GGRNA | NM_001031804.2

LOCUS       NM_001031804            6887 bp    mRNA    linear   PRI 11-JUL-2013
DEFINITION  Homo sapiens v-maf avian musculoaponeurotic fibrosarcoma oncogene
            homolog (MAF), transcript variant 2, mRNA.
ACCESSION   NM_001031804 XM_001134279 XM_001134280
VERSION     NM_001031804.2  GI:197313769
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6887)
  AUTHORS   Kottgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark
            C, Pistis G, Ruggiero D, O'Seaghdha CM, Haller T, Yang Q, Tanaka T,
            Johnson AD, Kutalik Z, Smith AV, Shi J, Struchalin M, Middelberg
            RP, Brown MJ, Gaffo AL, Pirastu N, Li G, Hayward C, Zemunik T,
            Huffman J, Yengo L, Zhao JH, Demirkan A, Feitosa MF, Liu X, Malerba
            G, Lopez LM, van der Harst P, Li X, Kleber ME, Hicks AA, Nolte IM,
            Johansson A, Murgia F, Wild SH, Bakker SJ, Peden JF, Dehghan A,
            Steri M, Tenesa A, Lagou V, Salo P, Mangino M, Rose LM, Lehtimaki
            T, Woodward OM, Okada Y, Tin A, Muller C, Oldmeadow C, Putku M,
            Czamara D, Kraft P, Frogheri L, Thun GA, Grotevendt A, Gislason GK,
            Harris TB, Launer LJ, McArdle P, Shuldiner AR, Boerwinkle E, Coresh
            J, Schmidt H, Schallert M, Martin NG, Montgomery GW, Kubo M,
            Nakamura Y, Tanaka T, Munroe PB, Samani NJ, Jacobs DR Jr, Liu K,
            D'Adamo P, Ulivi S, Rotter JI, Psaty BM, Vollenweider P, Waeber G,
            Campbell S, Devuyst O, Navarro P, Kolcic I, Hastie N, Balkau B,
            Froguel P, Esko T, Salumets A, Khaw KT, Langenberg C, Wareham NJ,
            Isaacs A, Kraja A, Zhang Q, Wild PS, Scott RJ, Holliday EG, Org E,
            Viigimaa M, Bandinelli S, Metter JE, Lupo A, Trabetti E, Sorice R,
            Doring A, Lattka E, Strauch K, Theis F, Waldenberger M, Wichmann
            HE, Davies G, Gow AJ, Bruinenberg M, Stolk RP, Kooner JS, Zhang W,
            Winkelmann BR, Boehm BO, Lucae S, Penninx BW, Smit JH, Curhan G,
            Mudgal P, Plenge RM, Portas L, Persico I, Kirin M, Wilson JF, Mateo
            Leach I, van Gilst WH, Goel A, Ongen H, Hofman A, Rivadeneira F,
            Uitterlinden AG, Imboden M, von Eckardstein A, Cucca F, Nagaraja R,
            Piras MG, Nauck M, Schurmann C, Budde K, Ernst F, Farrington SM,
            Theodoratou E, Prokopenko I, Stumvoll M, Jula A, Perola M, Salomaa
            V, Shin SY, Spector TD, Sala C, Ridker PM, Kahonen M, Viikari J,
            Hengstenberg C, Nelson CP, Meschia JF, Nalls MA, Sharma P,
            Singleton AB, Kamatani N, Zeller T, Burnier M, Attia J, Laan M,
            Klopp N, Hillege HL, Kloiber S, Choi H, Pirastu M, Tore S,
            Probst-Hensch NM, Volzke H, Gudnason V, Parsa A, Schmidt R,
            Whitfield JB, Fornage M, Gasparini P, Siscovick DS, Polasek O,
            Campbell H, Rudan I, Bouatia-Naji N, Metspalu A, Loos RJ, van Duijn
            CM, Borecki IB, Ferrucci L, Gambaro G, Deary IJ, Wolffenbuttel BH,
            Chambers JC, Marz W, Pramstaller PP, Snieder H, Gyllensten U,
            Wright AF, Navis G, Watkins H, Witteman JC, Sanna S, Schipf S,
            Dunlop MG, Tonjes A, Ripatti S, Soranzo N, Toniolo D, Chasman DI,
            Raitakari O, Kao WH, Ciullo M, Fox CS, Caulfield M, Bochud M and
            Gieger C.
