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2024-04-20 17:36:17, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001032283            4186 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens thymopoietin (TMPO), transcript variant 2, mRNA.
ACCESSION   NM_001032283
VERSION     NM_001032283.2  GI:296434314
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4186)
  AUTHORS   Ward,M.C., van der Watt,P.J., Tzoneva,G. and Leaner,V.D.
  TITLE     Deregulated LAP2alpha expression in cervical cancer associates with
            aberrant E2F and p53 activities
  JOURNAL   IUBMB Life 63 (11), 1018-1026 (2011)
   PUBMED   21990273
  REMARK    GeneRIF: this study provides evidence for elevated LAP2alpha
            expression in cervical cancer and suggests that E2F and p53
            activities associate with the positive and negative regulation of
            LAP2alpha expression, respectively
REFERENCE   2  (bases 1 to 4186)
  AUTHORS   Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B,
            Yusuf S, Gerstein HC, Engert JC and Anand S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   3  (bases 1 to 4186)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun. 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 4186)
  AUTHORS   Craig,D.W., Millis,M.P. and DiStefano,J.K.
  TITLE     Genome-wide SNP genotyping study using pooled DNA to identify
            candidate markers mediating susceptibility to end-stage renal
            disease attributed to Type 1 diabetes
  JOURNAL   Diabet. Med. 26 (11), 1090-1098 (2009)
   PUBMED   19929986
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   5  (bases 1 to 4186)
  AUTHORS   Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt
            TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M,
            Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ,
            Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S,
            Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD,
            Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE
            and Hingorani AD.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am. J. Hum. Genet. 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 4186)
  AUTHORS   Hara,H., Hayashi,K., Ohta,K., Itoh,N. and Ohta,M.
  TITLE     A new thymopoietin precursor gene from human thymus
  JOURNAL   Biochem. Mol. Biol. Int. 34 (5), 927-933 (1994)
   PUBMED   7703909
REFERENCE   7  (bases 1 to 4186)
  AUTHORS   Harris,C.A., Andryuk,P.J., Cline,S., Chan,H.K., Natarajan,A.,
            Siekierka,J.J. and Goldstein,G.
  TITLE     Three distinct human thymopoietins are derived from alternatively
            spliced mRNAs
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 91 (14), 6283-6287 (1994)
   PUBMED   7517549
REFERENCE   8  (bases 1 to 4186)
  AUTHORS   Heavner,G.A., Audhya,T. and Goldstein,G.
  TITLE     Peptide analogs of thymopentin distinguish distinct thymopoietin
            receptor specificities on two human T cell lines
  JOURNAL   Regul. Pept. 27 (2), 257-262 (1990)
   PUBMED   2158125
REFERENCE   9  (bases 1 to 4186)
  AUTHORS   Fuccello,A., Audhya,T., Talle,M.A. and Goldstein,G.
  TITLE     Immunoassay for bovine serum thymopoietin: discrimination from
            splenin by monoclonal antibodies
  JOURNAL   Arch. Biochem. Biophys. 228 (1), 292-298 (1984)
   PUBMED   6364989
REFERENCE   10 (bases 1 to 4186)
  AUTHORS   Twomey,J.J., Goldstein,G., Lewis,V.M., Bealmear,P.M. and Good,R.A.
  TITLE     Bioassay determinations of thymopoietin and thymic hormone levels
            in human plasma
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 74 (6), 2541-2545 (1977)
   PUBMED   302007
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB239672.1, BC053675.1,
            AB209297.1, BQ232508.1, BG676381.1, BM802949.1, AI055921.1 and
            AA992204.1.
            This sequence is a reference standard in the RefSeqGene project.
            On May 21, 2010 this sequence version replaced gi:73760404.
            
            Summary: The protein encoded by this gene resides in the nucleus
            and may play a role in the assembly of the nuclear lamina, and thus
            help maintain the structural organization of the nuclear envelope.
