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2024-03-28 20:58:35, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001040021            1561 bp    mRNA    linear   PRI 15-JUL-2013
DEFINITION  Homo sapiens CD14 molecule (CD14), transcript variant 2, mRNA.
ACCESSION   NM_001040021
VERSION     NM_001040021.2  GI:291575161
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1561)
  AUTHORS   Ranoa,D.R., Kelley,S.L. and Tapping,R.I.
  TITLE     Human lipopolysaccharide-binding protein (LBP) and CD14
            independently deliver triacylated lipoproteins to Toll-like
            receptor 1 (TLR1) and TLR2 and enhance formation of the ternary
            signaling complex
  JOURNAL   J. Biol. Chem. 288 (14), 9729-9741 (2013)
   PUBMED   23430250
  REMARK    GeneRIF: Human lipopolysaccharide-binding protein (LBP) and CD14
            independently deliver triacylated lipoproteins to Toll-like
            receptor 1 (TLR1) and TLR2 and enhance formation of the ternary
            signaling complex
REFERENCE   2  (bases 1 to 1561)
  AUTHORS   Kelley,S.L., Lukk,T., Nair,S.K. and Tapping,R.I.
  TITLE     The crystal structure of human soluble CD14 reveals a bent solenoid
            with a hydrophobic amino-terminal pocket
  JOURNAL   J. Immunol. 190 (3), 1304-1311 (2013)
   PUBMED   23264655
  REMARK    GeneRIF: The x-ray crystal structure of human CD14 contains an
            expanded pocket and alternative rim residues that are likely to be
            important for LPS binding and cell activation.  .
REFERENCE   3  (bases 1 to 1561)
  AUTHORS   Guo,S., Al-Sadi,R., Said,H.M. and Ma,T.Y.
  TITLE     Lipopolysaccharide causes an increase in intestinal tight junction
            permeability in vitro and in vivo by inducing enterocyte membrane
            expression and localization of TLR-4 and CD14
  JOURNAL   Am. J. Pathol. 182 (2), 375-387 (2013)
   PUBMED   23201091
  REMARK    GeneRIF: These studies show for the first time that
            lipopolysaccharide causes an increase in intestinal permeability
            via an intracellular mechanism involving TLR-4-dependent
            up-regulation of CD14 membrane expression.
REFERENCE   4  (bases 1 to 1561)
  AUTHORS   Munthe-Kaas,M.C., Bertelsen,R.J., Torjussen,T.M., Hjorthaug,H.S.,
            Undlien,D.E., Lyle,R., Gervin,K., Granum,B., Mowinckel,P.,
            Carlsen,K.H. and Carlsen,K.C.
  TITLE     Pet keeping and tobacco exposure influence CD14 methylation in
            childhood
  JOURNAL   Pediatr Allergy Immunol 23 (8), 747-754 (2012)
   PUBMED   23194293
  REMARK    GeneRIF: Pet keeping and tobacco smoke exposure small were
            associated with a smaller increase in CD14 methylation during
            childhood and lower CD14 methylation at 10 yr., indicating a CD14
            gene-environemnt interaction.
REFERENCE   5  (bases 1 to 1561)
  AUTHORS   Sarvari,M., Hrabovszky,E., Kallo,I., Solymosi,N., Liko,I.,
            Berchtold,N., Cotman,C. and Liposits,Z.
  TITLE     Menopause leads to elevated expression of macrophage-associated
            genes in the aging frontal cortex: rat and human studies identify
            strikingly similar changes
  JOURNAL   J Neuroinflammation 9, 264 (2012)
   PUBMED   23206327
  REMARK    GeneRIF: This study analysis revealed up-regulation of CD14, CD18,
            CD45, TLR2, TLR4, CD74, C1q, C3, CCL2, and down-regulation of CD36,
            CX3CR1, CX3CL1 and CD200 in postmenopausal women
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1561)
  AUTHORS   Schumann,R.R., Leong,S.R., Flaggs,G.W., Gray,P.W., Wright,S.D.,
            Mathison,J.C., Tobias,P.S. and Ulevitch,R.J.
