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2024-04-27 12:11:33, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001032284 3859 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens thymopoietin (TMPO), transcript variant 3, mRNA.
ACCESSION NM_001032284
VERSION NM_001032284.2 GI:296434315
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3859)
AUTHORS Ward,M.C., van der Watt,P.J., Tzoneva,G. and Leaner,V.D.
TITLE Deregulated LAP2alpha expression in cervical cancer associates with
aberrant E2F and p53 activities
JOURNAL IUBMB Life 63 (11), 1018-1026 (2011)
PUBMED 21990273
REMARK GeneRIF: this study provides evidence for elevated LAP2alpha
expression in cervical cancer and suggests that E2F and p53
activities associate with the positive and negative regulation of
LAP2alpha expression, respectively
REFERENCE 2 (bases 1 to 3859)
AUTHORS Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B,
Yusuf S, Gerstein HC, Engert JC and Anand S.
CONSRTM DREAM investigators
TITLE Variation at the NFATC2 locus increases the risk of
thiazolidinedione-induced edema in the Diabetes REduction
Assessment with ramipril and rosiglitazone Medication (DREAM) study
JOURNAL Diabetes Care 33 (10), 2250-2253 (2010)
PUBMED 20628086
REMARK GeneRIF: Observational study of gene-disease association,
gene-environment interaction, and pharmacogenomic / toxicogenomic.
(HuGE Navigator)
REFERENCE 3 (bases 1 to 3859)
AUTHORS Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
Snippe,H., Hibberd,M.L. and Seielstad,M.
TITLE New genetic associations detected in a host response study to
hepatitis B vaccine
JOURNAL Genes Immun. 11 (3), 232-238 (2010)
PUBMED 20237496
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 4 (bases 1 to 3859)
AUTHORS Craig,D.W., Millis,M.P. and DiStefano,J.K.
TITLE Genome-wide SNP genotyping study using pooled DNA to identify
candidate markers mediating susceptibility to end-stage renal
disease attributed to Type 1 diabetes
JOURNAL Diabet. Med. 26 (11), 1090-1098 (2009)
PUBMED 19929986
REMARK GeneRIF: Observational study and genome-wide association study of
gene-disease association. (HuGE Navigator)
REFERENCE 5 (bases 1 to 3859)
AUTHORS Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt
TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M,
Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ,
Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S,
Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD,
Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE
and Hingorani AD.
CONSRTM ASCOT investigators; NORDIL investigators; BRIGHT Consortium
TITLE Gene-centric association signals for lipids and apolipoproteins
identified via the HumanCVD BeadChip
JOURNAL Am. J. Hum. Genet. 85 (5), 628-642 (2009)
PUBMED 19913121
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 6 (bases 1 to 3859)
AUTHORS Hara,H., Hayashi,K., Ohta,K., Itoh,N. and Ohta,M.
TITLE A new thymopoietin precursor gene from human thymus
JOURNAL Biochem. Mol. Biol. Int. 34 (5), 927-933 (1994)
PUBMED 7703909
REFERENCE 7 (bases 1 to 3859)
AUTHORS Harris,C.A., Andryuk,P.J., Cline,S., Chan,H.K., Natarajan,A.,
Siekierka,J.J. and Goldstein,G.
TITLE Three distinct human thymopoietins are derived from alternatively
spliced mRNAs
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 91 (14), 6283-6287 (1994)
PUBMED 7517549
REFERENCE 8 (bases 1 to 3859)
AUTHORS Heavner,G.A., Audhya,T. and Goldstein,G.
TITLE Peptide analogs of thymopentin distinguish distinct thymopoietin
receptor specificities on two human T cell lines
JOURNAL Regul. Pept. 27 (2), 257-262 (1990)
PUBMED 2158125
REFERENCE 9 (bases 1 to 3859)
AUTHORS Fuccello,A., Audhya,T., Talle,M.A. and Goldstein,G.
TITLE Immunoassay for bovine serum thymopoietin: discrimination from
splenin by monoclonal antibodies
JOURNAL Arch. Biochem. Biophys. 228 (1), 292-298 (1984)
PUBMED 6364989
REFERENCE 10 (bases 1 to 3859)
AUTHORS Twomey,J.J., Goldstein,G., Lewis,V.M., Bealmear,P.M. and Good,R.A.
TITLE Bioassay determinations of thymopoietin and thymic hormone levels
in human plasma
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 74 (6), 2541-2545 (1977)
PUBMED 302007
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB239672.1, AB209297.1,
U09088.1, BQ232508.1, BG676381.1, BM802949.1, AI055921.1 and
AA992204.1.
On May 21, 2010 this sequence version replaced gi:73760400.
