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2024-03-29 01:53:32, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001014832            2765 bp    mRNA    linear   PRI 02-JUN-2013
DEFINITION  Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 4 (PAK4),
            transcript variant 3, mRNA.
ACCESSION   NM_001014832
VERSION     NM_001014832.1  GI:62422556
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2765)
  AUTHORS   Kim,S.H., Kim,S.R., Ihm,H.J., Oh,Y.S., Chae,H.D., Kim,C.H. and
            Kang,B.M.
  TITLE     Regulation of P21-activated kinase-4 by progesterone and tumor
            necrosis factor-alpha in human endometrium and its increased
            expression in advanced-stage endometriosis
  JOURNAL   J. Clin. Endocrinol. Metab. 98 (2), E238-E248 (2013)
   PUBMED   23293332
  REMARK    GeneRIF: increased expression of Pak4 might lead to the
            establishment and progression of endometriosis by enhanced cellular
            viability and invasiveness in endometrial cells.
REFERENCE   2  (bases 1 to 2765)
  AUTHORS   Wang,Z., Zhang,X., Yang,Z., Du,H., Wu,Z., Gong,J., Yan,J. and
            Zheng,Q.
  TITLE     MiR-145 regulates PAK4 via the MAPK pathway and exhibits an
            antitumor effect in human colon cells
  JOURNAL   Biochem. Biophys. Res. Commun. 427 (3), 444-449 (2012)
   PUBMED   22766504
  REMARK    GeneRIF: these findings demonstrate that miR-145 downregulates
            P-ERK expression by targeting PAK4 and leads to inhibition of tumor
            growth.
REFERENCE   3  (bases 1 to 2765)
  AUTHORS   Ha,B.H., Davis,M.J., Chen,C., Lou,H.J., Gao,J., Zhang,R.,
            Krauthammer,M., Halaban,R., Schlessinger,J., Turk,B.E. and
            Boggon,T.J.
  TITLE     Type II p21-activated kinases (PAKs) are regulated by an
            autoinhibitory pseudosubstrate
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 109 (40), 16107-16112 (2012)
   PUBMED   22988085
  REMARK    GeneRIF: Full-length PAK4 is constitutively autoinibited, but
            mutation of the pseudosubstrate releases this inhibition.
REFERENCE   4  (bases 1 to 2765)
  AUTHORS   Baskaran,Y., Ng,Y.W., Selamat,W., Ling,F.T. and Manser,E.
  TITLE     Group I and II mammalian PAKs have different modes of activation by
            Cdc42
  JOURNAL   EMBO Rep. 13 (7), 653-659 (2012)
   PUBMED   22653441
  REMARK    GeneRIF: PAK4 is strongly inhibited by an auto-inhibitory domain
            formed by amino acids 20 to 68.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2765)
  AUTHORS   Kesanakurti,D., Chetty,C., Rajasekhar Maddirela,D., Gujrati,M. and
            Rao,J.S.
  TITLE     Functional cooperativity by direct interaction between PAK4 and
            MMP-2 in the regulation of anoikis resistance, migration and
            invasion in glioma
  JOURNAL   Cell Death Dis 3, E445 (2012)
   PUBMED   23254288
  REMARK    GeneRIF: Interaction between PAK4 and MMP-2 regulated anoikis, cell
            migration and invasion in glioma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2765)
  AUTHORS   Lu,Y., Pan,Z.Z., Devaux,Y. and Ray,P.
  TITLE     p21-activated protein kinase 4 (PAK4) interacts with the
            keratinocyte growth factor receptor and participates in
            keratinocyte growth factor-mediated inhibition of oxidant-induced
            cell death
  JOURNAL   J. Biol. Chem. 278 (12), 10374-10380 (2003)
   PUBMED   12529371
  REMARK    GeneRIF: PAK4 interacts with KGF receptor and mediate
            anti-apoptosis effects of KGF on epithelial cells.
REFERENCE   7  (bases 1 to 2765)
  AUTHORS   Zhang,H., Li,Z., Viklund,E.K. and Stromblad,S.
