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2024-04-19 10:42:30, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001014431 2794 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens v-akt murine thymoma viral oncogene homolog 1 (AKT1),
transcript variant 3, mRNA.
ACCESSION NM_001014431
VERSION NM_001014431.1 GI:62241012
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2794)
AUTHORS Meng,Z.X., Li,S., Wang,L., Ko,H.J., Lee,Y., Jung,D.Y., Okutsu,M.,
Yan,Z., Kim,J.K. and Lin,J.D.
TITLE Baf60c drives glycolytic metabolism in the muscle and improves
systemic glucose homeostasis through Deptor-mediated Akt activation
JOURNAL Nat. Med. 19 (5), 640-645 (2013)
PUBMED 23563706
REMARK GeneRIF: Deptor is induced by the Baf60c-Six4 transcriptional
complex and mediates activation of Akt and glycolytic metabolism by
Baf60c in a cell-autonomous manner
REFERENCE 2 (bases 1 to 2794)
AUTHORS Riaz,A., Ilan,N., Vlodavsky,I., Li,J.P. and Johansson,S.
TITLE Characterization of heparanase-induced phosphatidylinositol
3-kinase-AKT activation and its integrin dependence
JOURNAL J. Biol. Chem. 288 (17), 12366-12375 (2013)
PUBMED 23504323
REMARK GeneRIF: Characterization of heparanase-induced
phosphatidylinositol 3-kinase-AKT activation and its integrin
dependence.
REFERENCE 3 (bases 1 to 2794)
AUTHORS Farrer,R.G., Farrer,J.R. and DeVries,G.H.
TITLE Platelet-derived growth factor-BB activates
calcium/calmodulin-dependent and -independent mechanisms that
mediate Akt phosphorylation in the neurofibromin-deficient human
Schwann cell line ST88-14
JOURNAL J. Biol. Chem. 288 (16), 11066-11073 (2013)
PUBMED 23457304
REMARK GeneRIF: the activation of the calcium/CaM/Akt pathway resulting
from stimulation of overexpressed PDGF receptor-beta may contribute
to the survival and tumorigenicity of MPNST cells.
REFERENCE 4 (bases 1 to 2794)
AUTHORS Novellasdemunt,L., Tato,I., Navarro-Sabate,A., Ruiz-Meana,M.,
Mendez-Lucas,A., Perales,J.C., Garcia-Dorado,D., Ventura,F.,
Bartrons,R. and Rosa,J.L.
TITLE Akt-dependent activation of the heart
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2)
isoenzyme by amino acids
JOURNAL J. Biol. Chem. 288 (15), 10640-10651 (2013)
PUBMED 23457334
REMARK GeneRIF: amino acids stimulate Fru-2,6-P2 synthesis by
Akt-dependent PFKFB2 phosphorylation and activation and show how
signaling and metabolism are inextricably linked.
REFERENCE 5 (bases 1 to 2794)
AUTHORS Read,R.D., Fenton,T.R., Gomez,G.G., Wykosky,J., Vandenberg,S.R.,
Babic,I., Iwanami,A., Yang,H., Cavenee,W.K., Mischel,P.S.,
Furnari,F.B. and Thomas,J.B.
TITLE A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO
kinases mediate cell proliferation and survival through TORC2-Akt
signaling in glioblastoma
JOURNAL PLoS Genet. 9 (2), E1003253 (2013)
PUBMED 23459592
REMARK GeneRIF: These results imply that, in glioblastoma cells,
constitutive Akt signaling drives RIO kinase overexpression, which
creates a feedforward loop that promotes and maintains oncogenic
Akt activity through stimulation of mTor signaling
REFERENCE 6 (bases 1 to 2794)
AUTHORS Coffer,P.J. and Woodgett,J.R.