  CONSRTM   LifeLines Cohort Study; CARDIoGRAM Consortium; DIAGRAM Consortium;
            ICBP Consortium; MAGIC Consortium
  TITLE     Genome-wide association analyses identify 18 new loci associated
            with serum urate concentrations
  JOURNAL   Nat. Genet. 45 (2), 145-154 (2013)
   PUBMED   23263486
REFERENCE   2  (bases 1 to 6887)
  AUTHORS   Bernhard,F., Landgraf,K., Kloting,N., Berthold,A., Buttner,P.,
            Friebe,D., Kiess,W., Kovacs,P., Bluher,M. and Korner,A.
  TITLE     Functional relevance of genes implicated by obesity genome-wide
            association study signals for human adipocyte biology
  JOURNAL   Diabetologia 56 (2), 311-322 (2013)
   PUBMED   23229156
  REMARK    GeneRIF: Results imply a regulatory role for TMEM18, BDNF, MTCH2
            and NEGR1 in adipocyte differentiation and biology. In addition, we
            show a variation of MAF expression during adipogenesis, while NPC1,
            PTER and SH2B1 were not regulated.
REFERENCE   3  (bases 1 to 6887)
  AUTHORS   Porcu,E., Medici,M., Pistis,G., Volpato,C.B., Wilson,S.G.,
            Cappola,A.R., Bos,S.D., Deelen,J., den Heijer,M., Freathy,R.M.,
            Lahti,J., Liu,C., Lopez,L.M., Nolte,I.M., O'Connell,J.R.,
            Tanaka,T., Trompet,S., Arnold,A., Bandinelli,S., Beekman,M.,
            Bohringer,S., Brown,S.J., Buckley,B.M., Camaschella,C., de
            Craen,A.J., Davies,G., de Visser,M.C., Ford,I., Forsen,T.,
            Frayling,T.M., Fugazzola,L., Gogele,M., Hattersley,A.T.,
            Hermus,A.R., Hofman,A., Houwing-Duistermaat,J.J., Jensen,R.A.,
            Kajantie,E., Kloppenburg,M., Lim,E.M., Masciullo,C., Mariotti,S.,
            Minelli,C., Mitchell,B.D., Nagaraja,R., Netea-Maier,R.T.,
            Palotie,A., Persani,L., Piras,M.G., Psaty,B.M., Raikkonen,K.,
            Richards,J.B., Rivadeneira,F., Sala,C., Sabra,M.M., Sattar,N.,
            Shields,B.M., Soranzo,N., Starr,J.M., Stott,D.J., Sweep,F.C.,
            Usala,G., van der Klauw,M.M., van Heemst,D., van Mullem,A.,
            Vermeulen,S.H., Visser,W.E., Walsh,J.P., Westendorp,R.G., Widen,E.,
            Zhai,G., Cucca,F., Deary,I.J., Eriksson,J.G., Ferrucci,L.,
            Fox,C.S., Jukema,J.W., Kiemeney,L.A., Pramstaller,P.P.,
            Schlessinger,D., Shuldiner,A.R., Slagboom,E.P., Uitterlinden,A.G.,
            Vaidya,B., Visser,T.J., Wolffenbuttel,B.H., Meulenbelt,I.,
            Rotter,J.I., Spector,T.D., Hicks,A.A., Toniolo,D., Sanna,S.,
            Peeters,R.P. and Naitza,S.
  TITLE     A meta-analysis of thyroid-related traits reveals novel loci and
            gender-specific differences in the regulation of thyroid function
  JOURNAL   PLoS Genet. 9 (2), E1003266 (2013)
   PUBMED   23408906
REFERENCE   4  (bases 1 to 6887)
  AUTHORS   Zhang,M., Clausell,A., Robinson,T., Yin,J., Chen,E., Johnson,L.,
            Weiss,G., Sabbaj,S., Lowe,R.M., Wagner,F.H., Goepfert,P.A.,
            Kutsch,O. and Cron,R.Q.
