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2024-04-25 17:18:31, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001018011 2262 bp mRNA linear PRI 16-JUN-2013
DEFINITION Homo sapiens zinc finger and BTB domain containing 16 (ZBTB16),
transcript variant 2, mRNA.
ACCESSION NM_001018011
VERSION NM_001018011.1 GI:66932931
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2262)
AUTHORS Jones,C., St-Jean,S., Frechette,I., Bergeron,D., Rivard,N. and
Boudreau,F.
TITLE Identification of a novel promyelocytic leukemia zinc-finger
isoform required for colorectal cancer cell growth and survival
JOURNAL Int. J. Cancer 133 (1), 58-66 (2013)
PUBMED 23280881
REMARK GeneRIF: The p65 PLZF isoform is crucial to maintain colorectal
cancer cell growth, adhesion and survival, and must occur
independently of the traditionally viewed transcriptional role of
PLZF in the course of these biological processes.
REFERENCE 2 (bases 1 to 2262)
AUTHORS Gerart,S., Siberil,S., Martin,E., Lenoir,C., Aguilar,C., Picard,C.,
Lantz,O., Fischer,A. and Latour,S.
TITLE Human iNKT and MAIT cells exhibit a PLZF-dependent proapoptotic
propensity that is counterbalanced by XIAP
JOURNAL Blood 121 (4), 614-623 (2013)
PUBMED 23223428
REMARK GeneRIF: Our findings identify a previously unknown pathway of
regulation of innate-like T-cell homeostasis depending on XIAP and
PLZF.
REFERENCE 3 (bases 1 to 2262)
AUTHORS Jeon,Y.K., Go,H., Nam,S.J., Keam,B., Kim,T.M., Jung,K.C.,
Kang,H.J., Lee,D.S., Huh,J.R. and Park,S.H.
TITLE Expression of the promyelocytic leukemia zinc-finger in
T-lymphoblastic lymphoma and leukemia has strong implications for
their cellular origin and greater association with initial bone
marrow involvement
JOURNAL Mod. Pathol. 25 (9), 1236-1245 (2012)
PUBMED 22555178
REMARK GeneRIF: Expression of the promyelocytic leukemia zinc-finger in
T-lymphoblastic lymphoma and leukemia has strong implications for
their cellular origin and greater association with initial bone
marrow involvement.
REFERENCE 4 (bases 1 to 2262)
AUTHORS Hsu,Y.H., Chen,Y.C., Chen,T.H., Sue,Y.M., Cheng,T.H., Chen,J.R. and
Chen,C.H.
TITLE Far-infrared therapy induces the nuclear translocation of PLZF
which inhibits VEGF-induced proliferation in human umbilical vein
endothelial cells
JOURNAL PLoS ONE 7 (1), E30674 (2012)
PUBMED 22292015
REMARK GeneRIF: Far infrared rays induce the nuclear translocation of PLZF
which inhibits VEGF-induced proliferation in HUVECs.
REFERENCE 5 (bases 1 to 2262)
AUTHORS Eidson,M., Wahlstrom,J., Beaulieu,A.M., Zaidi,B., Carsons,S.E.,
Crow,P.K., Yuan,J., Wolchok,J.D., Horsthemke,B., Wieczorek,D. and
Sant'Angelo,D.B.
TITLE Altered development of NKT cells, gammadelta T cells, CD8 T cells
and NK cells in a PLZF deficient patient
JOURNAL PLoS ONE 6 (9), E24441 (2011)
PUBMED 21915328
REMARK GeneRIF: PLZF appears to control the development and/or function of
a wide variety of human lymphocytes that represent more than 10% of
the total PBMCs.
REFERENCE 6 (bases 1 to 2262)
AUTHORS Hong,S.H., David,G., Wong,C.W., Dejean,A. and Privalsky,M.L.
TITLE SMRT corepressor interacts with PLZF and with the PML-retinoic acid
receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated
with acute promyelocytic leukemia
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 94 (17), 9028-9033 (1997)
PUBMED 9256429
REFERENCE 7 (bases 1 to 2262)
AUTHORS Dong,S., Zhu,J., Reid,A., Strutt,P., Guidez,F., Zhong,H.J.,
Wang,Z.Y., Licht,J., Waxman,S., Chomienne,C., Chen,Z., Zelent,A.
and Chen,S.J.
