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2024-03-29 09:17:18, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001012413            3192 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens shugoshin-like 1 (S. pombe) (SGOL1), transcript
            variant C1, mRNA.
ACCESSION   NM_001012413
VERSION     NM_001012413.2  GI:312922397
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3192)
  AUTHORS   Greenwood,T.A., Akiskal,H.S., Akiskal,K.K. and Kelsoe,J.R.
  CONSRTM   Bipolar Genome Study
  TITLE     Genome-wide association study of temperament in bipolar disorder
            reveals significant associations with three novel Loci
  JOURNAL   Biol. Psychiatry 72 (4), 303-310 (2012)
   PUBMED   22365631
REFERENCE   2  (bases 1 to 3192)
  AUTHORS   Liu,L., Zhang,N., Liu,J., Min,J., Ma,N., Liu,N., Liu,Y. and
            Zhang,H.
  TITLE     Lentivirus-mediated siRNA interference targeting SGO-1 inhibits
            human NSCLC cell growth
  JOURNAL   Tumour Biol. 33 (2), 515-521 (2012)
   PUBMED   22161216
  REMARK    GeneRIF: Lentivirus-mediated siRNA interference targeting SGO-1
            inhibits human NSCLC cell growth
REFERENCE   3  (bases 1 to 3192)
  AUTHORS   Kahyo,T., Iwaizumi,M., Shinmura,K., Matsuura,S., Nakamura,T.,
            Watanabe,Y., Yamada,H. and Sugimura,H.
  TITLE     A novel tumor-derived SGOL1 variant causes abnormal mitosis and
            unstable chromatid cohesion
  JOURNAL   Oncogene 30 (44), 4453-4463 (2011)
   PUBMED   21532624
  REMARK    GeneRIF: These results suggest that SGOL1-P1 may function as a
            negative factor to native SGOL1, and that abundant expression of
            SGOL1-P1 may be responsible for chromosomal instability.
REFERENCE   4  (bases 1 to 3192)
  AUTHORS   Kang,J., Chaudhary,J., Dong,H., Kim,S., Brautigam,C.A. and Yu,H.
  TITLE     Mitotic centromeric targeting of HP1 and its binding to Sgo1 are
            dispensable for sister-chromatid cohesion in human cells
  JOURNAL   Mol. Biol. Cell 22 (8), 1181-1190 (2011)
   PUBMED   21346195
  REMARK    GeneRIF: HP1alpha binding by INCENP or Shugoshin 1 (Sgo1) is
            dispensable for centromeric cohesion protection during mitosis of
            human cells, but might regulate yet unknown interphase functions of
            the chromosome passenger complex (CPC) or Sgo1 at the centromeres.
REFERENCE   5  (bases 1 to 3192)
  AUTHORS   Okamoto,N., Kuwahara,K., Ohta,K., Kitabatake,M., Takagi,K.,
            Mizuta,H., Kondo,E. and Sakaguchi,N.
  TITLE     Germinal center-associated nuclear protein (GANP) is involved in
            mRNA export of Shugoshin-1 required for centromere cohesion and in
            sister-chromatid exchange
  JOURNAL   Genes Cells 15 (5), 471-484 (2010)
   PUBMED   20384790
  REMARK    GeneRIF: Data show that human germinal center-associated nuclear
            protein (GANP) is critically involved in cell proliferation at the
            mitotic phase through its selective support of shugoshin-1 mRNA
            export.
REFERENCE   6  (bases 1 to 3192)
  AUTHORS   Wang,X. and Dai,W.
  TITLE     Shugoshin, a guardian for sister chromatid segregation
  JOURNAL   Exp. Cell Res. 310 (1), 1-9 (2005)
   PUBMED   16112668
  REMARK    GeneRIF: A comprehensive review of Sgo1 function in eukaryote at
            meiosis and mitosis.
            Review article
REFERENCE   7  (bases 1 to 3192)
  AUTHORS   McGuinness,B.E., Hirota,T., Kudo,N.R., Peters,J.M. and Nasmyth,K.
  TITLE     Shugoshin prevents dissociation of cohesin from centromeres during
            mitosis in vertebrate cells
  JOURNAL   PLoS Biol. 3 (3), E86 (2005)
   PUBMED   15737064
  REMARK    GeneRIF: A shugoshin-like protein associates with centromeres
            during prophase and disappears at the onset of anaphase
REFERENCE   8  (bases 1 to 3192)
  AUTHORS   Kitajima,T.S., Hauf,S., Ohsugi,M., Yamamoto,T. and Watanabe,Y.