  TITLE     Host factor transcriptional regulation contributes to preferential
            expression of HIV type 1 in IL-4-producing CD4 T cells
  JOURNAL   J. Immunol. 189 (6), 2746-2757 (2012)
   PUBMED   22875803
  REMARK    GeneRIF: c-Maf increases human immunodeficiency virus (HIV)-1
            expression in interleukin (IL)-4-producing CD4 T cells by binding
            the proximal HIV-1 long terminal repeat region (LTR) and augmenting
            HIV-1 transcription.
REFERENCE   5  (bases 1 to 6887)
  AUTHORS   Okada Y, Sim X, Go MJ, Wu JY, Gu D, Takeuchi F, Takahashi A, Maeda
            S, Tsunoda T, Chen P, Lim SC, Wong TY, Liu J, Young TL, Aung T,
            Seielstad M, Teo YY, Kim YJ, Lee JY, Han BG, Kang D, Chen CH, Tsai
            FJ, Chang LC, Fann SJ, Mei H, Rao DC, Hixson JE, Chen S, Katsuya T,
            Isono M, Ogihara T, Chambers JC, Zhang W, Kooner JS, Albrecht E,
            Yamamoto K, Kubo M, Nakamura Y, Kamatani N, Kato N, He J, Chen YT,
            Cho YS, Tai ES and Tanaka T.
  CONSRTM   KidneyGen Consortium; CKDGen Consortium; GUGC consortium
  TITLE     Meta-analysis identifies multiple loci associated with kidney
            function-related traits in east Asian populations
  JOURNAL   Nat. Genet. 44 (8), 904-909 (2012)
   PUBMED   22797727
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6887)
  AUTHORS   Christodoulopoulos,P., Cameron,L., Nakamura,Y., Lemiere,C.,
            Muro,S., Dugas,M., Boulet,L.P., Laviolette,M., Olivenstein,R. and
            Hamid,Q.
  TITLE     TH2 cytokine-associated transcription factors in atopic and
            nonatopic asthma: evidence for differential signal transducer and
            activator of transcription 6 expression
  JOURNAL   J. Allergy Clin. Immunol. 107 (4), 586-591 (2001)
   PUBMED   11295643
REFERENCE   7  (bases 1 to 6887)
  AUTHORS   Chesi,M., Bergsagel,P.L., Shonukan,O.O., Martelli,M.L.,
            Brents,L.A., Chen,T., Schrock,E., Ried,T. and Kuehl,W.M.
  TITLE     Frequent dysregulation of the c-maf proto-oncogene at 16q23 by
            translocation to an Ig locus in multiple myeloma
  JOURNAL   Blood 91 (12), 4457-4463 (1998)
   PUBMED   9616139
REFERENCE   8  (bases 1 to 6887)
  AUTHORS   Hedge,S.P., Kumar,A., Kurschner,C. and Shapiro,L.H.
  TITLE     c-Maf interacts with c-Myb to regulate transcription of an early
            myeloid gene during differentiation
  JOURNAL   Mol. Cell. Biol. 18 (5), 2729-2737 (1998)
   PUBMED   9566892
REFERENCE   9  (bases 1 to 6887)
  AUTHORS   Kurschner,C. and Morgan,J.I.
  TITLE     USF2/FIP associates with the b-Zip transcription factor, c-Maf, via
            its bHLH domain and inhibits c-Maf DNA binding activity
  JOURNAL   Biochem. Biophys. Res. Commun. 231 (2), 333-339 (1997)
   PUBMED   9070273
  REMARK    Erratum:[Biochem Biophys Res Commun 1997 Apr 7;233(1):293]
REFERENCE   10 (bases 1 to 6887)
  AUTHORS   Kerppola,T.K. and Curran,T.
