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2019-03-22 05:56:21, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001017535            4791 bp    mRNA    linear   PRI 15-JUL-2013
DEFINITION  Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor (VDR),
            transcript variant 2, mRNA.
ACCESSION   NM_001017535
VERSION     NM_001017535.1  GI:63054844
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4791)
  AUTHORS   Asano,L., Ito,I., Kuwabara,N., Waku,T., Yanagisawa,J., Miyachi,H.
            and Shimizu,T.
  TITLE     Structural basis for vitamin D receptor agonism by novel
            non-secosteroidal ligands
  JOURNAL   FEBS Lett. 587 (7), 957-963 (2013)
   PUBMED   23462137
  REMARK    GeneRIF: Data indicate that ligands changed the conformation of the
            vitamin D receptor (VDR), resulting in different hydrogen-bond
            networks depending on the potency of the ligand.
REFERENCE   2  (bases 1 to 4791)
  AUTHORS   Li,L., Wu,B., Liu,J.Y. and Yang,L.B.
  TITLE     Vitamin D receptor gene polymorphisms and type 2 diabetes: a
            meta-analysis
  JOURNAL   Arch. Med. Res. 44 (3), 235-241 (2013)
   PUBMED   23506721
  REMARK    GeneRIF: meta-analysis suggests that the FokI polymorphism of the
            VDR gene could be a risk factor for type 2 diabetes, especially in
            an Asian population
REFERENCE   3  (bases 1 to 4791)
  AUTHORS   Tiosano,D., Wildbaum,G., Gepstein,V., Verbitsky,O., Weisman,Y.,
            Karin,N. and Eztioni,A.
  TITLE     The role of vitamin D receptor in innate and adaptive immunity: a
            study in hereditary vitamin D-resistant rickets patients
  JOURNAL   J. Clin. Endocrinol. Metab. 98 (4), 1685-1693 (2013)
   PUBMED   23482605
  REMARK    GeneRIF: The role of vitamin D receptor in innate and adaptive
            immunity in vitamin D-resistant rickets.
REFERENCE   4  (bases 1 to 4791)
  AUTHORS   Chesney,R.W. and Han,X.
  TITLE     Differential regulation of TauT by calcitriol and retinoic acid via
            VDR/RXR in LLC-PK1 and MCF-7 cells
  JOURNAL   Adv. Exp. Med. Biol. 776, 291-305 (2013)
   PUBMED   23392891
  REMARK    GeneRIF: Expression of TauT is differentially regulated by Vitamin
            D(3) and retinoic acid via formation of VDR and RXR complexes in
            the nuclei in a cell type-dependent manner.
REFERENCE   5  (bases 1 to 4791)
  AUTHORS   Pervin,S., Hewison,M., Braga,M., Tran,L., Chun,R., Karam,A.,
            Chaudhuri,G., Norris,K. and Singh,R.
  TITLE     Down-regulation of vitamin D receptor in mammospheres: implications
            for vitamin D resistance in breast cancer and potential for
            combination therapy
  JOURNAL   PLoS ONE 8 (1), E53287 (2013)
   PUBMED   23341935
  REMARK    GeneRIF: Inhibition of VDR expression by siRNA led to a significant
            change in key epithelial mesenchymal transition-specific
            transcription factors and increased the ability of these cells to
            form mammospheres.
REFERENCE   6  (bases 1 to 4791)
  AUTHORS   Goto,H., Chen,K.S., Prahl,J.M. and DeLuca,H.F.
  TITLE     A single receptor identical with that from intestine/T47D cells
            mediates the action of 1,25-dihydroxyvitamin D-3 in HL-60 cells
  JOURNAL   Biochim. Biophys. Acta 1132 (1), 103-108 (1992)
   PUBMED   1324736
REFERENCE   7  (bases 1 to 4791)
  AUTHORS   Bugge,T.H., Pohl,J., Lonnoy,O. and Stunnenberg,H.G.
