GGRNA | NM_001010922.2

LOCUS       NM_001010922            4986 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens BCL2-like 15 (BCL2L15), mRNA.
ACCESSION   NM_001010922 XM_496384
VERSION     NM_001010922.2  GI:121949805
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4986)
  AUTHORS   Pujianto,D.A., Damdimopoulos,A.E., Sipila,P., Jalkanen,J.,
            Huhtaniemi,I. and Poutanen,M.
  TITLE     Bfk, a novel member of the bcl2 gene family, is highly expressed in
            principal cells of the mouse epididymis and demonstrates a
            predominant nuclear localization
  JOURNAL   Endocrinology 148 (7), 3196-3204 (2007)
   PUBMED   17412810
REFERENCE   2  (bases 1 to 4986)
  AUTHORS   Luo,H.Y., Yu,S.F. and Li,T.J.
  TITLE     Differential expression of apoptosis-related proteins in various
            cellular components of ameloblastomas
  JOURNAL   Int J Oral Maxillofac Surg 35 (8), 750-755 (2006)
   PUBMED   16690252
REFERENCE   3  (bases 1 to 4986)
  AUTHORS   Dempsey,C.E., Dive,C., Fletcher,D.J., Barnes,F.A., Lobo,A.,
            Bingle,C.D., Whyte,M.K. and Renshaw,S.A.
  TITLE     Expression of pro-apoptotic Bfk isoforms reduces during malignant
            transformation in the human gastrointestinal tract
  JOURNAL   FEBS Lett. 579 (17), 3646-3650 (2005)
   PUBMED   15961081
  REMARK    GeneRIF: In the transition from normal tissue to tumour,
            pro-apoptotic Bfk isoform expression is substantially reduced in up
            to 80% of tumours isolated from the human gastrointestinal tract
            compared to tumours from outside the gastrointestinal tract.
REFERENCE   4  (bases 1 to 4986)
  AUTHORS   Coultas,L., Pellegrini,M., Visvader,J.E., Lindeman,G.J., Chen,L.,
            Adams,J.M., Huang,D.C. and Strasser,A.
  TITLE     Bfk: a novel weakly proapoptotic member of the Bcl-2 protein family
            with a BH3 and a BH2 region
  JOURNAL   Cell Death Differ. 10 (2), 185-192 (2003)
   PUBMED   12700646
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI821052.1, AY265861.1, AL137856.24 and BX116361.1.
            On Jan 12, 2007 this sequence version replaced gi:58219053.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK289439.1, BM829833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025088, ERS025098 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               AI821052.1         1-172
            173-664             AY265861.1         1-492
            665-4649            AL137856.24        84225-88209         c
            4650-4986           BX116361.1         1-337               c
FEATURES             Location/Qualifiers
     source          1..4986
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..4986
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
                     /note="BCL2-like 15"
                     /db_xref="GeneID:440603"
                     /db_xref="HGNC:33624"
                     /db_xref="HPRD:16920"
     exon            1..299
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    155..157
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
                     /note="upstream in-frame stop codon"
     CDS             173..664
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
                     /note="pro-apoptotic Bcl-2 protein; bcl2-L-15"
                     /codon_start=1
                     /product="bcl-2-like protein 15"
                     /protein_id="NP_001010922.1"
                     /db_xref="GI:58219054"
                     /db_xref="CCDS:CCDS30809.1"
                     /db_xref="GeneID:440603"
                     /db_xref="HGNC:33624"
                     /db_xref="HPRD:16920"
                     /translation="

MKSSQTFEEQTECIVNTLLMDFLSPTLQVASRNLCCVDEVDSGEPCSFDVAIIAGRLRMLGDQFNGELEASAKNVIAETIKGQTGAILQDTVESLSKTWCAQDSSLAYERAFLAVSVKLLEYMAHIAPEVVGQVAIPMTGMINGNQAIREFIQGQGGWENLES

