LOCUS       NM_001039548            1952 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens kelch-like family member 35 (KLHL35), mRNA.
ACCESSION   NM_001039548
VERSION     NM_001039548.2  GI:259013519
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1952)
  AUTHORS   Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
            Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
            Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
            Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
            Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
            Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
            Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
            Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
            Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
            Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
            Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
            Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
            Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
            Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
            Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
            Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
            Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
            Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
            Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
            Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
            Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
            Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
            Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
            Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
            Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
            Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
            Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
            Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
            Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat. Genet. 36 (1), 40-45 (2004)
   PUBMED   14702039
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000744.4 and BC042952.2.
            On Sep 22, 2009 this sequence version replaced gi:88196793.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042952.2, BC057763.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-459               AP000744.4         120781-121239       c
            460-1952            BC042952.2         1-1493
FEATURES             Location/Qualifiers
     source          1..1952
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..1952
                     /gene="KLHL35"
                     /note="kelch-like family member 35"
                     /db_xref="GeneID:283212"
                     /db_xref="HGNC:26597"
     CDS             1..1752
                     /gene="KLHL35"
                     /note="kelch-like 35"
                     /codon_start=1
                     /product="kelch-like protein 35"
                     /protein_id="NP_001034637.2"
                     /db_xref="GI:259013520"
                     /db_xref="CCDS:CCDS44685.2"
                     /db_xref="GeneID:283212"
                     /db_xref="HGNC:26597"
                     /translation="

MRQGHAPEESEPGCEAPCAGPCHAQRVLQALNAYRRSGTLTDVVLRAGGRDFPCHRAALSAGSAYFRSLFAAGRPERGPAVVPVVPVAPEAPGTSPAGAAAALAVVLDYVYGAGVRLRAEDEAAAVLALAERLGVAGLREACVRFLEGRLRAANSLALRRVAAAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVVALLADPALGVAREEAVFEAAMRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFILGREAGALRTRPRRFMDLAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTRSEFAACALRNDVYVSGGHINSHDVWMFSSHLHTWIKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGGVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGGLMSKIFTYDPGTDVWGEAAVLPSPVESCGVTVCDGKVHILGGRDDRGESTDKVFTFDPSSGQVEVQPSLQRCTSSHGCVTIIQSLGR

"
     misc_feature    91..>210
                     /gene="KLHL35"
                     /note="BTB/POZ domain; Region: BTB; pfam00651"
                     /db_xref="CDD:201372"
     misc_feature    493..765
                     /gene="KLHL35"
                     /note="BTB And C-terminal Kelch; Region: BACK; smart00875"
                     /db_xref="CDD:197943"
     misc_feature    901..1050
                     /gene="KLHL35"
                     /note="Kelch domain; Region: Kelch; smart00612"
                     /db_xref="CDD:128874"
     misc_feature    1018..1140
                     /gene="KLHL35"
                     /note="Kelch motif; Region: Kelch_1; pfam01344"
                     /db_xref="CDD:201739"
     misc_feature    1150..1263
                     /gene="KLHL35"
                     /note="Kelch motif; Region: Kelch_1; pfam01344"
                     /db_xref="CDD:201739"
     misc_feature    <1321..1410
                     /gene="KLHL35"
                     /note="Kelch motif; Region: Kelch_1; pfam01344"
                     /db_xref="CDD:201739"
     misc_feature    1471..1593
                     /gene="KLHL35"
                     /note="Galactose oxidase, central domain; Region: Kelch_3;
                     cl02701"
                     /db_xref="CDD:207702"
     misc_feature    1567..1698
                     /gene="KLHL35"
                     /note="Galactose oxidase, central domain; Region: Kelch_3;
                     cl02701"
                     /db_xref="CDD:207702"
     exon            1..881
                     /gene="KLHL35"
                     /inference="alignment:Splign:1.39.8"
     STS             585..1609
                     /gene="KLHL35"
                     /db_xref="UniSTS:490036"
     exon            882..1066
                     /gene="KLHL35"
                     /inference="alignment:Splign:1.39.8"
     exon            1067..1185
                     /gene="KLHL35"
                     /inference="alignment:Splign:1.39.8"
     exon            1186..1374
                     /gene="KLHL35"
                     /inference="alignment:Splign:1.39.8"
     exon            1375..1563
                     /gene="KLHL35"
                     /inference="alignment:Splign:1.39.8"
     exon            1564..1938
                     /gene="KLHL35"
                     /inference="alignment:Splign:1.39.8"
     variation       1611
                     /gene="KLHL35"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11539810"
ORIGIN      