  TITLE     RXR alpha, a promiscuous partner of retinoic acid and thyroid
            hormone receptors
  JOURNAL   EMBO J. 11 (4), 1409-1418 (1992)
   PUBMED   1314167
REFERENCE   8  (bases 1 to 4791)
  AUTHORS   Szpirer,J., Szpirer,C., Riviere,M., Levan,G., Marynen,P.,
            Cassiman,J.J., Wiese,R. and DeLuca,H.F.
  TITLE     The Sp1 transcription factor gene (SP1) and the
            1,25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized on
            human chromosome arm 12q and rat chromosome 7
  JOURNAL   Genomics 11 (1), 168-173 (1991)
   PUBMED   1662663
REFERENCE   9  (bases 1 to 4791)
  AUTHORS   Saijo,T., Ito,M., Takeda,E., Huq,A.H., Naito,E., Yokota,I.,
            Sone,T., Pike,J.W. and Kuroda,Y.
  TITLE     A unique mutation in the vitamin D receptor gene in three Japanese
            patients with vitamin D-dependent rickets type II: utility of
            single-strand conformation polymorphism analysis for heterozygous
            carrier detection
  JOURNAL   Am. J. Hum. Genet. 49 (3), 668-673 (1991)
   PUBMED   1652893
REFERENCE   10 (bases 1 to 4791)
  AUTHORS   Yu,X.P., Mocharla,H., Hustmyer,F.G. and Manolagas,S.C.
  TITLE     Vitamin D receptor expression in human lymphocytes. Signal
            requirements and characterization by western blots and DNA
            sequencing
  JOURNAL   J. Biol. Chem. 266 (12), 7588-7595 (1991)
   PUBMED   1850412
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC121338.6, CF138099.1,
            BX355584.2, BC060832.1, AC004466.1, J03258.1, BM908433.1 and
            BQ002808.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes the nuclear hormone receptor for vitamin
            D3. This receptor also functions as a receptor for the secondary
            bile acid lithocholic acid. The receptor belongs to the family of
            trans-acting transcriptional regulatory factors and shows sequence
            similarity to the steroid and thyroid hormone receptors. Downstream
            targets of this nuclear hormone receptor are principally involved
            in mineral metabolism though the receptor regulates a variety of
            other metabolic pathways, such as those involved in the immune
            response and cancer. Mutations in this gene are associated with
            type II vitamin D-resistant rickets. A single nucleotide
            polymorphism in the initiation codon results in an alternate
            translation start site three codons downstream. Alternative
            splicing results in multiple transcript variants encoding different
            proteins. [provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 3. The resulting isoform (VDRA)
            is shorter at the N-terminus compared to isoform VDRB1. Variants 1
            and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: J03258.1, AB307700.1 [ECO:0000331]
            RNAseq introns       :: mixed/partial sample support ERS025081,
                                    ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC121338.6         15879-15894         c
            17-77               CF138099.1         7-67
            78-199              BX355584.2         62-183
            200-280             CF138099.1         68-148
            281-3544            BC060832.1         522-3785
            3545-3545           AC004466.1         48367-48367
            3546-3668           BC060832.1         3787-3909
            3669-3688           J03258.1           3499-3518
            3689-3976           J03258.1           3520-3807
            3977-4028           J03258.1           3809-3860
            4029-4100           J03258.1           3862-3933
            4101-4525           BM908433.1         185-609
            4526-4737           J03258.1           4356-4567
            4738-4772           J03258.1           4569-4603
            4773-4791           BQ002808.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..4791
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.11"
     gene            1..4791
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /note="vitamin D (1,25- dihydroxyvitamin D3) receptor"
                     /db_xref="GeneID:7421"
                     /db_xref="HGNC:12679"
                     /db_xref="HPRD:03463"
                     /db_xref="MIM:601769"
     exon            1..77
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /inference="alignment:Splign:1.39.8"
     variation       29
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11574011"