  TITLE     Human Bub1 defines the persistent cohesion site along the mitotic
            chromosome by affecting Shugoshin localization
  JOURNAL   Curr. Biol. 15 (4), 353-359 (2005)
   PUBMED   15723797
REFERENCE   9  (bases 1 to 3192)
  AUTHORS   Tang,Z., Sun,Y., Harley,S.E., Zou,H. and Yu,H.
  TITLE     Human Bub1 protects centromeric sister-chromatid cohesion through
            Shugoshin during mitosis
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (52), 18012-18017 (2004)
   PUBMED   15604152
  REMARK    GeneRIF: Bub1 protects centromeric cohesion through Shugoshin in
            mitosis
REFERENCE   10 (bases 1 to 3192)
  AUTHORS   Scanlan,M.J., Gout,I., Gordon,C.M., Williamson,B., Stockert,E.,
            Gure,A.O., Jager,D., Chen,Y.T., Mackay,A., O'Hare,M.J. and Old,L.J.
  TITLE     Humoral immunity to human breast cancer: antigen definition and
            quantitative analysis of mRNA expression
  JOURNAL   Cancer Immun. 1, 4 (2001)
   PUBMED   12747765
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG530826.1, AB193056.1, AF308299.1 and AC099057.3.
            On Nov 30, 2010 this sequence version replaced gi:60302878.
            
            Transcript Variant: This variant (C1) lacks an in-frame internal
            exon and the 3' exon, and contains an alternate 3' segment, as
            compared to variant A2. The resulting isoform (C1, also known as
            1AB) lacks an internal segment and has a shorter and distinct
            C-terminus, as compared to isoform A2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB187581.1, BX375095.2 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025084 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               BG530826.1         2-154
            154-938             AB193056.1         186-970
            939-1142            AF308299.1         845-1048
            1143-3192           AC099057.3         145527-147576       c
FEATURES             Location/Qualifiers
     source          1..3192
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.3"
     gene            1..3192
                     /gene="SGOL1"
                     /gene_synonym="NY-BR-85; SGO; Sgo1"
                     /note="shugoshin-like 1 (S. pombe)"
                     /db_xref="GeneID:151648"
                     /db_xref="HGNC:25088"
                     /db_xref="HPRD:12377"
                     /db_xref="MIM:609168"
     exon            1..148
                     /gene="SGOL1"
                     /gene_synonym="NY-BR-85; SGO; Sgo1"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    138..140
                     /gene="SGOL1"
                     /gene_synonym="NY-BR-85; SGO; Sgo1"
                     /note="upstream in-frame stop codon"
     exon            149..297
                     /gene="SGOL1"
                     /gene_synonym="NY-BR-85; SGO; Sgo1"
                     /inference="alignment:Splign:1.39.8"
     CDS             156..932
                     /gene="SGOL1"
                     /gene_synonym="NY-BR-85; SGO; Sgo1"
                     /note="isoform C1 is encoded by transcript variant C1;
                     shugoshin 1AB protein; shugoshin 1CD protein; shugoshin
                     1EF protein; shugoshin 1GH protein; shugoshin 1KL protein;
                     hSgo1; serologically defined breast cancer antigen
                     NY-BR-85"
                     /codon_start=1
                     /product="shugoshin-like 1 isoform C1"
                     /protein_id="NP_001012413.1"
                     /db_xref="GI:60302879"
                     /db_xref="CCDS:CCDS46772.1"
                     /db_xref="GeneID:151648"
                     /db_xref="HGNC:25088"
                     /db_xref="HPRD:12377"
                     /db_xref="MIM:609168"
                     /translation="