TITLE Amino-terminal protein-protein interaction motif (POZ-domain) is
responsible for activities of the promyelocytic leukemia zinc
finger-retinoic acid receptor-alpha fusion protein
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (8), 3624-3629 (1996)
PUBMED 8622986
REFERENCE 8 (bases 1 to 2262)
AUTHORS Reid,A., Gould,A., Brand,N., Cook,M., Strutt,P., Li,J., Licht,J.,
Waxman,S., Krumlauf,R. and Zelent,A.
TITLE Leukemia translocation gene, PLZF, is expressed with a speckled
nuclear pattern in early hematopoietic progenitors
JOURNAL Blood 86 (12), 4544-4552 (1995)
PUBMED 8541544
REFERENCE 9 (bases 1 to 2262)
AUTHORS Chen,S.J., Zelent,A., Tong,J.H., Yu,H.Q., Wang,Z.Y., Derre,J.,
Berger,R., Waxman,S. and Chen,Z.
TITLE Rearrangements of the retinoic acid receptor alpha and
promyelocytic leukemia zinc finger genes resulting from
t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia
JOURNAL J. Clin. Invest. 91 (5), 2260-2267 (1993)
PUBMED 8387545
REFERENCE 10 (bases 1 to 2262)
AUTHORS Chen,Z., Brand,N.J., Chen,A., Chen,S.J., Tong,J.H., Wang,Z.Y.,
Waxman,S. and Zelent,A.
TITLE Fusion between a novel Kruppel-like zinc finger gene and the
retinoic acid receptor-alpha locus due to a variant t(11;17)
translocation associated with acute promyelocytic leukaemia
JOURNAL EMBO J. 12 (3), 1161-1167 (1993)
PUBMED 8384553
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC026902.1 and BM969145.1.
Summary: This gene is a member of the Krueppel C2H2-type
zinc-finger protein family and encodes a zinc finger transcription
factor that contains nine Kruppel-type zinc finger domains at the
carboxyl terminus. This protein is located in the nucleus, is
involved in cell cycle progression, and interacts with a histone
deacetylase. Specific instances of aberrant gene rearrangement at
this locus have been associated with acute promyelocytic leukemia
(APL). Alternate transcriptional splice variants have been
characterized. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (2) differs in the 5' UTR compared
to variant 1. Variants 1 and 2 encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC026902.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025091 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-2218 BC026902.1 60-2277
2219-2262 BM969145.1 6-49 c
FEATURES Location/Qualifiers
source 1..2262
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q23.1"
gene 1..2262
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/note="zinc finger and BTB domain containing 16"
/db_xref="GeneID:7704"
/db_xref="HGNC:12930"
/db_xref="HPRD:11762"
/db_xref="MIM:176797"
exon 1..19
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/inference="alignment:Splign:1.39.8"
exon 20..1377
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/inference="alignment:Splign:1.39.8"
variation 60
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:371858413"
misc_feature 92..94
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/note="upstream in-frame stop codon"
variation 99
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="t"
/db_xref="dbSNP:371403983"
variation 109
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="c"
/db_xref="dbSNP:200061176"
CDS 110..2131
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/note="zinc finger protein 145 (Kruppel-like, expressed in
promyelocytic leukemia); zinc finger protein PLZF"
/codon_start=1
/product="zinc finger and BTB domain-containing protein
16"
/protein_id="NP_001018011.1"
/db_xref="GI:66932932"
/db_xref="CCDS:CCDS8367.1"
/db_xref="GeneID:7704"
/db_xref="HGNC:12930"
/db_xref="HPRD:11762"
/db_xref="MIM:176797"
/translation="
MDLTKMGMIQLQNPSHPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQHYTLDFLSPKTFQQILEYAYTATLQAKAEDLDDLLYAAEILEIEYLEEQCLKMLETIQASDDNDTEATMADGGAEEEEDRKARYLKNIFISKHSSEESGYASVAGQSLPGPMVDQSPSVSTSFGLSAMSPTKAAVDSLMTIGQSLLQGTLQPPAGPEEPTLAGGGRHPGVAEVKTEMMQVDEVPSQDSPGAAESSISGGMGDKVEERGKEGPGTPTRSSVITSARELHYGREESAEQVPPPAEAGQAPTGRPEHPAPPPEKHLGIYSVLPNHKADAVLSMPSSVTSGLHVQPALAVSMDFSTYGGLLPQGFIQRELFSKLGELAVGMKSESRTIGEQCSVCGVELPDNEAVEQHRKLHSGMKTYGCELCGKRFLDSLRLRMHLLAHSAGAKAFVCDQCGAQFSKEDALETHRQTHTGTDMAVFCLLCGKRFQAQSALQQHMEVHAGVRSYICSECNRTFPSHTALKRHLRSHTGDHPYECEFCGSCFRDESTLKSHKRIHTGEKPYECNGCGKKFSLKHQLETHYRVHTGEKPFECKLCHQRSRDYSAMIKHLRTHNGASPYQCTICTEYCPSLSSMQKHMKGHKPEEIPPDWRIEKTYLYLCYV
"
misc_feature 182..475
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/note="BTB/POZ domain; Region: BTB; pfam00651"
/db_xref="CDD:201372"
misc_feature 1289..1294
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/experiment="experimental evidence, no additional details
recorded"
/note="Breakpoint for translocation to form PLZF-RAR-alpha
oncogene; propagated from UniProtKB/Swiss-Prot (Q05516.2);
other site"
misc_feature <1451..1870
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/note="FOG: Zn-finger [General function prediction only];
Region: COG5048"
/db_xref="CDD:34653"
misc_feature 1490..1558
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/note="C2H2-type zinc finger; Region: zf-C2H2_6;
pfam13912"