  TITLE     Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos
            and Jun
  JOURNAL   Oncogene 9 (3), 675-684 (1994)
   PUBMED   8108109
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC038438.1, BF726289.1,
            BC081542.1, AC009159.12 and BE644986.1.
            On Aug 28, 2008 this sequence version replaced gi:73427805.
            
            Summary: The protein encoded by this gene is a DNA-binding, leucine
            zipper-containing transcription factor that acts as a homodimer or
            as a heterodimer. Depending on the binding site and binding
            partner, the encoded protein can be a transcriptional activator or
            repressor. This protein plays a role in the regulation of several
            cellular processes, including embryonic lens fiber cell
            development, increased T-cell susceptibility to apoptosis, and
            chondrocyte terminal differentiation. Defects in this gene are a
            cause of juvenile-onset pulverulent cataract as well as congenital
            cerulean cataract 4 (CCA4). Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jan 2010].
            
            Transcript Variant: This variant (2) represents an unspliced
            transcript compared to variant 1, which results in a frame-shift
            and a shorter isoform (b) with a distinct C-terminus compared to
            isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no quality transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-814               BC038438.1         1-814
            815-1147            BF726289.1         98-430
            1148-1338           BC038438.1         1145-1335
            1339-2115           BC081542.1         631-1407
            2116-6392           AC009159.12        100947-105223
            6393-6887           BE644986.1         1-495               c
FEATURES             Location/Qualifiers
     source          1..6887
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22-q23"
     gene            1..6887
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /note="v-maf avian musculoaponeurotic fibrosarcoma
                     oncogene homolog"
                     /db_xref="GeneID:4094"
                     /db_xref="HGNC:6776"
                     /db_xref="HPRD:01518"
                     /db_xref="MIM:177075"
     exon            1..6878
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /inference="alignment:Splign:1.39.8"
     variation       44
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2288066"
     misc_feature    662..664
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /note="upstream in-frame stop codon"
     variation       672
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3743596"
     variation       736
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:4081752"
     CDS             824..1945
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /note="isoform b is encoded by transcript variant 2; Avian
                     musculoaponeurotic fibrosarcoma (MAF) protooncogene;
                     transcription factor Maf; T lymphocyte c-maf long form;
                     c-maf proto-oncogene; proto-oncogene c-Maf"
                     /codon_start=1
                     /product="transcription factor Maf isoform b"
                     /protein_id="NP_001026974.1"
                     /db_xref="GI:73427806"
                     /db_xref="CCDS:CCDS42198.1"
                     /db_xref="GeneID:4094"