  TITLE     P21-activated kinase 4 interacts with integrin alpha v beta 5 and
            regulates alpha v beta 5-mediated cell migration
  JOURNAL   J. Cell Biol. 158 (7), 1287-1297 (2002)
   PUBMED   12356872
REFERENCE   8  (bases 1 to 2765)
  AUTHORS   Dan,C., Kelly,A., Bernard,O. and Minden,A.
  TITLE     Cytoskeletal changes regulated by the PAK4 serine/threonine kinase
            are mediated by LIM kinase 1 and cofilin
  JOURNAL   J. Biol. Chem. 276 (34), 32115-32121 (2001)
   PUBMED   11413130
REFERENCE   9  (bases 1 to 2765)
  AUTHORS   Bagrodia,S. and Cerione,R.A.
  TITLE     Pak to the future
  JOURNAL   Trends Cell Biol. 9 (9), 350-355 (1999)
   PUBMED   10461188
  REMARK    Review article
REFERENCE   10 (bases 1 to 2765)
  AUTHORS   Abo,A., Qu,J., Cammarano,M.S., Dan,C., Fritsch,A., Baud,V.,
            Belisle,B. and Minden,A.
  TITLE     PAK4, a novel effector for Cdc42Hs, is implicated in the
            reorganization of the actin cytoskeleton and in the formation of
            filopodia
  JOURNAL   EMBO J. 17 (22), 6527-6540 (1998)
   PUBMED   9822598
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG773480.1, BC025282.1,
            BC011368.1 and AB032968.1.
            
            Summary: PAK proteins, a family of serine/threonine p21-activating
            kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are
            critical effectors that link Rho GTPases to cytoskeleton
            reorganization and nuclear signaling. They serve as targets for the
            small GTP binding proteins Cdc42 and Rac and have been implicated
            in a wide range of biological activities. PAK4 interacts
            specifically with the GTP-bound form of Cdc42Hs and weakly
            activates the JNK family of MAP kinases. PAK4 is a mediator of
            filopodia formation and may play a role in the reorganization of
            the actin cytoskeleton. Multiple alternatively spliced transcript
            variants encoding distinct isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) lacks an exon in the 5' UTR,
            and encodes the same isoform (1), as compared to variant 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011368.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                BG773480.1         26-59
            35-102              BC025282.1         1-68
            103-2219            BC011368.1         81-2197
            2220-2765           AB032968.1         1780-2325
FEATURES             Location/Qualifiers
     source          1..2765
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..2765
                     /gene="PAK4"
                     /note="p21 protein (Cdc42/Rac)-activated kinase 4"
                     /db_xref="GeneID:10298"
                     /db_xref="HGNC:16059"
                     /db_xref="MIM:605451"
     exon            1..140
                     /gene="PAK4"
                     /inference="alignment:Splign:1.39.8"
     variation       56
                     /gene="PAK4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:71356837"
     variation       74
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4803205"
     variation       102
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:4803206"
     variation       116
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111999288"
     exon            141..366
                     /gene="PAK4"
                     /inference="alignment:Splign:1.39.8"
     variation       143
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376621337"
     variation       144
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370008929"
     variation       148
                     /gene="PAK4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:690929"
     variation       149
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201511246"
     variation       151
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149068416"
     variation       156
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373760840"
     variation       157
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376606539"
     CDS             163..1938
                     /gene="PAK4"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 3;
                     protein kinase related to S. cerevisiae STE20, effector
                     for Cdc42Hs; p21(CDKN1A)-activated kinase 4;
                     serine/threonine-protein kinase PAK 4; PAK-4;
                     p21-activated kinase 4"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PAK 4 isoform 1"
                     /protein_id="NP_001014832.1"
                     /db_xref="GI:62422557"
                     /db_xref="CCDS:CCDS12528.1"
                     /db_xref="GeneID:10298"
                     /db_xref="HGNC:16059"
                     /db_xref="MIM:605451"
                     /translation="
MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
"
     misc_feature    190..306
                     /gene="PAK4"
                     /note="PAK (p21 activated kinase) Binding Domain (PBD),
                     binds Cdc42p- and/or Rho-like small GTPases; also known as
                     the Cdc42/Rac interactive binding (CRIB) motif; has been
                     shown to inhibit transcriptional activation and cell
                     transformation mediated by the...; Region: CRIB_PAK_like;
                     cd01093"
                     /db_xref="CDD:29038"
     misc_feature    order(193..195,202..204,211..213,217..219,226..228,
                     277..279,289..291)
                     /gene="PAK4"
                     /note="GTPase interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:29038"
     misc_feature    235..1122
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O96013.1);
                     Region: Linker"
     misc_feature    283..285
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O96013.1); phosphorylation site"