Summary: The protein encoded by this gene resides in the nucleus
and may play a role in the assembly of the nuclear lamina, and thus
help maintain the structural organization of the nuclear envelope.
It may function as a receptor for the attachment of lamin filaments
to the inner nuclear membrane. Mutations in this gene are
associated with dilated cardiomyopathy. Alternatively spliced
transcript variants encoding different isoforms have been noted for
this gene. [provided by RefSeq, May 2010].
Transcript Variant: This (3) differs at the 3' end compared to
variant 1, resulting in a shorter isoform (gamma) with a distinct
C-terminus compared to isoform alpha.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AB209297.1, U09088.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025083 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-593 DB239672.1 1-593
594-1962 AB209297.1 531-1899
1963-2317 U09088.1 1905-2259
2318-2502 AB209297.1 2254-2438
2503-2774 BQ232508.1 73-344
2775-2799 AB209297.1 2492-2516
2800-3222 BG676381.1 204-626
3223-3614 BM802949.1 384-775
3615-3787 AI055921.1 4-176 c
3788-3859 AA992204.1 1-72 c
FEATURES Location/Qualifiers
source 1..3859
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q22"
gene 1..3859
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/note="thymopoietin"
/db_xref="GeneID:7112"
/db_xref="HGNC:11875"
/db_xref="HPRD:01777"
/db_xref="MIM:188380"
exon 1..574
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/inference="alignment:Splign:1.39.8"
variation 125
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="g"
/db_xref="dbSNP:186697764"
misc_feature 194..196
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/note="upstream in-frame stop codon"
variation 244
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="t"
/db_xref="dbSNP:370309699"
variation 283
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:374345638"
variation 285
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="c"
/db_xref="dbSNP:377404642"
variation 294
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="t"
/db_xref="dbSNP:144959639"
CDS 296..1333
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/note="isoform gamma is encoded by transcript variant 3;
LEM domain containing 4; lamina-associated polypeptide 2;
TP beta/gamma; TP alpha; thymopoietin-related peptide
isoform alpha; thymopoietin-related peptide isoforms
beta/gamma"
/codon_start=1
/product="thymopoietin isoform gamma"
/protein_id="NP_001027455.1"
/db_xref="GI:73760401"
/db_xref="CCDS:CCDS31880.1"
/db_xref="GeneID:7112"
/db_xref="HGNC:11875"
/db_xref="HPRD:01777"
/db_xref="MIM:188380"
/translation="
MPEFLEDPSVLTKDKLKSELVANNVTLPAGEQRKDVYVQLYLQHLTARNRPPLPAGTNSKGPPDFSSDEEREPTPVLGSGAAAAGRSRAAVGRKATKKTDKPRQEDKDDLDVTELTNEDLLDQLVKYGVNPGPIVGTTRKLYEKKLLKLREQGTESRSSTPLPTISSSAENTRQNGSNDSDRYSDNEEDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQVGEKTEERRVERDILKEMFPYEASTPTGISASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRSIPVWIKILLFVVVAVFLFLVYQAMETNQVNPFSNFLHVDPRKSN
"
misc_feature 299..445
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/note="Thymopoietin protein; Region: Thymopoietin;
pfam08198"
/db_xref="CDD:149323"
misc_feature 440..619
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P42167.2);
Region: Linker"
misc_feature 491..493
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 491..493
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 494..496
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 515..517
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 530..532
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 623..>709
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/note="LEM domain; Region: LEM; cl02649"
/db_xref="CDD:155036"
misc_feature 755..757
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 761..763
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 767..769
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 770..772
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 773..775
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 785..787
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 824..826
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P42167.2); phosphorylation site"
misc_feature 833..835
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P42167.2); phosphorylation site"
misc_feature 833..835
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 842..844
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 845..847
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P42167.2); phosphorylation site"
misc_feature 845..847
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 917..919
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (P42167.2); phosphorylation site"
misc_feature 926..928
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (P42167.2); phosphorylation site"
misc_feature 1100..1102
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
variation 308
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="t"
/db_xref="dbSNP:149067616"
variation 322
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="g"
/replace="t"
/db_xref="dbSNP:190115355"
variation 367
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="g"
/replace="t"
/db_xref="dbSNP:201960762"
variation 379
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:199549942"
variation 382
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="t"