/db_xref="CDD:206083"
misc_feature 1661..1729
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/note="Zinc finger, C2H2 type; Region: zf-C2H2; cl15478"
/db_xref="CDD:210117"
misc_feature 1703..1774
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/note="Zinc-finger double domain; Region: zf-H2C2_2;
pfam13465"
/db_xref="CDD:205643"
misc_feature 1790..1861
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/note="Zinc-finger double domain; Region: zf-H2C2_2;
pfam13465"
/db_xref="CDD:205643"
misc_feature 1874..1939
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/note="Zinc-finger double domain; Region: zf-H2C2_2;
pfam13465"
/db_xref="CDD:205643"
variation 153
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:368808235"
variation 154
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:114873121"
variation 159..160
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace=""
/replace="cc"
/db_xref="dbSNP:4020462"
variation 162
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:200118587"
variation 166
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:142115592"
variation 199
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:150708066"
STS 232..446
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/db_xref="UniSTS:99119"
variation 254
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="c"
/db_xref="dbSNP:200926841"
variation 316
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:201372671"
variation 371
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:112754090"
variation 397
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:373752900"
variation 427
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:367557148"
variation 442
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:200027612"
variation 507
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:370480903"
variation 508
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:35616762"
variation 518
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:368029529"
variation 523
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:147951342"
variation 535
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:149620068"
variation 545
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="g"
/db_xref="dbSNP:116000851"
variation 551
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:368725888"
variation 566
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="g"
/db_xref="dbSNP:200811309"
variation 598
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:141895562"
variation 599
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:372617173"
variation 620
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="g"
/db_xref="dbSNP:374962005"
variation 646
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:368971745"
variation 674
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:111746546"
variation 710
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:111515613"
variation 773
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="g"
/replace="t"
/db_xref="dbSNP:373854559"
variation 781
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:35784831"
variation 810
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:377612552"
variation 885
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:147732000"
variation 889
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:149153164"
variation 922
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:200225387"
variation 970
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:373185527"
STS 997..1116
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/standard_name="ZNF145"
/db_xref="UniSTS:36228"
variation 1032
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="c"
/db_xref="dbSNP:199676604"
variation 1048
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:143295857"
variation 1079
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="g"
/db_xref="dbSNP:377294039"
variation 1114
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:113757018"
variation 1115
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:140433448"
variation 1131
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:188510268"
variation 1138
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:145655784"
variation 1139
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:373798357"
variation 1145
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:376003797"
variation 1156
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:200705288"
variation 1180
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:138118636"
variation 1181
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:142709090"
variation 1221
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:370641059"
variation 1241
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:374279135"
variation 1267
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:116451759"
variation 1271
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:144726594"
variation 1280
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:368196682"
