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2024-04-20 21:34:24, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001012728 648 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens divergent-paired related homeobox (DPRX), mRNA. ACCESSION NM_001012728 VERSION NM_001012728.1 GI:61969663 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 648) AUTHORS Booth,H.A. and Holland,P.W. TITLE Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line JOURNAL Gene 387 (1-2), 7-14 (2007) PUBMED 17005330 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. This record has been curated by NCBI staff in collaboration with Anne Booth and Peter Holland. The reference sequence was derived from AC011487.5. Summary: Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the DPRX homeobox gene family. Evidence of mRNA expression has not yet been found for this gene. Multiple, related processed pseudogenes have been found which are thought to reflect expression of this gene in the germ line or embryonic cells. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support ERS025083, ERS025084 [ECO:0000350] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-79 AC011487.5 12089-12167 c 80-234 AC011487.5 9538-9692 c 235-648 AC011487.5 7214-7627 c FEATURES Location/Qualifiers source 1..648 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="19" /map="19q13.42" gene 1..648 /gene="DPRX" /note="divergent-paired related homeobox" /db_xref="GeneID:503834" /db_xref="HGNC:32166" /db_xref="HPRD:10561" /db_xref="MIM:611165" exon 1..79 /gene="DPRX" /inference="alignment:Splign:1.39.8" variation 3 /gene="DPRX" /replace="c" /replace="t" /db_xref="dbSNP:377556258" variation 12 /gene="DPRX" /replace="a" /replace="g" /db_xref="dbSNP:192884068" variation 33 /gene="DPRX" /replace="c" /replace="t" /db_xref="dbSNP:185410586" variation 37 /gene="DPRX" /replace="c" /replace="t" /db_xref="dbSNP:201192005" misc_feature 46..48 /gene="DPRX" /note="upstream in-frame stop codon" CDS 52..627 /gene="DPRX" /codon_start=1 /product="divergent paired-related homeobox" /protein_id="NP_001012746.1" /db_xref="GI:61969664" /db_xref="CCDS:CCDS33103.1" /db_xref="GeneID:503834" /db_xref="HGNC:32166" /db_xref="HPRD:10561" /db_xref="MIM:611165" /translation="
MPGSEDLRKGKDQMHSHRKRTMFTKKQLEDLNILFNENPYPNPSLQKEMASKIDIHPTVLQVWFKNHRAKLKKAKCKHIHQKQETPQPPIPEGGVSTSVGLRNADTLPRLPNAAHPIGLVYTGHRVPSFQLILYPNLKVPANDFIGHRIVHFGCCRDPNIYCLYPILESQVCAPSFHSGSPACSSNQSRER
"
misc_feature 103..276
/gene="DPRX"
/note="Homeodomain; DNA binding domains involved in the
transcriptional regulation of key eukaryotic developmental
processes; may bind to DNA as monomers or as homo- and/or
heterodimers, in a sequence-specific manner; Region:
homeodomain; cd00086"
/db_xref="CDD:28970"
misc_feature order(103..114,118..120,169..171,187..189,226..228,
232..237,244..249,253..261,265..270)
/gene="DPRX"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:28970"
misc_feature order(106..108,115..117,235..237,244..249,256..258)
/gene="DPRX"
/note="specific DNA base contacts [nucleotide binding];
other site"
/db_xref="CDD:28970"
variation 70
/gene="DPRX"
/replace="c"
/replace="t"
/db_xref="dbSNP:373799917"
variation 73
/gene="DPRX"
/replace="c"
/replace="t"
/db_xref="dbSNP:148896232"
exon 80..234
/gene="DPRX"
/inference="alignment:Splign:1.39.8"
variation 81
/gene="DPRX"
/replace="c"
/replace="t"
/db_xref="dbSNP:373534330"
variation 103
/gene="DPRX"
/replace="a"
/replace="g"
/db_xref="dbSNP:200068987"
variation 128
/gene="DPRX"
/replace="a"
/replace="c"
/db_xref="dbSNP:143612661"
variation 148
/gene="DPRX"
/replace="a"
/replace="g"
/db_xref="dbSNP:201720065"
variation 178
/gene="DPRX"
/replace="c"
/replace="g"
/db_xref="dbSNP:150927264"
