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2024-04-19 11:20:04, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001018060 2354 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens apoptosis-inducing factor, mitochondrion-associated, 3
(AIFM3), transcript variant 2, mRNA.
ACCESSION NM_001018060
VERSION NM_001018060.2 GI:226437566
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2354)
AUTHORS Yang,W., Sun,T., Cao,J., Liu,F., Tian,Y. and Zhu,W.
TITLE Downregulation of miR-210 expression inhibits proliferation,
induces apoptosis and enhances radiosensitivity in hypoxic human
hepatoma cells in vitro
JOURNAL Exp. Cell Res. 318 (8), 944-954 (2012)
PUBMED 22387901
REMARK GeneRIF: AIFM3 is a direct target of miR-210 in human hepatoma
cells.
REFERENCE 2 (bases 1 to 2354)
AUTHORS Lin'kova,N.S., Katanugina,A.S. and Khavinson,V.Kh.
TITLE [Expression of AIF and CGRP markers in pineal gland and thymus
during aging]
JOURNAL Adv Gerontol 24 (4), 601-605 (2011)
PUBMED 22550867
REMARK GeneRIF: The expression of apoptosis-inducing factor was identified
in pineal gland and thymus, but it did not change with age.
REFERENCE 3 (bases 1 to 2354)
AUTHORS Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
TITLE Genetic variants in nuclear-encoded mitochondrial genes influence
AIDS progression
JOURNAL PLoS ONE 5 (9), E12862 (2010)
PUBMED 20877624
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 2354)
AUTHORS Satoh,J., Obayashi,S., Misawa,T., Sumiyoshi,K., Oosumi,K. and
Tabunoki,H.
TITLE Protein microarray analysis identifies human cellular prion protein
interactors
JOURNAL Neuropathol. Appl. Neurobiol. 35 (1), 16-35 (2009)
PUBMED 18482256
REFERENCE 5 (bases 1 to 2354)
AUTHORS Ashktorab,H., Dashwood,R.H., Dashwood,M.M., Zaidi,S.I.,
Hewitt,S.M., Green,W.R., Lee,E.L., Daremipouran,M., Nouraie,M.,
Malekzadeh,R. and Smoot,D.T.
TITLE H. pylori-induced apoptosis in human gastric cancer cells mediated
via the release of apoptosis-inducing factor from mitochondria
JOURNAL Helicobacter 13 (6), 506-517 (2008)
PUBMED 19166416
REMARK GeneRIF: H. pylori triggers apoptosis in AGS cells via interaction
with death receptors in the plasma membrane, leading to the
cleavage of procaspase-8, release of cytochrome c and AIF from
mitochondria, and activation of subsequent downstream apoptotic
events
REFERENCE 6 (bases 1 to 2354)
AUTHORS Urbano,A., Lakshmanan,U., Choo,P.H., Kwan,J.C., Ng,P.Y., Guo,K.,
Dhakshinamoorthy,S. and Porter,A.
TITLE AIF suppresses chemical stress-induced apoptosis and maintains the
transformed state of tumor cells
JOURNAL EMBO J. 24 (15), 2815-2826 (2005)
PUBMED 16001080
REMARK GeneRIF: AIF maintains the transformed state of colon cancer cells
through its NADH oxidase activity, by mechanisms that involve
complex I function.
REFERENCE 7 (bases 1 to 2354)
AUTHORS Xie,Q., Lin,T., Zhang,Y., Zheng,J. and Bonanno,J.A.
TITLE Molecular cloning and characterization of a human AIF-like gene
with ability to induce apoptosis
JOURNAL J. Biol. Chem. 280 (20), 19673-19681 (2005)
PUBMED 15764604
REMARK GeneRIF: AIFL has 598 amino acids, with a characteristic Rieske
domain and a pyridine nucleotide-disulfide oxidoreductase domain
(Pyr_redox). AIFL shares 35% homology with AIF, mainly in the
Pyr_redox domain.
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DA396585.1, BC032485.1 and BQ028401.1.
On Apr 8, 2009 this sequence version replaced gi:65787453.
Transcript Variant: This variant (2) lacks an in-frame exon in the
3' coding region compared to variant 1. This results in a shorter
protein (isoform 2) compared to isoform 1.