variation 1282
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="g"
/db_xref="dbSNP:371963458"
variation 1285
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:138594849"
variation 1292
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:149262112"
variation 1309
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="g"
/replace="t"
/db_xref="dbSNP:207472352"
variation 1344
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:368472066"
variation 1357
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:116066082"
exon 1378..1475
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/inference="alignment:Splign:1.39.8"
variation 1388
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:371953230"
variation 1402
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="g"
/db_xref="dbSNP:375573362"
variation 1405
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:148436647"
variation 1427
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:141621748"
variation 1450
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:369917864"
exon 1476..1562
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/inference="alignment:Splign:1.39.8"
variation 1488
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:147151121"
variation 1507
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:116547293"
variation 1522
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:202099154"
exon 1563..1733
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/inference="alignment:Splign:1.39.8"
variation 1576
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:140189842"
variation 1586
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:375570317"
variation 1612
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="g"
/replace="t"
/db_xref="dbSNP:145667225"
variation 1621
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:117928729"
variation 1637
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:143447302"
variation 1651
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:147709798"
variation 1723
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:139901986"
exon 1734..1901
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/inference="alignment:Splign:1.39.8"
STS 1735..1897
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/db_xref="UniSTS:99223"
variation 1735
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:111400906"
variation 1789
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="c"
/db_xref="dbSNP:145751819"
variation 1798
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="c"
/db_xref="dbSNP:370528130"
variation 1808
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="c"
/db_xref="dbSNP:115957435"
variation 1832
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:145635689"
variation 1848
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:1047222"
exon 1902..2252
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/inference="alignment:Splign:1.39.8"
variation 1958
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:121434606"
variation 1972
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="g"
/db_xref="dbSNP:376061668"
variation 1978
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:202060139"
variation 2086
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:201532309"
variation 2104
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:114107235"
variation 2105
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="t"
/db_xref="dbSNP:370636939"
variation 2141
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:377609979"
variation 2144
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:371293614"
variation 2146
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:3088357"
variation 2147
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:368652898"
variation 2152
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:201739085"
variation 2155
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:115496918"
variation 2156
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:373656983"
variation 2163
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="g"
/replace="t"
/db_xref="dbSNP:111960851"
variation 2180
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:374340897"
variation 2191
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:58686003"
polyA_signal 2210..2215
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
polyA_site 2224
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/experiment="experimental evidence, no additional details
recorded"
variation 2225..2226
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace=""
/replace="a"
/db_xref="dbSNP:113522699"
variation 2237
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="g"
/db_xref="dbSNP:11214915"
polyA_site 2249
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
ORIGIN