variation 212
/gene="DPRX"
/replace="a"
/replace="g"
/db_xref="dbSNP:370267683"
exon 235..648
/gene="DPRX"
/inference="alignment:Splign:1.39.8"
variation 311
/gene="DPRX"
/replace=""
/replace="a"
/db_xref="dbSNP:144585982"
variation 315
/gene="DPRX"
/replace="c"
/replace="g"
/db_xref="dbSNP:368786641"
variation 344
/gene="DPRX"
/replace="a"
/replace="g"
/db_xref="dbSNP:371142421"
variation 348
/gene="DPRX"
/replace="c"
/replace="t"
/db_xref="dbSNP:140829869"
variation 369
/gene="DPRX"
/replace="a"
/replace="c"
/db_xref="dbSNP:374419575"
variation 380
/gene="DPRX"
/replace="g"
/replace="t"
/db_xref="dbSNP:368484033"
variation 386
/gene="DPRX"
/replace="a"
/replace="g"
/db_xref="dbSNP:144673249"
variation 398
/gene="DPRX"
/replace="c"
/replace="t"
/db_xref="dbSNP:368343082"
variation 402
/gene="DPRX"
/replace="c"
/replace="t"
/db_xref="dbSNP:138559564"
variation 403
/gene="DPRX"
/replace="a"
/replace="g"
/db_xref="dbSNP:371523408"
variation 404
/gene="DPRX"
/replace="g"
/replace="t"
/db_xref="dbSNP:201734272"
variation 413
/gene="DPRX"
/replace="a"
/replace="g"
/db_xref="dbSNP:202096492"
variation 417
/gene="DPRX"
/replace="a"
/replace="g"
/db_xref="dbSNP:141641052"
variation 424
/gene="DPRX"
/replace="c"
/replace="t"
/db_xref="dbSNP:150237904"
variation 425
/gene="DPRX"
/replace="a"
/replace="g"
/db_xref="dbSNP:138900772"
variation 434
/gene="DPRX"
/replace="a"
/replace="c"
/db_xref="dbSNP:201290452"
variation 454
/gene="DPRX"
/replace="c"
/replace="t"
/db_xref="dbSNP:376708716"
variation 487
/gene="DPRX"
/replace="a"
/replace="g"
/db_xref="dbSNP:370046757"
variation 517
/gene="DPRX"
/replace="c"
/replace="t"
/db_xref="dbSNP:201435914"
variation 528
/gene="DPRX"
/replace="c"
/replace="t"
/db_xref="dbSNP:200737613"
variation 532
/gene="DPRX"
/replace="c"
/replace="t"
/db_xref="dbSNP:369622900"
variation 537
/gene="DPRX"
/replace="c"
/replace="t"
/db_xref="dbSNP:10408805"
variation 538
/gene="DPRX"
/replace="c"
/replace="t"
/db_xref="dbSNP:373577936"
variation 543
/gene="DPRX"
/replace="c"
/replace="t"
/db_xref="dbSNP:377588451"
variation 553
/gene="DPRX"
/replace="g"
/replace="t"
/db_xref="dbSNP:10409173"
variation 568
/gene="DPRX"
/replace="a"
/replace="g"
/db_xref="dbSNP:370339375"
variation 572
/gene="DPRX"
/replace="c"
/replace="t"
/db_xref="dbSNP:367690331"
variation 581
/gene="DPRX"
/replace="a"
/replace="g"
/db_xref="dbSNP:372699403"
variation 609
/gene="DPRX"
/replace="c"
/replace="t"
/db_xref="dbSNP:184384115"
variation 616
/gene="DPRX"
/replace="c"
/replace="t"
/db_xref="dbSNP:377492034"
variation 617
/gene="DPRX"
/replace="a"
/replace="g"
/db_xref="dbSNP:370961873"
variation 643
/gene="DPRX"
/replace="a"
/replace="c"
/db_xref="dbSNP:374553934"
ORIGIN
tgctagttcttatccctggacctgaacccaggcgcacatctggattagaagatgccaggctcagaggatcttcgtaaaggcaaggaccagatgcattcacacaggaaacgaaccatgttcactaagaagcaactggaagatctgaacatcttgttcaatgagaacccatacccaaaccccagccttcagaaagaaatggcctcgaaaatagacatacacccaacagtactgcaggtctggttcaagaatcacagagcaaaactcaagaaagcgaaatgcaagcatattcatcaaaaacaagaaactccacaaccgccaataccagagggtggggtctccaccagtgtcggcctgagaaatgcagacacactacccagattgcccaacgctgctcacccgatcggcctggtgtacacgggtcatcgagtcccctcattccagctcatcctgtaccccaacctcaaggtccctgcaaatgacttcattggccacagaatagtccattttggctgctgccgagatcctaatatatactgcctctaccccattttggaatcccaagtttgcgctccaagcttccattctggctctcctgcctgttcatctaaccaaagtcgagagagatgataaatacaaaaagtcacatgt
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:503834 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
GeneID:503834 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
GeneID:503834 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:503834 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
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