/db_xref="dbSNP:114074541"
variation 409
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="c"
/db_xref="dbSNP:200619128"
variation 411
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:374578351"
variation 421
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:372903897"
variation 423
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:371427406"
variation 455
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="t"
/db_xref="dbSNP:376363219"
variation 456..457
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="cc"
/replace="g"
/db_xref="dbSNP:368465288"
variation 520
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:59027673"
variation 526
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="t"
/db_xref="dbSNP:139576816"
variation 560
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="g"
/db_xref="dbSNP:200177466"
exon 575..701
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/inference="alignment:Splign:1.39.8"
variation 626
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:201838047"
variation 645
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:141387097"
variation 650
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="g"
/replace="t"
/db_xref="dbSNP:113967157"
variation 653
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="c"
/db_xref="dbSNP:200420073"
variation 665
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="t"
/db_xref="dbSNP:375619307"
variation 676
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="t"
/db_xref="dbSNP:370093524"
variation 677
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:200943582"
exon 702..860
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/inference="alignment:Splign:1.39.8"
variation 771
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="t"
/db_xref="dbSNP:183244086"
variation 792
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="c"
/db_xref="dbSNP:147012167"
variation 829
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="t"
/db_xref="dbSNP:200016687"
variation 852
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:200923649"
exon 861..958
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/inference="alignment:Splign:1.39.8"
variation 907
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="c"
/db_xref="dbSNP:377624930"
variation 931
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="g"
/db_xref="dbSNP:371253652"
variation 949
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:138298699"
exon 959..1047
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/inference="alignment:Splign:1.39.8"
variation 976
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace=""
/replace="g"
/db_xref="dbSNP:34204719"
variation 992
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="t"
/db_xref="dbSNP:147928797"
variation 1012
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="g"
/db_xref="dbSNP:141552430"
exon 1048..3854
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/inference="alignment:Splign:1.39.8"
variation 1087
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:144913822"
variation 1111
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="g"
/replace="t"
/db_xref="dbSNP:373609093"
variation 1129
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:370301550"
variation 1145
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:199545670"
variation 1196..1197
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace=""
/replace="c"
/db_xref="dbSNP:34001294"
variation 1205
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:115843977"
variation 1235
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="g"
/replace="t"
/db_xref="dbSNP:368180278"
variation 1241..1242
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace=""
/replace="gtttttttt"
/db_xref="dbSNP:144209787"
variation 1249
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="g"
/replace="t"
/db_xref="dbSNP:1058288"
variation 1255
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="c"
/db_xref="dbSNP:200202696"
STS 1262..1453
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/standard_name="RH11218"
/db_xref="UniSTS:90434"
variation 1264
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:61744201"
variation 1265
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:368843309"
variation 1317
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="g"
/db_xref="dbSNP:200273530"
variation 1334
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:1058300"
variation 1338
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="t"
/db_xref="dbSNP:140261783"
variation 1351
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="t"
/db_xref="dbSNP:371223654"
variation 1438
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="t"
/db_xref="dbSNP:7966614"
polyA_signal 1444..1449
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
variation 1448
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="c"
/db_xref="dbSNP:1802615"
polyA_site 1478
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
variation 1544
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:192775311"
variation 1620..1621
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace=""
/replace="a"
/db_xref="dbSNP:372357069"
variation 1621
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace=""
/replace="a"
/db_xref="dbSNP:35567478"
variation 1765
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="g"
