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2024-04-20 13:05:45, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001034914 2735 bp mRNA linear PRI 09-JUN-2013
DEFINITION Homo sapiens Kv channel interacting protein 3, calsenilin (KCNIP3),
transcript variant 2, mRNA.
ACCESSION NM_001034914
VERSION NM_001034914.1 GI:78190494
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2735)
AUTHORS Holliday,K.L., McBeth,J., Macfarlane,G., Huhtaniemi,I.T.,
Bartfai,G., Casanueva,F.F., Forti,G., Kula,K., Punab,M.,
Vanderschueren,D., Wu,F.C. and Thomson,W.
TITLE Investigating the role of pain-modulating pathway genes in
musculoskeletal pain
JOURNAL Eur J Pain 17 (1), 28-34 (2013)
PUBMED 22730276
REMARK GeneRIF: Genetic variation in the DREAM pathway genes was
associated with the extent of pain reporting in a population-based
cohort.
REFERENCE 2 (bases 1 to 2735)
AUTHORS Quaas,M., Muller,G.A. and Engeland,K.
TITLE p53 can repress transcription of cell cycle genes through a
p21(WAF1/CIP1)-dependent switch from MMB to DREAM protein complex
binding at CHR promoter elements
JOURNAL Cell Cycle 11 (24), 4661-4672 (2012)
PUBMED 23187802
REMARK GeneRIF: p53 can repress transcription of cell cycle genes through
a p21(WAF1/CIP1)-dependent switch from MMB to DREAM protein complex
binding at CHR promoter elements.
REFERENCE 3 (bases 1 to 2735)
AUTHORS Ramachandran,P.L., Craig,T.A., Atanasova,E.A., Cui,G., Owen,B.A.,
Bergen,H.R. III, Mer,G. and Kumar,R.
TITLE The potassium channel interacting protein 3 (DREAM/KChIP3)
heterodimerizes with and regulates calmodulin function
JOURNAL J. Biol. Chem. 287 (47), 39439-39448 (2012)
PUBMED 23019329
REMARK GeneRIF: The potassium channel interacting protein 3 (DREAM/KChIP3)
heterodimerizes with and regulates calmodulin function.
REFERENCE 4 (bases 1 to 2735)
AUTHORS Jang,C., Choi,J.K., Na,Y.J., Jang,B., Wasco,W., Buxbaum,J.D.,
Kim,Y.S. and Choi,E.K.
TITLE Calsenilin regulates presenilin 1/gamma-secretase-mediated
N-cadherin epsilon-cleavage and beta-catenin signaling
JOURNAL FASEB J. 25 (12), 4174-4183 (2011)
PUBMED 21852538
REMARK GeneRIF: expression of calsenilin leads to a disruption of
presenilin 1/gamma-secretase-mediated epsilon-cleavage of
N-cadherin, which results in the significant accumulation of
N-cadherin C-terminal fragment 1
REFERENCE 5 (bases 1 to 2735)
AUTHORS Nor Rashid,N., Yusof,R. and Watson,R.J.
TITLE Disruption of repressive p130-DREAM complexes by human
papillomavirus 16 E6/E7 oncoproteins is required for cell-cycle
progression in cervical cancer cells
JOURNAL J. Gen. Virol. 92 (PT 11), 2620-2627 (2011)
PUBMED 21813705
REMARK GeneRIF: The results show that continued human papillomavirus 16
E6/E7 expression is necessary in cervical cancer cells to prevent
cell-cycle arrest by a repressive p130-DREAM complex.
REFERENCE 6 (bases 1 to 2735)
AUTHORS Leissring,M.A., Yamasaki,T.R., Wasco,W., Buxbaum,J.D., Parker,I.
and LaFerla,F.M.
TITLE Calsenilin reverses presenilin-mediated enhancement of calcium
signaling
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 97 (15), 8590-8593 (2000)
PUBMED 10900016
REFERENCE 7 (bases 1 to 2735)
AUTHORS An,W.F., Bowlby,M.R., Betty,M., Cao,J., Ling,H.P., Mendoza,G.,
Hinson,J.W., Mattsson,K.I., Strassle,B.W., Trimmer,J.S. and
Rhodes,K.J.
TITLE Modulation of A-type potassium channels by a family of calcium
sensors
JOURNAL Nature 403 (6769), 553-556 (2000)
PUBMED 10676964
REFERENCE 8 (bases 1 to 2735)
AUTHORS Carrion,A.M., Link,W.A., Ledo,F., Mellstrom,B. and Naranjo,J.R.
TITLE DREAM is a Ca2+-regulated transcriptional repressor
JOURNAL Nature 398 (6722), 80-84 (1999)
PUBMED 10078534
REFERENCE 9 (bases 1 to 2735)
AUTHORS Carrion,A.M., Mellstrom,B. and Naranjo,J.R.
