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2024-04-20 14:54:14, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001033925 3945 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens TIA1 cytotoxic granule-associated RNA binding
protein-like 1 (TIAL1), transcript variant 2, mRNA.
ACCESSION NM_001033925
VERSION NM_001033925.1 GI:77695911
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3945)
AUTHORS Singh,N.N., Seo,J., Ottesen,E.W., Shishimorova,M., Bhattacharya,D.
and Singh,R.N.
TITLE TIA1 prevents skipping of a critical exon associated with spinal
muscular atrophy
JOURNAL Mol. Cell. Biol. 31 (5), 935-954 (2011)
PUBMED 21189287
REMARK GeneRIF: TIA1 and TIAR proteins are intron-associated positive
regulators of SMN2 exon 7 splicing.
REFERENCE 2 (bases 1 to 3945)
AUTHORS Gottschald,O.R., Malec,V., Krasteva,G., Hasan,D., Kamlah,F.,
Herold,S., Rose,F., Seeger,W. and Hanze,J.
TITLE TIAR and TIA-1 mRNA-binding proteins co-aggregate under conditions
of rapid oxygen decline and extreme hypoxia and suppress the
HIF-1alpha pathway
JOURNAL J Mol Cell Biol 2 (6), 345-356 (2010)
PUBMED 20980400
REMARK GeneRIF: Severe hypoxia caused co-aggregation of TIAR/TIA-1 and
these proteins suppressed HIF-1alpha expression.
REFERENCE 3 (bases 1 to 3945)
AUTHORS Bossowski,A., Czarnocka,B., Bardadin,K., Moniuszko,A.,
Lyczkowska,A., Czerwinska,J., Dadan,J. and Bossowska,A.
TITLE Identification of chosen apoptotic (TIAR and TIA-1) markers
expression in thyroid tissues from adolescents with immune and
non-immune thyroid diseases
JOURNAL Folia Histochem. Cytobiol. 48 (2), 178-184 (2010)
PUBMED 20675271
REMARK GeneRIF: Data show that apoptotic (TIAR and TIA-1) marker
expression in thyroid tissues from adolescents with immune thyroid
diseases is higher than in non-immune thyroid diseases.
REFERENCE 4 (bases 1 to 3945)
AUTHORS Wang,Z., Kayikci,M., Briese,M., Zarnack,K., Luscombe,N.M., Rot,G.,
Zupan,B., Curk,T. and Ule,J.
TITLE iCLIP predicts the dual splicing effects of TIA-RNA interactions
JOURNAL PLoS Biol. 8 (10), E1000530 (2010)
PUBMED 21048981
REMARK GeneRIF: Data show that TIA1 and TIAL1 bind at the same positions
on human RNAs, and are consistent with a model where TIA proteins
shorten the time available for definition of an alternative exon by
enhancing recognition of the preceding 5' splice site.
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 3945)
AUTHORS Lu,L., Wang,S., Zheng,L., Li,X., Suswam,E.A., Zhang,X.,
Wheeler,C.G., Nabors,L.B., Filippova,N. and King,P.H.
TITLE Amyotrophic lateral sclerosis-linked mutant SOD1 sequesters Hu
antigen R (HuR) and TIA-1-related protein (TIAR): implications for
impaired post-transcriptional regulation of vascular endothelial
growth factor
JOURNAL J. Biol. Chem. 284 (49), 33989-33998 (2009)
PUBMED 19805546
REMARK GeneRIF: SOD1 sequesters Hu antigen R (HuR) and TIA-1-related
protein (TIAR) and has a role in impaired post-transcriptional
regulation of vascular endothelial growth factor
REFERENCE 6 (bases 1 to 3945)
AUTHORS Jin,K., Li,W., Nagayama,T., He,X., Sinor,A.D., Chang,J., Mao,X.,
Graham,S.H., Simon,R.P. and Greenberg,D.A.
TITLE Expression of the RNA-binding protein TIAR is increased in neurons
after ischemic cerebral injury
JOURNAL J. Neurosci. Res. 59 (6), 767-774 (2000)
PUBMED 10700014
REFERENCE 7 (bases 1 to 3945)
AUTHORS Doi,T., Minami,T., Itoh,M., Aburatani,H., Kawabe,Y., Kodama,T.,
Kondo,N., Satoh,Y., Asayama,T. and Imanishi,T.