gcgctcccggccgctctcgcctcctctattggcccaggaagcccacccagccccgccacgcagagcccagaaggaaagaaagcctcatgcctgagccgaggggagcaccatggatctgacaaaaatgggcatgatccagctgcagaaccctagccaccccacggggctactgtgcaaggccaaccagatgcggctggccgggactttgtgcgatgtggtcatcatggtggacagccaggagttccacgcccaccggacggtgctggcctgcaccagcaagatgtttgagatcctcttccaccgcaatagtcaacactatactttggacttcctctcgccaaagaccttccagcagattctggagtatgcatatacagccacgctgcaagccaaggcggaggacctggatgacctgctgtatgcggccgagatcctggagatcgagtacctggaggaacagtgcctgaagatgctggagaccatccaggcctcagacgacaatgacacggaggccaccatggccgatggcggggccgaggaagaagaggaccgcaaggctcggtacctcaagaacatcttcatctcgaagcattccagcgaggagagtgggtatgccagtgtggctggacagagcctccctgggcccatggtggaccagagcccttcagtctccacttcatttggtctttcagccatgagtcccaccaaggctgcagtggacagtttgatgaccataggacagtctctcctgcagggaactcttcagccacctgcagggcccgaggagccaactctggctgggggtgggcggcaccctggggtggctgaggtgaagacggagatgatgcaggtggatgaggtgcccagccaggacagccctggggcagccgagtccagcatctcaggagggatgggggacaaggttgaggaaagaggcaaagaggggcctgggaccccgactcgaagcagcgtcatcaccagtgctagggagctacactatgggcgagaggagagtgccgagcaggtgccacccccagctgaggctggccaggcccccactggccgacctgagcacccagcacccccgcctgagaagcatctgggcatctactccgtgttgcccaaccacaaggctgacgctgtattgagcatgccgtcttccgtgacctctggcctccacgtgcagcctgccctggctgtctccatggacttcagcacctatggggggctgctgccccagggcttcatccagagggagctgttcagcaagctgggggagctggctgtgggcatgaagtcagagagccggaccatcggagagcagtgcagcgtgtgtggggtcgagcttcctgataacgaggctgtggagcagcacaggaagctgcacagtgggatgaagacgtacgggtgcgagctctgcgggaagcggttcctggatagtttgcggctgagaatgcacttactggctcattcagcgggtgccaaagcctttgtctgtgatcagtgcggtgcacagttttcgaaggaggatgccctggagacacacaggcagacccatactggcactgacatggccgtcttctgtctgctgtgtgggaagcgcttccaggcgcagagcgcactgcagcagcacatggaggtccacgcgggcgtgcgcagctacatctgcagtgagtgcaaccgcaccttccccagccacacggctctcaaacgccacctgcgctcacatacaggcgaccacccctacgagtgtgagttctgtggcagctgcttccgggatgagagcacactcaagagccacaaacgcatccacacgggtgagaaaccctacgagtgcaatggctgtggcaagaagttcagcctcaagcatcagctggagacgcactatagggtgcacacaggtgagaagccctttgagtgtaagctctgccaccagcgctcccgggactactcggccatgatcaagcacctgagaacgcacaacggcgcctcgccctaccagtgcaccatctgcacagagtactgccccagcctctcctccatgcagaagcacatgaagggccacaagcccgaggagatcccgcccgactggaggatagagaagacgtacctctacctgtgctatgtgtgaagggaggcccgcggcggtggagccgagcggggagccaggaaagaagagttggagtgagatgaaggaaggactatgacaaataaaaaaggaaaagaaaaaaaaaaacagaaggaaaaggaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:7704 -> Molecular function: GO:0003677 [DNA binding] evidence: IDA
GeneID:7704 -> Molecular function: GO:0003677 [DNA binding] evidence: NAS
GeneID:7704 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:7704 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
GeneID:7704 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IDA
GeneID:7704 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:7704 -> Biological process: GO:0001823 [mesonephros development] evidence: ISS
GeneID:7704 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:7704 -> Biological process: GO:0006915 [apoptotic process] evidence: NAS
GeneID:7704 -> Biological process: GO:0007417 [central nervous system development] evidence: ISS
GeneID:7704 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IEA
GeneID:7704 -> Biological process: GO:0009880 [embryonic pattern specification] evidence: IEA
GeneID:7704 -> Biological process: GO:0009952 [anterior/posterior pattern specification] evidence: IEA
GeneID:7704 -> Biological process: GO:0016567 [protein ubiquitination] evidence: IEA
GeneID:7704 -> Biological process: GO:0030097 [hemopoiesis] evidence: IDA
GeneID:7704 -> Biological process: GO:0030097 [hemopoiesis] evidence: TAS
GeneID:7704 -> Biological process: GO:0030099 [myeloid cell differentiation] evidence: TAS
GeneID:7704 -> Biological process: GO:0032332 [positive regulation of chondrocyte differentiation] evidence: IMP
GeneID:7704 -> Biological process: GO:0035116 [embryonic hindlimb morphogenesis] evidence: IEA
GeneID:7704 -> Biological process: GO:0035136 [forelimb morphogenesis] evidence: IEA
GeneID:7704 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IEA
GeneID:7704 -> Biological process: GO:0045600 [positive regulation of fat cell differentiation] evidence: IMP
GeneID:7704 -> Biological process: GO:0045638 [negative regulation of myeloid cell differentiation] evidence: ISS
GeneID:7704 -> Biological process: GO:0045778 [positive regulation of ossification] evidence: IDA
GeneID:7704 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
GeneID:7704 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: NAS
GeneID:7704 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IDA
GeneID:7704 -> Biological process: GO:0048133 [male germ-line stem cell division] evidence: IEA
GeneID:7704 -> Biological process: GO:0051216 [cartilage development] evidence: IDA
GeneID:7704 -> Biological process: GO:0061036 [positive regulation of cartilage development] evidence: IDA
GeneID:7704 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:7704 -> Cellular component: GO:0016604 [nuclear body] evidence: IDA
GeneID:7704 -> Cellular component: GO:0016605 [PML body] evidence: IDA
GeneID:7704 -> Cellular component: GO:0016607 [nuclear speck] evidence: IDA
GeneID:7704 -> Cellular component: GO:0017053 [transcriptional repressor complex] evidence: IDA
by
@meso_cacase at
DBCLS
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