctcttcatctgggctgctcacaccaaccggaaagagtacaccttaatgaaggcatatcgtgtggcatgagcaagaaactgcctgctttacaattgccatttttatttttttaaaataatactgatattttccccacctctcaattgtttttaatttttatttgtggatataccattttattatgaaaatctattttatttatacacattcaccactaaatacacacttaataccactaaaatttatgtggtttactttaagcgatgccatctttcaaataaactaatctaggtctagacagaaagaaatggatagagacttgacacaaatttatgaaagaaaattgggagtaggaatgtgaccgaaaacaagttgtgctaatgtctgttagacttttcagtaaaactaaagtaactgtatctgttcaactaaaaactctatattagtttctttgggaaacctctcatcgtcaaaactttatgttcactttgctgttgtagatagccagtcaaccagcagtattagtgctgttttcaaagatttaagctctataaaattgggaaattatctaagatcattttccctaagcattgacacatagcttcatctgaggtgagatatggcagctgtttgtatctgcactgtgtctgtctacaaaaagtgaaaaatacagtgtttacttgaaattttaactttgtaactgcaagaattccagttcagccgggcgaggattagtattatttttaactctccgtaagattttcagtaccaccaaattgttttggattttttttctttcctcttcacataccagggttattaaaagtgtgctttctttttacattatattacagttacaaggtaaaattcctcaactgctatttatttattccagcccagtactataaagaacgtttcaccataatgaccctccagagctgggaaacctaccacaagatctaaagttctggctgtccattaacctccaactatggtctttatttcttgtggtaatatgatgtgcctttccttgcctaaatcccttcctggtgtgtatcaacattatttaatgtcttctaattcagtcatttttttataagtatgtctataaacattgaactttaaaaaacttatttatttattccactactgtagcaattgacagattaaaaaaatgtaacttcataatttcttaccataacctcaatgtcttttttaaaaaataaaattaaaaatgaaaagagactcaattgtaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:56650 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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