MAKERCLKKSFQDSLEDIKKRMKEKRNKNLAEIGKRRSFIAAPCQIITNTSTLLKNYQDNNKMLVLALENEKSKVKEAQDIILQLRKECYYLTCQLYALKGKLTSQQTVEPAQNQEICSSGMDPNSDDSSRNLFVKDLPQIPLEETELPGQGESFQIEATPPETQQSPHLSLKDITNVSLYPVVKIRRLSLSPKKNKASPAVALPKRRCTASVNYKEPTLASKLRRGDPFTDLCFLNSPIFKQKKDLRRSKKSMKQIQ
"
     misc_feature    219..356
                     /gene="SGOL1"
                     /gene_synonym="NY-BR-85; SGO; Sgo1"
                     /note="Shugoshin N-terminal coiled-coil region; Region:
                     Shugoshin_N; pfam07558"
                     /db_xref="CDD:203682"
     misc_feature    759..836
                     /gene="SGOL1"
                     /gene_synonym="NY-BR-85; SGO; Sgo1"
                     /note="Shugoshin C terminus; Region: Shugoshin_C;
                     pfam07557"
                     /db_xref="CDD:191783"
     exon            298..494
                     /gene="SGOL1"
                     /gene_synonym="NY-BR-85; SGO; Sgo1"
                     /inference="alignment:Splign:1.39.8"
     exon            495..571
                     /gene="SGOL1"
                     /gene_synonym="NY-BR-85; SGO; Sgo1"
                     /inference="alignment:Splign:1.39.8"
     exon            572..630
                     /gene="SGOL1"
                     /gene_synonym="NY-BR-85; SGO; Sgo1"
                     /inference="alignment:Splign:1.39.8"
     exon            631..820
                     /gene="SGOL1"
                     /gene_synonym="NY-BR-85; SGO; Sgo1"
                     /inference="alignment:Splign:1.39.8"
     exon            821..3192
                     /gene="SGOL1"
                     /gene_synonym="NY-BR-85; SGO; Sgo1"
                     /inference="alignment:Splign:1.39.8"
     variation       939
                     /gene="SGOL1"
                     /gene_synonym="NY-BR-85; SGO; Sgo1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1052930"
     STS             1324..1411
                     /gene="SGOL1"
                     /gene_synonym="NY-BR-85; SGO; Sgo1"
                     /standard_name="D8S2279"
                     /db_xref="UniSTS:473907"
     STS             1353..1486
                     /gene="SGOL1"
                     /gene_synonym="NY-BR-85; SGO; Sgo1"
                     /standard_name="D7S2067E"
                     /db_xref="UniSTS:151120"
     STS             1477..2746
                     /gene="SGOL1"
                     /gene_synonym="NY-BR-85; SGO; Sgo1"
                     /standard_name="GDB:631813"
                     /db_xref="UniSTS:158430"
     STS             2726..2831
                     /gene="SGOL1"
                     /gene_synonym="NY-BR-85; SGO; Sgo1"
                     /standard_name="D11S3114"
                     /db_xref="UniSTS:152207"
     STS             2813..2890
                     /gene="SGOL1"
                     /gene_synonym="NY-BR-85; SGO; Sgo1"
                     /standard_name="D8S2279"
                     /db_xref="UniSTS:473907"
ORIGIN      
gaatgtggcggcggtagttccaggcgacggcggacggtggtacggtcctggagggcccagtgcgcggggctagccgtggctggagagcttcgaagagccttgaaatgtgaggaggaggaagatagctgttgcagaagtagtggccaaggcaaaagatggccaaggaaagatgcctgaaaaagtcctttcaagatagtcttgaagacataaagaagcgaatgaaagagaaaaggaataaaaacttggcagagattggcaaacgcaggtcttttatagctgcaccatgccaaataatcaccaacacttctacactgctgaaaaattaccaagacaacaacaaaatgttagttttagctttggaaaatgaaaaatccaaagtgaaagaagcccaagatatcatcctacagctgagaaaagaatgttactatctcacatgtcagctatatgcattgaaaggaaaacttacatcacaacaaacagtagaacctgctcagaaccaggaaatatgttcctctggaatggaccccaatagtgatgacagctccagaaatttatttgtgaaggatttaccgcaaattcctcttgaagaaactgaacttccaggacaaggagaatcatttcaaatagaagctacaccacctgaaactcagcagtcacctcatcttagcctgaaggatatcaccaatgtctccttgtatcctgttgtgaaaatcagaagactttctctttctccaaaaaagaataaagcaagcccagcagtggctctgcctaaacgtaggtgcacagccagcgtgaactataaggagcccaccctcgcttcgaaactgagaagaggggacccttttacagatttgtgttttttgaattctcctattttcaagcagaaaaaggatttgagacgttctaaaaaaagtatgaaacaaatacaatgaaggttttgttggatattgtttaaattcaatctacacctctttctgttgcttcaggagaggatctgtaagagtacacaaacagagtgagccattgccatagaatattctcttgacaggaccctagctcataaacatttcttcagaactatacttcaaatgggatgctttgtattaaaactttaataaatttaatttattttttcttttgaatataaataactgagcttaagcattatcatcatatcgatttcttatgctgcctaaacctcttaattttagtcgaaatatatctttttttttttttggaggcggaatttcattcttgttgcccaggctggagtgcaatggcacgatctcagcttaccgcaacctccgcctcccaggttcaagcgattctcctgcctcagactcccgagtagctgggactacaggcatgtgccactacgcccggctaattttgtatttttagtagagacagggtttctccatgttggtcaggttgctctcaaactcccaacctcaggtgatctgcccacctcggcctcccaaagtgctgggattactgagccactgtgcccagcccaaaatgtatcttatacaaacattgtagaaatgaataatgattactcaaataagatcttttaattataagcttctggcatctctatttttcccttaagtaggggatactaaagtgaatgattttctaagaggatcttttgaaactctttagtacaatatttgagtaaaataaattattgtggatcttttgaaactctgtgtagtattcgagtaaaataaatatttgacatttacagtagggtacaccctaagttgtttatgaattccttataccactgttatatttaatttttcagataaaatatgtatgggaaaatgactagagaaattgattcttttttaggctcagggacaagataagtgactaattgtgaaccccaagctctaattgtatgttcagagtgatgtctccataaaattacaaatgtcatgtactttcagggtagctccttatttagtcagaaatctcagagattaaatgtgtgaatatttagggtttttgcatatttttgaccaaccaatgaaagcgaattagttcagtttagaaagtttgatgtctatacttgtatatacctctttaaattttagaactttgtaggttattcatttttaaagagcaataaagtttgtataagatagtgattgctttccttctattctttaaatatcaaaaatagagtatctctctgtcttcactattctcatccttggacatttcctctcccctccccttggtattctcttttttgaggggggggtgttctaggtgagttaatccttagtattttcagtagtcattgctataaaactctcagcttcccctccatactttcaacctaacacttctctctcccaacttatctctgtgtaatctcccagttcatgattaacaaattataattttattgagggactgttctaatcctgatatctcagattttcttggctgttatctccctatctttctgtattctatgtcagtcagagccaaaatccttttcatcatcccaaatttttctatccgccacatcactgattcatacaccctagtcttccatcacagtctcttaatttttaagttttttttttcttactactcccttcatacttattctttaatttcatggaaacactagagtagctatcttaaactaagactacagaccattaaaaagtcagtttctcagccaggcacgagaaactactaacacctgtaatcccagcactttgggaggccaaggcgggcagatcacgagaggtcaaggagatcgagaccatcctggctaatacggtgaaaccccgtctctactaaaaatagaaaaaattagccaggcgcctgtagtcccagctacttgggaggctgaggcaggagaacggcgtgaacccgggaggcggagcttgcagtgagccgagatggtgccactgcactccagcctgggtgacagagcgagactccatctcaaaaaaaaaaaaaaaacagtttctcagtccatgtaaccacctttcaaatgatcagtagccatatgtggctagtggttaccatattagacaattgaggaaatattgaacatttccatcatcacagaaagtacagttggactatgggccaaatctagcacaccacctgcttctggatggtcttcaacctaagaatagtttttacgtttttaaatagttg
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:151648 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:151648 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
            GeneID:151648 -> Biological process: GO:0007059 [chromosome segregation] evidence: IDA
            GeneID:151648 -> Biological process: GO:0007067 [mitosis] evidence: IEA
            GeneID:151648 -> Biological process: GO:0008608 [attachment of spindle microtubules to kinetochore] evidence: IDA
            GeneID:151648 -> Biological process: GO:0010457 [centriole-centriole cohesion] evidence: IDA
            GeneID:151648 -> Biological process: GO:0045132 [meiotic chromosome segregation] evidence: IEA
            GeneID:151648 -> Biological process: GO:0051301 [cell division] evidence: IEA
            GeneID:151648 -> Cellular component: GO:0000775 [chromosome, centromeric region] evidence: IDA
            GeneID:151648 -> Cellular component: GO:0000776 [kinetochore] evidence: IDA
            GeneID:151648 -> Cellular component: GO:0000777 [condensed chromosome kinetochore] evidence: IEA
            GeneID:151648 -> Cellular component: GO:0000779 [condensed chromosome, centromeric region] evidence: IDA
            GeneID:151648 -> Cellular component: GO:0000780 [condensed nuclear chromosome, centromeric region] evidence: IEA
            GeneID:151648 -> Cellular component: GO:0000922 [spindle pole] evidence: IDA
            GeneID:151648 -> Cellular component: GO:0005813 [centrosome] evidence: IDA
            GeneID:151648 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:151648 -> Cellular component: GO:0030892 [mitotic cohesin complex] evidence: IDA

by @meso_cacase at DBCLS
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