     misc_feature    457..459
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:05675"
     misc_feature    472..474
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O96013.1); phosphorylation site"
     misc_feature    472..474
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:05675"
     misc_feature    604..606
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O96013.1); phosphorylation site"
     misc_feature    604..606
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:05675"
     misc_feature    661..663
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O96013.1); phosphorylation site"
     misc_feature    661..663
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:05675"
     misc_feature    703..705
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O96013.1); phosphorylation site"
     misc_feature    703..705
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    703..705
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:05675"
     misc_feature    721..723
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (O96013.1); phosphorylation site"
     misc_feature    745..747
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O96013.1); phosphorylation site"
     misc_feature    781..783
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:05675"
     misc_feature    934..936
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O96013.1); phosphorylation site"
     misc_feature    934..936
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:05675"
     misc_feature    961..963
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O96013.1); phosphorylation site"
     misc_feature    1033..1035
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O96013.1); phosphorylation site"
     misc_feature    1033..1035
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:05675"
     misc_feature    1054..1131
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O96013.1);
                     Region: GEF-interaction domain (GID)"
     misc_feature    1063..1917
                     /gene="PAK4"
                     /note="Catalytic domain of the Protein Serine/Threonine
                     Kinase, Group II p21-activated kinase; Region:
                     STKc_PAK_II; cd06648"
                     /db_xref="CDD:132979"
     misc_feature    1138..1878
                     /gene="PAK4"
                     /note="Serine/Threonine protein kinases, catalytic domain;
                     Region: S_TKc; smart00220"
                     /db_xref="CDD:197582"
     misc_feature    order(1141..1155,1165..1167,1204..1206,1210..1212,
                     1237..1239,1297..1299,1345..1359,1363..1368,1375..1377,
                     1480..1482,1486..1497,1501..1503,1531..1536,1543..1545,
                     1582..1596,1600..1602,1681..1683,1708..1716)
                     /gene="PAK4"
                     /note="active site"
                     /db_xref="CDD:132979"
     misc_feature    order(1141..1155,1165..1167,1204..1206,1210..1212,
                     1297..1299,1345..1359,1363..1368,1375..1377,1492..1497,
                     1501..1503,1531..1536)
                     /gene="PAK4"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:132979"
     misc_feature    order(1150..1155,1237..1239,1480..1482,1486..1494,
                     1543..1545,1582..1596,1600..1602,1681..1683,1708..1716)
                     /gene="PAK4"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:132979"
     misc_feature    1531..1602
                     /gene="PAK4"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:132979"
     misc_feature    1582..1584
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (O96013.1); phosphorylation site"
     misc_feature    1582..1584
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1594..1596
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:05675"
     variation       198
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370966374"
     variation       200
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146498509"
     variation       204
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141017388"
     variation       207
                     /gene="PAK4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200199299"
     variation       209
                     /gene="PAK4"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:66579155"
     variation       210
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199730416"
     variation       222
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:114564484"
     variation       223
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146583353"
     variation       231
                     /gene="PAK4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199597836"
     variation       237
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113813881"
     variation       246
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:75096376"
     variation       291
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373656030"
     variation       292
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200500244"
     variation       321
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377525201"
     variation       322
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148292608"
     variation       326
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112229040"
     variation       336
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200638581"
     variation       354
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141602417"
     variation       357
                     /gene="PAK4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:371051871"
     variation       358
                     /gene="PAK4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373324891"
     variation       359
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376845802"