/replace="t"
/db_xref="dbSNP:184293463"
variation 1786
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:188145139"
variation 1816
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:181982566"
variation 1886
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="t"
/db_xref="dbSNP:1058309"
variation 1894..1896
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace=""
/replace="tgt"
/db_xref="dbSNP:375546327"
variation 1904
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:11109526"
variation 1944
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:137958470"
variation 1958
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:371174437"
variation 2068
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:374141361"
STS 2120..2260
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/standard_name="WI-18798"
/db_xref="UniSTS:26994"
variation 2245
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:75544449"
STS 2335..2915
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/standard_name="GDB:631802"
/db_xref="UniSTS:158429"
STS 2336..2438
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/standard_name="D11S3114"
/db_xref="UniSTS:152207"
STS 2407..2546
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/standard_name="D16S325"
/db_xref="UniSTS:147089"
variation 2414
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="g"
/replace="t"
/db_xref="dbSNP:12816564"
STS 2420..2510
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
variation 2537
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="c"
/db_xref="dbSNP:186285844"
variation 2594..2595
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace=""
/replace="a"
/db_xref="dbSNP:200555771"
variation 2604
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="t"
/db_xref="dbSNP:189099847"
variation 2651
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="g"
/replace="t"
/db_xref="dbSNP:181561458"
variation 2682
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:149485655"
variation 2772
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="t"
/db_xref="dbSNP:186744278"
variation 2773
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="t"
/db_xref="dbSNP:191087791"
variation 2775
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:28535939"
variation 2788
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="t"
/db_xref="dbSNP:183137615"
STS 2796..2914
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/standard_name="D10S2448"
/db_xref="UniSTS:474444"
variation 2848
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:186047886"
variation 2849
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="c"
/db_xref="dbSNP:7973946"
variation 2856
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="t"
/db_xref="dbSNP:147137090"
variation 2884
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:3177178"
variation 2889
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="t"
/db_xref="dbSNP:138693048"
variation 2898
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:3177180"
variation 2917
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:143292209"
variation 2921
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="g"
/replace="t"
/db_xref="dbSNP:112838469"
variation 2932
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="t"
/db_xref="dbSNP:189533759"
variation 2977..2980
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace=""
/replace="tgga"
/db_xref="dbSNP:374509575"
variation 3105
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="c"
/db_xref="dbSNP:373125491"
variation 3198
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:370919987"
variation 3209
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="g"
/replace="t"
/db_xref="dbSNP:371728742"
variation 3249
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="t"
/db_xref="dbSNP:148592104"
variation 3281
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="t"
/db_xref="dbSNP:142900397"
variation 3282
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:73140468"
variation 3319..3320
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace=""
/replace="aa"
/db_xref="dbSNP:57778879"
variation 3320..3321
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace=""
/replace="aa"
/db_xref="dbSNP:67347959"
variation 3374
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace=""
/replace="g"
/db_xref="dbSNP:71704696"
variation 3391
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="g"
/db_xref="dbSNP:1044435"
variation 3409
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="c"
/db_xref="dbSNP:183276162"
variation 3444..3447
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace=""
/replace="tttc"
/db_xref="dbSNP:368618126"
STS 3541..3746
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/standard_name="RH44347"
/db_xref="UniSTS:67628"
variation 3637..3639
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace=""
/replace="tta"
/db_xref="dbSNP:57900732"
STS 3639..3739
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/standard_name="WI-11271"
/db_xref="UniSTS:35646"
variation 3671
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:371446465"
variation 3679
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="t"
/db_xref="dbSNP:369299135"
polyA_signal 3686..3691
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
variation 3703
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="c"
