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2024-04-23 15:52:36, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001029865 1032 bp mRNA linear PRI 25-MAR-2013 DEFINITION Homo sapiens developing brain homeobox 1 (DBX1), mRNA. ACCESSION NM_001029865 XM_061930 VERSION NM_001029865.2 GI:304434795 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1032) AUTHORS Gray,P.A., Hayes,J.A., Ling,G.Y., Llona,I., Tupal,S., Picardo,M.C., Ross,S.E., Hirata,T., Corbin,J.G., Eugenin,J. and Del Negro,C.A. TITLE Developmental origin of preBotzinger complex respiratory neurons JOURNAL J. Neurosci. 30 (44), 14883-14895 (2010) PUBMED 21048147 REMARK GeneRIF: Dbx1-derived neurons are essential for the transgenic expression and generation of respiratory behavior both in vitro and in vivo. REFERENCE 2 (bases 1 to 1032) AUTHORS Pierani,A., Moran-Rivard,L., Sunshine,M.J., Littman,D.R., Goulding,M. and Jessell,T.M. TITLE Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1 JOURNAL Neuron 29 (2), 367-384 (2001) PUBMED 11239429 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC068860.9. On Aug 25, 2010 this sequence version replaced gi:71274177. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on cross-species transcript alignments. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-367 AC068860.9 36823-37189 c 368-469 AC068860.9 36056-36157 c 470-672 AC068860.9 33902-34104 c 673-1032 AC068860.9 33079-33438 c FEATURES Location/Qualifiers source 1..1032 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="11" /map="11p15.1" gene 1..1032 /gene="DBX1" /note="developing brain homeobox 1" /db_xref="GeneID:120237" /db_xref="HGNC:33185" CDS 1..1032 /gene="DBX1" /note="developing brain homeobox protein 1" /codon_start=1 /product="homeobox protein DBX1" /protein_id="NP_001025036.2" /db_xref="GI:304434796" /db_xref="GeneID:120237" /db_xref="HGNC:33185" /translation="
MMFPGLLAPPAGYPSLLRPTPTLTLPQSLQSAFSGHSSFLVEDLIRISRPPAYLPRSVPTASMSPPRQGAPTALTDTGASDLGSPGPGSRRGGSPPTAFSPASETTFLKFGVNAILSSGPRTETSPALLQSVPPKTFAFPYFEGSFQPFIRSSYFPASSSVVPIPGTFSWPLAARGKPRRGMLRRAVFSDVQRKALEKMFQKQKYISKPDRKKLAAKLGLKDSQVKIWFQNRRMKWRNSKERELLSSGGCREQTLPTKLNPHPDLSDVGQKGPGNEEEEEGPGSPSHRLAYHASSDPQHLRDPRLPGPLPPSPAHSSSPGKPSDFSDSEEEEEGEEQEEITVS
"
misc_feature 550..720
/gene="DBX1"
/note="Homeodomain; DNA binding domains involved in the
transcriptional regulation of key eukaryotic developmental
processes; may bind to DNA as monomers or as homo- and/or
heterodimers, in a sequence-specific manner; Region:
homeodomain; cd00086"
/db_xref="CDD:28970"
misc_feature order(550..558,562..564,613..615,631..633,670..672,
676..681,688..693,697..705,709..714)
/gene="DBX1"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:28970"
misc_feature order(550..552,559..561,679..681,688..693,700..702)
/gene="DBX1"
/note="specific DNA base contacts [nucleotide binding];
other site"
/db_xref="CDD:28970"
exon 1..367
/gene="DBX1"
/inference="alignment:Splign:1.39.8"
variation complement(71)
/gene="DBX1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370463805"
variation complement(130)
/gene="DBX1"
/replace="c"
/replace="t"
/db_xref="dbSNP:189086023"
variation complement(254)
/gene="DBX1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374564065"
variation complement(266)
/gene="DBX1"
/replace="a"
/replace="g"
/db_xref="dbSNP:199851463"
variation complement(269)
/gene="DBX1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370098161"
variation complement(309)
/gene="DBX1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374881641"
variation complement(318)
/gene="DBX1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139729153"
exon 368..469
/gene="DBX1"
/inference="alignment:Splign:1.39.8"
variation complement(370)
/gene="DBX1"
/replace="a"
/replace="t"
/db_xref="dbSNP:151039617"
variation complement(379)
/gene="DBX1"
/replace="c"
/replace="g"
/db_xref="dbSNP:371630209"
variation complement(384)
/gene="DBX1"
/replace="g"
/replace="t"
/db_xref="dbSNP:368653074"
variation complement(401)
/gene="DBX1"
/replace="c"
/replace="t"
/db_xref="dbSNP:145387898"
variation complement(406)
/gene="DBX1"
/replace="a"
/replace="t"
/db_xref="dbSNP:139870931"
variation complement(411)
/gene="DBX1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375302728"
variation complement(431)
/gene="DBX1"
/replace="c"
/replace="g"
/db_xref="dbSNP:147543596"