atgcggcaaggccatgcgccggaggagtcggagccgggctgcgaagcgccgtgcgcgggtccgtgccacgcgcagcgcgtgctgcaggccctgaacgcctaccggcggagcggcaccctcaccgacgtggtgctgcgcgccggcgggcgcgactttccgtgccaccgcgcggcgctcagcgcgggcagcgcctacttccgcagcttgttcgcggccgggcggcccgagcgcggcccggccgtggtgccagtggtgccagtagctcccgaggcgccaggcacgagcccggccggggcggcggcggcgctggccgtggtgctcgactacgtgtacggagcgggcgtgcggctgcgcgcggaggacgaggcggcggccgtgctggcgctggcggagcggctgggcgtggcgggcctgcgcgaggcctgcgtgcgctttctcgagggccgcctgcgcgccgccaacagcctagcgctgcgccgcgtggccgccgccttctcgctggccccgctggccgagcgctgcggccgcgtcctgcgtcaggccttcgccgaggtggcgcgccacgccgacttcctggagctggcgcctgacgaggtggtggcgctgctggcggaccccgcgctgggcgtggcgcgcgaggaggccgtgtttgaagcggccatgcgctgggtgcgccacgacgcgccggcccgccgcggccagctgcgacgcctgctggagcacgtgcgcctgccgctactggcgcccgcttacttcctggagaaggtggaggcggacgagctgctgcaggcctgcggcgagtgccgcccgctgctgctcgaggctcgcgcctgcttcatcctgggccgcgaggccggtgcgctgcggacccggccgcggagattcatggacctagctgaagtgatcgtggtcatcggcggttgcgaccgcaaaggtctcctgaagctgcccttcgccgatgcctaccatccagagagccagcggtggaccccactgcccagcctgcccggctacactcgctcagaattcgccgcctgtgctctccgcaatgacgtctacgtctccggaggccacatcaacagtcatgatgtgtggatgtttagctcccatctgcacacctggatcaaggtagcctctctgcacaagggcaggtggaggcacaagatggcagttgtgcaggggcagctgttcgcggtgggtggcttcgacggcctgaggcgcctgcacagcgtggagcgctacgaccccttctccaacacctgggcggccgccgcgcccctcccggaggccgtgagctcggcggcggtggcgtcctgcgcgggcaagctcttcgtgattgggggcgccaggcagggcggcgtcaacacggacaaggtgcagtgctttgaccccaaggaggaccggtggagcctgcggtcaccagcacccttctcacagcggtgtctcgaggctgtctcccttgaggacaccatctatgtcatggggggtctcatgagcaaaatcttcacctatgatccaggcacagatgtgtggggggaggcagctgtcctccccagccctgtggaaagctgtggagtcactgtgtgtgacgggaaggtccacatccttggcgggcgggatgatcgcggagaaagcaccgataaggtcttcacctttgaccccagcagtgggcaggtggaggtccagccatccctgcagcgctgcaccagctcccacggctgtgtcaccatcatccagagcttgggcaggtgattcagatttggacagcctgagccaggaggcggagaggcaggcggagctcagatgcacactctgctccctcatggcacctccacgcaaacagcccttaacttaatggtcccttttcttgtataaataaaatcttgttgggtctgtgttccagctgcagtctgccctgcctggagatggaatgtctaaaaaaaaaaaaaaaa

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