     exon            367..825
                     /gene="PAK4"
                     /inference="alignment:Splign:1.39.8"
     variation       375
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368355444"
     variation       377
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372186735"
     variation       411
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202071466"
     variation       471
                     /gene="PAK4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:144141109"
     variation       477
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376964135"
     variation       480
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375296515"
     variation       485
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:114116556"
     variation       486
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:55711468"
     variation       487
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200319983"
     variation       495
                     /gene="PAK4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376684961"
     variation       524
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374813703"
     variation       525
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:185941563"
     variation       534
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:115339655"
     variation       566
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56099436"
     variation       571
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200644444"
     variation       577
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35655056"
     variation       579
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369143802"
     variation       594
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1045562"
     variation       601
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199622580"
     variation       624
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369129733"
     variation       695
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373168150"
     variation       706
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376102097"
     variation       723
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371641844"
     variation       753
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377431095"
     variation       769
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370979504"
     variation       789
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375542750"
     variation       817
                     /gene="PAK4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200780929"
     exon            826..1260
                     /gene="PAK4"
                     /inference="alignment:Splign:1.39.8"
     variation       826
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370852872"
     variation       830
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371684690"
     variation       831
                     /gene="PAK4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:138516359"
     variation       832
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375872670"
     variation       841
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200391013"
     variation       869
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368557621"
     variation       874
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371973365"
     variation       905
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199929260"
     variation       930
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375137743"
     variation       936
                     /gene="PAK4"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:35120836"
     variation       982
                     /gene="PAK4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200534045"
     variation       997
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369318453"
     variation       999
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190702581"
     variation       1030
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375957288"
     STS             1056..1352
                     /gene="PAK4"
                     /standard_name="MARC_20651-20652:1024691026:1"
                     /db_xref="UniSTS:268460"
     variation       1101
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369018322"
     variation       1108
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143998317"
     variation       1110
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201587224"
     variation       1115
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147291859"
     variation       1143
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374237195"
     variation       1146
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371904272"
     variation       1176
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370908993"
     variation       1180
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140420249"
     variation       1190
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149267288"
     variation       1191
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144457438"
     variation       1206
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148400225"
     exon            1261..1394
                     /gene="PAK4"
                     /inference="alignment:Splign:1.39.8"
     variation       1288
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375220515"
     variation       1311
                     /gene="PAK4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:146831773"
     variation       1316
                     /gene="PAK4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:142488595"
     variation       1329
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368459616"
     variation       1371
                     /gene="PAK4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:56306494"
     variation       1377
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11559035"
     variation       1379
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146517848"
     variation       1380
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372653621"
     exon            1395..1521
                     /gene="PAK4"
                     /inference="alignment:Splign:1.39.8"
     variation       1401
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376504839"
     variation       1419
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139956496"
     variation       1420
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370017586"
     variation       1440
                     /gene="PAK4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374443098"
     variation       1448
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377696830"
     variation       1449
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116665223"
     variation       1458
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371674508"
     variation       1477
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375117492"
     variation       1485
                     /gene="PAK4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:146720735"
     variation       1488
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11559036"
     variation       1491
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141004307"
     exon            1522..1647
                     /gene="PAK4"
                     /inference="alignment:Splign:1.39.8"
     variation       1528
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11559033"
     variation       1574
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373414547"
     variation       1584
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56286946"
     variation       1585
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11559034"
     variation       1590
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201757969"
     variation       1623
                     /gene="PAK4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200775475"
     variation       1628
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147024501"
     variation       1633
                     /gene="PAK4"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:34054211"
     variation       1635
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138564503"
     variation       1638
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144059751"
     exon            1648..1782
                     /gene="PAK4"
                     /inference="alignment:Splign:1.39.8"
     variation       1662
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:151137853"
     variation       1666
                     /gene="PAK4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:193920877"
     variation       1693
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141267072"
     variation       1703
                     /gene="PAK4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368539931"
     variation       1704
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146955542"
     variation       1713
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375810830"
     variation       1714
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372098486"
     variation       1734
                     /gene="PAK4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:111768373"
     variation       1740
                     /gene="PAK4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11559037"
     variation       1764
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201791285"
     exon            1783..2765
                     /gene="PAK4"
                     /inference="alignment:Splign:1.39.8"
     variation       1814
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200026990"
     variation       1824
                     /gene="PAK4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:34569811"
     variation       1825
                     /gene="PAK4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:56084716"
     variation       1848
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:55747949"
     variation       1855
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150747591"
     variation       1879
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:149210444"
     variation       1946
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371711789"
     variation       1974
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376520116"
     variation       2034
                     /gene="PAK4"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:113335516"
     variation       2047
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186511166"
     variation       2110
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377438234"
     variation       2111
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143251867"
     variation       2191
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3752161"
     variation       2219
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:79890280"
     variation       2220
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:45573536"
     variation       2234
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374106536"
     variation       2319..2320
                     /gene="PAK4"
                     /replace=""
                     /replace="tg"
                     /db_xref="dbSNP:3833875"
     variation       2320..2321
                     /gene="PAK4"
                     /replace=""
                     /replace="tg"
                     /db_xref="dbSNP:373786885"
     variation       2321..2322
                     /gene="PAK4"
                     /replace=""
                     /replace="gt"
                     /db_xref="dbSNP:142481159"
