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2024-04-19 16:02:33, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001033910 4013 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens TNF receptor-associated factor 5 (TRAF5), transcript
variant 3, mRNA.
ACCESSION NM_001033910
VERSION NM_001033910.2 GI:198442869
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4013)
AUTHORS Shen,J., Qiao,Y.Q., Ran,Z.H. and Wang,T.R.
TITLE Up-regulation and pre-activation of TRAF3 and TRAF5 in inflammatory
bowel disease
JOURNAL Int J Med Sci 10 (2), 156-163 (2013)
PUBMED 23329887
REMARK GeneRIF: TRAF3 and TRAF5 are overexpressed in inflammatory bowel
disease
REFERENCE 2 (bases 1 to 4013)
AUTHORS Tao,T., Cheng,C., Ji,Y., Xu,G., Zhang,J., Zhang,L. and Shen,A.
TITLE Numbl inhibits glioma cell migration and invasion by suppressing
TRAF5-mediated NF-kappaB activation
JOURNAL Mol. Biol. Cell 23 (14), 2635-2644 (2012)
PUBMED 22593207
REMARK GeneRIF: Numbl interacted with tumor necrosis factor
receptor-associated factor 5, which signals upstream and is
required for the activation of NF-kappaB, and committed it to
proteasomal degradation by promoting K48-linked polyubiquitination
of TRAF5
REFERENCE 3 (bases 1 to 4013)
AUTHORS Casabonne,D., Reina,O., Benavente,Y., Becker,N., Maynadie,M.,
Foretova,L., Cocco,P., Gonzalez-Neira,A., Nieters,A., Boffetta,P.,
Middeldorp,J.M. and de Sanjose,S.
TITLE Single nucleotide polymorphisms of matrix metalloproteinase 9
(MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus
in chronic lymphocytic leukemia: results from the European
case-control study EpiLymph
JOURNAL Haematologica 96 (2), 323-327 (2011)
PUBMED 21048031
REMARK GeneRIF: Observational study of gene-disease association and
gene-environment interaction. (HuGE Navigator)
REFERENCE 4 (bases 1 to 4013)
AUTHORS Lee,K.M., Baris,D., Zhang,Y., Hosgood,H.D. III, Menashe,I.,
Yeager,M., Zahm,S.H., Wang,S.S., Purdue,M.P., Chanock,S., Zheng,T.,
Rothman,N. and Lan,Q.
TITLE Common single nucleotide polymorphisms in immunoregulatory genes
and multiple myeloma risk among women in Connecticut
JOURNAL Am. J. Hematol. 85 (8), 560-563 (2010)
PUBMED 20568250
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 5 (bases 1 to 4013)
AUTHORS Mosbruger,T.L., Duggal,P., Goedert,J.J., Kirk,G.D., Hoots,W.K.,
Tobler,L.H., Busch,M., Peters,M.G., Rosen,H.R., Thomas,D.L. and
Thio,C.L.
TITLE Large-scale candidate gene analysis of spontaneous clearance of
hepatitis C virus
JOURNAL J. Infect. Dis. 201 (9), 1371-1380 (2010)
PUBMED 20331378
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 6 (bases 1 to 4013)
AUTHORS Hsu,H., Solovyev,I., Colombero,A., Elliott,R., Kelley,M. and
Boyle,W.J.
TITLE ATAR, a novel tumor necrosis factor receptor family member, signals
through TRAF2 and TRAF5
JOURNAL J. Biol. Chem. 272 (21), 13471-13474 (1997)
PUBMED 9153189
REFERENCE 7 (bases 1 to 4013)
AUTHORS Tang,X.X., Pleasure,D.E. and Ikegaki,N.
TITLE cDNA cloning, chromosomal localization, and expression pattern of
EPLG8, a new member of the EPLG gene family encoding ligands of
EPH-related protein-tyrosine kinase receptors
JOURNAL Genomics 41 (1), 17-24 (1997)
PUBMED 9126477
REFERENCE 8 (bases 1 to 4013)
AUTHORS Aizawa,S., Nakano,H., Ishida,T., Horie,R., Nagai,M., Ito,K.,
Yagita,H., Okumura,K., Inoue,J. and Watanabe,T.
TITLE Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2
are involved in CD30-mediated NFkappaB activation
JOURNAL J. Biol. Chem. 272 (4), 2042-2045 (1997)
PUBMED 8999898
REFERENCE 9 (bases 1 to 4013)
AUTHORS Ishida,T.K., Tojo,T., Aoki,T., Kobayashi,N., Ohishi,T.,
Watanabe,T., Yamamoto,T. and Inoue,J.
