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2024-03-28 22:00:54, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001033030            1538 bp    mRNA    linear   PRI 17-MAR-2013
DEFINITION  Homo sapiens Fas apoptotic inhibitory molecule (FAIM), transcript
            variant 1, mRNA.
ACCESSION   NM_001033030
VERSION     NM_001033030.1  GI:74271910
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1538)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   2  (bases 1 to 1538)
  AUTHORS   Li,G., Qu,L., Meng,G., Bai,X., Dai,K. and Zheng,X.
  TITLE     Crystallization and preliminary X-ray crystallographic studies of
            human FAIM protein
  JOURNAL   Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (PT 8),
            935-937 (2010)
   PUBMED   20693673
  REMARK    GeneRIF: FAIM (1-90) was crystallized and diffracted to a
            resolution of 2.5 A; the crystal belonged to space group P3(1),
            with unit-cell parameters a=b=58.02, c=71.11 A, alpha=beta=90,
            gamma=120 degrees.
REFERENCE   3  (bases 1 to 1538)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am. J. Hum. Genet. 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 1538)
  AUTHORS   Kaku,H. and Rothstein,T.L.
  TITLE     Fas apoptosis inhibitory molecule enhances CD40 signaling in B
            cells and augments the plasma cell compartment
  JOURNAL   J. Immunol. 183 (3), 1667-1674 (2009)
   PUBMED   19592656
  REMARK    GeneRIF: FAIM acts to specifically enhance CD40 signaling for
            NF-kappaB activation, IRF-4 expression, and BCL-6 down-regulation
            in vitro, but has no effect on its own
            Erratum:[J Immunol. 2010 Jul 1;185(1):771]
REFERENCE   5  (bases 1 to 1538)
  AUTHORS   Segura,M.F., Sole,C., Pascual,M., Moubarak,R.S., Perez-Garcia,M.J.,
            Gozzelino,R., Iglesias,V., Badiola,N., Bayascas,J.R., Llecha,N.,
            Rodriguez-Alvarez,J., Soriano,E., Yuste,V.J. and Comella,J.X.
  TITLE     The long form of Fas apoptotic inhibitory molecule is expressed
            specifically in neurons and protects them against death
            receptor-triggered apoptosis
  JOURNAL   J. Neurosci. 27 (42), 11228-11241 (2007)
   PUBMED   17942717
  REMARK    GeneRIF: Expression of the long form of Fas apoptotic inhibitory
            molecule (FAIML) results in the protection of neurons from the
            cytotoxic actions of death ligands.
REFERENCE   6  (bases 1 to 1538)
  AUTHORS   Choi,C.Y., Reimers,K., Allmeling,C., Kall,S., Choi,Y.H. and
            Vogt,P.M.
  TITLE     Inhibition of apoptosis by expression of antiapoptotic proteins in
            recombinant human keratinocytes
  JOURNAL   Cell Transplant 16 (6), 663-674 (2007)
   PUBMED   17912957
  REMARK    GeneRIF: Human keratinocytes were transfected with either Flip,
            Faim, or Lifeguard (LFG). Our results suggest that heterotopic
            expression of antiapoptotic proteins can induce the resistance of
            keratinocytes to a major mechanism of rejection.
REFERENCE   7  (bases 1 to 1538)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm. Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 1538)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol. Vis. 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1538)
  AUTHORS   Schneider,T.J., Fischer,G.M., Donohoe,T.J., Colarusso,T.P. and
            Rothstein,T.L.
  TITLE     A novel gene coding for a Fas apoptosis inhibitory molecule (FAIM)
            isolated from inducibly Fas-resistant B lymphocytes
  JOURNAL   J. Exp. Med. 189 (6), 949-956 (1999)
   PUBMED   10075978
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK125477.1, BM469375.1 and
            BC012478.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The protein encoded by this gene protects against death
            receptor-triggered apoptosis and regulates B-cell signaling and
            differentiation. Several transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-367               AK125477.1         95-461
            368-775             BM469375.1         263-670
            776-1538            BC012478.1         191-953
FEATURES             Location/Qualifiers
     source          1..1538
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.3"
     gene            1..1538
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /note="Fas apoptotic inhibitory molecule"
                     /db_xref="GeneID:55179"
                     /db_xref="HGNC:18703"
                     /db_xref="HPRD:16874"
     exon            1..238
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /inference="alignment:Splign:1.39.8"
     variation       42
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:190414611"
     variation       166
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:370004730"
     exon            239..672
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /inference="alignment:Splign:1.39.8"
     variation       368
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:13077766"
     variation       465
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368256520"
     variation       492
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186303917"
     misc_feature    500..502
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /note="upstream in-frame stop codon"
     variation       511
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150603273"
     variation       588
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368013436"
     CDS             593..1234
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /note="isoform a is encoded by transcript variant 1; fas
                     apoptotic inhibitory molecule 1"
                     /codon_start=1
                     /product="fas apoptotic inhibitory molecule 1 isoform a"
                     /protein_id="NP_001028202.1"
                     /db_xref="GI:74271911"
                     /db_xref="CCDS:CCDS33864.1"
                     /db_xref="GeneID:55179"
                     /db_xref="HGNC:18703"
                     /db_xref="HPRD:16874"
                     /translation="