TITLE Molecular cloning and characterisation of a novel putative
protein-serine kinase related to the cAMP-dependent and protein
kinase C families
JOURNAL Eur. J. Biochem. 205 (3), 1217 (1992)
PUBMED 1533586
REMARK Correction to:[Eur J Biochem. 1991 Oct 15;201(2):475-81. PMID:
1718748]
REFERENCE 7 (bases 1 to 2794)
AUTHORS Coffer,P.J. and Woodgett,J.R.
TITLE Molecular cloning and characterisation of a novel putative
protein-serine kinase related to the cAMP-dependent and protein
kinase C families
JOURNAL Eur. J. Biochem. 201 (2), 475-481 (1991)
PUBMED 1718748
REMARK Erratum:[Eur J Biochem. 1992 May 1;205(3):1217. PMID: 1533586]
REFERENCE 8 (bases 1 to 2794)
AUTHORS Jones,P.F., Jakubowicz,T., Pitossi,F.J., Maurer,F. and
Hemmings,B.A.
TITLE Molecular cloning and identification of a serine/threonine protein
kinase of the second-messenger subfamily
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88 (10), 4171-4175 (1991)
PUBMED 1851997
REFERENCE 9 (bases 1 to 2794)
AUTHORS Staal,S.P., Huebner,K., Croce,C.M., Parsa,N.Z. and Testa,J.R.
TITLE The AKT1 proto-oncogene maps to human chromosome 14, band q32
JOURNAL Genomics 2 (1), 96-98 (1988)
PUBMED 3384441
REFERENCE 10 (bases 1 to 2794)
AUTHORS Staal,S.P.
TITLE Molecular cloning of the akt oncogene and its human homologues AKT1
and AKT2: amplification of AKT1 in a primary human gastric
adenocarcinoma
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 84 (14), 5034-5037 (1987)
PUBMED 3037531
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from CN414251.1 and BC000479.2.
This sequence is a reference standard in the RefSeqGene project.
Summary: The serine-threonine protein kinase encoded by the AKT1
gene is catalytically inactive in serum-starved primary and
immortalized fibroblasts. AKT1 and the related AKT2 are activated
by platelet-derived growth factor. The activation is rapid and
specific, and it is abrogated by mutations in the pleckstrin
homology domain of AKT1. It was shown that the activation occurs
through phosphatidylinositol 3-kinase. In the developing nervous
system AKT is a critical mediator of growth factor-induced neuronal
survival. Survival factors can suppress apoptosis in a
transcription-independent manner by activating the serine/threonine
kinase AKT1, which then phosphorylates and inactivates components
of the apoptotic machinery. Mutations in this gene have been
associated with the Proteus syndrome. Multiple alternatively
spliced transcript variants have been found for this gene.
[provided by RefSeq, Jul 2011].
Transcript Variant: This variant (3) lacks the 5' exon, but has an
upstream alternate 5' exon, as compared to variant 1. Variants 1
and 3 encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC000479.2 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-65 CN414251.1 3-67
66-2794 BC000479.2 1-2729
FEATURES Location/Qualifiers
source 1..2794
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="14"
/map="14q32.32"
gene 1..2794
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/note="v-akt murine thymoma viral oncogene homolog 1"
/db_xref="GeneID:207"
/db_xref="HGNC:391"
/db_xref="HPRD:01261"
/db_xref="MIM:164730"
exon 1..261
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/inference="alignment:Splign:1.39.8"
variation 40
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="c"
/replace="g"
/db_xref="dbSNP:3002448"
exon 262..386
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/inference="alignment:Splign:1.39.8"
variation 295
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="a"
/replace="g"
/db_xref="dbSNP:34790457"
variation 296
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="c"
/replace="g"
/db_xref="dbSNP:34757714"
misc_feature 302..304
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/note="upstream in-frame stop codon"
variation 333
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="c"
/replace="t"
/db_xref="dbSNP:28730786"
CDS 341..1783
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/EC_number="2.7.11.1"
/note="rac protein kinase alpha; RAC-PK-alpha;
proto-oncogene c-Akt; PKB alpha; protein kinase B alpha"
/codon_start=1
/product="RAC-alpha serine/threonine-protein kinase"
/protein_id="NP_001014431.1"