            It may function as a receptor for the attachment of lamin filaments
            to the inner nuclear membrane. Mutations in this gene are
            associated with dilated cardiomyopathy. Alternatively spliced
            transcript variants encoding different isoforms have been noted for
            this gene. [provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (2) differs at the 3' end compared
            to variant 1, resulting in a shorter isoform (beta) with a distinct
            C-terminus compared to isoform alpha.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053675.1, U09087.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025083 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-593               DB239672.1         1-593
            594-2596            BC053675.1         540-2542
            2597-2829           AB209297.1         2206-2438
            2830-3101           BQ232508.1         73-344
            3102-3126           AB209297.1         2492-2516
            3127-3549           BG676381.1         204-626
            3550-3941           BM802949.1         384-775
            3942-4114           AI055921.1         4-176               c
            4115-4186           AA992204.1         1-72                c
FEATURES             Location/Qualifiers
     source          1..4186
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q22"
     gene            1..4186
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /note="thymopoietin"
                     /db_xref="GeneID:7112"
                     /db_xref="HGNC:11875"
                     /db_xref="HPRD:01777"
                     /db_xref="MIM:188380"
     exon            1..574
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /inference="alignment:Splign:1.39.8"
     variation       125
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:186697764"
     misc_feature    194..196
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /note="upstream in-frame stop codon"
     variation       244
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370309699"
     variation       283
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374345638"
     variation       285
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:377404642"
     variation       294
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:144959639"
     CDS             296..1660
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /note="isoform beta is encoded by transcript variant 2;
                     LEM domain containing 4; lamina-associated polypeptide 2;
                     TP beta/gamma; TP alpha; thymopoietin-related peptide
                     isoform alpha; thymopoietin-related peptide isoforms
                     beta/gamma"
                     /codon_start=1
                     /product="thymopoietin isoform beta"
                     /protein_id="NP_001027454.1"
                     /db_xref="GI:73760405"
                     /db_xref="CCDS:CCDS31879.1"
                     /db_xref="GeneID:7112"
                     /db_xref="HGNC:11875"
                     /db_xref="HPRD:01777"
                     /db_xref="MIM:188380"
                     /translation="
MPEFLEDPSVLTKDKLKSELVANNVTLPAGEQRKDVYVQLYLQHLTARNRPPLPAGTNSKGPPDFSSDEEREPTPVLGSGAAAAGRSRAAVGRKATKKTDKPRQEDKDDLDVTELTNEDLLDQLVKYGVNPGPIVGTTRKLYEKKLLKLREQGTESRSSTPLPTISSSAENTRQNGSNDSDRYSDNEEDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQSYSQAGITETEWTSGSSKGGPLQALTRESTRGSRRTPRKRVETSEHFRIDGPVISESTPIAETIMASSNESLVVNRVTGNFKHASPILPITEFSDIPRRAPKKPLTRAEVGEKTEERRVERDILKEMFPYEASTPTGISASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRSIPVWIKILLFVVVAVFLFLVYQAMETNQVNPFSNFLHVDPRKSN
"
     misc_feature    296..1525
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P42167.2);
                     Region: Nucleoplasmic (Potential)"
     misc_feature    299..445
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /note="Thymopoietin protein; Region: Thymopoietin;
                     pfam08198"
                     /db_xref="CDD:149323"
     misc_feature    440..619
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P42167.2);
                     Region: Linker"
     misc_feature    491..493
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    491..493
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    494..496
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    515..517
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    530..532
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    623..>709
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /note="LEM domain; Region: LEM; cl02649"
                     /db_xref="CDD:155036"
     misc_feature    707..1024
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P42167.2);
                     Region: NAKAP95-binding N"
     misc_feature    755..757
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    761..763
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    767..769
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    770..772
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    773..775
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    785..787
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    824..826
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P42167.2); phosphorylation site"
     misc_feature    833..835
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P42167.2); phosphorylation site"
     misc_feature    833..835
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    842..844
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    845..847
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P42167.2); phosphorylation site"
     misc_feature    845..847
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    917..919
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P42167.2); phosphorylation site"
     misc_feature    926..928
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P42167.2); phosphorylation site"
     misc_feature    1088..1090
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P42167.2); phosphorylation site"
     misc_feature    1169..1171
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P42167.2); phosphorylation site"
     misc_feature    1190..1408
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P42167.2);
                     Region: Binds lamins B"
     misc_feature    1193..1417
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P42167.2);
                     Region: NAKAP95-binding C"
     misc_feature    1211..1213