  TITLE     Structure and function of lipopolysaccharide binding protein
  JOURNAL   Science 249 (4975), 1429-1431 (1990)
   PUBMED   2402637
REFERENCE   7  (bases 1 to 1561)
  AUTHORS   Setoguchi,M., Nasu,N., Yoshida,S., Higuchi,Y., Akizuki,S. and
            Yamamoto,S.
  TITLE     Mouse and human CD14 (myeloid cell-specific leucine-rich
            glycoprotein) primary structure deduced from cDNA clones
  JOURNAL   Biochim. Biophys. Acta 1008 (2), 213-222 (1989)
   PUBMED   2472171
REFERENCE   8  (bases 1 to 1561)
  AUTHORS   Simmons,D.L., Tan,S., Tenen,D.G., Nicholson-Weller,A. and Seed,B.
  TITLE     Monocyte antigen CD14 is a phospholipid anchored membrane protein
  JOURNAL   Blood 73 (1), 284-289 (1989)
   PUBMED   2462937
REFERENCE   9  (bases 1 to 1561)
  AUTHORS   Ferrero,E. and Goyert,S.M.
  TITLE     Nucleotide sequence of the gene encoding the monocyte
            differentiation antigen, CD14
  JOURNAL   Nucleic Acids Res. 16 (9), 4173 (1988)
   PUBMED   2453848
REFERENCE   10 (bases 1 to 1561)
  AUTHORS   Goyert,S.M., Ferrero,E., Rettig,W.J., Yenamandra,A.K., Obata,F. and
            Le Beau,M.M.
  TITLE     The CD14 monocyte differentiation antigen maps to a region encoding
            growth factors and receptors
  JOURNAL   Science 239 (4839), 497-500 (1988)
   PUBMED   2448876
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA426297.1, BC010507.2 and
            W74441.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Mar 26, 2010 this sequence version replaced gi:91105158.
            
            Summary: The protein encoded by this gene is a surface antigen that
            is preferentially expressed on monocytes/macrophages. It cooperates
            with other proteins to mediate the innate immune response to
            bacterial lipopolysaccharide. Alternative splicing results in
            multiple transcript variants encoding the same protein. [provided
            by RefSeq, Mar 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1-4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA426297.1, BI517425.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-518               DA426297.1         1-518
            519-1544            BC010507.2         332-1357
            1545-1561           W74441.1           1-17                c
FEATURES             Location/Qualifiers
     source          1..1561
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..1561
                     /gene="CD14"
                     /note="CD14 molecule"
                     /db_xref="GeneID:929"
                     /db_xref="HGNC:1628"
                     /db_xref="MIM:158120"
     exon            1..171
                     /gene="CD14"
                     /inference="alignment:Splign:1.39.8"
     exon            172..295
                     /gene="CD14"
                     /inference="alignment:Splign:1.39.8"
     STS             221..504
                     /gene="CD14"
                     /standard_name="PMC148872P1"
                     /db_xref="UniSTS:271024"
     misc_feature    239..241
                     /gene="CD14"
                     /note="upstream in-frame stop codon"
     CDS             293..1420
                     /gene="CD14"
                     /note="monocyte differentiation antigen CD14; myeloid
                     cell-specific leucine-rich glycoprotein"
                     /codon_start=1
                     /product="monocyte differentiation antigen CD14 precursor"
                     /protein_id="NP_001035110.1"
                     /db_xref="GI:91105159"
                     /db_xref="CCDS:CCDS4232.1"
                     /db_xref="GeneID:929"
                     /db_xref="HGNC:1628"
                     /db_xref="MIM:158120"
                     /translation="
MERASCLLLLLLPLVHVSATTPEPCELDDEDFRCVCNFSEPQPDWSEAFQCVSAVEVEIHAGGLNLEPFLKRVDADADPRQYADTVKALRVRRLTVGAAQVPAQLLVGALRVLAYSRLKELTLEDLKITGTMPPLPLEATGLALSSLRLRNVSWATGRSWLAELQQWLKPGLKVLSIAQAHSPAFSCEQVRAFPALTSLDLSDNPGLGERGLMAALCPHKFPAIQNLALRNTGMETPTGVCAALAAAGVQPHSLDLSHNSLRATVNPSAPRCMWSSALNSLNLSFAGLEQVPKGLPAKLRVLDLSCNRLNRAPQPDELPEVDNLTLDGNPFLVPGTALPHEGSMNSGVVPACARSTLSVGVSGTLVLLQGARGFA
"
     sig_peptide     293..349
                     /gene="CD14"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     mat_peptide     350..1417