/replace="t"
/db_xref="dbSNP:1044514"
polyA_site 3714
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
variation 3744
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:200354667"
variation 3754
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="t"
/db_xref="dbSNP:150669486"
polyA_signal 3766..3771
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
polyA_site 3787
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
polyA_signal 3801..3806
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
variation 3801
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
/replace="a"
/replace="g"
/db_xref="dbSNP:34963912"
polyA_site 3854
/gene="TMPO"
/gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
ORIGIN
gttcttggggcgtgggcgaagcaggctgctcgcctcctgcctgtagtgtgtgggctggggttggtgcgagcttccagcttggccgcagttggttcgtagttcggctctggggtcttttgtgtccgggtctggcttggctttgtgtccgcgagtttttgttccgctccgcagcgctcttcccgggcaggagccgtgaggctcggaggcggcagcgcggtccccggccaggagcaagcgcgccggcgtgagcggcggcggcaaaggctgtggggagggggcttcgcagatccccgagatgccggagttcctggaagacccctcggtcctgacaaaagacaagttgaagagtgagttggtcgccaacaatgtgacgctgccggccggggagcagcgcaaagacgtgtacgtccagctctacctgcagcacctcacggctcgcaaccggccgccgctccccgccggcaccaacagcaaggggcccccggacttctccagtgacgaagagcgcgagcccaccccggtcctcggctctggggccgccgccgcgggccggagccgagcagccgtcggcaggaaagccacaaaaaaaactgataaacccagacaagaagataaagatgatctagatgtaacagagctcactaatgaagatcttttggatcagcttgtgaaatacggagtgaatcctggtcctattgtgggaacaaccaggaagctatatgagaaaaagcttttgaaactgagggaacaaggaacagaatcaagatcttctactcctctgccaacaatttcttcttcagcagaaaatacaaggcagaatggaagtaatgattctgacagatacagtgacaatgaagaagactctaaaatagagctcaagcttgagaagagagaaccactaaagggcagagcaaagactccagtaacactcaagcaaagaagagttgagcacaatcaggtgggagaaaaaacagaggaaagaagagtagaaagggatattcttaaggaaatgttcccctatgaagcatctacaccaacaggaattagtgctagttgccgcagaccaatcaaaggggctgcaggccggccattagaactcagtgatttcaggatggaggagtctttttcatctaaatatgttcctaagtatgttcccttggcagatgtcaagtcagaaaagacaaaaaagggacgctccattcccgtatggataaaaattttgctgtttgttgttgtggcagtttttttgtttttggtctatcaagctatggaaaccaaccaagtaaatcccttctctaattttcttcatgttgaccctagaaaatccaactgaatggtatctctttggcacgttcaacttggtctcctattttcaataactgttgaaaaacatttgtgtacacttgttgactccaagaactaaaaataatgtgatttcgcctcaataaatgtagtatttcattgaaaagcaaacaaaatatatataaatggacttcattaaaatgtttttgaactttggactagtaggagatcactttgtgccatatgaataatcttttttagctctggaactttttgtaggctttatttttttaatgtgggcatcttatttcatttttgaaaaaatgtatatgttttttgtgtatttgggaaacgaagggtgaaacatggtagtataatgtgaagctacacatttaaatacttagaattcttacagaaaagattttaagaattattctctgctgaataaaaactgcaaatatgtgaaacataatgaaattcagtaagaggaaaagtaacttggttgtactttttgtaactgcaacaaagtttgatggtgtttatgaggaaaagtacagcaataatctcttctgtaacctttattaatagtaatgttgttgtagccctatcatactcactttttaagacacagtatcatgaaagtcctatttcagtaagacccatttacatacagtagatttttagcagagatcttttagtgtaacatacatattttagagaattgttggctagctgtacatgttttgaaaagctgtttagctagctataaggctataattggaaatttgtattttttatttacagcaaaacatttattcagtcatccagtttgctaccaaaatatgttttagataagtgtgtgtatgtttgtttagaagttagaaattgtaaacactggtcttatgtttcatttggattcattattgcattgtcttgttaccagaaacaaattttgccgagctttttttgccctatatttcccagcataatttgattagaaagtacaaaaagggccaggcgcggtggcttacgcctgtaatcccagcactttgggaggccagggcgggtggatcacgaggtcaagagatcaagaccatcctggccaacatggtgaaaccccgtctctactaaaaatacaaaaaaattagctgggcgtgatgatgtgcgcctgtagtcctgtctactagggagactgaggcaggagaatcgtttgaacccaggaggcagaggttgcagtgagcagagattacgtcactgcactgtagcctggcgacagagcaagactccatctcaaaaaaaataaaaaagtacaaaaagtacttgcttttatattacatcataagcagtagttaataaagttgtatactcttaagaggtgggcattatgattattttttatttttttattttttatgagatggagtctcactcttgtcacccagactgtagtgcagtggcacgatctgggctcgatgcaacctctgcctcccaggttcaagcaattttcctgcctcggcagagacggggtttcaccatgttggccaggctggtctcgaacccctgacctcaagtgatcagcccacctcagcttcccaaagtgctgggattacaggtgtgatccactgcacccggccggcattatgattttgtgtactcttgaaatggttatctttgtggatgatttttttttttaagctgaaacttacctcatgaataacttgattaaagtagtaggtgattaaaatttcaatagaatcaaatgagacaaaaattttaaactgactcatttgagtttcaactttacagtcattgaccataaagcacactaaaaatgtaagttatttttaaatacatctgaaataaaaatacttactaaaaaggaagaagccgaagatgtatatttagaccagcacacaattttgatttcaattagccttattctaatatttagcttttagatctttcatacacattttcacgtactttgcaattgagaccagaaagacttgtaggtctttctgcagaatgagtgggtccttgcaaagtgagtgggaaacttactcctagatcagaaatgtttgcctctctgagtaaaatgtttctttcagatgagccatagagggggcaccttttactcaacttttctttgttttgaaactttgtttcccatactgttttcagccttttgtttataattagaaattgtgagaagcttcatttagtgtttaaaaatgtggggagataaatcagacttaacatgtatgtaagatcaattcacttaaaagtatggtccaaatagcaaaaataggaccaggtgaaacatgtagtcattttttaaaaacatgtacttggtcttttgtgtgtgtctgttttattccattagaataaatgtgtccttgatgtaaatgcaaagcatttcttcctgattaaattgtagatgtagactttacaatataattcaataataaaaagtaattaacctctagttttgtcgttgcaataaatggttttcagatagcacaaactgtgatttctggataacatttcttatgaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:7112 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:7112 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:7112 -> Molecular function: GO:0005521 [lamin binding] evidence: TAS
GeneID:7112 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
GeneID:7112 -> Cellular component: GO:0000785 [chromatin] evidence: IDA
GeneID:7112 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:7112 -> Cellular component: GO:0005634 [nucleus] evidence: TAS
GeneID:7112 -> Cellular component: GO:0005635 [nuclear envelope] evidence: TAS
GeneID:7112 -> Cellular component: GO:0005637 [nuclear inner membrane] evidence: IEA
GeneID:7112 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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