##Evidence-Data-START##
Transcript exon combination :: BC032485.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025088 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
gene product(s) localized to mito. :: PMID: 15764604; reported by
MitoCarta
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-33 DA396585.1 23-55
34-2342 BC032485.1 1-2309
2343-2354 BQ028401.1 9-20 c
FEATURES Location/Qualifiers
source 1..2354
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="22"
/map="22q11.21"
gene 1..2354
/gene="AIFM3"
/gene_synonym="AIFL"
/note="apoptosis-inducing factor,
mitochondrion-associated, 3"
/db_xref="GeneID:150209"
/db_xref="HGNC:26398"
exon 1..78
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
exon 79..249
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 105
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:375049491"
misc_feature 120..122
/gene="AIFM3"
/gene_synonym="AIFL"
/note="upstream in-frame stop codon"
variation 194
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:372042715"
variation 197
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:201078355"
variation 216
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:371215112"
CDS 219..2015
/gene="AIFM3"
/gene_synonym="AIFL"
/note="isoform 2 is encoded by transcript variant 2;
apoptosis-inducing factor like; apoptosis-inducing factor
3"
/codon_start=1
/product="apoptosis-inducing factor 3 isoform 2"
/protein_id="NP_001018070.1"
/db_xref="GI:65787454"
/db_xref="CCDS:CCDS33605.1"
/db_xref="GeneID:150209"
/db_xref="HGNC:26398"
/translation="
MGGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRAYQGNGTARHFHTEERLSTPHPYPSPQDCVEAAVCHVKDLENGQMREVELGWGKVLLVKDNGEFHALGHKCPHYGAPLVKGVLSRGRVRCPWHGACFNISTGDLEDFPGLDSLHKFQVKIEKEKVYVRASKQALQLQRRTKVMAKCISPSAGYSSSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDRPKLSKSLDTQPEQLALRPKEFFRAYGIEVLTEAQVVTVDVRTKKVVFKDGFKLEYSKLLLAPGSSPKTLSCKGKEVENVFTIRTPEDANRVVRLARGRNVVVVGAGFLGMEVAAYLTEKAHSVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELRGQEGKLKEVVLKSSKVVRADVCVVGIGAVPATGFLRQSGIGLDSRGFIPVNKMMQTNVPGVFAAGDAVTFPLAWRNNRKVNIPHWQMAHAQGRVAAQNMLAQEAEMSTVPYLWTAMFGKSLRYAGYGEGFDDVIIQGDLEELKFVAFYTKGDEVIAVASMNYDPIVSKVAEVLASGRAIRKREVETGDMSWLTGKGS
"
misc_feature 426..710
/gene="AIFM3"
/gene_synonym="AIFL"
/note="AIFL (apoptosis-inducing factor like) family,
N-terminal Rieske domain; members of this family show
similarity to human AIFL, containing an N-terminal Rieske
domain and a C-terminal pyridine nucleotide-disulfide
oxidoreductase domain (Pyr_redox). The...; Region:
Rieske_AIFL_N; cd03478"
/db_xref="CDD:58548"
misc_feature order(543..545,549..554,600..602,609..611,615..617)
/gene="AIFM3"
/gene_synonym="AIFL"
/note="[2Fe-2S] cluster binding site [ion binding]; other
site"
/db_xref="CDD:58548"
misc_feature 804..1637
/gene="AIFM3"
/gene_synonym="AIFL"
/note="Pyridine nucleotide-disulphide oxidoreductase;
Region: Pyr_redox_2; pfam07992"
/db_xref="CDD:203833"
misc_feature 813..>908
/gene="AIFM3"
/gene_synonym="AIFL"
/note="NAD(P)-binding Rossmann-like domain; Region:
NAD_binding_8; pfam13450"
/db_xref="CDD:205628"
misc_feature 1242..1430
/gene="AIFM3"
/gene_synonym="AIFL"
/note="Pyridine nucleotide-disulphide oxidoreductase;
Region: Pyr_redox; pfam00070"
/db_xref="CDD:200974"
variation 224
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:148333657"
variation 229
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:146335337"
variation 230
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:374136982"
exon 250..463
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 296
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:114399555"
variation 307
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:373088207"
variation 330
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:376327467"
variation 335
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="c"
/db_xref="dbSNP:59876863"
variation 343
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:370994357"
variation 370
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:373462664"
variation 378
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:142848384"
variation 413
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:71312796"
variation 431
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="t"
/db_xref="dbSNP:142254599"
variation 441
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:150622444"
variation 446
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:139684602"
variation 452
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:183325820"
exon 464..573
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 468
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="c"
/db_xref="dbSNP:377274696"
variation 493..494
/gene="AIFM3"
/gene_synonym="AIFL"
/replace=""
/replace="a"
/db_xref="dbSNP:34371345"
variation 494
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:149749799"
variation 528
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:367600638"
variation 529
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:371361440"
variation 531
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:375928890"
variation 548
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:151248970"
variation 554
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:148456772"
exon 574..683
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 585
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:370362252"
variation 598
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:374048838"
variation 611
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:368820001"
variation 657
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:201450835"
exon 684..728
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 698
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:200048332"
variation 710
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:201969997"
variation 711
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:56179977"
variation 715
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:147613113"
exon 729..825
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 744
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:142117053"
variation 753
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:144287643"
variation 791