TITLE Protein kinase A-dependent derepression of the human prodynorphin
gene via differential binding to an intragenic silencer element
JOURNAL Mol. Cell. Biol. 18 (12), 6921-6929 (1998)
PUBMED 9819380
REFERENCE 10 (bases 1 to 2735)
AUTHORS Buxbaum,J.D., Choi,E.K., Luo,Y., Lilliehook,C., Crowley,A.C.,
Merriam,D.E. and Wasco,W.
TITLE Calsenilin: a calcium-binding protein that interacts with the
presenilins and regulates the levels of a presenilin fragment
JOURNAL Nat. Med. 4 (10), 1177-1181 (1998)
PUBMED 9771752
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DQ148486.1 and BC012850.1.
Summary: This gene encodes a member of the family of voltage-gated
potassium (Kv) channel-interacting proteins, which belong to the
recoverin branch of the EF-hand superfamily. Members of this family
are small calcium binding proteins containing EF-hand-like domains.
They are integral subunit components of native Kv4 channel
complexes that may regulate A-type currents, and hence neuronal
excitability, in response to changes in intracellular calcium. The
encoded protein also functions as a calcium-regulated
transcriptional repressor, and interacts with presenilins.
Alternatively spliced transcript variants encoding different
isoforms have been described. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (2) includes an alternate in-frame
segment in the 5' coding region and uses a downstream start codon,
compared to variant 1. The resulting protein (isoform 2) is shorter
and has a unique N-terminus, compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: DQ148486.1, AL540923.3 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025085 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-693 DQ148486.1 1-693
694-850 BC012850.1 806-962
851-2735 BC012850.1 965-2849
FEATURES Location/Qualifiers
source 1..2735
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q21.1"
gene 1..2735
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/note="Kv channel interacting protein 3, calsenilin"
/db_xref="GeneID:30818"
/db_xref="HGNC:15523"
/db_xref="HPRD:05232"
/db_xref="MIM:604662"
CDS 1..693
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/note="isoform 2 precursor is encoded by transcript
variant 2; calsenilin, presenilin-binding protein, EF hand
transcription factor; DRE-antagonist modulator; A-type
potassium channel modulatory protein 3; potassium channel
interacting protein 3; kv channel-interacting protein 3"
/codon_start=1
/product="calsenilin isoform 2 precursor"
/protein_id="NP_001030086.1"
/db_xref="GI:78190495"
/db_xref="CCDS:CCDS33245.1"
/db_xref="GeneID:30818"
/db_xref="HGNC:15523"
/db_xref="HPRD:05232"
/db_xref="MIM:604662"
/translation="
MGIQGMELCAMAVVVLLFIAVLKQFGILEPISMEDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYAQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGYITKEEMLAIMKSIYDMMGRHTYPILREDAPAEHVERFFEKMDRNQDGVVTIEEFLEACQKDENIMSSMQLFENVI
"
sig_peptide 1..84
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
misc_feature 112..114
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:02799"
misc_feature 157..657
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/note="Ca2+-binding protein (EF-Hand superfamily) [Signal
transduction mechanisms / Cytoskeleton / Cell division and
chromosome partitioning / General function prediction
only]; Region: FRQ1; COG5126"
/db_xref="CDD:34727"
misc_feature 310..498
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/note="EF-hand, calcium binding motif; A diverse
superfamily of calcium sensors and calcium signal
modulators; most examples in this alignment model have 2
active canonical EF hands. Ca2+ binding induces a
conformational change in the EF-hand motif, leading to...;
Region: EFh; cd00051"
/db_xref="CDD:28933"
misc_feature order(337..339,343..345,349..351,370..372,445..447,
451..453,457..459,478..480)
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28933"
misc_feature 418..636
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/note="EF-hand, calcium binding motif; A diverse
superfamily of calcium sensors and calcium signal
modulators; most examples in this alignment model have 2
active canonical EF hands. Ca2+ binding induces a
conformational change in the EF-hand motif, leading to...;
Region: EFh; cd00051"
/db_xref="CDD:28933"
misc_feature order(445..447,451..453,457..459,478..480,589..591,
595..597,601..603,622..624)
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28933"
exon 1..103
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/inference="alignment:Splign:1.39.8"
exon 104..228
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/inference="alignment:Splign:1.39.8"
variation 111
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:368408153"
variation 112
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:199867139"
variation 139
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:199540663"
variation 140
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:370915474"
STS 145..271
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/standard_name="MARC_13819-13820:1006878275:1"
/db_xref="UniSTS:267569"
STS 177..275
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/standard_name="MARC_16025-16026:1017084488:1"
/db_xref="UniSTS:267937"
variation 181
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:145627120"
variation 183
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:374545956"
STS 187..541
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/standard_name="Kcnip3"
/db_xref="UniSTS:478921"