/db_xref="GI:62241013"
/db_xref="CCDS:CCDS9994.1"
/db_xref="GeneID:207"
/db_xref="HGNC:391"
/db_xref="HPRD:01261"
/db_xref="MIM:164730"
/translation="
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
"
misc_feature 356..661
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/note="Akt pleckstrin homology (PH) domain; Region:
PH_Akt; cd01241"
/db_xref="CDD:176317"
misc_feature order(380..382,386..388,407..409,413..421)
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/note="putative phosphoinositide binding site [chemical
binding]; other site"
/db_xref="CDD:176317"
misc_feature 380..397
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P31749.2);
Region: Inositol-(1,3,4,5)-tetrakisphosphate binding"
misc_feature 380..382
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P31749.2); acetylation site"
misc_feature 398..400
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P31749.2); acetylation site"
misc_feature 407..415
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P31749.2);
Region: Inositol-(1,3,4,5)-tetrakisphosphate binding"
misc_feature 710..712
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P31749.2); phosphorylation site"
misc_feature 710..712
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 716..718
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, alternate; propagated from
UniProtKB/Swiss-Prot (P31749.2); phosphorylation site"
misc_feature 716..718
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 725..727
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, alternate; propagated from
UniProtKB/Swiss-Prot (P31749.2); phosphorylation site"
misc_feature 725..727
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 788..1564
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature 800..1771
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/note="Catalytic domain of the Protein Serine/Threonine
Kinase, Protein Kinase B; Region: STKc_PKB; cd05571"
/db_xref="CDD:173662"
misc_feature order(806..811,815..820,830..832,869..871,875..877,
911..913,920..922,971..973,1019..1030,1040..1042,
1046..1048,1058..1060,1160..1162,1166..1168,1172..1177,
1181..1183,1211..1216,1223..1225,1265..1288,1361..1363,
1379..1381,1388..1390,1652..1654,1664..1666)
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/note="active site"
/db_xref="CDD:173662"
misc_feature order(806..811,815..817,830..832,869..871,875..877,
971..973,1019..1030,1040..1042,1160..1162,1166..1168,
1172..1177,1181..1183,1211..1216,1652..1654)
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173662"
misc_feature order(818..820,911..913,920..922,1040..1042,1046..1048,
1058..1060,1160..1162,1166..1168,1172..1174,1223..1225,
1265..1288,1361..1363,1379..1381,1388..1390,1664..1666)
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173662"
misc_feature 866..868
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine, by TNK2; propagated from
UniProtKB/Swiss-Prot (P31749.2); phosphorylation site"
misc_feature 1022..1030
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P31749.2);
Region: Inhibitor binding"
misc_feature 1211..1282
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173662"
misc_feature 1262..1264
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="dephosphorylation site; modified site"
/db_xref="HPRD:08912"
misc_feature 1262..1264
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by PDPK1; propagated from
UniProtKB/Swiss-Prot (P31749.2); phosphorylation site"
misc_feature 1262..1264
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03954"
misc_feature 1262..1264
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:05556"
misc_feature 1262..1264
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:13000"
misc_feature 1262..1264
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1283..1285
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01819"
misc_feature 1316..1318
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01819"
misc_feature 1688..1690
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/note="turn motif phosphorylation site [posttranslational
modification]; other site"
/db_xref="CDD:173662"
misc_feature 1688..1690
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1724..1726
