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2024-04-25 19:23:30, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001025097 1713 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens proteasome (prosome, macropain) subunit, alpha type, 8
(PSMA8), transcript variant 3, mRNA.
ACCESSION NM_001025097
VERSION NM_001025097.1 GI:68303564
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1713)
AUTHORS Nusbaum,C., Zody,M.C., Borowsky,M.L., Kamal,M., Kodira,C.D.,
Taylor,T.D., Whittaker,C.A., Chang,J.L., Cuomo,C.A., Dewar,K.,
FitzGerald,M.G., Yang,X., Abouelleil,A., Allen,N.R., Anderson,S.,
Bloom,T., Bugalter,B., Butler,J., Cook,A., DeCaprio,D., Engels,R.,
Garber,M., Gnirke,A., Hafez,N., Hall,J.L., Norman,C.H., Itoh,T.,
Jaffe,D.B., Kuroki,Y., Lehoczky,J., Lui,A., Macdonald,P.,
Mauceli,E., Mikkelsen,T.S., Naylor,J.W., Nicol,R., Nguyen,C.,
Noguchi,H., O'Leary,S.B., O'Neill,K., Piqani,B., Smith,C.L.,
Talamas,J.A., Topham,K., Totoki,Y., Toyoda,A., Wain,H.M.,
Young,S.K., Zeng,Q., Zimmer,A.R., Fujiyama,A., Hattori,M.,
Birren,B.W., Sakaki,Y. and Lander,E.S.
TITLE DNA sequence and analysis of human chromosome 18
JOURNAL Nature 437 (7058), 551-555 (2005)
PUBMED 16177791
REMARK Erratum:[Nature. 2005 Dec 1;438(7068):696. O'Neill, Keith [added]]
REFERENCE 2 (bases 1 to 1713)
AUTHORS Margottin-Goguet,F., Hsu,J.Y., Loktev,A., Hsieh,H.M., Reimann,J.D.
and Jackson,P.K.
TITLE Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin
ligase activates the anaphase promoting complex to allow
progression beyond prometaphase
JOURNAL Dev. Cell 4 (6), 813-826 (2003)
PUBMED 12791267
REFERENCE 3 (bases 1 to 1713)
AUTHORS Claverol,S., Burlet-Schiltz,O., Girbal-Neuhauser,E., Gairin,J.E.
and Monsarrat,B.
TITLE Mapping and structural dissection of human 20 S proteasome using
proteomic approaches
JOURNAL Mol. Cell Proteomics 1 (8), 567-578 (2002)
PUBMED 12376572
REMARK GeneRIF: This article provides an overview of some of the
components in the human 20 S proteasome.
REFERENCE 4 (bases 1 to 1713)
AUTHORS Geley,S., Kramer,E., Gieffers,C., Gannon,J., Peters,J.M. and
Hunt,T.
TITLE Anaphase-promoting complex/cyclosome-dependent proteolysis of human
cyclin A starts at the beginning of mitosis and is not subject to
the spindle assembly checkpoint
JOURNAL J. Cell Biol. 153 (1), 137-148 (2001)
PUBMED 11285280
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BC042820.1 and BC025393.1.
Transcript Variant: This variant (3) uses two different alternate
in-frame splice sites in the coding region, compared to variant 1,
resulting in a shorter protein (isoform 3).
##Evidence-Data-START##
Transcript exon combination :: BC025393.1, CV024283.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025084, ERS025085 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-30 BC042820.1 1-30
31-616 BC025393.1 19-604
617-1165 BC042820.1 731-1279
1166-1713 BC025393.1 1154-1701
FEATURES Location/Qualifiers
source 1..1713
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="18"
/map="18q11.2"
gene 1..1713
/gene="PSMA8"
/gene_synonym="PSMA7L"
/note="proteasome (prosome, macropain) subunit, alpha
type, 8"
/db_xref="GeneID:143471"
/db_xref="HGNC:22985"
/db_xref="HPRD:11322"
exon 1..216
/gene="PSMA8"
/gene_synonym="PSMA7L"
/inference="alignment:Splign:1.39.8"
variation 20
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="g"
/replace="t"
/db_xref="dbSNP:79042990"
variation 60
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="t"
/db_xref="dbSNP:76463276"
variation 70
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="t"
/db_xref="dbSNP:375979811"
variation 76
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="t"
/db_xref="dbSNP:367810883"
variation 87
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="c"
/replace="g"
/db_xref="dbSNP:199655437"
misc_feature 103..105
/gene="PSMA8"
/gene_synonym="PSMA7L"
/note="upstream in-frame stop codon"
variation 103
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="c"
/replace="t"
/db_xref="dbSNP:369422702"
variation 113
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="c"
/db_xref="dbSNP:367607416"
CDS 115..753
/gene="PSMA8"
/gene_synonym="PSMA7L"
/EC_number="3.4.25.1"
/note="isoform 3 is encoded by transcript variant 3"
/codon_start=1
/product="proteasome subunit alpha type-7-like isoform 3"
/protein_id="NP_001020268.1"
/db_xref="GI:68303565"
/db_xref="CCDS:CCDS45843.1"
/db_xref="GeneID:143471"
/db_xref="HGNC:22985"
/db_xref="HPRD:11322"
/translation="
MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEIEKEKEEAEKKKSKKSV
"
misc_feature 127..693
/gene="PSMA8"
/gene_synonym="PSMA7L"
/note="proteasome subunit alpha; Provisional; Region:
PRK03996"
/db_xref="CDD:179701"
misc_feature 127..639
/gene="PSMA8"
/gene_synonym="PSMA7L"
/note="proteasome_alpha_type_7. The 20S proteasome,
multisubunit proteolytic complex, is the central enzyme of
nonlysosomal protein degradation in both the cytosol and
nucleus. It is composed of 28 subunits arranged as four
homoheptameric rings that stack on...; Region:
proteasome_alpha_type_7; cd03755"
/db_xref="CDD:48453"
misc_feature order(133..144,148..153,157..162,172..174,181..183,
190..195,202..204,226..228,235..243,247..252,343..345,
352..354,361..366,373..387,439..441,454..459,463..465,
469..474,478..480)
/gene="PSMA8"
/gene_synonym="PSMA7L"
/note="alpha subunit interaction site [polypeptide
binding]; other site"
/db_xref="CDD:48453"
variation 133
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="t"
/db_xref="dbSNP:371585912"
exon 217..229
/gene="PSMA8"
/gene_synonym="PSMA7L"
/inference="alignment:Splign:1.39.8"
variation 226
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="c"
/db_xref="dbSNP:376403017"
variation 227
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="g"
/db_xref="dbSNP:369017941"
exon 230..354
/gene="PSMA8"
/gene_synonym="PSMA7L"
/inference="alignment:Splign:1.39.8"
variation 269
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="g"
/db_xref="dbSNP:146900756"
variation 297
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="g"
/db_xref="dbSNP:138692405"
variation 304
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="g"
/db_xref="dbSNP:141138094"
variation 305
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="g"
/db_xref="dbSNP:150332181"
variation 317
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="c"
/replace="t"
/db_xref="dbSNP:137990346"
variation 332
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="g"
/db_xref="dbSNP:371854509"
variation 340
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="g"
/db_xref="dbSNP:375557530"
variation 348
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="g"
/db_xref="dbSNP:369804246"
exon 355..477
/gene="PSMA8"
/gene_synonym="PSMA7L"
/inference="alignment:Splign:1.39.8"
variation 371
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="g"
/db_xref="dbSNP:377524722"
variation 396
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="c"
/replace="t"
/db_xref="dbSNP:149476347"
variation 422
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="g"
/db_xref="dbSNP:371109228"
variation 443
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="g"
/db_xref="dbSNP:201810632"
variation 449
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="g"
/db_xref="dbSNP:200739878"
variation 466
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="c"
/replace="g"
/db_xref="dbSNP:200476943"
exon 478..597
/gene="PSMA8"
/gene_synonym="PSMA7L"
/inference="alignment:Splign:1.39.8"
variation 491
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="c"
/replace="g"
/db_xref="dbSNP:146000809"
variation 496
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="t"
/db_xref="dbSNP:370534304"
variation 511
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="c"
/replace="t"
/db_xref="dbSNP:139896833"
variation 512
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="g"
/db_xref="dbSNP:141896498"
variation 571
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="g"
/db_xref="dbSNP:146272213"
variation 592
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="c"
/replace="t"
/db_xref="dbSNP:148724967"
exon 598..660
/gene="PSMA8"
/gene_synonym="PSMA7L"
/inference="alignment:Splign:1.39.8"
variation 611
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="g"
/db_xref="dbSNP:142265503"
variation 617
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="g"
/db_xref="dbSNP:17852261"
exon 661..1697
/gene="PSMA8"
/gene_synonym="PSMA7L"
/inference="alignment:Splign:1.39.8"
variation 670
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="g"
/replace="t"
/db_xref="dbSNP:145392373"
STS 708..992
/gene="PSMA8"
/gene_synonym="PSMA7L"
/standard_name="SHGC-82018"
/db_xref="UniSTS:102988"
variation 709
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="g"
/replace="t"
/db_xref="dbSNP:17852262"
variation 772
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="c"
/replace="g"
/db_xref="dbSNP:201321706"
variation 832
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace=""
/replace="a"
/db_xref="dbSNP:368685303"
variation 868
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="g"
/replace="t"
/db_xref="dbSNP:138505570"
variation 951
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="c"
/replace="g"
/db_xref="dbSNP:2069310"
variation 1064