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P42167.2); phosphorylation site"
     misc_feature    1211..1213
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1229..1231
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P42167.2); phosphorylation site"
     misc_feature    1238..1240
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P42167.2); phosphorylation site"
     misc_feature    1379..1381
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P42167.2); phosphorylation site"
     misc_feature    1427..1429
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1448..1450
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P42167.2); phosphorylation site"
     misc_feature    1526..1597
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P42167.2);
                     transmembrane region"
     variation       308
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149067616"
     variation       322
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:190115355"
     variation       367
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201960762"
     variation       379
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199549942"
     variation       382
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:114074541"
     variation       409
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200619128"
     variation       411
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374578351"
     variation       421
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372903897"
     variation       423
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371427406"
     variation       455
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376363219"
     variation       456..457
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="cc"
                     /replace="g"
                     /db_xref="dbSNP:368465288"
     variation       520
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:59027673"
     variation       526
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139576816"
     variation       560
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200177466"
     exon            575..701
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /inference="alignment:Splign:1.39.8"
     variation       626
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201838047"
     variation       645
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141387097"
     variation       650
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:113967157"
     variation       653
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200420073"
     variation       665
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375619307"
     variation       676
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370093524"
     variation       677
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200943582"
     exon            702..860
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /inference="alignment:Splign:1.39.8"
     variation       771
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:183244086"
     variation       792
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:147012167"
     variation       829
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200016687"
     variation       852
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200923649"
     exon            861..958
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /inference="alignment:Splign:1.39.8"
     STS             903..1024
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /standard_name="SHGC-58801"
                     /db_xref="UniSTS:94447"
     variation       907
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:377624930"
     variation       931
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371253652"
     variation       949
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138298699"
     exon            959..1078
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /inference="alignment:Splign:1.39.8"
     variation       1072
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200238614"
     exon            1079..1174
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /inference="alignment:Splign:1.39.8"
     variation       1101
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142891873"
     variation       1107
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:190515788"
     variation       1151
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199594991"
     STS             1152..1301
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /standard_name="RH48814"
                     /db_xref="UniSTS:39587"
     variation       1154
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:7133258"
     exon            1175..1285
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /inference="alignment:Splign:1.39.8"
     variation       1222
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:374561277"
     variation       1244
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:368800243"
     variation       1275
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372379540"
     exon            1286..1374
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /inference="alignment:Splign:1.39.8"
     variation       1303
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:34204719"
     variation       1319
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:147928797"
     variation       1339
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:141552430"
     exon            1375..4181
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /inference="alignment:Splign:1.39.8"
     variation       1414
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144913822"
     variation       1438
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373609093"
     variation       1456
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370301550"
     variation       1472
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199545670"
     variation       1523..1524
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:34001294"
     variation       1532
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:115843977"
     variation       1562
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368180278"
     variation       1568..1569
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace=""
                     /replace="gtttttttt"
                     /db_xref="dbSNP:144209787"
     variation       1576
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1058288"
     variation       1582