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:02799"
misc_feature 1745..1762
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/note="hydrophobic motif (HM); other site"
/db_xref="CDD:173662"
misc_feature 1757..1759
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="dephosphorylation site; modified site"
/db_xref="HPRD:08912"
misc_feature 1757..1759
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by MTOR, alternate; propagated from
UniProtKB/Swiss-Prot (P31749.2); phosphorylation site"
misc_feature 1757..1759
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03842"
misc_feature 1757..1759
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03954"
misc_feature 1757..1759
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:05556"
misc_feature 1757..1759
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1757..1759
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:15245"
misc_feature 1760..1762
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine; propagated from
UniProtKB/Swiss-Prot (P31749.2); phosphorylation site"
misc_feature 1760..1762
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
exon 387..515
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/inference="alignment:Splign:1.39.8"
variation 467
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="c"
/replace="t"
/db_xref="dbSNP:11555436"
exon 516..627
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/inference="alignment:Splign:1.39.8"
exon 628..775
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/inference="alignment:Splign:1.39.8"
variation 772
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="c"
/replace="t"
/db_xref="dbSNP:17846825"
exon 776..907
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/inference="alignment:Splign:1.39.8"
variation 840
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="c"
/replace="t"
/db_xref="dbSNP:11555433"
exon 908..973
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/inference="alignment:Splign:1.39.8"
variation 940
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="c"
/replace="t"
/db_xref="dbSNP:61761191"
variation 944
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="c"
/replace="t"
/db_xref="dbSNP:2230506"
exon 974..1042
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/inference="alignment:Splign:1.39.8"
exon 1043..1168
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/inference="alignment:Splign:1.39.8"
variation 1066
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="a"
/replace="g"
/db_xref="dbSNP:1130233"
variation 1150
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="a"
/replace="g"
/db_xref="dbSNP:2230508"
exon 1169..1297
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/inference="alignment:Splign:1.39.8"
STS 1194..1274
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/standard_name="PMC15397P1"
/db_xref="UniSTS:271279"
variation 1291
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="a"
/replace="c"
/db_xref="dbSNP:17846831"
exon 1298..1512
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/inference="alignment:Splign:1.39.8"
variation 1410
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="c"
/replace="t"
/db_xref="dbSNP:11555432"
variation 1502
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="a"
/replace="c"
/db_xref="dbSNP:11555431"
exon 1513..1600
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/inference="alignment:Splign:1.39.8"
variation 1519
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="c"
/replace="t"
/db_xref="dbSNP:11555434"
exon 1601..1703
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/inference="alignment:Splign:1.39.8"
exon 1704..2775
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/inference="alignment:Splign:1.39.8"
variation 1721
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="g"
/replace="t"
/db_xref="dbSNP:11555435"
variation 1832
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="a"
/replace="g"
/db_xref="dbSNP:11555430"
variation 1893
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="c"
/replace="t"
/db_xref="dbSNP:17846821"
variation 1904
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="c"
/replace="t"
/db_xref="dbSNP:17846826"