variation complement(457..459)
/gene="DBX1"
/replace=""
/replace="tct"
/db_xref="dbSNP:369552737"
variation complement(458..460)
/gene="DBX1"
/replace=""
/replace="ctt"
/db_xref="dbSNP:144687409"
exon 470..672
/gene="DBX1"
/inference="alignment:Splign:1.39.8"
variation complement(511)
/gene="DBX1"
/replace="a"
/replace="c"
/db_xref="dbSNP:200639137"
variation complement(528)
/gene="DBX1"
/replace="g"
/replace="t"
/db_xref="dbSNP:143300593"
variation complement(538)
/gene="DBX1"
/replace="a"
/replace="c"
/db_xref="dbSNP:831464"
variation complement(566)
/gene="DBX1"
/replace="c"
/replace="g"
/db_xref="dbSNP:144313400"
variation complement(591)
/gene="DBX1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201030070"
variation complement(632)
/gene="DBX1"
/replace="a"
/replace="g"
/db_xref="dbSNP:149273490"
variation complement(656)
/gene="DBX1"
/replace="c"
/replace="g"
/db_xref="dbSNP:373580487"
variation complement(666)
/gene="DBX1"
/replace="c"
/replace="g"
/db_xref="dbSNP:370302720"
exon 673..1032
/gene="DBX1"
/inference="alignment:Splign:1.39.8"
variation complement(681)
/gene="DBX1"
/replace="c"
/replace="t"
/db_xref="dbSNP:371870483"
variation complement(716)
/gene="DBX1"
/replace="c"
/replace="g"
/db_xref="dbSNP:61732859"
variation complement(784)
/gene="DBX1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374712847"
variation complement(795)
/gene="DBX1"
/replace="c"
/replace="t"
/db_xref="dbSNP:140374117"
variation complement(802)
/gene="DBX1"
/replace="g"
/replace="t"
/db_xref="dbSNP:372353326"
variation complement(812)
/gene="DBX1"
/replace="a"
/replace="g"
/db_xref="dbSNP:202066986"
variation complement(814)
/gene="DBX1"
/replace="g"
/replace="t"
/db_xref="dbSNP:146204094"
variation complement(818)
/gene="DBX1"
/replace="a"
/replace="c"
/db_xref="dbSNP:200861778"
variation complement(825)
/gene="DBX1"
/replace="c"
/replace="g"
/db_xref="dbSNP:187014041"
variation complement(849)
/gene="DBX1"
/replace="a"
/replace="c"
/db_xref="dbSNP:371876111"
variation complement(853)
/gene="DBX1"
/replace="a"
/replace="c"
/db_xref="dbSNP:199599086"
variation complement(904)
/gene="DBX1"
/replace="a"
/replace="g"
/db_xref="dbSNP:61732858"
variation complement(924)
/gene="DBX1"
/replace="a"
/replace="g"
/db_xref="dbSNP:143111791"
variation complement(946)
/gene="DBX1"
/replace="c"
/replace="t"
/db_xref="dbSNP:369450809"
variation complement(970)
/gene="DBX1"
/replace="g"
/replace="t"
/db_xref="dbSNP:77893331"
variation complement(971)
/gene="DBX1"
/replace="a"
/replace="t"
/db_xref="dbSNP:75377938"
variation complement(973)
/gene="DBX1"
/replace="c"
/replace="t"
/db_xref="dbSNP:149083489"
variation complement(979)
/gene="DBX1"
/replace="c"
/replace="g"
/db_xref="dbSNP:374957339"
variation complement(987)
/gene="DBX1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147705838"
ORIGIN
atgatgttccccggcctcctcgcgccccccgccgggtaccctagcctcctgcggcccacgcccaccttgacgctgccccagtccttgcagtcggcattttccggccactccagcttcctggtggaggatctgatccgcatcagccgaccccccgcctacctgccccgcagcgtgcccaccgccagcatgtcgccgcccaggcagggggcccccacggccctcaccgacacgggggcctcggacctgggctccccgggtcccggcagccgacggggcggctctccgccgactgccttctcccctgccagcgagacgacgtttctgaagtttggagtgaacgccatcctctcctcggggcccagaacagaaacatccccagccttgctccagagcgtccctcccaagaccttcgcctttccctacttcgaagggtcttttcagcctttcatcagatcttcttatttcccagcttcctccagcgtggtgcccatccccgggaccttctcctggccgctggccgcgcgcgggaagcctcggcggggcatgctgcgtcgagcagtcttctccgacgtgcagcggaaggcgctggagaagatgttccagaagcagaagtacatcagcaagcccgaccgcaagaagctggcggccaagctgggcctgaaagactcgcaggtgaaaatctggttccagaaccgacgcatgaaatggcggaactccaaggagcgcgaactcctgtctagcgggggctgtcgcgagcagaccctgcccaccaagctcaatccgcacccggacctcagcgacgtgggccagaagggccctgggaacgaagaggaggaggagggcccgggcagccccagccaccgcctggcctaccacgcgtcctccgacccccagcacctgcgggacccgcggctgccagggccgctgcccccctcgcccgcgcactcgagcagtcccgggaaaccttcggacttctcagattccgaggaggaagaggagggcgaggaacaggaggaaatcaccgtgtcctag
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:120237 -> Molecular function: GO:0000976 [transcription regulatory region sequence-specific DNA binding] evidence: IEA
GeneID:120237 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
GeneID:120237 -> Biological process: GO:0007275 [multicellular organismal development] evidence: IEA
GeneID:120237 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
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