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:201015871"
variation 814
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:144284647"
variation 818
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="g"
/replace="t"
/db_xref="dbSNP:200165374"
variation 825
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:151146728"
exon 826..938
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 836
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:178266"
variation 846
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:140062749"
variation 858
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:150271585"
variation 868
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="g"
/replace="t"
/db_xref="dbSNP:145844241"
variation 879
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:370089581"
variation 885
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:202122018"
variation 896
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:373816290"
variation 903
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:140711648"
variation 914
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:145844603"
variation 917
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:138399322"
variation 924
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:201527012"
exon 939..1025
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 953
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:78729788"
variation 956
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:142889178"
variation 959
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:143272206"
variation 977
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:200227096"
variation 990
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:148304997"
exon 1026..1117
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 1029
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:199698549"
variation 1041
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:371705249"
variation 1043
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:376361841"
variation 1058
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:141390776"
variation 1059
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:201100852"
exon 1118..1248
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 1128
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:5752353"
variation 1167
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="c"
/db_xref="dbSNP:377284602"
variation 1171
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:150801089"
variation 1174
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:139810844"
variation 1199
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:149430218"
variation 1208
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:7285694"
variation 1209
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:201655926"
variation 1210
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:181636008"
variation 1216
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:147200843"
variation 1220
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:369535222"
variation 1221
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:185338332"
variation 1225
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:372650074"
variation 1227
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:200032972"
variation 1239
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:140466618"
variation 1241
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:369724765"
exon 1249..1364
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 1273
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:145487001"
variation 1274
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:369219792"
variation 1294
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:45606234"
variation 1315
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:373473269"
variation 1316
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:186357127"
variation 1321
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="g"
/replace="t"
/db_xref="dbSNP:371098629"
variation 1341
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:139501949"
variation 1343
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:142530985"
variation 1352
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="t"
/db_xref="dbSNP:178269"
exon 1365..1436
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 1380
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:140732562"
variation 1382
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:373121171"
variation 1388
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:201592533"
variation 1396
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="g"
/replace="t"
/db_xref="dbSNP:145883640"
variation 1403
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:186295000"
exon 1437..1500
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 1440
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:146611400"
variation 1446
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:141335687"
variation 1469
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:370782854"
variation 1470
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:374823610"
variation 1484
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:146322967"
variation 1488
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:376592022"
exon 1501..1577
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 1536
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:138766186"
variation 1542
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:201028984"
variation 1564
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="t"
/db_xref="dbSNP:150983915"
exon 1578..1695
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 1588
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:140853714"
variation 1619
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:202070098"
variation 1653
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:143682848"
variation 1664
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:73392570"
exon 1696..1794
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 1698
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:373787248"
variation 1741
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:61356271"