variation 204
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="g"
/replace="t"
/db_xref="dbSNP:368795741"
exon 229..298
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/inference="alignment:Splign:1.39.8"
variation 239
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:141060640"
variation 276
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:187761251"
variation 278
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:35658670"
variation 293..294
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace=""
/replace="g"
/db_xref="dbSNP:35743633"
exon 299..369
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/inference="alignment:Splign:1.39.8"
variation 309
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:138182369"
variation 341
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:199875087"
variation 342
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:374058648"
variation 346
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:144496841"
variation 351
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:376244075"
exon 370..477
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/inference="alignment:Splign:1.39.8"
variation 379
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="g"
/replace="t"
/db_xref="dbSNP:141755482"
variation 441
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="g"
/db_xref="dbSNP:147356740"
variation 444
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:145007185"
variation 445
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:148795481"
variation 464
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="c"
/db_xref="dbSNP:151292265"
exon 478..582
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/inference="alignment:Splign:1.39.8"
variation 480
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="g"
/db_xref="dbSNP:146570394"
variation 481
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="t"
/db_xref="dbSNP:368098567"
variation 492
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:371878238"
variation 504
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:113278660"
variation 539
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201212949"
variation 549
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:370900651"
variation 551
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:367742048"
variation 552
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:200368654"
variation 555
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:138092705"
exon 583..645
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/inference="alignment:Splign:1.39.8"
variation 613
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="c"
/db_xref="dbSNP:373974351"
exon 646..2721
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/inference="alignment:Splign:1.39.8"
variation 685
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:143143467"
variation 696
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="g"
/db_xref="dbSNP:375950494"
STS 697..872
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/standard_name="D2S2159"
/db_xref="UniSTS:9796"
variation 709
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:369341853"
variation 710
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="g"
/replace="t"
/db_xref="dbSNP:201316906"
variation 760..761
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace=""
/replace="t"
/db_xref="dbSNP:34912974"
variation 813..816
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace=""
/replace="ac"
/db_xref="dbSNP:375367798"
variation 814..815
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace=""
/replace="ac"
/db_xref="dbSNP:72135616"
variation 821..822
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace=""
/replace="ac"
/replace="cacacacaca"
/db_xref="dbSNP:10656976"
variation 823..824
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace=""
/replace="ca"
/replace="cacaca"
/db_xref="dbSNP:67633424"
variation 850..851
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace=""
/replace="ca"
/replace="cacaca"
/db_xref="dbSNP:58903840"
variation 950
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="g"
/db_xref="dbSNP:149210524"
variation 955
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:143382219"
variation 962
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:6730587"
variation 1045..1046
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace=""
/replace="g"
/db_xref="dbSNP:35454355"
variation 1074
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:376247477"
variation 1478
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="g"
/replace="t"
/db_xref="dbSNP:190606635"
variation 1584
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:374641024"
variation 1593
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:368385894"
STS 1656..1780
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/standard_name="RH18424"
/db_xref="UniSTS:58637"
variation 1712
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="c"
/db_xref="dbSNP:115648949"
variation 1815
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:183191177"
variation 1884
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:371897976"
variation 1916
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:373407358"
variation 2005
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:376849218"
variation 2137
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:185608702"
variation 2202
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:115884085"