     exon            78..199
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /inference="alignment:Splign:1.39.8"
     variation       102..103
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:17883984"
     misc_feature    118..120
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /note="upstream in-frame stop codon"
     exon            200..280
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /inference="alignment:Splign:1.39.8"
     exon            281..428
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /inference="alignment:Splign:1.39.8"
     CDS             283..1566
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /note="isoform VDRA is encoded by transcript variant 2;
                     vitamin D3 receptor; vitamin D nuclear receptor variant 1;
                     1,25-dihydroxyvitamin D3 receptor; nuclear receptor
                     subfamily 1 group I member 1"
                     /codon_start=1
                     /product="vitamin D3 receptor isoform VDRA"
                     /protein_id="NP_001017535.1"
                     /db_xref="GI:63054845"
                     /db_xref="CCDS:CCDS8757.1"
                     /db_xref="GeneID:7421"
                     /db_xref="HGNC:12679"
                     /db_xref="HPRD:03463"
                     /db_xref="MIM:601769"
                     /translation="
MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGNEIS
"
     misc_feature    292..294
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /note="Region: alternate start codon"
     misc_feature    328..648
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /note="DNA-binding domain of vitamin D receptors (VDR) is
                     composed of two C4-type zinc fingers; Region: NR_DBD_VDR;
                     cd06955"
                     /db_xref="CDD:143513"
     misc_feature    order(352..354,361..363,403..405,412..414,460..462,
                     478..480,508..510,517..519)
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /note="zinc binding site [ion binding]; other site"
                     /db_xref="CDD:143513"
     misc_feature    order(382..390,406..411,415..417,427..432,499..504,
                     520..522,562..567,580..582)
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143513"
     misc_feature    order(463..468,505..507,556..561)
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:143513"
     misc_feature    571..855
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P11473.1);
                     Region: Hinge"
     misc_feature    652..>759
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /note="The ligand binding domain of nuclear receptors, a
                     family of ligand-activated transcription regulators;
                     Region: NR_LBD; cl11397"
                     /db_xref="CDD:209301"
     misc_feature    856..1563
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P11473.1);
                     Region: Ligand-binding"
     misc_feature    904..906
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:00277"
     misc_feature    949..1560
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /note="The ligand binding domain of vitamin D receptors, a
                     member of the nuclear receptor superfamily; Region:
                     NR_LBD_VDR; cd06933"
                     /db_xref="CDD:132731"
     misc_feature    order(961..963,970..972,979..984,991..993,1093..1095,
                     1102..1107,1114..1116,1138..1140,1144..1146,1180..1182,
                     1189..1191,1195..1197,1471..1473,1483..1485,1492..1494)
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:132731"
     misc_feature    961..993
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P11473.1);
                     Region: Vitamin D3 binding"
     misc_feature    order(1006..1008,1018..1020,1036..1038,1051..1053,
                     1057..1062,1072..1074,1528..1533,1540..1545,1555..1560)
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /note="coactivator recognition site [polypeptide binding];
                     other site"
                     /db_xref="CDD:132731"
     misc_feature    1093..1116
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P11473.1);
                     Region: Vitamin D3 binding"
     variation       284
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2228570"
     variation       339
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2228572"
     exon            429..559
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /inference="alignment:Splign:1.39.8"