                     /gene="CD14"
                     /product="monocyte differentiation antigen CD14"
     misc_feature    416..559
                     /gene="CD14"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P08571.2);
                     Region: Ligand-binding pocket rim"
     misc_feature    539..646
                     /gene="CD14"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P08571.2);
                     Region: LRR 2"
     misc_feature    647..724
                     /gene="CD14"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P08571.2);
                     Region: LRR 3"
     misc_feature    725..808
                     /gene="CD14"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P08571.2);
                     Region: LRR 4"
     misc_feature    809..880
                     /gene="CD14"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P08571.2);
                     Region: LRR 5"
     misc_feature    881..964
                     /gene="CD14"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P08571.2);
                     Region: LRR 6"
     misc_feature    965..1045
                     /gene="CD14"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P08571.2);
                     Region: LRR 7"
     misc_feature    1046..1126
                     /gene="CD14"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P08571.2);
                     Region: LRR 8"
     misc_feature    1127..1189
                     /gene="CD14"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P08571.2);
                     Region: LRR 9"
     misc_feature    1190..1255
                     /gene="CD14"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P08571.2);
                     Region: LRR 10"
     misc_feature    1256..1339
                     /gene="CD14"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P08571.2);
                     Region: LRR 11"
     exon            296..1548
                     /gene="CD14"
                     /inference="alignment:Splign:1.39.8"
     variation       307
                     /gene="CD14"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3138079"
     STS             381..546
                     /gene="CD14"
                     /standard_name="RH17946"
                     /db_xref="UniSTS:4037"
     STS             482..908
                     /gene="CD14"
                     /standard_name="PMC108311P1"
                     /db_xref="UniSTS:270134"
     STS             712..1277
                     /gene="CD14"
                     /standard_name="PMC98826P1"
                     /db_xref="UniSTS:273681"
     variation       902
                     /gene="CD14"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2228049"
     STS             1105..1370
                     /gene="CD14"
                     /standard_name="PMC136845P1"
                     /db_xref="UniSTS:270804"
     variation       1153
                     /gene="CD14"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:13763"
     STS             1248..1334
                     /gene="CD14"
                     /standard_name="RH67904"
                     /db_xref="UniSTS:34631"
     STS             1283..1426
                     /gene="CD14"
                     /standard_name="RH11569"
                     /db_xref="UniSTS:73130"
     STS             1313..1464
                     /gene="CD14"
                     /standard_name="G62118"
                     /db_xref="UniSTS:139164"
     variation       1512
                     /gene="CD14"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:5744456"
     polyA_signal    1526..1531
                     /gene="CD14"
     variation       1540
                     /gene="CD14"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:3776138"
     polyA_site      1548
                     /gene="CD14"
ORIGIN      
