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2024-04-19 11:03:44, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001031853 2970 bp mRNA linear PRI 01-JUL-2013
DEFINITION Homo sapiens inscuteable homolog (Drosophila) (INSC), transcript
variant 1, mRNA.
ACCESSION NM_001031853 XM_370613
VERSION NM_001031853.4 GI:507417924
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2970)
AUTHORS Mapelli,M. and Gonzalez,C.
TITLE On the inscrutable role of Inscuteable: structural basis and
functional implications for the competitive binding of NuMA and
Inscuteable to LGN
JOURNAL Open Biol 2 (8), 120102 (2012)
PUBMED 22977735
REMARK GeneRIF: Studies indicate that the Inscuteable (Insc)and NuMA are
mutually exclusive interactors of LGN.
Review article
REFERENCE 2 (bases 1 to 2970)
AUTHORS Tao,S., Wang,Z., Feng,J., Hsu,F.C., Jin,G., Kim,S.T., Zhang,Z.,
Gronberg,H., Zheng,L.S., Isaacs,W.B., Xu,J. and Sun,J.
TITLE A genome-wide search for loci interacting with known prostate
cancer risk-associated genetic variants
JOURNAL Carcinogenesis 33 (3), 598-603 (2012)
PUBMED 22219177
REFERENCE 3 (bases 1 to 2970)
AUTHORS Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
Gibbs,R.A. and Butte,N.F.
TITLE Novel genetic loci identified for the pathophysiology of childhood
obesity in the Hispanic population
JOURNAL PLoS ONE 7 (12), E51954 (2012)
PUBMED 23251661
REFERENCE 4 (bases 1 to 2970)
AUTHORS Yuzawa,S., Kamakura,S., Iwakiri,Y., Hayase,J. and Sumimoto,H.
TITLE Structural basis for interaction between the conserved cell
polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched
protein (LGN)
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 108 (48), 19210-19215 (2011)
PUBMED 22074847
REMARK GeneRIF: mInsc-LGN interaction is vital for stabilization of LGN
and for intracellular localization of mInsc.
REFERENCE 5 (bases 1 to 2970)
AUTHORS Vural,A., Oner,S., An,N., Simon,V., Ma,D., Blumer,J.B. and
Lanier,S.M.
TITLE Distribution of activator of G-protein signaling 3 within the
aggresomal pathway: role of specific residues in the
tetratricopeptide repeat domain and differential regulation by the
AGS3 binding partners Gi(alpha) and mammalian inscuteable
JOURNAL Mol. Cell. Biol. 30 (6), 1528-1540 (2010)
PUBMED 20065032
REMARK GeneRIF: These data present AGS3, G-proteins, and mInsc as
candidate proteins involved in regulating cellular stress
associated with protein-processing pathologies.
REFERENCE 6 (bases 1 to 2970)
AUTHORS Izaki,T., Kamakura,S., Kohjima,M. and Sumimoto,H.
TITLE Two forms of human Inscuteable-related protein that links Par3 to
the Pins homologues LGN and AGS3
JOURNAL Biochem. Biophys. Res. Commun. 341 (4), 1001-1006 (2006)
PUBMED 16458856
REMARK GeneRIF: cloning of two distinct cDNAs from Insc gene, which is
differentially expressed from alternative first exons;Insc proteins
bind to the Pins homologues LGN and AGS3, and also to Par3 and
Par3beta
REFERENCE 7 (bases 1 to 2970)
AUTHORS Katoh,M. and Katoh,M.
TITLE Identification and characterization of human Inscuteable gene in
silico
JOURNAL Int. J. Mol. Med. 11 (1), 111-116 (2003)
PUBMED 12469229
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AB236159.1 and DY654442.1.
On May 25, 2013 this sequence version replaced gi:99028952.
Summary: In Drosophila, neuroblasts divide asymmetrically into
another neuroblast at the apical side and a smaller ganglion mother
cell on the basal side. Cell polarization is precisely regulated by
2 apically localized multiprotein signaling complexes that are
tethered by Inscuteable, which regulates their apical localization
(Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar
2008].
Transcript Variant: This variant (1) encodes the longest isoform
(a).