     exon            560..744
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /inference="alignment:Splign:1.39.8"
     variation       726
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2229828"
     exon            745..865
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /inference="alignment:Splign:1.39.8"
     exon            866..1037
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /inference="alignment:Splign:1.39.8"
     variation       970
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11574090"
     exon            1038..1189
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /inference="alignment:Splign:1.39.8"
     STS             1052..1159
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /standard_name="VDR"
                     /db_xref="UniSTS:503993"
     exon            1190..1306
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /inference="alignment:Splign:1.39.8"
     variation       1191
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12721365"
     exon            1307..4775
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /inference="alignment:Splign:1.39.8"
     variation       1332
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4987032"
     variation       1338
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:731236"
     variation       1367
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11574115"
     variation       1488
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2229829"
     STS             1506..2087
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /standard_name="VDRU1"
                     /db_xref="UniSTS:463500"
     variation       1750
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11574116"
     variation       1788
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11574117"
     variation       1975
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11574118"
     STS             2000..2611
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /standard_name="VDRU2"
                     /db_xref="UniSTS:463501"
     variation       2003
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11574119"
     variation       2094
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11574120"
     variation       2167
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11574121"
     variation       2214
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11574122"
     variation       2255
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11574123"
     variation       2314
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11574124"
     variation       2359
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11574125"
     variation       2360
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11574126"
     variation       2458
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11574127"
     STS             2520..3144
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /standard_name="VDRU3"
                     /db_xref="UniSTS:463502"
     STS             2744..2886
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /standard_name="WI-17447"
                     /db_xref="UniSTS:55150"
     variation       2745..2746
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:201007499"
     variation       2745
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:11574128"
     variation       2792
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11574129"
     variation       2815..2816
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace=""
                     /replace="ccagc"
                     /db_xref="dbSNP:11574130"
     variation       2885
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11574131"
     variation       3043
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11574132"
     STS             3069..3657
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /standard_name="VDRU4"
                     /db_xref="UniSTS:463503"
     variation       3086
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:11574133"
     variation       3232
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11574134"
     variation       3407
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:12088"
     variation       3431
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11540149"
     variation       3472
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:9729"
     variation       3589
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11574135"
     STS             3592..4246