variation 2389
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:3732333"
variation 2437
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:140694377"
variation 2502
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="g"
/replace="t"
/db_xref="dbSNP:15981"
variation 2518
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="c"
/db_xref="dbSNP:17119268"
variation 2626
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:367927662"
variation 2638
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:371747275"
polyA_signal 2699..2704
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
polyA_signal 2704..2709
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
polyA_site 2721
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
ORIGIN
atgggcatccagggcatggagctgtgcgccatggccgtggtggtgctgctgttcatcgccgtcctcaagcagttcggcatcctggagcccatatccatggaagatagcagcgacagtgagctggagctgtccacggtgcgccaccagccagaggggctggaccagctgcaggcccagaccaagttcaccaagaaggagctgcagtctctctacaggggctttaagaatgagtgtcccacgggcctggtggacgaagacaccttcaaactcatttacgcgcagttcttccctcagggagatgccaccacctatgcacacttcctcttcaacgcctttgatgcggacgggaacggggccatccactttgaggactttgtggttggcctctccatcctgctgcggggcacagtccacgagaagctcaagtgggcctttaatctctacgacattaacaaggatggctacatcaccaaagaggagatgctggccatcatgaagtccatctatgacatgatgggccgccacacctaccccatcctgcgggaggacgcgccggcggagcacgtggagaggttcttcgagaaaatggaccggaaccaggatggggtagtgaccattgaagagttcctggaggcctgtcagaaggatgagaacatcatgagctccatgcagctgtttgagaatgtcatctaggacacgtccaaaggagtgcatggccacagccacctccacccccaagaaacctccatcctgccaggagcagcctccaagaaacttttaaaaaatagatttgcaaaaagtgaacagattgctacacacacacacacacacacacacacacacacacacagccattcatctgggctggcagaggggacagagttcagggaggggctgagtctggctaggggccgagtccaggagccccagccagcccttcccaggccagcgaggcgaggctgcctctgggtgagtggctgacagagcaggtctgcaggccaccagctgctggatgtcaccaagaaggggctcgagtgcccctgcaggggagggtccaatctccggtgtgagcccacctcgtcccgttctccattctgctttcttgccacacagtgggccggccccaggctcccctggtctcctccccgtagccactctctgcccactacctatgcttctagaaagcccctcacctcaggaccccagagggaccagctggggggcaggggggagagggggtaatggaggccaagcctgcagctttctggaaattcttccctgggggtcccaggatcccctgctactccactgacctggaagagctgggtaccaggccacccactgtggggcaagcctgagtggtgaggggccactgggccccattctccctccatggcaggaaggcgggggatttcaagtttagggattgggtcgtggtggagaatctgagggcactctctgccagctccacagggtgggatgagcctctccttgccccagtcctggttcagtgggaatgcagtgggtggggctgtacacaccctccagcacagactgttccctccaaggtcctcttaggtcccgggaggaacgtggttcagagactggcagccagggagcccggggcagagctcagaggagtctgggaaggggcgtgtccctcctcttcctgtagtgcccctcccatggcccagcagcttggctgagccccctctcctgaagcagtgtcgccgtccctctgccttgcacaaaaagcacaagcattccttagcagctcaggcgcagccctagtgggagcccagcacactgcttctcggaggccaggccctcctgctggctgaggcttgggcccagtagccccaatatggtggccctggggaagaggccttgggggtctgctctgtgcctgggatcagtggggccccaaagcccagcccggctgaccaacattcaaaagcacaaaccctggggactctgcttggctgtcccctccatctggggatggagaatgccagcccaaagctggagccaatggtgagggctgagagggctgtggctgggtggtcagcagaaacccccaggaggagagagatgctgctcccgcctgattggggcctcacccagaaggaacccggtcccaggccgcatggcccctccaggaacattcccacataatacattccatcacagccagcccagctccactcagggctggcccggggagtccccgtgtgccccaagaggctagccccagggtgagcagggccctcagaggaaaggcagtatggcggaggccatgggggcccctcggcattcacacacagcctggcctcccctgcggagctgcatggacgcctggctccaggctccaggctgactgggggcctctgcctccaggagggcatcagctttccctggctcagggatcttctccctcccctcacccgctgcccagccctcccagctggtgtcactctgcctctaaggccaaggcctcaggagagcatcaccaccacacccctgccggccttggccttggggccagactggctgcacagcccaaccaggaggggtctgcctcccacgctgggacacagaccggccgcatgtctgcatggcagaagcgtctcccttggccacggcctgggagggtggttcctgttctcagcatccactaatattcagtcctgtatattttaataaaataaacttgacaaaggaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:30818 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:30818 -> Molecular function: GO:0003714 [transcription corepressor activity] evidence: TAS
GeneID:30818 -> Molecular function: GO:0005244 [voltage-gated ion channel activity] evidence: IEA
GeneID:30818 -> Molecular function: GO:0005267 [potassium channel activity] evidence: IEA
GeneID:30818 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IEA
GeneID:30818 -> Molecular function: GO:0008022 [protein C-terminus binding] evidence: IEA
GeneID:30818 -> Molecular function: GO:0015459 [potassium channel regulator activity] evidence: IEA
GeneID:30818 -> Molecular function: GO:0048306 [calcium-dependent protein binding] evidence: IEA
GeneID:30818 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IEA
GeneID:30818 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:30818 -> Biological process: GO:0006357 [regulation of transcription from RNA polymerase II promoter] evidence: TAS
GeneID:30818 -> Biological process: GO:0006886 [intracellular protein transport] evidence: IEA
GeneID:30818 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:30818 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:30818 -> Biological process: GO:0007610 [behavior] evidence: IEA
GeneID:30818 -> Biological process: GO:0019233 [sensory perception of pain] evidence: IEA
GeneID:30818 -> Biological process: GO:0043523 [regulation of neuron apoptotic process] evidence: IEA
GeneID:30818 -> Biological process: GO:0048265 [response to pain] evidence: IEA
GeneID:30818 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:30818 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IEA
GeneID:30818 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IEA
GeneID:30818 -> Cellular component: GO:0005829 [cytosol] evidence: IEA
GeneID:30818 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
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DBCLS
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