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="t"
/db_xref="dbSNP:192674845"
polyA_signal 1139..1144
/gene="PSMA8"
/gene_synonym="PSMA7L"
polyA_site 1166
/gene="PSMA8"
/gene_synonym="PSMA7L"
/experiment="experimental evidence, no additional details
recorded"
variation 1319
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="g"
/db_xref="dbSNP:3794196"
variation 1493
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="t"
/db_xref="dbSNP:368290560"
variation 1501
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="g"
/db_xref="dbSNP:184708358"
variation 1561
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="c"
/replace="t"
/db_xref="dbSNP:189047996"
variation 1631
/gene="PSMA8"
/gene_synonym="PSMA7L"
/replace="a"
/replace="g"
/db_xref="dbSNP:181678938"
polyA_signal 1677..1682
/gene="PSMA8"
/gene_synonym="PSMA7L"
polyA_site 1697
/gene="PSMA8"
/gene_synonym="PSMA7L"
/experiment="experimental evidence, no additional details
recorded"
ORIGIN
gaggcgcgtgtggaagcgcttccgggcggtagcacgctgtgttggcggcggctccccgcttgcctcagctgcagcagcgggaagctcggtggcaagcccttgtagtcctgtgcgatggcgtctcgatatgacagggcgatcactgtcttctccccagacggacacctttttcaagttgaatatgcccaggaagcggtgaagaaaggatccaccgcggtcggaattcgaggacttactgctgatgctagagtagtaataaacagagcccgtgtggagtgccagagccataagcttacggttgaggacccagtcactgtagaatacataactcgcttcatagcaactttaaagcagaaatatacccaaagcaatggacgaagaccttttggtatttctgccttaattgtaggttttgatgatgatggtatctcaagattgtatcagacagatccttctggtacttatcatgcttggaaggcaaatgcaataggccgaagtgctaaaactgttcgagaatttctagaaaagaattacacagaagatgccatagcaagtgacagtgaagctatcaagttagcaataaaagctttgctagaagttgtccagtctggtggaaaaaacattgaacttgctataataagaagaaatcaacctttgaagatgtttagtgcaaaagaagttgaattatatgtaactgaaatagaaaaggaaaaggaagaagcagagaagaaaaaatcaaagaaatctgtctaattcttaggatgaccactgggaggtcttaatgttttgttttattgtactgcctgaggttgtttagtgaaattttagaggaaaacagttattttgcagcattacatgcagtacttgtgtgatgttttgagaatgccagatctgtggctgtcttcattctattacatagtcaaacataggtttatgtgaagattttctttgaaaggggatttcagtaattgttgagagcagtcataattccacataagcctgagactctataatttgtccagtgtcttacttaccttcatatatgcaaatataattttaaaaaattttttaattaaaaaaatttaataatttggtgatgtttgaatattgactgtcagttaaggacatagctattccaaataaactaaatataatattgagctgcatttctcaaagaatgacaaaagcatccttatactgatgagttcttaaaattttgtcagagccttcttcattttacaatattttgttatttttattttacctttttcattttacaatatttcgttatttttattttacctttttcattttacaagttgcaatatattgtttcgttcatggaacaaatataggctgaattcaaacatgcaattaaagcatgggaagagcttctaagggcatcttaacaggatgctacatgaaaataaggaaagaaattaatacatatcacttttagtttagatttttattttatctcaagtatgtccagtgtgttcggtttgttacatattccatgaaatatctgagtgtgtattttatgattggtattatggaaggcttattgggggaacaagaaaaatataaaaagtgatctctgcccacggaaaggatttaatccaaatggtccacaagaggaatgtgcttaattcctacagtgagtttatatttttgaaaataaaagctagtaaatattcaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:143471 -> Molecular function: GO:0004298 [threonine-type endopeptidase activity] evidence: IEA
GeneID:143471 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: TAS
GeneID:143471 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
GeneID:143471 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS
GeneID:143471 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS
GeneID:143471 -> Biological process: GO:0006521 [regulation of cellular amino acid metabolic process] evidence: TAS
GeneID:143471 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:143471 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS
GeneID:143471 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:143471 -> Biological process: GO:0016032 [viral process] evidence: TAS
GeneID:143471 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
GeneID:143471 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
GeneID:143471 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS
GeneID:143471 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS
GeneID:143471 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS
GeneID:143471 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
GeneID:143471 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
GeneID:143471 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:143471 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:143471 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:143471 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:143471 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:143471 -> Cellular component: GO:0019773 [proteasome core complex, alpha-subunit complex] evidence: IEA
GeneID:143471 -> Cellular component: GO:1990111 [spermatoproteasome complex] evidence: ISS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001020268 -> EC 3.4.25.1
by
@meso_cacase at
DBCLS
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