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200202696"
     STS             1589..1780
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /standard_name="RH11218"
                     /db_xref="UniSTS:90434"
     variation       1591
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61744201"
     variation       1592
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368843309"
     variation       1644
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200273530"
     variation       1661
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1058300"
     variation       1665
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140261783"
     variation       1678
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371223654"
     variation       1765
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:7966614"
     polyA_signal    1771..1776
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
     variation       1775
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1802615"
     polyA_site      1805
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
     variation       1871
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192775311"
     variation       1947..1948
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:372357069"
     variation       1948
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:35567478"
     variation       2092
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:184293463"
     variation       2113
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188145139"
     variation       2143
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181982566"
     variation       2213
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1058309"
     variation       2221..2223
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace=""
                     /replace="tgt"
                     /db_xref="dbSNP:375546327"
     variation       2231
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11109526"
     variation       2271
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:137958470"
     variation       2285
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371174437"
     variation       2395
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374141361"
     STS             2447..2587
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /standard_name="WI-18798"
                     /db_xref="UniSTS:26994"
     variation       2572
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:75544449"
     STS             2662..3242
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /standard_name="GDB:631802"
                     /db_xref="UniSTS:158429"
     STS             2663..2765
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /standard_name="D11S3114"
                     /db_xref="UniSTS:152207"
     STS             2734..2873
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /standard_name="D16S325"
                     /db_xref="UniSTS:147089"
     variation       2741
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:12816564"
     STS             2747..2837
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /standard_name="D8S2279"
                     /db_xref="UniSTS:473907"
     variation       2864
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:186285844"
     variation       2921..2922
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:200555771"
     variation       2931
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:189099847"
     variation       2978
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:181561458"
     variation       3009
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149485655"
     variation       3099
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186744278"
     variation       3100
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191087791"
     variation       3102
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:28535939"
     variation       3115
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:183137615"
     STS             3123..3241
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /standard_name="D10S2448"
                     /db_xref="UniSTS:474444"
     variation       3175
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186047886"
     variation       3176
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:7973946"
     variation       3183
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147137090"
     variation       3211
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3177178"
     variation       3216
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:138693048"
     variation       3225
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3177180"
     variation       3244
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143292209"
     variation       3248
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:112838469"
     variation       3259
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189533759"
     variation       3304..3307
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace=""
                     /replace="tgga"
                     /db_xref="dbSNP:374509575"
     variation       3432
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:373125491"
     variation       3525
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370919987"
     variation       3536
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:371728742"
     variation       3576
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148592104"
     variation       3608
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142900397"
     variation       3609
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:73140468"
     variation       3646..3647
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace=""
                     /replace="aa"
                     /db_xref="dbSNP:57778879"
     variation       3647..3648
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace=""
                     /replace="aa"
                     /db_xref="dbSNP:67347959"
     variation       3701
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:71704696"
     variation       3718
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1044435"
     variation       3736
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:183276162"
     variation       3771..3774
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace=""
                     /replace="tttc"
                     /db_xref="dbSNP:368618126"
     STS             3868..4073
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /standard_name="RH44347"