##Evidence-Data-START##
Transcript exon combination :: AB236159.1 [ECO:0000332]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-729 AB236159.1 1-729
730-1151 DY654442.1 12-433 c
1152-2970 AB236159.1 1152-2970
FEATURES Location/Qualifiers
source 1..2970
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11p15.2"
gene 1..2970
/gene="INSC"
/note="inscuteable homolog (Drosophila)"
/db_xref="GeneID:387755"
/db_xref="HGNC:33116"
/db_xref="MIM:610668"
exon 1..142
/gene="INSC"
/inference="alignment:Splign:1.39.8"
CDS 47..1786
/gene="INSC"
/note="isoform a is encoded by transcript variant 1;
protein inscuteable homolog"
/codon_start=1
/product="protein inscuteable homolog isoform a"
/protein_id="NP_001027024.3"
/db_xref="GI:99028953"
/db_xref="CCDS:CCDS41621.1"
/db_xref="GeneID:387755"
/db_xref="HGNC:33116"
/db_xref="MIM:610668"
/translation="
MRRPPGNGEAASEGPGGWGLWGVQESRRLCCAGHDRCKQALLQIGINMMALPGGRHLDSVTLPGQRLHLMQVDSVQRWMEDLKLMTECECMCVLQAKPISLEEDAQGDLILAGGPGPGDPLQLLLKRGWVISTELRRIGQKLAQDRWARVHSMSVRLTCHARSMVSEYSAVSRNSLKEMGEIEKLLMEKCSELSAVTERCLQVENEHVLKSMKACVSETLSMLGQHFGQLLELALTREVQALVRKIDASDNIYTTESTTGNLFSLTQEGAPLCRIIAKEGGVVALFKVCRQDSFRCLYPQALRTLASICCVEEGVHQLEKVDGVLCLADILTDNSHSEATRAEAAAVVAQVTSPHLPVTQHLSSFLESMEEIVTALVKLCQEASSGEVFLLASAALANITFFDTMACEMLLQLNAIRVLLEACSDKQRVDTPYTRDQIVTILANMSVLEQCASDIIQENGVQLIMGMLSEKPRSGTPAEVAACERVQQKAAVTLARLSRDPDVAREAVRLSCMSRLIELCRSPSERNSSDAVLVACLAALRRLAGVCPEGLQDSDFQQLVQPRLVDSFLLCSNMEESFV
"
misc_feature 1772..1783
/gene="INSC"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q1MX18.1);
Region: PDZ-binding"
exon 143..243
/gene="INSC"
/inference="alignment:Splign:1.39.8"
exon 244..589
/gene="INSC"
/inference="alignment:Splign:1.39.8"
exon 590..642
/gene="INSC"
/inference="alignment:Splign:1.39.8"
exon 643..766
/gene="INSC"
/inference="alignment:Splign:1.39.8"
exon 767..880
/gene="INSC"
/inference="alignment:Splign:1.39.8"
exon 881..1006
/gene="INSC"
/inference="alignment:Splign:1.39.8"
exon 1007..1178
/gene="INSC"
/inference="alignment:Splign:1.39.8"
exon 1179..1357
/gene="INSC"
/inference="alignment:Splign:1.39.8"
exon 1358..1424
/gene="INSC"
/inference="alignment:Splign:1.39.8"
exon 1425..1580
/gene="INSC"
/inference="alignment:Splign:1.39.8"
exon 1581..1657
/gene="INSC"
/inference="alignment:Splign:1.39.8"
exon 1658..2954
/gene="INSC"
/inference="alignment:Splign:1.39.8"
ORIGIN
ggcctctgtaaggagacttggagtcgctgcagccaaggctggagccatgagacggccccctggcaatggagaggcggccagcgaaggtccaggtggctggggtctatggggagtccaggagtccaggaggctgtgctgtgccggtcacgaccgctgcaagcaggctttgctgcagattgggatcaacatgatggcactgcctggaggtcgccacctggactccgtcaccctgccgggtcagcggctacacctgatgcaggtggactcagtccagcgctggatggaagatctgaagctcatgaccgagtgcgagtgcatgtgtgtcctgcaggccaagcccatcagcctggaagaggatgcacagggtgacctcatcctggcaggtggccctggccctggagaccccctgcagctgctgctcaaacggggttgggtcattagcacagagctgcgcaggatcgggcagaagctggcccaggaccgctgggcacgggtgcacagcatgagcgtgcgtctgacctgccatgcccgctccatggtcagcgagtacagtgctgtcagcaggaactccttgaaggaaatgggcgagattgagaagctgctaatggagaaatgctcggagctctcggcagtcacagagaggtgccttcaggttgagaatgagcatgtcctgaagtcaatgaaggcctgcgtgagtgagaccctgagcatgctgggccagcactttggtcagctgctggagctggccctgacacgggaggttcaggcactggtgagaaaaattgatgcctcagacaatatctacaccacagagtccaccacagggaacctgttcagcctgacccaggagggggctcccttgtgccgcatcatagccaaggagggtggggtcgtagcactcttcaaggtttgccggcaggacagtttccggtgcttgtacccccaggcgctccgcacgctggcctccatctgctgcgtggaagagggtgtccaccagctggagaaggtggatggcgttctgtgcttggccgacatcctgaccgacaacagccactcagaggccacacgggctgaggctgcggctgtggtggcccaggtcacctccccacacctgcccgtcacccagcacctcagtagcttcctggagagcatggaggagatcgtgacagccctcgtcaaactgtgccaagaggcctcatcaggggaagtcttcctactggcctctgcggcccttgccaacatcacgttctttgacacaatggcctgcgagatgctcctgcagttgaatgccatccgtgttctcctggaagcctgcagtgacaagcagagagtggacacgccttacactcgggaccagattgtgaccatcttggcaaacatgtctgtcctagaacagtgtgcctctgacatcattcaggaaaatggggtccagcttatcatgggcatgctgtctgaaaaaccaaggtctgggactcctgctgaagtggcagcctgtgagcgagtccagcagaaagctgcagtgaccctggctcgtctcagccgagacccagatgtggcacgggaggccgtgcggctcagctgcatgtcccgtctcatcgagctctgcagatccccatcagagaggaacagcagtgacgccgtgcttgtggcctgcctggctgctctgcgtagattggctggggtctgccctgaaggcctccaggactctgactttcagcagttggtccagcctcggctggtggactccttcttactctgcagcaacatggaggagagttttgtgtagtgagtgtgggcgaagaaatacatttggctgttctcacaccccctctgactatgcaccagtgaacacatctgagtacataccagctctcctcatcttcttatttatacttaacttatttttgtgtgaaataaatggaggacaaaatcttagagcaacatcatcaaacagtctttggtccttgagaatcttctttgtgttttattttttgatttctgtagcttttcagttgcagatgttgaaattcgtaatgacaaatatgacaaattgtcatgggtgattccacttcatcttattttttctactctcactatacaatcttgcctcattttttaaaactttggaaccagaggatttcaactgcctagcaagttttttttttaagttggatttgctcttcccaaaaatctaaaatgaatttaataattgggtagaatatattggaaagaagtttctttttctttaataaatggaatcatataaaatgtatcccggattttcttattaaattgtattttaaactaggttcttgcttcccaggtttcattccccaaaaacttttccaaccattaaaagtacacacagaattgtcttgttttcataggtgtataaataggttaagttctgagtgacttagtgagaaaccaaagtgactttcaaaaatacacccaaaggcaccagaaaccctgcttcctttggcttctttgcttttgtgtaacctcctgttcacctcctggtgaatagaatcctcagatgaggcttattgaatgattgattcctcctcaaaagtatacttgaaagcagtggtgtgctgaagccagctcatgcccactcacaagggacaactgtgagaatttcttcctaactctgcactcagtgaccttgcgttggtagccatgagctacttcatgagccctcatgttgaaattggccatagtgggagtatttacaccacagaaattcacagatgctataaagcacagctttcgctttttttttttttagagagagctggtttaccaatttcactgcttgaaagtatcacaaaaatctggggatccttttgaaaatataaatgccatcatattgtgatataatttatacaatataatataattgtgtaaaatcatgattataataatgtttcaataaacatttcttaaattcccaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:387755 -> Biological process: GO:0000132 [establishment of mitotic spindle orientation] evidence: IEA
GeneID:387755 -> Biological process: GO:0007399 [nervous system development] evidence: IEA
GeneID:387755 -> Biological process: GO:0060487 [lung epithelial cell differentiation] evidence: IEA
GeneID:387755 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
GeneID:387755 -> Cellular component: GO:0045177 [apical part of cell] evidence: IEA
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