"
     exon            300..421
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
                     /inference="alignment:Splign:1.39.8"
     exon            422..646
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
                     /inference="alignment:Splign:1.39.8"
     exon            647..4973
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
                     /inference="alignment:Splign:1.39.8"
     polyA_signal    747..752
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
     polyA_site      783
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
     STS             1185..1287
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
                     /standard_name="D11S2921"
                     /db_xref="UniSTS:152074"
     STS             1365..2675
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
                     /standard_name="RH79802"
                     /db_xref="UniSTS:88688"
     STS             1400..2679
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
                     /standard_name="GDB:631813"
                     /db_xref="UniSTS:158430"
     variation       1433
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1217383"
     STS             4527..4708
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
                     /standard_name="RH98904"
                     /db_xref="UniSTS:89565"
     variation       4649
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1217384"
ORIGIN

cctttctgagcagctgtgtttgaagaaagctagtgggaaaagttccaggattacatgtcaggaaactacaagaggtagaaacatttgttgatttaccagtgtttttaacttcctgctgggctgaaaactgcttgtttcgtggaaaagcaaaacttgacagcaaacatctaaaatgaagagctcccaaacttttgaggaacaaacggaatgcattgtgaacactctactcatggacttcttgagcccaacattgcaggttgccagccggaacctatgctgtgtagatgaagtagattcaggagagccttgttcttttgatgtggctatcattgctggtcgccttcggatgttgggtgaccagttcaacggagaattggaagcttctgccaaaaacgtcattgcagaaaccattaagggacagacaggagctatactccaggacactgtggaatctctcagcaagacctggtgtgctcaggattccagcttagcttatgagagagcttttctggcagtgtcagtgaaacttcttgagtacatggctcacattgctcctgaagtagtgggacaggtggctatccccatgacgggtatgatcaatgggaaccaagccatccgggagttcatccagggccagggaggttgggaaaatctggagagctgaagagttggagctattcacgagactgaacatcacttccttgttgactgattgggtgattgattcctgggaattcaaacaaacaaataaaaaagcacttttttcattttatcagaactgaacttagctgaataagttattttttactgattgttaaagttgggagcagctgccagaggcctgcagagttggtttttgttttgttttgttttgtcaacttaatgcaaaccacagagattttctactttctgttttcacatgagttttaatgaggttctgttgaagcaaagacccctagacacaaagtaatgacttgttagtagtggaattataagcaacagggcaggcctttgctggaggtattttgagagaaagggagaacaatggaaactatttcttcagatgtagccctgtcttttggtaagaattgtgcctactaattttgcaatttaaaggatttcaggaagctttttggttgaaaaatcttgtttttttttttttagacgtagtctcactctgtcacccaggctggagtgcagtggtgcgatctcagctcactgcaagctccacctcccggtttcactccattctcctgcctcagcctcctgagtagctgggactacaggagcccgccatcacgcccggctaattttttgtatttttagtagagatgaggtttcgccgtgttagccaggatggtctggatctcctgacctcgtgattcgcccgccttggcctcccaaagtgctgggattacaggcgtgagccaccacgcccggcctaaaatcttgttattttaagttgagcattttcattcaaaatcatccctaaacttcatgttaatttcacctgagaaggactattttatgcattttagaggttggaagcaaaaaacaaacaaacaaacaaaaacagttgtttctactaggaaggtcaaagaaaataaaagttactccatttttactgccacaggatgcaggaagtgctggcccacatctaggacagcaaggccaccccagcttagatgaagctagctgcataacacaaagctttaaaagtgtggttcacacaccacttgtggaccttattgaattgctgattcgcattcctagagattctgattctgtaggggtaggctggagcctaggaacctaccttttaaactagttccataggtgattctgatgtacatatagagtgtgacagccatcactatagagaatagattgataaattacaacccacgcgtcaaatctggcttgctgtcttattttgtaaataaagttttattggaatagagcaacattcacttgtttacatattgtccatggccgcttttgtgctacaatggcagagttgaatgattatagaagaccatatggctggttaagtccaaaatatttactagctggccctttacagaaaaagttggctgaccccttctctaaatcaacatttctccttggtaactgaaactctattacagtcctgacaattccagcaaacacagctgtagatagggtttaaactcaaagatatttaactcttctttgggaacttagtctccatatgtttgttagttcttgcataatccacagtttctctgggtcttcagccaatcagagagctctgtagctcctgagtagtccatttctctggccctacaagtgagagtgattggaagcaaagcttatgatttgtatgatcttgtatctcaaaatagtccttaatgatctaatagattagtaggcagtcatcaggtagagactccaaaaaccagactactttcctaaatatcaagaagaaaggcattgctacagtgattcatgaaaagcagcattaataactttggctaaagtttaacaaagctaaccacttcccctctatcagccagccatctatgtatctcctctaaatgcagagaagtaaatatgtagtgctgttaatacatttttgctttttaaagttatgctttgtcctggcgcagtggctcatgcctgtaatcccagcactttgggaggccaaggcgggtggatcacctgaggttaggagtttgagaccagcctggccaacatggtgaaaccctgtctctgctaaaaatacaaaaaattagccaggcttggtggcacgtgcctgtaatgccagctactcaggaggctgaggcaggagaatcacttgaacctgggaggcggaggttgctgtgagctgagttcgcgccattgcactccagcctgggctacaaaagcgaaactgtctaaaaaaaaaaaaagaaaataaataaagttatgctttttcctctattcctagttaaatcacaacaagttagtaatccataaatgatgtgtcctgtttctctttagtagaaattatatttttggctaccagttaagaaacttgtactcctttgtcccttatgttactataaactcaagatgatgagttttgtggtatttgacttcataggcaaaatcaaaatttttactttgttgctattctgttttatgaaataaacttctgtctatgcatttgaactaagtttcagcaaattcaatctaaattgaataattccagctcccagttttatcctatgttgctcataaaacagttccaagtatactgcattatcttgagatttgaagatatggtgcccacggggattatactaggcaaatgcgttaagcagctctggcctaggtgttgtgtattttaagagactctatcttaggagagcttaagtgattgggctgcaggaagaagacattgtaacccaggaattaaaaatggattcagattgcctgattttaacactttagtttcaccataggctaattatgtgacattgggcaagagacataattcttctgtaccttagtttctacatttgtaaaatagagatgatttggtaacttattaataagatttttgtgagagataaataaaacaaatacattttgtaaagggtgagtacttggaatattttaaacactgtgccattagcaatttggaattctgtgttatgcagttcataaggttctagcttgacttttttctctctccattaaccctgtctctcacagatgcaaaccactcttaatggctttactttcacatcaatgtgagtgattcctaaatatgatttatttcccttctcaattccatacccacagatgcttattatttatttatgtgtacctttcttatccccatactctccctgtttgcgatacaactagctcaaaacctcagtcatttttaccttgtctctctctctccagtccaactcacccaactagtttttctcatttgttacttcatttttgtcctggttcttctaccagatttattagcaactgcctggactattaataaagcctcctacttaggctttcaatagattgttctgttcctgctccattccagtctgtcctatatactgccatcagattgatcaaagctgtggtttctttgtctattattttgattcatttttagatatggtatcattcatttttaaatttaacataccaatgaagattacaagacttaaacatcttatcagaagggggcatttattttttaaatcaagaaataactttccaaaagcattgctttgaatgccattctcttaaagtccttcagtggaacttttgagtgtgattagacatgttcattatcttgattgtagtgattttatgggtgatgatttcacaccaacttatcaaactgcatactttgaaatgtgtagtttattgtacatcagcactaccttaataaggttgttttttttaaaaaaaaaaaaaaaaccttcagctgctccctactgttcatcaaataacagtctgatattcaaattcccccagtatctggccctaactgccctatatagccttaatcaatcatgattctcctctacaatcccaatgctctagtataaccgagccagtcactaaagctgccctcctcctactgttccctatgtttcatattcctttttctgaggctctacctgtagacatcttcaagacccaacccaactgtcatgaagccttctccatgaaggctatccatataaccagaataagaagtggtctttgcctccttgaacttttgtttgtaccacttttatgtttcttatccaaaaaatggccttaagttgtaattatctgtatagtcatcttccccactaggataaaggattgctgaatgatacaatttgttgtatacttctgtaacacccctcctcttcattatctggcatgtacatcgatattaaaaatattcattaaatgaatgaatagctgattgactcagaaaaaaaaaaaaaa

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