                     /db_xref="UniSTS:67628"
     variation       3964..3966
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace=""
                     /replace="tta"
                     /db_xref="dbSNP:57900732"
     STS             3966..4066
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /standard_name="WI-11271"
                     /db_xref="UniSTS:35646"
     variation       3998
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371446465"
     variation       4006
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369299135"
     polyA_signal    4013..4018
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
     variation       4030
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1044514"
     polyA_site      4041
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
     variation       4071
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200354667"
     variation       4081
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:150669486"
     polyA_signal    4093..4098
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
     polyA_site      4114
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
     polyA_signal    4128..4133
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
     variation       4128
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34963912"
     polyA_site      4181
                     /gene="TMPO"
                     /gene_synonym="CMD1T; LAP2; LEMD4; PRO0868; TP"
ORIGIN      
gttcttggggcgtgggcgaagcaggctgctcgcctcctgcctgtagtgtgtgggctggggttggtgcgagcttccagcttggccgcagttggttcgtagttcggctctggggtcttttgtgtccgggtctggcttggctttgtgtccgcgagtttttgttccgctccgcagcgctcttcccgggcaggagccgtgaggctcggaggcggcagcgcggtccccggccaggagcaagcgcgccggcgtgagcggcggcggcaaaggctgtggggagggggcttcgcagatccccgagatgccggagttcctggaagacccctcggtcctgacaaaagacaagttgaagagtgagttggtcgccaacaatgtgacgctgccggccggggagcagcgcaaagacgtgtacgtccagctctacctgcagcacctcacggctcgcaaccggccgccgctccccgccggcaccaacagcaaggggcccccggacttctccagtgacgaagagcgcgagcccaccccggtcctcggctctggggccgccgccgcgggccggagccgagcagccgtcggcaggaaagccacaaaaaaaactgataaacccagacaagaagataaagatgatctagatgtaacagagctcactaatgaagatcttttggatcagcttgtgaaatacggagtgaatcctggtcctattgtgggaacaaccaggaagctatatgagaaaaagcttttgaaactgagggaacaaggaacagaatcaagatcttctactcctctgccaacaatttcttcttcagcagaaaatacaaggcagaatggaagtaatgattctgacagatacagtgacaatgaagaagactctaaaatagagctcaagcttgagaagagagaaccactaaagggcagagcaaagactccagtaacactcaagcaaagaagagttgagcacaatcagagctattctcaagctggaataactgagactgaatggacaagtggatcttcaaaaggcggacctctgcaggcattaactagggaatctacaagagggtcaagaagaactccaaggaaaagggtggaaacttcagaacattttcgtatagatggtccagtaatttcagagagtactcccatagctgaaactataatggcttcaagcaacgaatccttagttgtcaatagggtgactggaaatttcaagcatgcatctcctattctgccaatcactgaattctcagacatacccagaagagcaccaaagaaaccattgacaagagctgaagtgggagaaaaaacagaggaaagaagagtagaaagggatattcttaaggaaatgttcccctatgaagcatctacaccaacaggaattagtgctagttgccgcagaccaatcaaaggggctgcaggccggccattagaactcagtgatttcaggatggaggagtctttttcatctaaatatgttcctaagtatgttcccttggcagatgtcaagtcagaaaagacaaaaaagggacgctccattcccgtatggataaaaattttgctgtttgttgttgtggcagtttttttgtttttggtctatcaagctatggaaaccaaccaagtaaatcccttctctaattttcttcatgttgaccctagaaaatccaactgaatggtatctctttggcacgttcaacttggtctcctattttcaataactgttgaaaaacatttgtgtacacttgttgactccaagaactaaaaataatgtgatttcgcctcaataaatgtagtatttcattgaaaagcaaacaaaatatatataaatggacttcattaaaatgtttttgaactttggactagtaggagatcactttgtgccatatgaataatcttttttagctctggaactttttgtaggctttatttttttaatgtgggcatcttatttcatttttgaaaaaatgtatatgttttttgtgtatttgggaaacgaagggtgaaacatggtagtataatgtgaagctacacatttaaatacttagaattcttacagaaaagattttaagaattattctctgctgaataaaaactgcaaatatgtgaaacataatgaaattcagtaagaggaaaagtaacttggttgtactttttgtaactgcaacaaagtttgatggtgtttatgaggaaaagtacagcaataatctcttctgtaacctttattaatagtaatgttgttgtagccctatcatactcactttttaagacacagtatcatgaaagtcctatttcagtaagacccatttacatacagtagatttttagcagagatcttttagtgtaacatacatattttagagaattgttggctagctgtacatgttttgaaaagctgtttagctagctataaggctataattggaaatttgtattttttatttacagcaaaacatttattcagtcatccagtttgctaccaaaatatgttttagataagtgtgtgtatgtttgtttagaagttagaaattgtaaacactggtcttatgtttcatttggattcattattgcattgtcttgttaccagaaacaaattttgccgagctttttttgccctatatttcccagcataatttgattagaaagtacaaaaagggccaggcgcggtggcttacgcctgtaatcccagcactttgggaggccagggcgggtggatcacgaggtcaagagatcaagaccatcctggccaacatggtgaaaccccgtctctactaaaaatacaaaaaaattagctgggcgtgatgatgtgcgcctgtagtcctgtctactagggagactgaggcaggagaatcgtttgaacccaggaggcagaggttgcagtgagcagagattacgtcactgcactgtagcctggcgacagagcaagactccatctcaaaaaaaataaaaaagtacaaaaagtacttgcttttatattacatcataagcagtagttaataaagttgtatactcttaagaggtgggcattatgattattttttatttttttattttttatgagatggagtctcactcttgtcacccagactgtagtgcagtggcacgatctgggctcgatgcaacctctgcctcccaggttcaagcaattttcctgcctcggcagagacggggtttcaccatgttggccaggctggtctcgaacccctgacctcaagtgatcagcccacctcagcttcccaaagtgctgggattacaggtgtgatccactgcacccggccggcattatgattttgtgtactcttgaaatggttatctttgtggatgatttttttttttaagctgaaacttacctcatgaataacttgattaaagtagtaggtgattaaaatttcaatagaatcaaatgagacaaaaattttaaactgactcatttgagtttcaactttacagtcattgaccataaagcacactaaaaatgtaagttatttttaaatacatctgaaataaaaatacttactaaaaaggaagaagccgaagatgtatatttagaccagcacacaattttgatttcaattagccttattctaatatttagcttttagatctttcatacacattttcacgtactttgcaattgagaccagaaagacttgtaggtctttctgcagaatgagtgggtccttgcaaagtgagtgggaaacttactcctagatcagaaatgtttgcctctctgagtaaaatgtttctttcagatgagccatagagggggcaccttttactcaacttttctttgttttgaaactttgtttcccatactgttttcagccttttgtttataattagaaattgtgagaagcttcatttagtgtttaaaaatgtggggagataaatcagacttaacatgtatgtaagatcaattcacttaaaagtatggtccaaatagcaaaaataggaccaggtgaaacatgtagtcattttttaaaaacatgtacttggtcttttgtgtgtgtctgttttattccattagaataaatgtgtccttgatgtaaatgcaaagcatttcttcctgattaaattgtagatgtagactttacaatataattcaataataaaaagtaattaacctctagttttgtcgttgcaataaatggttttcagatagcacaaactgtgatttctggataacatttcttatgaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:7112 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
            GeneID:7112 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:7112 -> Molecular function: GO:0005521 [lamin binding] evidence: TAS
            GeneID:7112 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
            GeneID:7112 -> Cellular component: GO:0000785 [chromatin] evidence: IDA
            GeneID:7112 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:7112 -> Cellular component: GO:0005634 [nucleus] evidence: TAS
            GeneID:7112 -> Cellular component: GO:0005635 [nuclear envelope] evidence: TAS
            GeneID:7112 -> Cellular component: GO:0005637 [nuclear inner membrane] evidence: IEA
            GeneID:7112 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA

by @meso_cacase at DBCLS
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