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /standard_name="VDRU5"
                     /db_xref="UniSTS:463504"
     STS             3592..3990
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /standard_name="VDRU5-PoA"
                     /db_xref="UniSTS:463505"
     variation       3703
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12721386"
     variation       3709
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:2853562"
     variation       3792
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11574136"
     variation       4022
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11574137"
     variation       4159
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11168263"
     variation       4357
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2853563"
     variation       4393
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11574138"
     STS             4495..4667
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /standard_name="RH17584"
                     /db_xref="UniSTS:5822"
     variation       4540
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:11574139"
     polyA_signal    4753..4758
                     /gene="VDR"
                     /gene_synonym="NR1I1"
     polyA_site      4775
                     /gene="VDR"
                     /gene_synonym="NR1I1"
ORIGIN      
ctgcttgtcaaaaggcggcagcggagccgtgtgcgccgggagcgcggaacagcttgtccacccgccggccggaccagggctcctgaacctagcccagctggacggagaaatggactctagcctcctctgatagcctcatgccaggccccgtgcacattgctttgcttgcctccctcaatcctcatagcttctctttgggaagcctttgggtctgaagtgtctgtgagacctcacagaagagcacccctgggctccacttacctgccccctgctccttcagggatggaggcaatggcggccagcacttccctgcctgaccctggagactttgaccggaacgtgccccggatctgtggggtgtgtggagaccgagccactggctttcacttcaatgctatgacctgtgaaggctgcaaaggcttcttcaggcgaagcatgaagcggaaggcactattcacctgccccttcaacggggactgccgcatcaccaaggacaaccgacgccactgccaggcctgccggctcaaacgctgtgtggacatcggcatgatgaaggagttcattctgacagatgaggaagtgcagaggaagcgggagatgatcctgaagcggaaggaggaggaggccttgaaggacagtctgcggcccaagctgtctgaggagcagcagcgcatcattgccatactgctggacgcccaccataagacctacgaccccacctactccgacttctgccagttccggcctccagttcgtgtgaatgatggtggagggagccatccttccaggcccaactccagacacactcccagcttctctggggactcctcctcctcctgctcagatcactgtatcacctcttcagacatgatggactcgtccagcttctccaatctggatctgagtgaagaagattcagatgacccttctgtgaccctagagctgtcccagctctccatgctgccccacctggctgacctggtcagttacagcatccaaaaggtcattggctttgctaagatgataccaggattcagagacctcacctctgaggaccagatcgtactgctgaagtcaagtgccattgaggtcatcatgttgcgctccaatgagtccttcaccatggacgacatgtcctggacctgtggcaaccaagactacaagtaccgcgtcagtgacgtgaccaaagccggacacagcctggagctgattgagcccctcatcaagttccaggtgggactgaagaagctgaacttgcatgaggaggagcatgtcctgctcatggccatctgcatcgtctccccagatcgtcctggggtgcaggacgccgcgctgattgaggccatccaggaccgcctgtccaacacactgcagacgtacatccgctgccgccacccgcccccgggcagccacctgctctatgccaagatgatccagaagctagccgacctgcgcagcctcaatgaggagcactccaagcagtaccgctgcctctccttccagcctgagtgcagcatgaagctaacgccccttgtgctcgaagtgtttggcaatgagatctcctgactaggacagcctgtggcggtgcctgggtggggctgctcctccagggccacgtgccaggcccggggctggcggctactcagcagccctcctcaccccgtctggggttcagcccctcctctgccacctcccctatccacccagcccattctctctcctgtccaacctaacccctttcctgcgggcttttccccggtcccttgagacctcagccatgaggagttgctgtttgtttgacaaagaaacccaagtgggggcagagggcagaggctggaggcagggccttgcccagagatgcctccaccgctgcctaagtggctgctgactgatgttgagggaacagacaggagaaatgcatccattcctcagggacagagacacctgcacctccccccactgcaggccccgcttgtccagcgcctagtggggtctccctctcctgcctactcacgataaataatcggcccacagctcccaccccacccccttcagtgcccaccaacatcccattgccctggttatattctcacgggcagtagctgtggtgaggtgggttttcttcccatcactggagcaccaggcacgaacccacctgctgagagacccaaggaggaaaaacagacaaaaacagcctcacagaagaatatgacagctgtccctgtcaccaagctcacagttcctcgccctgggtctaaggggttggttgaggtggaagccctccttccacggatccatgtagcaggactgaattgtccccagtttgcagaaaagcacctgccgacctcgtcctccccctgccagtgccttacctcctgcccaggagagccagccctccctgtcctcctcggatcaccgagagtagccgagagcctgctcccccaccccctccccaggggagagggtctggagaagcagtgagccgcatcttctccatctggcagggtgggatggaggagaagaattttcagaccccagcggctgagtcatgatctccctgccgcctcaatgtggttgcaaggccgctgttcacccacagggctaagagctagcgctgccgcaccccagagtgtgggaagggagagcggggcagtctcgggtggctagtcagagagagtgtttgggggttccgtgatgtagggtaaggtgccttcttattctcactccaccacccaaaagtcaaaaggtgcctgtgaggcaggggcggagtgatacaacttcaagtgcatgctctctgcagccagcccagcccagctggtgggaagcgtctgtccgtttactccaaggtggggtctttgtgagagtgagctgtaggtgtgcgggaccggtacagaaaggcgttcttcgaggtggatcacagaggcttcttcagatcagtgcttgagtttggggaatgcggccgcattccctgagtcaccaggaatgttaaagtcagtgggaacgtgactgccccaactcctggaagctgtgtccttgcacctgcatccgtagttccctgaaaacccagagaggaatcagacttcacactgcaagagccttggtgtccacctggccccatgtctctcagaattcttcaggtggaaaaacatctgaaagccacgttccttactgcagaatagcatatatatcgcttaatcttaaatttattagatatgagttgttttcagactcagactccatttgtattatagtctaatatacagggtagcaggtaccactgatttggagatatttatggggggagaacttacattgtgaaacttctgtacattaattattattgctgttgttattttacaagggtctagggagagacccttgtttgattttagctgcagaacgtattggtccagcttgctcttcagtgggagaaaacacttgtaagttgctaaacgagtcaatcccctcattcaggaaaactgacagaggagggcgtgactcacccaagcatatataactagctagaagtgggccaggacaggcccggcgcggtggctcacgcctgtaatcccagcagtttgggaggtcgaggtaggtggatcacctgaggtcgggagttcgagaccaacctgaccaacatggagaaaccctgtctctattaaaaatacaaaaaaaaaaaaaaaaaaaatagccgggcatggtggcgcaagcctgtaatcccagctactcaggaggctgaggcagaagaattgaacccaggaggtggaggttgcagtgagctgagatcgtgccgttactctccaacctggacaacaagagcgaaactccgtcttagaagtggaccaggacaggaccagattttggagtcatggtccggtgtccttttcactacaccatgtttgagctcagacccccactctcattccccaggtggctgacccagtccctgggggaagccctggatttcagaaagagcaagtctggatctgggaccctttccttccttccctggcttgtaactccaccaacccatcagaaggagaaggaaggagactcacctctgcctcaatgtgaatcagaccctaccccaccacgatgtggccctggcctgctgggctctccacctcagccttggataatgctgttgcctcatctataacatgcatttgtctttgtaatgtcaccaccttcccagctctccctctggccctgccttcttcggggaactcctggaaatatcagttactcagccctgggccccaccacctaggccactcctccaaaggaagtctaggagctgggaggaaaagaaaagaggggaaaatgagtttttatggggctgaacggggagaaaaggtcatcatcgattctactttagaatgagagtgtgaaatagacatttgtaaatgtaaaacttttaaggtatatcattataactgaaggagaaggtgccccaaaatgcaagattttccacaagattcccagagacaggaaaatcctctggctggctaactggaagcatgtaggagaatccaagcgaggtcaacagagaaggcaggaatgtgtggcagatttagtgaaagctagagatatggcagcgaaaggatgtaaacagtgcctgctgaatgatttccaaagagaaaaaaagtttgccagaagtttgtcaagtcaaccaatgtagaaagctttgcttatggtaataaaaatggctcatacttatatagcacttactttgttgcaagtactgctgtaaataaatgctttatgcaaaccaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:7421 -> Molecular function: GO:0003677 [DNA binding] evidence: IDA
            GeneID:7421 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IDA
            GeneID:7421 -> Molecular function: GO:0003707 [steroid hormone receptor activity] evidence: IEA
            GeneID:7421 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:7421 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
            GeneID:7421 -> Molecular function: GO:0008434 [calcitriol receptor activity] evidence: IDA
            GeneID:7421 -> Molecular function: GO:0038186 [lithocholic acid receptor activity] evidence: IDA
            GeneID:7421 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:7421 -> Molecular function: GO:0046965 [retinoid X receptor binding] evidence: IPI
            GeneID:7421 -> Molecular function: GO:0070644 [vitamin D response element binding] evidence: IDA
            GeneID:7421 -> Molecular function: GO:1902098 [calcitriol binding] evidence: IDA
            GeneID:7421 -> Molecular function: GO:1902121 [lithocholic acid binding] evidence: IDA
            GeneID:7421 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:7421 -> Biological process: GO:0000902 [cell morphogenesis] evidence: IMP
            GeneID:7421 -> Biological process: GO:0006367 [transcription initiation from RNA polymerase II promoter] evidence: TAS
            GeneID:7421 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
            GeneID:7421 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IDA
            GeneID:7421 -> Biological process: GO:0010467 [gene expression] evidence: TAS
            GeneID:7421 -> Biological process: GO:0010628 [positive regulation of gene expression] evidence: IMP
            GeneID:7421 -> Biological process: GO:0010839 [negative regulation of keratinocyte proliferation] evidence: IMP
            GeneID:7421 -> Biological process: GO:0010980 [positive regulation of vitamin D 24-hydroxylase activity] evidence: IDA
            GeneID:7421 -> Biological process: GO:0038183 [bile acid signaling pathway] evidence: IDA
            GeneID:7421 -> Biological process: GO:0045618 [positive regulation of keratinocyte differentiation] evidence: IMP
            GeneID:7421 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
            GeneID:7421 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IMP
            GeneID:7421 -> Biological process: GO:0046697 [decidualization] evidence: IEP
            GeneID:7421 -> Biological process: GO:0060558 [regulation of calcidiol 1-monooxygenase activity] evidence: ISS
            GeneID:7421 -> Biological process: GO:0070561 [vitamin D receptor signaling pathway] evidence: IDA
            GeneID:7421 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:7421 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS

by @meso_cacase at DBCLS
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