variation 2032
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="c"
/replace="g"
/db_xref="dbSNP:61761249"
variation 2051
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="c"
/replace="t"
/db_xref="dbSNP:34558581"
variation 2106
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:1130245"
variation 2151
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="a"
/replace="c"
/db_xref="dbSNP:34865723"
variation 2174
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="g"
/replace="t"
/db_xref="dbSNP:35416681"
STS 2292..2549
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/standard_name="RH69160"
/db_xref="UniSTS:12879"
variation 2328
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="g"
/replace="t"
/db_xref="dbSNP:1804268"
variation 2337
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="c"
/replace="t"
/db_xref="dbSNP:1130295"
variation 2487
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="c"
/replace="t"
/db_xref="dbSNP:1130443"
STS 2492..2614
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/standard_name="RH101916"
/db_xref="UniSTS:96251"
STS 2528..2757
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/standard_name="STS-AA041305"
/db_xref="UniSTS:79362"
variation 2569..2570
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace=""
/replace="ttgaccttttcgac"
/replace="ttgacctttttgac"
/db_xref="dbSNP:3840005"
STS 2597..2752
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/standard_name="RH47592"
/db_xref="UniSTS:42837"
variation 2601
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="c"
/replace="t"
/db_xref="dbSNP:3803305"
variation 2636
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="c"
/replace="t"
/db_xref="dbSNP:17846828"
variation 2643
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="a"
/replace="g"
/db_xref="dbSNP:17846829"
variation 2752
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
/replace="c"
/replace="t"
/db_xref="dbSNP:1130526"
polyA_signal 2756..2761
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
polyA_site 2775
/gene="AKT1"
/gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC;
RAC-ALPHA"
ORIGIN
cggcaggaccgagcgcggcaggcggctggcccagcgcagccagcgcggcccgaaggacgggagcaggcggccgagcaccgagcgctgggcaccgggcaccgagcggcggcggcacgcgaggcccggccccgagcagcgcccccgcccgccgcggcctccagcccggccccgcccagcgccggcccgcggggatgcggagcggcgggcgccggaggccgcggcccggctaggcccgcgctcgcgcccggacgcggcggcccgaggctgtggccaggccagctgggctcggggagcgccagcctgagaggagcgcgtgagcgtcgcgggagcctcgggcaccatgagcgacgtggctattgtgaaggagggttggctgcacaaacgaggggagtacatcaagacctggcggccacgctacttcctcctcaagaatgatggcaccttcattggctacaaggagcggccgcaggatgtggaccaacgtgaggctcccctcaacaacttctctgtggcgcagtgccagctgatgaagacggagcggccccggcccaacaccttcatcatccgctgcctgcagtggaccactgtcatcgaacgcaccttccatgtggagactcctgaggagcgggaggagtggacaaccgccatccagactgtggctgacggcctcaagaagcaggaggaggaggagatggacttccggtcgggctcacccagtgacaactcaggggctgaagagatggaggtgtccctggccaagcccaagcaccgcgtgaccatgaacgagtttgagtacctgaagctgctgggcaagggcactttcggcaaggtgatcctggtgaaggagaaggccacaggccgctactacgccatgaagatcctcaagaaggaagtcatcgtggccaaggacgaggtggcccacacactcaccgagaaccgcgtcctgcagaactccaggcaccccttcctcacagccctgaagtactctttccagacccacgaccgcctctgctttgtcatggagtacgccaacgggggcgagctgttcttccacctgtcccgggagcgtgtgttctccgaggaccgggcccgcttctatggcgctgagattgtgtcagccctggactacctgcactcggagaagaacgtggtgtaccgggacctcaagctggagaacctcatgctggacaaggacgggcacattaagatcacagacttcgggctgtgcaaggaggggatcaaggacggtgccaccatgaagaccttttgcggcacacctgagtacctggcccccgaggtgctggaggacaatgactacggccgtgcagtggactggtgggggctgggcgtggtcatgtacgagatgatgtgcggtcgcctgcccttctacaaccaggaccatgagaagctttttgagctcatcctcatggaggagatccgcttcccgcgcacgcttggtcccgaggccaagtccttgctttcagggctgctcaagaaggaccccaagcagaggcttggcgggggctccgaggacgccaaggagatcatgcagcatcgcttctttgccggtatcgtgtggcagcacgtgtacgagaagaagctcagcccacccttcaagccccaggtcacgtcggagactgacaccaggtattttgatgaggagttcacggcccagatgatcaccatcacaccacctgaccaagatgacagcatggagtgtgtggacagcgagcgcaggccccacttcccccagttctcctactcggccagcggcacggcctgaggcggcggtggactgcgctggacgatagcttggagggatggagaggcggcctcgtgccatgatctgtatttaatggtttttatttctcgggtgcatttgagagaagccacgctgtcctctcgagcccagatggaaagacgtttttgtgctgtgggcagcaccctcccccgcagcggggtagggaagaaaactatcctgcgggttttaatttatttcatccagtttgttctccgggtgtggcctcagccctcagaacaatccgattcacgtagggaaatgttaaggacttctgcagctatgcgcaatgtggcattggggggccgggcaggtcctgcccatgtgtcccctcactctgtcagccagccgccctgggctgtctgtcaccagctatctgtcatctctctggggccctgggcctcagttcaacctggtggcaccagatgcaacctcactatggtatgctggccagcaccctctcctgggggtggcaggcacacagcagccccccagcactaaggccgtgtctctgaggacgtcatcggaggctgggcccctgggatgggaccagggatgggggatgggccagggtttacccagtgggacagaggagcaaggtttaaatttgttattgtgtattatgttgttcaaatgcattttgggggtttttaatctttgtgacaggaaagccctcccccttccccttctgtgtcacagttcttggtgactgtcccaccgggagcctccccctcagatgatctctccacggtagcacttgaccttttcgacgcttaacctttccgctgtcgccccaggccctccctgactccctgtgggggtggccatccctgggcccctccacgcctcctggccagacgctgccgctgccgctgcaccacggcgtttttttacaacattcaactttagtatttttactattataatataatatggaaccttccctccaaattcttcaataaaagttgcttttcaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:207 -> Molecular function: GO:0004672 [protein kinase activity] evidence: TAS
GeneID:207 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:207 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: TAS
GeneID:207 -> Molecular function: GO:0005080 [protein kinase C binding] evidence: IEA
GeneID:207 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:207 -> Molecular function: GO:0005524 [ATP binding] evidence: IC
GeneID:207 -> Molecular function: GO:0005524 [ATP binding] evidence: IDA
GeneID:207 -> Molecular function: GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding] evidence: IDA
GeneID:207 -> Molecular function: GO:0016301 [kinase activity] evidence: IDA
GeneID:207 -> Molecular function: GO:0019899 [enzyme binding] evidence: ISS
GeneID:207 -> Molecular function: GO:0030235 [nitric-oxide synthase regulator activity] evidence: IMP
GeneID:207 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
GeneID:207 -> Molecular function: GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding] evidence: IDA
GeneID:207 -> Molecular function: GO:0071889 [14-3-3 protein binding] evidence: IPI
GeneID:207 -> Biological process: GO:0000060 [protein import into nucleus, translocation] evidence: IMP
GeneID:207 -> Biological process: GO:0001649 [osteoblast differentiation] evidence: IEA
GeneID:207 -> Biological process: GO:0001893 [maternal placenta development] evidence: IEA
GeneID:207 -> Biological process: GO:0001934 [positive regulation of protein phosphorylation] evidence: IDA
GeneID:207 -> Biological process: GO:0005978 [glycogen biosynthetic process] evidence: IEA
GeneID:207 -> Biological process: GO:0005979 [regulation of glycogen biosynthetic process] evidence: IMP
GeneID:207 -> Biological process: GO:0006006 [glucose metabolic process] evidence: IEA
GeneID:207 -> Biological process: GO:0006412 [translation] evidence: IEA
GeneID:207 -> Biological process: GO:0006417 [regulation of translation] evidence: IEA
GeneID:207 -> Biological process: GO:0006464 [cellular protein modification process] evidence: TAS
GeneID:207 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
GeneID:207 -> Biological process: GO:0006469 [negative regulation of protein kinase activity] evidence: IMP
GeneID:207 -> Biological process: GO:0006469 [negative regulation of protein kinase activity] evidence: ISS
GeneID:207 -> Biological process: GO:0006809 [nitric oxide biosynthetic process] evidence: TAS
GeneID:207 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:207 -> Biological process: GO:0006924 [activation-induced cell death of T cells] evidence: IMP
GeneID:207 -> Biological process: GO:0006954 [inflammatory response] evidence: IEA
GeneID:207 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:207 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS
GeneID:207 -> Biological process: GO:0007186 [G-protein coupled receptor signaling pathway] evidence: TAS
GeneID:207 -> Biological process: GO:0007281 [germ cell development] evidence: IEA
GeneID:207 -> Biological process: GO:0007568 [aging] evidence: IEA
GeneID:207 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
GeneID:207 -> Biological process: GO:0008283 [cell proliferation] evidence: TAS
GeneID:207 -> Biological process: GO:0008286 [insulin receptor signaling pathway] evidence: IMP
GeneID:207 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: TAS
GeneID:207 -> Biological process: GO:0008637 [apoptotic mitochondrial changes] evidence: IEA