variation 1753
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:147210962"
variation 1757
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:140507708"
variation 1764
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:367937547"
exon 1795..1870
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 1799
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:141235166"
variation 1800
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:377494972"
variation 1801
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="g"
/replace="t"
/db_xref="dbSNP:371219265"
variation 1806
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:374162437"
variation 1833
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="g"
/replace="t"
/db_xref="dbSNP:367787216"
exon 1871..1975
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 1889
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:150768856"
variation 1903
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="t"
/db_xref="dbSNP:368864004"
variation 1914
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:371794358"
variation 1930
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="c"
/db_xref="dbSNP:9620700"
variation 1951
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:116635261"
exon 1976..2344
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 1979
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="t"
/db_xref="dbSNP:200537959"
variation 1982
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:375943087"
variation 1999
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:370473954"
variation 2016
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:149904114"
variation 2024
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:199601611"
variation 2027
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:368429589"
variation 2033
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:372669531"
variation 2039
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:374539558"
variation 2071
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:142727436"
variation 2105
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:190042788"
variation 2186
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="c"
/db_xref="dbSNP:6005114"
variation 2254
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:7292968"
variation 2255
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:115986263"
variation 2260
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="c"
/db_xref="dbSNP:181674065"
variation 2288
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:146061792"
variation 2301
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:389183"
variation 2306
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:367851"
ORIGIN
cgccccgcccgcgcctccccgcccccccgcgcccgcggccccaagcggttcccgagcccaggcccgcgccgagcccaggtcctagagcagctccagcaggatggcggctccagcgtctctaaggcctgcagggggtccagccccatggggggcgccctaggcctccgacagctccccatctgtgctcctgcctgccggccatcctcaggccactcgccatgggcggctgcttctccaaacccaaaccagtggagctcaagatcgaggtggtgctgcctgagaaggagcgaggcaaggaggagctgtcggccagtgggaagggcagcccccgggcctaccagggcaatggcacggcccgccacttccacacggaggagcgcctgtccacccctcacccctaccccagccctcaggattgcgtggaggctgctgtctgccacgtcaaggacctcgagaatggccagatgcgggaagtggagctgggctgggggaaggtgttgctggtgaaggacaatggggagttccacgccctgggccataagtgtccgcactacggcgcacccctggtgaaaggcgttctgtcccgtggtcgggtgcgctgcccctggcacggcgcctgcttcaacatcagcactggggacctggaggacttccctggcctggacagtctacacaagttccaggtgaagattgagaaggagaaggtgtacgtccgggccagcaagcaggccctacagctgcagcgaaggaccaaggtgatggccaagtgtatctctccaagtgctgggtacagcagtagcaccaatgtgctcattgtgggtgcaggtgcagctggcctggtgtgtgcagagacactgcggcaggagggcttctccgaccggatcgtcctgtgcacgctagaccggcaccttccctacgaccgtcccaagctcagcaagtccctggacacacagcctgagcagctggccctgaggcccaaggagtttttccgagcctatggcatcgaggtgctcaccgaggctcaggtggtcacagtggacgtgagaactaagaaggtcgtgttcaaggatggcttcaagctggagtacagcaagctgctgctggcaccagggagcagccccaagactctgagctgcaaaggcaaagaagtggagaacgtgttcactatccggacgccagaggatgccaatcgcgtggtgaggctggcccgaggccgcaacgtggtcgtcgtgggagccggcttcctggggatggaggtggccgcttacctgacggagaaggcccactctgtgtctgtggtggagctggaggagacgcccttcaggaggttcctgggggagcgcgtgggtcgtgccctcatgaagatgtttgagaacaaccgggtgaagttctacatgcagacggaggtgtctgagctgcggggccaggagggaaagctgaaggaggttgtgctgaagagcagcaaggtcgtgcgggctgacgtctgcgtggtgggcattggtgcagtgcccgccacaggcttcctgaggcaaagcggcatcggtttggattcccgaggcttcatccctgtcaacaagatgatgcagaccaatgtcccaggcgtgtttgcagctggcgatgctgtcaccttcccccttgcctggaggaacaaccgcaaagtgaacattccacattggcagatggctcatgctcaggggcgcgtggcagcccagaacatgttggcgcaggaggcggagatgagcactgtgccctacctctggaccgccatgtttggcaagagcctgcgctacgcgggctacggagaaggcttcgacgacgtcatcatccagggggatctggaggagctgaagtttgtggctttttacactaaaggcgacgaggtgatcgccgtggccagcatgaactacgatcccattgtgtccaaggtcgctgaggtgctggcctcaggccgtgccatccggaagcgggaggtggagactggcgacatgtcctggcttacggggaaaggatcctgagctcacatgcagtagacttgggcaggcaaagggggcaccaagggcacaggccaagccttgggggcaggtgccaatctccagtcccaggatcccccagggcagaacctgagccctcccagtgcttgccttcagccacctggctcccctcctgggaggcctctgctggatccagaagatgctcaaccctcaaggcctctgctgccactgacagctggcactggaggcaggacaagccctgcctcttctccctctattgggactggtcccctgaagaaccctgcaacatgttagacattaccgtaaaattaaaacgcacaaatttgcagatcaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:150209 -> Molecular function: GO:0016491 [oxidoreductase activity] evidence: IEA
GeneID:150209 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:150209 -> Molecular function: GO:0050660 [flavin adenine dinucleotide binding] evidence: IEA
GeneID:150209 -> Molecular function: GO:0051537 [2 iron, 2 sulfur cluster binding] evidence: IEA
GeneID:150209 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:150209 -> Biological process: GO:0006917 [induction of apoptosis] evidence: IDA
GeneID:150209 -> Biological process: GO:0022900 [electron transport chain] evidence: IEA
GeneID:150209 -> Biological process: GO:0045454 [cell redox homeostasis] evidence: IEA
GeneID:150209 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:150209 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:150209 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA
GeneID:150209 -> Cellular component: GO:0005743 [mitochondrial inner membrane] evidence: IDA
GeneID:150209 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001018070 -> EC 1.-.-.-
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.