TITLE An alternative form of nucleolysin binds to a T-cluster DNA in the
silencer element of platelet factor 4 gene
JOURNAL Biochem. Biophys. Res. Commun. 235 (3), 625-630 (1997)
PUBMED 9207209
REFERENCE 8 (bases 1 to 3945)
AUTHORS Dember,L.M., Kim,N.D., Liu,K.Q. and Anderson,P.
TITLE Individual RNA recognition motifs of TIA-1 and TIAR have different
RNA binding specificities
JOURNAL J. Biol. Chem. 271 (5), 2783-2788 (1996)
PUBMED 8576255
REFERENCE 9 (bases 1 to 3945)
AUTHORS Taupin,J.L., Tian,Q., Kedersha,N., Robertson,M. and Anderson,P.
TITLE The RNA-binding protein TIAR is translocated from the nucleus to
the cytoplasm during Fas-mediated apoptotic cell death
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (5), 1629-1633 (1995)
PUBMED 7533298
REFERENCE 10 (bases 1 to 3945)
AUTHORS Kawakami,A., Tian,Q., Duan,X., Streuli,M., Schlossman,S.F. and
Anderson,P.
TITLE Identification and functional characterization of a TIA-1-related
nucleolysin
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (18), 8681-8685 (1992)
PUBMED 1326761
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC030025.1, M96954.1,
AC012468.10, AK125264.1 and AA972022.1.
This sequence is a reference standard in the RefSeqGene project.
Summary: The protein encoded by this gene is a member of a family
of RNA-binding proteins, has three RNA recognition motifs (RRMs),
and binds adenine and uridine-rich elements in mRNA and pre-mRNAs
of a wide range of genes. It regulates various activities including
translational control, splicing and apoptosis. Alternate
transcriptional splice variants, encoding different isoforms, have
been characterized. The different isoforms have been show to
function differently with respect to post-transcriptional
silencing. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (2) uses an alternate in-frame
splice site in the coding region, compared to variant 1, resulting
in a longer protein (isoform 2).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK290984.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-574 BC030025.1 6-579
575-693 M96954.1 56-174
694-744 AC012468.10 43164-43214 c
745-1967 M96954.1 175-1397
1968-3710 AK125264.1 20-1762
3711-3945 AA972022.1 1-235 c
FEATURES Location/Qualifiers
source 1..3945
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q"
gene 1..3945
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/note="TIA1 cytotoxic granule-associated RNA binding
protein-like 1"
/db_xref="GeneID:7073"
/db_xref="HGNC:11804"
/db_xref="HPRD:04563"
/db_xref="MIM:603413"
exon 1..596
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/inference="alignment:Splign:1.39.8"
variation 116
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/replace="a"
/replace="c"
/db_xref="dbSNP:17516000"
misc_feature 289..291
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/note="upstream in-frame stop codon"
CDS 565..1743
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/note="isoform 2 is encoded by transcript variant 2;
TIA-1-related nucleolysin; T-cluster binding protein;
nucleolysin TIAR; aging-associated gene 7 protein"
/codon_start=1
/product="nucleolysin TIAR isoform 2"
/protein_id="NP_001029097.1"
/db_xref="GI:77695912"
/db_xref="CCDS:CCDS31295.1"
/db_xref="GeneID:7073"
/db_xref="HGNC:11804"
/db_xref="HPRD:04563"
/db_xref="MIM:603413"
/translation="
MMEDDGQPRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEQPDSRRVNSSVGFSVLQHTSNDPYCFVEFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGMASYQTQ
"
misc_feature 586..1416
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/note="RNA-binding proteins (RRM domain) [General function
prediction only]; Region: COG0724"
/db_xref="CDD:223796"
misc_feature 592..885
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/note="RNA recognition motif 1 in nucleolysin TIAR and
similar proteins; Region: RRM1_TIAR; cd12616"
/db_xref="CDD:241060"
misc_feature 763..765
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 901..1140
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/note="RNA recognition motif 2 in nucleolysin TIAR and
similar proteins; Region: RRM2_TIAR; cd12617"
/db_xref="CDD:241061"