TITLE TRAF5, a novel tumor necrosis factor receptor-associated factor
family protein, mediates CD40 signaling
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (18), 9437-9442 (1996)
PUBMED 8790348
REFERENCE 10 (bases 1 to 4013)
AUTHORS Nakano,H., Oshima,H., Chung,W., Williams-Abbott,L., Ware,C.F.,
Yagita,H. and Okumura,K.
TITLE TRAF5, an activator of NF-kappaB and putative signal transducer for
the lymphotoxin-beta receptor
JOURNAL J. Biol. Chem. 271 (25), 14661-14664 (1996)
PUBMED 8663299
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB290838.1, AB000509.1,
U69108.1 and BU676629.1.
On Sep 10, 2008 this sequence version replaced gi:77404347.
Summary: The scaffold protein encoded by this gene is a member of
the tumor necrosis factor receptor-associated factor (TRAF) protein
family and contains a meprin and TRAF homology (MATH) domain, a
RING-type zinc finger, and two TRAF-type zinc fingers. TRAF
proteins are associated with, and mediate signal transduction from
members of the TNF receptor superfamily. This protein is one of the
components of a multiple protein complex which binds to tumor
necrosis factor (TNF) receptor cytoplasmic domains and mediates
TNF-induced activation. Alternate transcriptional splice variants
have been characterized. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (3) differs in the 5' UTR compared
to variant 1. Variants 1, 2 and 3 encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AB000509.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-561 DB290838.1 1-561
562-2215 AB000509.1 531-2184
2216-2807 U69108.1 2072-2663
2808-3998 AB000509.1 2777-3967
3999-4013 BU676629.1 3-17 c
FEATURES Location/Qualifiers
source 1..4013
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q32"
gene 1..4013
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/note="TNF receptor-associated factor 5"
/db_xref="GeneID:7188"
/db_xref="HGNC:12035"
/db_xref="HPRD:03834"
/db_xref="MIM:602356"
exon 1..84
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/inference="alignment:Splign:1.39.8"
exon 85..303
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/inference="alignment:Splign:1.39.8"
CDS 86..1759
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/note="RING finger protein 84"
/codon_start=1
/product="TNF receptor-associated factor 5"
/protein_id="NP_001029082.1"
/db_xref="GI:77404348"
/db_xref="CCDS:CCDS1497.1"
/db_xref="GeneID:7188"
/db_xref="HGNC:12035"
/db_xref="HPRD:03834"
/db_xref="MIM:602356"
/translation="
MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLFLKVAVDLTDLEDL
"
misc_feature 206..334
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/note="Zinc finger, C3HC4 type (RING finger); Region:
zf-C3HC4_2; pfam13923"
/db_xref="CDD:206094"
misc_feature 215..328
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/note="RING-finger (Really Interesting New Gene) domain, a
specialized type of Zn-finger of 40 to 60 residues that
binds two atoms of zinc; defined by the 'cross-brace'
motif C-X2-C-X(9-39)-C-X(1-3)-
H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved
in...; Region: RING; cd00162"
/db_xref="CDD:29102"
misc_feature order(218..220,227..229,263..265,269..271,278..280,
287..289,317..319,326..328)
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/note="cross-brace motif; other site"
/db_xref="CDD:29102"
misc_feature 467..634
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/note="TRAF-type zinc finger; Region: zf-TRAF; pfam02176"
/db_xref="CDD:190233"
misc_feature 632..808
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/note="TRAF-type zinc finger; Region: zf-TRAF; pfam02176"
/db_xref="CDD:190233"
misc_feature 860..1105
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/note="Biogenesis of lysosome-related organelles complex-1
subunit 2; Region: BLOC1_2; pfam10046"
/db_xref="CDD:163611"
misc_feature 1118..1756
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (O00463.2);
Region: Interaction with EIF2AK2/PKR"
misc_feature 1295..1735
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/note="Tumor Necrosis Factor Receptor (TNFR)-Associated
Factor (TRAF) family, TRAF5 subfamily, TRAF domain,
C-terminal MATH subdomain; TRAF molecules serve as adapter
proteins that link TNFRs and downstream kinase cascades
resulting in the activation of...; Region: MATH_TRAF5;
cd03780"
/db_xref="CDD:58111"
misc_feature order(1304..1306,1310..1312,1394..1399,1490..1492,
1499..1501,1550..1552)
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/note="trimer interface [polypeptide binding]; other site"
/db_xref="CDD:58111"
misc_feature order(1418..1420,1424..1426,1469..1471,1583..1585,
1634..1645)
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/note="TNFR binding site; other site"
/db_xref="CDD:58111"
variation 121
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:370825088"
variation 129
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="t"
/db_xref="dbSNP:192648296"
variation 131
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:200654269"
variation 132
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:377497907"
variation 143
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:148579195"
variation 157
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:370299075"
variation 176
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:374226783"
variation 180
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:199814704"
variation 190
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="t"
/db_xref="dbSNP:368844464"
variation 197
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:368567277"
variation 198
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:201400842"
variation 215