     variation       2332..2333
                     /gene="PAK4"
                     /replace=""
                     /replace="tg"
                     /db_xref="dbSNP:67439622"
     variation       2361
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:13228"
     variation       2384
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:114113304"
     variation       2412..2413
                     /gene="PAK4"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:34766623"
     variation       2457
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11559032"
     variation       2475..2476
                     /gene="PAK4"
                     /replace=""
                     /replace="tt"
                     /db_xref="dbSNP:377017717"
     variation       2507
                     /gene="PAK4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:114754037"
     variation       2568
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11559031"
     STS             2610..2736
                     /gene="PAK4"
                     /standard_name="RH12716"
                     /db_xref="UniSTS:3224"
     variation       2699
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:73933820"
     variation       2706
                     /gene="PAK4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11122"
     variation       2710
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:45472902"
     variation       2727
                     /gene="PAK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370782442"
     polyA_signal    2742..2747
                     /gene="PAK4"
     variation       2750
                     /gene="PAK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181552710"
     polyA_site      2759
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
     polyA_site      2761
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
     polyA_site      2765
                     /gene="PAK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
ORIGIN      
agccccggatgttcgttggggattcaacatggcggcgggagtgtccgcggtggtggcggtgcaagagagctgagggaggcgcgagggcgcggagttccaggtcgagcagttaggccgcgagcgactgcggcgccgagccggccgcaccgagtccccggcaccatgtttgggaagaggaagaagcgggtggagatctccgcgccgtccaacttcgagcaccgcgtgcacacgggcttcgaccagcacgagcagaagttcacggggctgccccgccagtggcagagcctgatcgaggagtcggctcgccggcccaagcccctcgtcgaccccgcctgcatcacctccatccagcccggggcccccaagaccatcgtgcggggcagcaaaggtgccaaagatggggccctcacgctgctgctggacgagtttgagaacatgtcggtgacacgctccaactccctgcggagagacagcccgccgccgcccgcccgtgcccgccaggaaaatgggatgccagaggagccggccaccacggccagagggggcccagggaaggcaggcagccgaggccggttcgccggtcacagcgaggcgggtggcggcagtggtgacaggcgacgggcggggccagagaagaggcccaagtcttccagggagggctcagggggtccccaggagtcctcccgggacaaacgccccctctccgggcctgatgtcggcaccccccagcctgctggtctggccagtggggcgaaactggcagctggccggccctttaacacctacccgagggctgacacggaccacccatcccggggtgcccagggggagcctcatgacgtggcccctaacgggccatcagcggggggcctggccatcccccagtcctcctcctcctcctcccggcctcccacccgagcccgaggtgcccccagccctggagtgctgggaccccacgcctcagagccccagctggcccctccagcctgcacccccgccgcccctgctgttcctgggccccctggcccccgctcaccacagcgggagccacagcgagtatcccatgagcagttccgggctgccctgcagctggtggtggacccaggcgacccccgctcctacctggacaacttcatcaagattggcgagggctccacgggcatcgtgtgcatcgccaccgtgcgcagctcgggcaagctggtggccgtcaagaagatggacctgcgcaagcagcagaggcgcgagctgctcttcaacgaggtggtaatcatgagggactaccagcacgagaatgtggtggagatgtacaacagctacctggtgggggacgagctctgggtggtcatggagttcctggaaggaggcgccctcaccgacatcgtcacccacaccaggatgaacgaggagcagatcgcggccgtgtgccttgcagtgctgcaggccctgtcggtgctccacgcccagggcgtcatccaccgggacatcaagagcgactcgatcctgctgacccatgatggcagggtgaagctgtcagactttgggttctgcgcccaggtgagcaaggaagtgccccgaaggaagtcgctggtcggcacgccctactggatggccccagagctcatctcccgccttccctacgggccagaggtagacatctggtcgctggggataatggtgattgagatggtggacggagagcccccctacttcaacgagccacccctcaaagccatgaagatgattcgggacaacctgccaccccgactgaagaacctgcacaaggtgtcgccatccctgaagggcttcctggaccgcctgctggtgcgagaccctgcccagcgggccacggcagccgagctgctgaagcacccattcctggccaaggcagggccgcctgccagcatcgtgcccctcatgcgccagaaccgcaccagatgaggcccagcgcccttcccctcaaccaaagagccccccgggtcacccccgccccactgaggccagtagggggccaggcctcccactcctcccagcccgggagatgctccgcgtggcaccaccctccttgctgggggtagatgagaccctactactgaactccagttttgatctcgtgacttttagaaaaacacagggactcgtgggagcaagcgaggctcccaggacccccaccctctgggacaggccctcccccatgttcttctgtctccaggaagggcagcggccctcccatcactggaagtctgcagtgggggtcgctgggggtggagagaacactaagaggtgaacatgtatgagtgtgtgcacgcgtgtgagtgtgcatgtgtgtgtgtgcaaaggtccagccaccccgtcctccagcctgcaaggggtgtctggcgccttgcctgacacccagccccctctccccctgagccattgtgggggtcgatcatgaatgtccgaagagtggccttttcccgtagccctgcgccccctttctgtggctggatggggagacaggtcagggccccccaccctctccagcccctgcagcaaatgactactgcacctggacagcctcctcttttctagaagtctatttatattgtcattttataacactctagcccctgcccttattgggggacagatggtccctgtcctgcggggtggccctggcagaaccactgcctgaagaaccaggttcctgcccggtcagcgcagccccagcccgcccacccctgcctcgagttagttttacaattaaaacattgtcttgttttgtg
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:10298 -> Molecular function: GO:0004672 [protein kinase activity] evidence: NAS
            GeneID:10298 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IEA
            GeneID:10298 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:10298 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:10298 -> Biological process: GO:0006928 [cellular component movement] evidence: TAS
            GeneID:10298 -> Biological process: GO:0007010 [cytoskeleton organization] evidence: TAS
            GeneID:10298 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
            GeneID:10298 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
            GeneID:10298 -> Biological process: GO:0008283 [cell proliferation] evidence: TAS
            GeneID:10298 -> Biological process: GO:0016049 [cell growth] evidence: TAS
            GeneID:10298 -> Biological process: GO:0016477 [cell migration] evidence: TAS
            GeneID:10298 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_001014832 -> EC 2.7.11.1

by @meso_cacase at DBCLS
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