misc_feature 1228..1446
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/note="RNA recognition motif 3 in nucleolysin TIAR and
similar proteins; Region: RRM3_TIAR; cd12620"
/db_xref="CDD:241064"
exon 597..693
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/inference="alignment:Splign:1.39.8"
exon 694..843
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/inference="alignment:Splign:1.39.8"
exon 844..898
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/inference="alignment:Splign:1.39.8"
exon 899..986
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/inference="alignment:Splign:1.39.8"
STS 945..1544
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/standard_name="Tial1"
/db_xref="UniSTS:479295"
exon 987..1062
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/inference="alignment:Splign:1.39.8"
exon 1063..1171
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/inference="alignment:Splign:1.39.8"
exon 1172..1267
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/inference="alignment:Splign:1.39.8"
exon 1268..1352
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/inference="alignment:Splign:1.39.8"
exon 1353..1476
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/inference="alignment:Splign:1.39.8"
exon 1477..1616
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/inference="alignment:Splign:1.39.8"
exon 1617..3943
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/inference="alignment:Splign:1.39.8"
STS 1728..1959
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/standard_name="RH81093"
/db_xref="UniSTS:84885"
STS 1731..1922
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/standard_name="RH80809"
/db_xref="UniSTS:86914"
polyA_signal 1977..1982
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
polyA_signal 1986..1991
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
polyA_site 1996
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/experiment="experimental evidence, no additional details
recorded"
polyA_site 2024
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/experiment="experimental evidence, no additional details
recorded"
STS 2056..2864
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/standard_name="TIAL1_1101"
/db_xref="UniSTS:277814"
STS 2241..2388
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/standard_name="RH78958"
/db_xref="UniSTS:75095"
STS 2564..2684
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/standard_name="STS-N39410"
/db_xref="UniSTS:56407"
polyA_signal 2693..2698
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
polyA_site 2716
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/experiment="experimental evidence, no additional details
recorded"
polyA_signal 3710..3715
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
polyA_site 3729
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/experiment="experimental evidence, no additional details
recorded"
polyA_signal 3906..3911
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
polyA_site 3940
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
ORIGIN
tcttcacgtcccagcgcgggtgggcgccggcggctcctcttaaccacaggttccagaagtcctctgcagaagtgcttccctctctcatttccaggaccacaattcccagagacttcggcttcacgacgtttctctttttgcccgatctctcccggagctggctgggcttcggccggccagaggcccacagcgacgacgtgatccgtcgtgagcgggtcccagggtttcctcggcggcccttttttctctcccctcggtcgtcccccttgcaggctgtcgcggctggcctgagcggtgacctggcgggtcgcgcctgcgctctgccctgtttcctgcctggctggtggcggcggccattttgttcatcctcctcctcctcctgctcctcctggttggagcgcagtgtccggagcgggctggggggagagagcccgagagcagggttcggtgccttttcctctgtccccagccggtgcccagagcccccctccccttcctccccaccccctcccctccccaaccctgccctcccccttgtcccgggatcgctccgtcgcacccaccatgatggaagacgacgggcagccccggactctatacgtaggtaacctttccagagatgtgacagaagtccttatacttcagttgttcagtcagattggaccctgtaaaagctgtaaaatgataacagagcaacccgatagcagaagggtcaactcttctgttggattttctgttttgcagcatacaagcaatgacccatattgctttgtggaattttatgaacacagagatgcagctgctgcattagctgctatgaatgggagaaaaattttgggaaaggaggtcaaagtaaactgggcaaccacaccaagtagccagaaaaaagatacttccaatcacttccatgtgtttgttggggatttgagtccagaaattacaacagaagatatcaaatcagcatttgccccctttggtaaaatatcggatgcccgggtagttaaagacatggcaactggaaaatccaaaggctatggttttgtatctttttataacaaactggatgcagaaaatgcgattgtgcatatgggcggtcagtggttgggtggtcgtcaaatccgaaccaattgggccactcgtaaaccacctgcacctaaaagtacacaagaaaacaacactaagcagttgagatttgaagatgtagtaaaccagtcaagtccaaaaaattgtactgtgtactgtggaggaattgcgtctgggttaacagatcagcttatgagacagacattctcaccatttggacaaattatggaaataagagttttcccagaaaagggctattcatttgtcagattttcaacccatgaaagtgcagcccatgccattgtttcggtgaacggtactacgattgaaggacatgtggttaaatgctattggggtaaagaatctcctgatatgactaaaaacttccaacaggttgactatagtcaatggggccaatggagccaagtgtatggaaacccacaacagtatggacagtatatggcaaatgggtggcaagtaccgccttatggagtatacgggcaaccatggaatcaacaaggatttggagtagatcaatcaccttctgctgcttggatgggtggatttggtgctcagcctccccaaggacaagctcctccccctgtaatacctcctcctaaccaagccggatatggtatggcaagttaccaaacacagtgagccgggactctaaaaaaaaattgtaattcatgataggcttcgatttcctgtgacactctgaagacatgaaagtagacatcggaaaatgaaaatatttattttaaaaattgaaatgtttggaacctttagcacagatttgctttggtgaaggacacgtgtcttctagttctgcctttttaagtttttgttcatgatggatatgaacatgatttttctttatgtacaaaaactaaaataaagtcaataaagacaattctgactacaaattttgatataataggaaaaatggctaatacattttgattcttagatactattccatttttatcttgctgttcagtattttaactcactgtgtttttaaaagagcaaaaaagggaggatcgtgaaaacctgggaatcacatataagttcatcctgaatcctgatactcccctccccttccctgaggtggaccacatttgaagtcagcagagaaaaagtgtgatattcagaagaaatgcgtgattttggagtcgctttggaggaaatattttctttctctatgcctaaagaaactgaagccagactgaagttttgcaccctaaaaaaggaacagcattgtttgagttacttgagcaaatgttggtggtccacgttaagacatatttttaaaacttccaaaagtgtcgattattaaaattgtagtattttacatttcattttggggggaaatccaagtatggtgtttgtattgaagtcagacagtcatacttgtgcttttacatgaagtttaaatgatacatattgtaaatattcaataactacagtgtttaaaaagcatgcttcaacatagaagtagcagcaatgtaattatttgaagtaacacttaacacactccgctgcattgaatgcagtggattgatcagaatgttaagactgacatttccaaggttggctactatgtaaaattaaaattacacaaattgtgcagaaaaagccttaattttaatttcatacaatctttgatgcattagtatgttctaaaatgtcattgggaattagttttttgtttttgtttttttttttttttttttttgctttacattacttggtatgtaaataccttgattaaaaccttgtaaaccaatttcaaggttactataagttgtatagtacaagtgttttttaaaaatcttggggtgtttttaaaaattaagatatattttgcccaagaatttttttaacaagattgctaaaaacatcttatttagacacttcaatgtaccaatttataattggatattcagtttaaatagtacacagagttgtggcttttattttcaattaatttttttccttgtgggcagtgtgcatggtataataagcctgagcagaggcttaagttgtatgtgtgcagagtttgtaaaggaatcaattggaagatgcagaagaccgaggtttgctttcaaggtatttttcaggctgtgtgggtaaaatttgcctcaaatttctatcaaacaggaatgtaaaatagataaaatcctatgtatttgaattgtcagagctagggagtgcaaatgttttggcaatgtattcaaaatgctggcctgggcaccaaagagaaaatagccttttacagttacatagtaagatgcgattagtacccacaaattactgttttctaaacatttgaagttttacgattagctttaaaataatgattttataaattggtggtcacaataattttggtattactttcctccttttcccacttagcaatatagccaaatgtattcaacataaaaattcatagggtctgaaattcatagctgggccaaattttttatggcaccttagttttaccataatggtcatctattacactcttctgttataaaatatacccttatttcttttgtttatagtatctttgaggaatgtttttggaaaagttaatttatattttatagggagaacactcaataaattatgttaactgtgcccccgagttaaaaattttatgagtatatgtgaaacttgaacaactgaagactttttttaattgataaaaatgcttagtatgcctgttttggtctgccagtaaattaagtagcttattgagataactaacagctaaatatagctgtagtgtttcctgactgtatattctatgatttaataaaattatccagactagttatattgccacagtaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:7073 -> Molecular function: GO:0000166 [nucleotide binding] evidence: IEA
GeneID:7073 -> Molecular function: GO:0003723 [RNA binding] evidence: TAS
GeneID:7073 -> Molecular function: GO:0017091 [AU-rich element binding] evidence: IEA
GeneID:7073 -> Biological process: GO:0006357 [regulation of transcription from RNA polymerase II promoter] evidence: TAS
GeneID:7073 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:7073 -> Biological process: GO:0006917 [induction of apoptosis] evidence: TAS
GeneID:7073 -> Biological process: GO:0006952 [defense response] evidence: TAS
GeneID:7073 -> Biological process: GO:0007281 [germ cell development] evidence: IEA
GeneID:7073 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IEA
GeneID:7073 -> Biological process: GO:0017145 [stem cell division] evidence: IEA
GeneID:7073 -> Cellular component: GO:0005634 [nucleus] evidence: ISS
GeneID:7073 -> Cellular component: GO:0005737 [cytoplasm] evidence: ISS
GeneID:7073 -> Cellular component: GO:0005764 [lysosome] evidence: TAS
GeneID:7073 -> Cellular component: GO:0010494 [cytoplasmic stress granule] evidence: ISS
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