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:141533849"
variation 216
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:372772119"
variation 250
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:200989117"
variation 285
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:374448179"
exon 304..361
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/inference="alignment:Splign:1.39.8"
variation 315
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="g"
/db_xref="dbSNP:138541263"
variation 333
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:371824899"
variation 344
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:200231390"
variation 359
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:201150771"
exon 362..463
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/inference="alignment:Splign:1.39.8"
variation 379
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:2230778"
variation 417
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:143951452"
variation 420
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:139835688"
variation 444
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="g"
/replace="t"
/db_xref="dbSNP:3946808"
exon 464..628
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/inference="alignment:Splign:1.39.8"
variation 513
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="t"
/db_xref="dbSNP:377704147"
variation 514
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:369624806"
variation 519
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:143474206"
variation 529
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:34155984"
variation 533
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:183953361"
variation 534
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:374099125"
variation 559
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="g"
/replace="t"
/db_xref="dbSNP:187481865"
variation 562
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:2230779"
variation 575
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:200980823"
variation 614
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:376733808"
exon 629..706
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/inference="alignment:Splign:1.39.8"
variation 641
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:2271458"
variation 684
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:149809182"
exon 707..781
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/inference="alignment:Splign:1.39.8"
variation 722
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:200289585"
variation 723
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:377012367"
variation 729
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:370068812"
variation 766
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:145765066"
variation 772
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="g"
/replace="t"
/db_xref="dbSNP:79833851"
variation 776
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:374585053"
variation 780
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:113925874"
exon 782..874
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/inference="alignment:Splign:1.39.8"
variation 805
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:186895220"
variation 807
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:200691417"
variation 819
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:147658016"
variation 825
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:370187802"
variation 837
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:143383996"
variation 872
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:368184278"
exon 875..1015
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/inference="alignment:Splign:1.39.8"
variation 887
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:200398415"
variation 907
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:140547533"
variation 925
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="g"
/replace="t"
/db_xref="dbSNP:368057468"
variation 971
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:367768103"
variation 987
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:371288296"
variation 996
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:138593370"
variation 1013
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="g"
/db_xref="dbSNP:146187607"
variation 1014
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:149548418"
exon 1016..1184
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/inference="alignment:Splign:1.39.8"
variation 1083
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="t"
/db_xref="dbSNP:200530774"
variation 1124
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:369840198"
variation 1139
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:374270138"
variation 1157
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="g"
/db_xref="dbSNP:2230780"
exon 1185..4003
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/inference="alignment:Splign:1.39.8"
variation 1187
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:147396608"
variation 1197
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:201823574"
variation 1200
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:377065340"
variation 1208
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="t"
/db_xref="dbSNP:200020406"
variation 1218
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:192860244"
variation 1239
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:113770101"
variation 1258
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:369475274"
variation 1263
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:373368870"
variation 1276