                     /db_xref="HGNC:6776"
                     /db_xref="HPRD:01518"
                     /db_xref="MIM:177075"
                     /translation="

MASELAMSNSDLPTSPLAMEYVNDFDLMKFEVKKEPVETDRIISQCGRLIAGGSLSSTPMSTPCSSVPPSPSFSAPSPGSGSEQKAHLEDYYWMTGYPQQLNPEALGFSPEDAVEALISNSHQLQGGFDGYARGAQQLAAAAGAGAGASLGGSGEEMGPAAAVVSAVIAAAAAQSGAGPHYHHHHHHAAGHHHHPTAGAPGAAGSAAASAGGAGGAGGGGPASAGGGGGGGGGGGGGGAAGAGGALHPHHAAGGLHFDDRFSDEQLVTMSVRELNRQLRGVSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHVLESEKNQLLQQVDHLKQEISRLVRERDAYKEKYEKLVSSGFRENGSSSDNPSSPEFFM

"
     misc_feature    1079..1183
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /note="Maf N-terminal region; Region: Maf_N; pfam08383"
                     /db_xref="CDD:116963"
     misc_feature    1199..1942
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O75444.2);
                     Region: Represses ARE-mediated transcription"
     misc_feature    1604..1882
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /note="bZIP Maf transcription factor; Region: bZIP_Maf;
                     pfam03131"
                     /db_xref="CDD:190534"
     misc_feature    1685..1762
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O75444.2);
                     Region: Basic motif (By similarity)"
     misc_feature    1769..1834
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O75444.2);
                     Region: Leucine-zipper (By similarity)"
     variation       902
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:866051"
     variation       1882
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1046957"
     variation       2158
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1046958"
     variation       2635
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1802313"
     variation       2708
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1046729"
     variation       2914
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200762268"
     STS             4012..4176
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /standard_name="RH47061"
                     /db_xref="UniSTS:4100"
     polyA_signal    4066..4071
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
     polyA_site      4104
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
     polyA_signal    4226..4231
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
     polyA_site      4254
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
     STS             4645..4752
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /standard_name="RH41999"
                     /db_xref="UniSTS:71709"
     variation       4831
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1055708"
     variation       5054
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3826106"
     variation       5363
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3743597"
     variation       5500
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:40965"
     variation       5821
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:30413"
     polyA_signal    6369..6374
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
     polyA_site      6392
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
     variation       6442
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2287974"
     variation       6451
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:30412"
     variation       6666
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:30411"
     polyA_site      6878