MLLPFIRTLPLLCYNHLLVSPDSATLSPPYSLEKMTDLVAVWDVALSDGVHKIEFEHGTTSGKRVVYVDGKEEIRKEWMFKLVGKETFYVGAAKTKATINIDAISGFAYEYTLEINGKSLKKYMEDRSKTTNTWVLHMDGENFRIVLEKDAMDVWCNGKKLETAGEFVDDGTETHFSIGNHDCYIKAVSSGKRKEGIIHTLIVDNREIPEIAS
"
     misc_feature    701..1222
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /note="Fas apoptotic inhibitory molecule (FAIM1); Region:
                     FAIM1; pfam06905"
                     /db_xref="CDD:148495"
     variation       596
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367804345"
     variation       645
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139741354"
     variation       655
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:811322"
     exon            673..805
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /inference="alignment:Splign:1.39.8"
     variation       677
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200135625"
     variation       687
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187659517"
     variation       707
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201485286"
     variation       751
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148507350"
     variation       799
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369058786"
     variation       805
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368988098"
     exon            806..1034
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /inference="alignment:Splign:1.39.8"
     variation       843
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373117151"
     variation       883
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372907141"
     variation       941
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:183886148"
     variation       989
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376276693"
     variation       992
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369178291"
     variation       1004
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372730133"
     variation       1029
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:145389845"
     exon            1035..1084
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /inference="alignment:Splign:1.39.8"
     variation       1043
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:641320"
     variation       1050
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373425343"
     variation       1051
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377724151"
     variation       1054
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61753268"
     variation       1073
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145920343"
     variation       1074
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:13043"
     variation       1083
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141740200"
     variation       1084
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150321985"
     exon            1085..1531
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /inference="alignment:Splign:1.39.8"
     variation       1098
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201538540"
     variation       1109
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370123817"
     variation       1126
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138002065"
     variation       1146..1147
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:35777696"
     variation       1154
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:374829953"
     variation       1170
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200351586"
     variation       1180
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:186964615"
     variation       1187
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149453397"
     variation       1193
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190624264"
     variation       1207
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201710308"
     variation       1357
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:139843076"
     variation       1448
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370851305"
     variation       1457
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112327774"
     variation       1511..1512
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /replace=""
                     /replace="aata"
                     /db_xref="dbSNP:149445173"
ORIGIN      
tgggtccgtggcggcgggaggggtggcctcctgcgctggtcgccccaggggacctgagaggcgcgacaaacagtcggcgcgtttggtactcgcgcctgcagagctttcaacctccgcgccggctgcgcctgtttctcggccaggggagcaaggccacgcggcctacgcagccgagtcggaaccaaccggttgtttggtgaaacctaccccagagcctcccgcggcccacagagcacagacagaatctccctctgtcacccaggctggagtgcagtggcatgatctcggctcactgcaacctccacctcccgggttcaagcgattcttgtgcctcagcctccggagtagctgggatttacagacgtgcgctaccatgcccggcaaatttttctatttttgcaaagacaggatttcaccgttttgtccaggctggtcttgaactattgacctcaagtgatccgaccgccttgacctcccaaagtgctgggattacggggtgtgagccatcgcgcctggccactttctccaaagttttaaaccaaagccttcttcggcagagctacgacccttcctctatggcccattctatcctatgctgcttccctttataaggacactcccactgttgtgctataatcatctcttggtatctccggactctgccactctgagccctccttacagcctagaaaaaatgacagatctcgtagctgtttgggatgttgctttaagtgacggagtccacaagatcgaatttgaacatgggactacatcaggcaaacgagtagtatatgtagatggaaaggaagagataagaaaagagtggatgttcaaattagtgggcaaagaaacattctatgttggagctgcaaagacaaaagcgaccataaatatagacgctatcagtggttttgcttatgaatatactctggaaattaatgggaaaagtctcaagaagtatatggaggacagatcaaaaaccaccaatacttgggtattacacatggatggtgagaactttagaattgttttggaaaaagatgctatggacgtatggtgcaatggtaaaaaattggagacagcgggtgagtttgtagatgatgggactgaaactcacttcagtatcgggaaccatgactgttacataaaggctgtcagtagtgggaagcggaaagaagggattattcatactctcattgtggataatagagaaatcccagagattgcaagttaatgaattttcatcttaagaagtaaagatcaggactttttaattactgtggtaattaaatgtgttcagtatgtacttatcagtacatttagtctgcaatgttttaattttttaaaaagttacatgaaactaacattccaagggtcaggaaaaaaaccaattatgtatagtcataaaaattacaatttatgatgcaaataatgtaaaatgttttaaagacaaatggcaaataagatatggaccaaagtcactaatgttttacaacagtaacctttactataataaatacttttaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:55179 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:55179 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IEA
            GeneID:55179 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA

by @meso_cacase at DBCLS
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