aattctaccccccttggtgccaacagatgaggttcacaatctcttccacaaaacatgcagttaaatatctgaggatattcagggacttggatttggtggcaggagatcaacataaaccaagacaaggaagaagtcaaagaaatgaatcaagtagattctctgggatataagaggcagccgaagagttcacaagtgtgaagcctggaagccggcgggtgccgctgtgtaggaaagaagctaaagcacttccagagcctgtccggagctcagaggttcggaagacttatcgaccatggagcgcgcgtcctgcttgttgctgctgctgctgccgctggtgcacgtctctgcgaccacgccagaaccttgtgagctggacgatgaagatttccgctgcgtctgcaacttctccgaacctcagcccgactggtccgaagccttccagtgtgtgtctgcagtagaggtggagatccatgccggcggtctcaacctagagccgtttctaaagcgcgtcgatgcggacgccgacccgcggcagtatgctgacacggtcaaggctctccgcgtgcggcggctcacagtgggagccgcacaggttcctgctcagctactggtaggcgccctgcgtgtgctagcgtactcccgcctcaaggaactgacgctcgaggacctaaagataaccggcaccatgcctccgctgcctctggaagccacaggacttgcactttccagcttgcgcctacgcaacgtgtcgtgggcgacagggcgttcttggctcgccgagctgcagcagtggctcaagccaggcctcaaggtactgagcattgcccaagcacactcgcctgccttttcctgcgaacaggttcgcgccttcccggcccttaccagcctagacctgtctgacaatcctggactgggcgaacgcggactgatggcggctctctgtccccacaagttcccggccatccagaatctagcgctgcgcaacacaggaatggagacgcccacaggcgtgtgcgccgcactggcggcggcaggtgtgcagccccacagcctagacctcagccacaactcgctgcgcgccaccgtaaaccctagcgctccgagatgcatgtggtccagcgccctgaactccctcaatctgtcgttcgctgggctggaacaggtgcctaaaggactgccagccaagctcagagtgctcgatctcagctgcaacagactgaacagggcgccgcagcctgacgagctgcccgaggtggataacctgacactggacgggaatcccttcctggtccctggaactgccctcccccacgagggctcaatgaactccggcgtggtcccagcctgtgcacgttcgaccctgtcggtgggggtgtcgggaaccctggtgctgctccaaggggcccggggctttgcctaagatccaagacagaataatgaatggactcaaactgccttggcttcaggggagtcccgtcaggacgttgaggacttttcgaccaattcaaccctttgccccacctttattaaaatcttaaacaacgggtcaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:929 -> Molecular function: GO:0001530 [lipopolysaccharide binding] evidence: IDA
            GeneID:929 -> Molecular function: GO:0001847 [opsonin receptor activity] evidence: TAS
            GeneID:929 -> Molecular function: GO:0016019 [peptidoglycan receptor activity] evidence: TAS
            GeneID:929 -> Molecular function: GO:0070891 [lipoteichoic acid binding] evidence: IDA
            GeneID:929 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS
            GeneID:929 -> Biological process: GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] evidence: TAS
            GeneID:929 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS
            GeneID:929 -> Biological process: GO:0006909 [phagocytosis] evidence: TAS
            GeneID:929 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:929 -> Biological process: GO:0006954 [inflammatory response] evidence: IEA
            GeneID:929 -> Biological process: GO:0007166 [cell surface receptor signaling pathway] evidence: TAS
            GeneID:929 -> Biological process: GO:0007249 [I-kappaB kinase/NF-kappaB cascade] evidence: TAS
            GeneID:929 -> Biological process: GO:0009408 [response to heat] evidence: IEA
            GeneID:929 -> Biological process: GO:0032760 [positive regulation of tumor necrosis factor production] evidence: IDA
            GeneID:929 -> Biological process: GO:0034134 [toll-like receptor 2 signaling pathway] evidence: TAS
            GeneID:929 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS
            GeneID:929 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS
            GeneID:929 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS
            GeneID:929 -> Biological process: GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] evidence: TAS
            GeneID:929 -> Biological process: GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] evidence: TAS
            GeneID:929 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:929 -> Biological process: GO:0045807 [positive regulation of endocytosis] evidence: IEA
            GeneID:929 -> Biological process: GO:0050715 [positive regulation of cytokine secretion] evidence: IEA
            GeneID:929 -> Biological process: GO:0071222 [cellular response to lipopolysaccharide] evidence: IDA
            GeneID:929 -> Biological process: GO:0071223 [cellular response to lipoteichoic acid] evidence: IDA
            GeneID:929 -> Cellular component: GO:0005576 [extracellular region] evidence: TAS
            GeneID:929 -> Cellular component: GO:0005615 [extracellular space] evidence: IEA
            GeneID:929 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
            GeneID:929 -> Cellular component: GO:0009986 [cell surface] evidence: IEA
            GeneID:929 -> Cellular component: GO:0010008 [endosome membrane] evidence: TAS
            GeneID:929 -> Cellular component: GO:0031225 [anchored to membrane] evidence: IEA
            GeneID:929 -> Cellular component: GO:0045121 [membrane raft] evidence: IEA

by @meso_cacase at DBCLS
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