                     /gene="MAF"
                     /gene_synonym="c-MAF; CCA4"
ORIGIN

gaggctttaaaatcttttttcatcttctagctgtagctcgggctgcttgtcggcttggcctccccctcccccctttgctctctgcctcgtctttccccaggacttcgctattttgcttttttaaaaaaaggcaagaaagaactaaactcccccctccctctcctccagtcgggctgcacctctgccttgcactttgcacagaggtagagagcgcgcgagggagagagaggaaagaaaaaaaataataaagagagccaagcagaagaggaggcgagaagcatgaagtgttaactcccccgtgccaaggcccgcgccgcccggacagacgcccgccgcgcctccagccccgagcggacgccgcgcgcgccctgcctgcagcccgggccggcgaggcgagcccttccttatgcaaagcgcgcagcggagcggcgagcgggggacgccgcgcaccgggccgggctcctccagcttcgccgccgcagccaccaccgccgccaccgcagctcgcggaggatcttcccgagcctgaagccgccggctcggcgcgcaaggaggcgagcgagcaaggaggggccggggcgagcgagggagcacattggcgtgagcaggggggagggagggcgggcgcggggggcgcgggcagggcgggggggtgtgtgtgtgagcgcgctcggaggtttcgggccagccaccgccgcgcaagctagaagcgccccagcccggcaagctggctcacccgctggccacccagcacagcccgctggcccctctcctgcagcccatctggcggagcggcggcggcggcggcggcggcggcaggagaatggcatcagaactggcaatgagcaactccgacctgcccaccagtcccctggccatggaatatgttaatgacttcgatctgatgaagtttgaagtgaaaaaggaaccggtggagaccgaccgcatcatcagccagtgcggccgtctcatcgccgggggctcgctgtcctccacccccatgagcacgccgtgcagctcggtgcccccttcccccagcttctcggcgcccagcccgggctcgggcagcgagcagaaggcgcacctggaagactactactggatgaccggctacccgcagcagctgaaccccgaggcgctgggcttcagccccgaggacgcggtcgaggcgctcatcagcaacagccaccagctccagggcggcttcgatggctacgcgcgcggggcgcagcagctggccgcggcggccggggccggtgccggcgcctccttgggcggcagcggcgaggagatgggccccgccgccgccgtggtgtccgccgtgatcgccgcggccgccgcgcagagcggcgcgggcccgcactaccaccaccaccaccaccacgccgccggccaccaccaccacccgacggccggcgcgcccggcgccgcgggcagcgcggccgcctcggccggtggcgctgggggcgcgggcggcggtggcccggccagcgctgggggcggcggcggcggcggcggcggcggaggcggcgggggcgcggcgggggcggggggcgccctgcacccgcaccacgccgccggcggcctgcacttcgacgaccgcttctccgacgagcagctggtgaccatgtctgtgcgcgagctgaaccggcagctgcgcggggtcagcaaggaggaggtgatccggctgaagcagaagaggcggaccctgaaaaaccgcggctatgcccagtcctgccgcttcaagagggtgcagcagagacacgtcctggagtcggagaagaaccagctgctgcagcaagtcgaccacctcaagcaggagatctccaggctggtgcgcgagagggacgcgtacaaggagaaatacgagaagttggtgagcagcggcttccgagaaaacggctcgagcagcgacaacccgtcctctcccgagtttttcatgtgagtctgacacgcgattccagctagccaccctgataagtgctccgcgggggtccggctcgggtgtgggcttgctagttctagagccatgctcgccaccacctcaccacccccacccccaccgagtttggcccccttggccccctacacacacacaaacccgcacgcacacaccacacacacacacacacacacacacacaccccacaccctgctcgagtttgtggtggtggtggctgttttaaactggggagggaatgggtgtctggctcatggattgccaatctgaaattctccataacttgctagcttgttttttttttttttttacacccccccgccccacccccggacttgcacaatgttcaatgatctcagcagagttcttcatgtgaaacgttgatcacctttgaagcctgcatcattcacatattttttcttcttcttccccttcagttcatgaactggtgttcattttctgtgtgtgtgtgtgttttattttgtttggatttttttttttaattttacttttagagcttgctgtgttgcccaccttttttccaacctccaccctcactccttctcaacccatctcttccgagatgaaagaaaaaaaaaagcaaagtttttttttcttctcctgagttcttcatgtgagattgagcttgcaaaggaaaaaaaaatgtgaaatgttatagacttgcagcgtgccgagttccatcgggttttttttttagcattgttatgctaaaatagagaaaaaaatcctcatgaaccttccacaatcaagcctgcatcaaccttctgggtgtgacttgtgagttttggccttgtgatgccaaatctgagagtttagtctgccattaaaaaaactcattctcatctcatgcattattatgcttgctactttgtcttagcaacaatgaactataactgtttcaaagactttatggaaaagagacattatattaataaaaaaaaaaagcctgcatgctggacatgtatggtataattattttttcctttttttttccttttggcttggaaatggacgttcgaagacttatagcatggcattcatacttttgttttattgcctcatgacttttttgagtttagaacaaaacagtgcaaccgtagagccttcttcccatgaaattttgcatctgctccaaaactgctttgagttactcagaacttcaacctcccaatgcactgaaggcattccttgtcaaagataccagaatgggttacacatttaacctggcaaacattgaagaactcttaatgttttctttttaataagaatgacgccccactttggggactaaaattgtgctattgccgagaagcagtctaaaatttattttttaaaaagagaaactgccccattatttttggtttgttttatttttattttatattttttggcttttggtcattgtcaaatgtggaatgctctgggtttctagtatataatttaattctagtttttataatctgttagcccagttaaaatgtatgctacagataaaggaatgttatagataaatttgaaagagttaggtctgtttagctgtagattttttaaacgattgatgcactaaattgtttactattgtgatgttaaggggggtagagtttgcaaggggactgtttaaaaaaagtagcttatacagcatgtgcttgcaacttaaatataagttgggtatgtgtagtctttgctataccactgactgtattgaaaaccaaagtattaagaggggaaacgcccctgtttatatctgtaggggtattttacattcaaaaatgtatgtttttttttcttttcaaaattaaagtatttgggactgaattgcactaagatataacctgcaagcatataatacaaaaaaaaattgcaaaactgtttagaacgctaataaaatttatgcagttataaaaatggcattactgcacagttttaagatgatgcagatttttttacagttgtattgtggtgcagaactggattttctgtaacttaaaaaaaaatccacagttttaaaggcaataatcagtaaatgttattttcagggactgacatcctgtctttaaaaagaaatgaaaagtaaatcttaccacaataaatataaaaaaatcttgtcagttacttttcttttacatattttgctgtgcaaaattgttttatatcttgagttactaactaaccacgcgtgttgttcctatgtgcttttctttcattttcaattctggttatatcaagaaaagaataatctacaataataaacggcatttttttttgattctgtactcagtttcttagtgtacagtttaactgggcccaacaacctcgttaaaagtgtaaaatgcatccttttctccagtggaaggattcctggaggaatagggagacagtaattcagggtgaaattataggctgttttttgaagtgaggaggctggccccatatactgattagcaatatttaatatagatgtaaattatgacctcatttttttctccccaaagttttcagttttcaaatgagttgagccataattgcccttggtaggaaaaacaaaacaaaacagtggaactaggcttcctgagcatggccctacacttctgatcaggagcaaagccatccatagacagaggagccggacaaatatggcgcatcagaggtggcttgcgcacatatgcattgaacggtaaagagaaacagcgcttgccttttcactaaagttgactatttttccttcttctcttacacaccgagattttcttgttagcaaggcctgacaagatttaacataaacatgacaaatcatagttgtttgttttgttttgcttttctctttaacactgaagatcatttgtcttaaataggaaaaagaaaatccactccttacttccatatttccaagtacatatctggtttaaactatgttatcaaatcatatttcaccgtgaatattcagtggagaacttctctacctggatgagctagtaatgatttcagatcatgctatccccagaaataaaagcaaaaaataatacctgtgtggaatataggctgtgctttgatttactggtatttaccccaaaataggctgtgtatgggggctgacttaaagatcccttggaaagactcaaaactaccttcactagtaggactcctaagcgctgacctatttttaaatgacacaaattcatgaaactaatgttacaaattcatgcagtttgcactcttagtcatcttcccctagcacaccaatagaatgttagacaaagccagcactgttttgaaaatacagccaaacacgatgacttttgttttgttttctgccgttcttaaaagaaaaaaagataatattgcaactctgactgaaagacttatttttaagaaaacaggttgtgtttggtgctgctaagttctggccagtttatcatctggccttcctgcctattttttacaaaacacgaagacagtgtgtaacctcgacattttgaccttcctttatgtgctagtttagacaggctcctgaatccacacttaattttgcttaacaaaagtcttaatagtaaacctcccctcatgagcttgaagtcaagtgttcttgacttcagatatttctttcctttttttttttttttcctcatcacaactaagagatacacaaactctgaagaagcagaaatggagagaatgcttttaacaaaaaagcatctgatgaaagattttaggcaaacattctcaaaataagagtgatattctggatgtagttattgcagttatctcatgacaaatgaggcctggattggaaggaaaatatagttgtgtagaattaagcattttgataggaatctacaaggtagttgaatataataagcaggtttgggcccccaaactttagaaaatcaaatgcaaaggtgctggcaaaaatgaggtttgagtggctggctgtaagagaaggttaactcctagtaaaaggcatttttagaaataacaattactgaaaactttgaagtatagtgggagtagcaaacaaatacatgttttttttttcttacaaagaactcctaaatcctgagtaagtgccattcattacaataagtctctaaatttaaaaaaaaaaaaatcatatgaggaaatctagctttcccctttacgctgcgtttgatctttgtctaaatagtgttaaaattcctttcattccaattacagaactgagcccactcgcaagttggagccatcagtgggatacgccacattttggaagccccagcatcgtgtacttaccagtgtgttcacaaaatgaaatttgtgtgagagctgtacattaaaaaaaatcatcattattattattatttgcagtcatggagaaccacctacccctgacttctgtttagtctcctttttaaataaaaattactgtgttagagaagaaggctattaaatgtagtagttaactatgcctcttgtctgggggtttcatagagaccggtaggaaagcgcactcctgcttttcgatttatggtgtgtgcaagtaaacaggtgcattgctttcaacctgccatactagttttaaaaattcactgaaattacaaagatacatatatatgcatatatataatggaaagtttcccggaatgcaacaattagcattttaaaatcatatataggcatgcacattctaaatagtactttttcatgcttcattgtttctctggcagataattttactaagaagaaaaatagatattcgactccccttccctaaacaaatccacgggcagaggctccagcggagccgagccccctggttttctcgtaggccctagacggtgttgcatttatcagtgatgtcaaacgtgctcatttgtcagacatagctgtaaatgaaaacaatgtgtggcaaaatacaaagttaaaaaaaaaa

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