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:183479167"
variation 1344
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:376419381"
variation 1347
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="g"
/replace="t"
/db_xref="dbSNP:78225734"
variation 1348
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:370454821"
variation 1363
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:147675295"
variation 1388
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:201191929"
variation 1395
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:145871946"
variation 1402
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:369820230"
variation 1404
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:372814574"
variation 1405
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:200264560"
variation 1537
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:201629340"
variation 1538
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:143776579"
variation 1549
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:142045639"
variation 1596
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:377398420"
variation 1639
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:145342244"
variation 1670
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:201555136"
variation 1690
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:147801247"
variation 1691
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:149314484"
variation 1708
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:139643718"
variation 1729
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:147270768"
variation 1734
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:78164002"
variation 1742
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:191471582"
variation 1768
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:371227861"
variation 1803
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="g"
/replace="t"
/db_xref="dbSNP:183601818"
variation 1942
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="g"
/replace="t"
/db_xref="dbSNP:188266749"
variation 2216
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="t"
/db_xref="dbSNP:1046690"
variation 2315
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:75241000"
variation 2343
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:75076283"
variation 2369
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="g"
/db_xref="dbSNP:146769184"
variation 2482
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:372987588"
variation 2513
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:147929313"
variation 2542
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:71640009"
variation 2563
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="t"
/db_xref="dbSNP:79012864"
variation 2609
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="g"
/db_xref="dbSNP:150478547"
variation 2624
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:111307232"
variation 2667
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="g"
/replace="t"
/db_xref="dbSNP:370926928"
variation 2680
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:149568330"
variation 2792
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:202021817"
STS 2893..2981
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
variation 2935
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:143220164"
variation 2938
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:192988383"
variation 2978
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:138874475"
variation 3033
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="g"
/replace="t"
/db_xref="dbSNP:184674809"
variation 3059
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:377712073"
variation 3061
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:141997541"
variation 3081
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:58510761"
variation 3107
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="t"
/db_xref="dbSNP:190349032"
variation 3121
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:368281988"
variation 3185..3186
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace=""
/replace="ca"
/db_xref="dbSNP:372838455"
variation 3237
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:12143280"
variation 3257
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="g"
/replace="t"
/db_xref="dbSNP:181563780"
variation 3351
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="t"
/db_xref="dbSNP:146257194"
variation 3387
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:74137663"
variation 3428..3429
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace=""
/replace="c"
/db_xref="dbSNP:35232266"
variation 3476..3478
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace=""
/replace="ata"
/db_xref="dbSNP:376828636"
variation 3478
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:139298194"
variation 3566
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:186323245"
variation 3624
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:79204495"
variation 3646
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:370923000"
variation 3667
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:189164345"
STS 3757..3914
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/standard_name="SHGC-76306"
/db_xref="UniSTS:35516"
variation 3789
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="g"
/db_xref="dbSNP:181868298"
polyA_site 3846
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
variation 3909
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="g"
/db_xref="dbSNP:74137664"
variation 3914
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="g"
/replace="t"
/db_xref="dbSNP:6690648"
variation 3992
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:141801188"
polyA_site 3998
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
polyA_site 4003
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
ORIGIN
gcttcgccgccgccgccggccgcagccaggagcagcagccgcgcctgcagaccggcctcgcggagcccgcgcgccgagccccacaatggcttattcagaagagcataaaggtatgccctgtggtttcatccgccagaattccggcaactccatttccttggactttgagcccagtatagagtaccagtttgtggagcggttggaagagcgctacaaatgtgccttctgccactcggtgcttcacaacccccaccagacaggatgtgggcaccgcttctgccagcactgcatcctgtccctgagagaattaaacacagtgccaatctgccctgtagataaagaggtcatcaaatctcaggaggtttttaaagacaattgttgcaaaagagaagtcctcaacttatatgtatattgcagcaatgctcctggatgtaatgccaaggttattctgggccggtaccaggatcaccttcagcagtgcttatttcaacctgtgcagtgttctaatgagaagtgccgggagccagtcctacggaaagacctgaaagagcatttgagtgcatcctgtcagtttcgaaaggaaaaatgcctttattgcaaaaaggatgtggtagtcatcaatctacagaatcatgaggaaaacttgtgtcctgaatacccagtattttgtcccaacaattgtgcgaagattattctaaaaactgaggtagatgaacacctggctgtatgtcctgaagctgagcaagactgtccttttaagcactatggctgtgctgtaacggataaacggaggaacctgcagcaacatgagcattcagccttacgggagcacatgcgtttggttttagaaaagaatgtccaattagaagaacagatttctgacttacacaagagcctagaacagaaagaaagtaaaatccagcagctagcagaaactataaagaaacttgaaaaggagttcaagcagtttgcacagttgtttggcaaaaatggaagcttcctcccaaacatccaggtttttgccagtcacattgacaagtcagcttggctagaagctcaagtgcatcaattattacaaatggttaaccagcaacaaaataaatttgacctgagacctttgatggaagcagttgatacagtgaaacagaaaattaccctgctagaaaacaatgatcaaagattagccgttttagaagaggaaactaacaaacatgatacccacattaatattcataaagcacagctgagtaaaaatgaagagcgatttaaactgctggagggtacttgctataatggaaagctcatttggaaggtgacagattacaagatgaagaagagagaggcggtggatgggcacacagtgtccatcttcagccagtccttctacaccagccgctgtggctaccggctctgtgctagagcatacctgaatggggatgggtcagggagggggtcacacctgtccctatactttgtggtcatgcgaggagagtttgactcactgttgcagtggccattcaggcagagggtgaccctgatgcttctggaccagagtggcaaaaagaacattatggagaccttcaaacctgaccccaatagcagcagctttaaaagacctgatggggagatgaacattgcatctggctgtccccgctttgtggctcattctgttttggagaatgccaagaacgcctacattaaagatgacactctgttcttgaaagtggccgtggacttaactgacctggaggatctctagtcactgttatggggtgataagaggacttcttggggccagaactgtggaggagagcacatttgattatcatattgacctggatttagactcaaagcacatttgtatttgcctttttccttaacgtttgaagtcagtttaaaacttctgaagtgctgtctttttacattttactctgtcccagtttgaaacttaaaactcttagaatattctcttattatttatatttttatatttcttgaaagatggtaagtttcttgaagtttttggggcgtttctcttttactggtgcttagcgcagtgtctcgggcactctaaatattgagtgttatggaggacacagaggtagcagaatcccagttgaaaatgttttgatattttattgtttggcctattgattctagacctggccttaagtctgcaaaagccatctttataaggtaggctgttccagttaagtagtgggtgatgtagttacaaagataatatgctcagtttggacctttttttcagttaaatgctaaatatatgaaaattactatacctctaagtattttcatgaaattcaccagcagtttgcaagcacagttttgcaaggctgcataagaactggtgaatggggtaagcattttcattcttcctgctgaagtaaagcagaaagtactgcatagtatatgagatatagccagctagctaaagttcagattttgttaggttcaaccctatgaaaaaaactattttcataggtcaaaaatggtaaaaaattagcagtttcataagattcaaccaaataaatatatatatacacacacacatacatatacacctatatatgtgtgtatacaaacagttcgaatgtattttggtgacagtaataaatcaatgtgaggatggatagaatttagtatatgatagagaaaatgtcataaatggataaaaggaatttacaacttgaggagaaaacctttacaatttcctatgggtgtcagaagtactctcagcgaaaactgatggctaaaacagtatctactattctctgataactttttttttgagacagagtttcattgtcacccaggctggagtacagtggcatgatctcagctcactgcaaactctgcctcccgaattcaagtgattctcctgcctcagcctcctgagtagctgggattacaggcgcccgtcaccacacccaggtaatttttgtatttttagtagagacggagttttgccatgttggccaagctgatctcaaactcctgacctcaagtgatctgcccgcctcggcctcccaaagtgctgagattacaggcatgacccaccgcgtcaagcctctgacaactattgaatttgtaagctgctatgcaaatgggcatttatataaacttgtgatgtttcttgtcagaattctgagtactctgtgaagaacagaaatgatcatattcttatgcatctatctgtatgggtctgaaggtgtatatacaaactgagatgagtccttatgactcttgataagcctgagtttaacaacaacaaaaatgccaagttgtcctgagcccttctgcgttgttatgccacttccctactgctcatatgcacgctggctcccctgggcacgcaaggatgagtatgggccatgggcccctgtagagctgcttacctggtgatgaccatgcaccttacaatttctgaacagttaaccctatagaagcatgctttatatgagtgtcttctgggaagaggaaccttcttaatctcttctgtgggattttcaaaatgctaaagactcacactgcagcaatcatcccagatgattaaattcaaagaaataggttcacaacaggaatatactgaagaactagagtgtcactgctggtgaactgtggcacggttgctcaacacatcacctcggacaaattcaggaagcatttctttagcccacaagtccagacccaggtgctctgtatgtttgtttttaatattcatcatatccaagttcactctgtcttcctgagcagtggaagatcatattgctgtaacttcttttaagtagttgatgtggaaaacattttaaagtgaatttgtcaaaatgctggttttgtgttttatccaacttttgtgcatatatataaagtatgtcatggcatggtttgcttaggagttcagagttccttcatcatcgaaatagtgattaagtgatcccagaacaaggaatactagagtaaaaagcacctctttttcacaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:7188 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: IEA
GeneID:7188 -> Molecular function: GO:0004871 [signal transducer activity] evidence: IEA
GeneID:7188 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:7188 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:7188 -> Molecular function: GO:0031625 [ubiquitin protein ligase binding] evidence: IPI
GeneID:7188 -> Molecular function: GO:0031996 [thioesterase binding] evidence: IPI
GeneID:7188 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:7188 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:7188 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IEA
GeneID:7188 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: IEA
GeneID:7188 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IEP
GeneID:7188 -> Biological process: GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] evidence: IMP
GeneID:7188 -> Biological process: GO:0051092 [positive regulation of NF-kappaB transcription factor activity] evidence: IMP
GeneID:7188 -> Cellular component: GO:0005813 [centrosome] evidence: IDA
GeneID:7188 -> Cellular component: GO:0005829 [cytosol] evidence: IDA
GeneID:7188 -> Cellular component: GO:0009898 [internal side of plasma membrane] evidence: ISS
GeneID:7188 -> Cellular component: GO:0035631 [CD40 receptor complex] evidence: ISS
by
@meso_cacase at
DBCLS
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