GeneID:207 -> Biological process: GO:0009408 [response to heat] evidence: TAS
GeneID:207 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:207 -> Biological process: GO:0010507 [negative regulation of autophagy] evidence: IMP
GeneID:207 -> Biological process: GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport] evidence: IMP
GeneID:207 -> Biological process: GO:0010765 [positive regulation of sodium ion transport] evidence: IEA
GeneID:207 -> Biological process: GO:0010907 [positive regulation of glucose metabolic process] evidence: IMP
GeneID:207 -> Biological process: GO:0010951 [negative regulation of endopeptidase activity] evidence: IMP
GeneID:207 -> Biological process: GO:0010975 [regulation of neuron projection development] evidence: ISS
GeneID:207 -> Biological process: GO:0015758 [glucose transport] evidence: IEA
GeneID:207 -> Biological process: GO:0016044 [cellular membrane organization] evidence: TAS
GeneID:207 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
GeneID:207 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
GeneID:207 -> Biological process: GO:0016310 [phosphorylation] evidence: IDA
GeneID:207 -> Biological process: GO:0016567 [protein ubiquitination] evidence: IEA
GeneID:207 -> Biological process: GO:0018105 [peptidyl-serine phosphorylation] evidence: IDA
GeneID:207 -> Biological process: GO:0030030 [cell projection organization] evidence: IEA
GeneID:207 -> Biological process: GO:0030154 [cell differentiation] evidence: TAS
GeneID:207 -> Biological process: GO:0030163 [protein catabolic process] evidence: IEA
GeneID:207 -> Biological process: GO:0030168 [platelet activation] evidence: TAS
GeneID:207 -> Biological process: GO:0030307 [positive regulation of cell growth] evidence: IDA
GeneID:207 -> Biological process: GO:0030334 [regulation of cell migration] evidence: IMP
GeneID:207 -> Biological process: GO:0030334 [regulation of cell migration] evidence: TAS
GeneID:207 -> Biological process: GO:0031018 [endocrine pancreas development] evidence: TAS
GeneID:207 -> Biological process: GO:0031295 [T cell costimulation] evidence: TAS
GeneID:207 -> Biological process: GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle] evidence: IDA
GeneID:207 -> Biological process: GO:0031999 [negative regulation of fatty acid beta-oxidation] evidence: IMP
GeneID:207 -> Biological process: GO:0032094 [response to food] evidence: IEA
GeneID:207 -> Biological process: GO:0032270 [positive regulation of cellular protein metabolic process] evidence: ISS
GeneID:207 -> Biological process: GO:0032287 [peripheral nervous system myelin maintenance] evidence: IEA
GeneID:207 -> Biological process: GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] evidence: IEA
GeneID:207 -> Biological process: GO:0032869 [cellular response to insulin stimulus] evidence: IMP
GeneID:207 -> Biological process: GO:0032869 [cellular response to insulin stimulus] evidence: ISS
GeneID:207 -> Biological process: GO:0033138 [positive regulation of peptidyl-serine phosphorylation] evidence: IDA
GeneID:207 -> Biological process: GO:0034405 [response to fluid shear stress] evidence: IMP
GeneID:207 -> Biological process: GO:0035556 [intracellular signal transduction] evidence: IDA
GeneID:207 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
GeneID:207 -> Biological process: GO:0042593 [glucose homeostasis] evidence: IEA
GeneID:207 -> Biological process: GO:0042640 [anagen] evidence: IEA
GeneID:207 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IEA
GeneID:207 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IDA
GeneID:207 -> Biological process: GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: ISS
GeneID:207 -> Biological process: GO:0043491 [protein kinase B signaling cascade] evidence: IEA
GeneID:207 -> Biological process: GO:0043536 [positive regulation of blood vessel endothelial cell migration] evidence: IDA
GeneID:207 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:207 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:207 -> Biological process: GO:0045429 [positive regulation of nitric oxide biosynthetic process] evidence: IMP
GeneID:207 -> Biological process: GO:0045600 [positive regulation of fat cell differentiation] evidence: IMP
GeneID:207 -> Biological process: GO:0045725 [positive regulation of glycogen biosynthetic process] evidence: IMP
GeneID:207 -> Biological process: GO:0045725 [positive regulation of glycogen biosynthetic process] evidence: NAS
GeneID:207 -> Biological process: GO:0045792 [negative regulation of cell size] evidence: IEA
GeneID:207 -> Biological process: GO:0045861 [negative regulation of proteolysis] evidence: IMP
GeneID:207 -> Biological process: GO:0045907 [positive regulation of vasoconstriction] evidence: IEA
GeneID:207 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA
GeneID:207 -> Biological process: GO:0046209 [nitric oxide metabolic process] evidence: TAS
GeneID:207 -> Biological process: GO:0046326 [positive regulation of glucose import] evidence: IMP
GeneID:207 -> Biological process: GO:0046329 [negative regulation of JNK cascade] evidence: IEA
GeneID:207 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: TAS
GeneID:207 -> Biological process: GO:0046889 [positive regulation of lipid biosynthetic process] evidence: IMP
GeneID:207 -> Biological process: GO:0048009 [insulin-like growth factor receptor signaling pathway] evidence: IMP
GeneID:207 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
GeneID:207 -> Biological process: GO:0048015 [phosphatidylinositol-mediated signaling] evidence: TAS
GeneID:207 -> Biological process: GO:0050999 [regulation of nitric-oxide synthase activity] evidence: TAS
GeneID:207 -> Biological process: GO:0051000 [positive regulation of nitric-oxide synthase activity] evidence: IMP
GeneID:207 -> Biological process: GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] evidence: IDA
GeneID:207 -> Biological process: GO:0051146 [striated muscle cell differentiation] evidence: IEA
GeneID:207 -> Biological process: GO:0060644 [mammary gland epithelial cell differentiation] evidence: TAS
GeneID:207 -> Biological process: GO:0060709 [glycogen cell differentiation involved in embryonic placenta development] evidence: IEA
GeneID:207 -> Biological process: GO:0060716 [labyrinthine layer blood vessel development] evidence: IEA
GeneID:207 -> Biological process: GO:0070141 [response to UV-A] evidence: IDA
GeneID:207 -> Biological process: GO:0071364 [cellular response to epidermal growth factor stimulus] evidence: IEA
GeneID:207 -> Biological process: GO:0071456 [cellular response to hypoxia] evidence: IEA
GeneID:207 -> Biological process: GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] evidence: IMP
GeneID:207 -> Biological process: GO:0090201 [negative regulation of release of cytochrome c from mitochondria] evidence: ISS
GeneID:207 -> Biological process: GO:0097193 [intrinsic apoptotic signaling pathway] evidence: TAS
GeneID:207 -> Biological process: GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] evidence: TAS
GeneID:207 -> Biological process: GO:1901976 [regulation of cell cycle checkpoint] evidence: TAS
GeneID:207 -> Biological process: GO:1902176 [negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress] evidence: NAS
GeneID:207 -> Biological process: GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] evidence: TAS
GeneID:207 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:207 -> Cellular component: GO:0005634 [nucleus] evidence: TAS
GeneID:207 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:207 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:207 -> Cellular component: GO:0005737 [cytoplasm] evidence: ISS
GeneID:207 -> Cellular component: GO:0005737 [cytoplasm] evidence: TAS
GeneID:207 -> Cellular component: GO:0005819 [spindle] evidence: IEA
GeneID:207 -> Cellular component: GO:0005829 [cytosol] evidence: IDA
GeneID:207 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:207 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:207 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:207 -> Cellular component: GO:0015630 [microtubule cytoskeleton] evidence: IDA
GeneID:207 -> Cellular component: GO:0030027 [lamellipodium] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001014431 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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