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2020-10-24 07:32:04, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001009                755 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens ribosomal protein S5 (RPS5), mRNA.
ACCESSION   NM_001009
VERSION     NM_001009.3  GI:71164878
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 755)
  AUTHORS   Ian'shina,D.D., Malygin,A.A. and Karpova,G.G.
  TITLE     [Mutual effect of human ribosomal proteins S5 and S16 on their
            binding with 18S rRNA fragment 1203-1236/1521-1698]
  JOURNAL   Mol. Biol. (Mosk.) 43 (4), 700-708 (2009)
   PUBMED   19807034
  REMARK    GeneRIF: Mutual effect of human ribosomal proteins S5 and S16 on
            their binding with 18S rRNA fragment 1203-1236/1521-1698
REFERENCE   2  (bases 1 to 755)
  AUTHORS   Maggi,L.B. Jr., Kuchenruether,M., Dadey,D.Y., Schwope,R.M.,
            Grisendi,S., Townsend,R.R., Pandolfi,P.P. and Weber,J.D.
  TITLE     Nucleophosmin serves as a rate-limiting nuclear export chaperone
            for the Mammalian ribosome
  JOURNAL   Mol. Cell. Biol. 28 (23), 7050-7065 (2008)
   PUBMED   18809582
REFERENCE   3  (bases 1 to 755)
  AUTHORS   Pisarev,A.V., Kolupaeva,V.G., Yusupov,M.M., Hellen,C.U. and
            Pestova,T.V.
  TITLE     Ribosomal position and contacts of mRNA in eukaryotic translation
            initiation complexes
  JOURNAL   EMBO J. 27 (11), 1609-1621 (2008)
   PUBMED   18464793
REFERENCE   4  (bases 1 to 755)
  AUTHORS   Galkin,O., Bentley,A.A., Gupta,S., Compton,B.A., Mazumder,B.,
            Kinzy,T.G., Merrick,W.C., Hatzoglou,M., Pestova,T.V., Hellen,C.U.
            and Komar,A.A.
  TITLE     Roles of the negatively charged N-terminal extension of
            Saccharomyces cerevisiae ribosomal protein S5 revealed by
            characterization of a yeast strain containing human ribosomal
            protein S5
  JOURNAL   RNA 13 (12), 2116-2128 (2007)
   PUBMED   17901157
  REMARK    GeneRIF: Transfected into yeast cells, plays an important role in
            maintaining the accuracy of translation.
REFERENCE   5  (bases 1 to 755)
  AUTHORS   Yu,Y., Ji,H., Doudna,J.A. and Leary,J.A.
  TITLE     Mass spectrometric analysis of the human 40S ribosomal subunit:
            native and HCV IRES-bound complexes
  JOURNAL   Protein Sci. 14 (6), 1438-1446 (2005)
   PUBMED   15883184
REFERENCE   6  (bases 1 to 755)
  AUTHORS   Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K.,
            Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A.
  TITLE     Characterization of the human small-ribosomal-subunit proteins by
            N-terminal and internal sequencing, and mass spectrometry
  JOURNAL   Eur. J. Biochem. 239 (1), 144-149 (1996)
   PUBMED   8706699
REFERENCE   7  (bases 1 to 755)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem. Cell Biol. 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   8  (bases 1 to 755)
  AUTHORS   Frigerio,J.M., Dagorn,J.C. and Iovanna,J.L.
  TITLE     Cloning, sequencing and expression of the L5, L21, L27a, L28, S5,
            S9, S10 and S29 human ribosomal protein mRNAs
  JOURNAL   Biochim. Biophys. Acta 1262 (1), 64-68 (1995)
   PUBMED   7772601
REFERENCE   9  (bases 1 to 755)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   10 (bases 1 to 755)
  AUTHORS   Mundus,D.A., Bulygin,K.N., Yamkovoy,V.I., Malygin,A.A.,
            Repkova,M.N., Vratskikh,L.V., Venijaminova,A.G., Vladimirov,S.N.
            and Karpova,G.G.
  TITLE     Structural arrangement of the codon-anticodon interaction area in
            human placenta ribosomes. Affinity labelling of the 40S subunits by
            derivatives of oligoribonucleotides containing the AUG codon
  JOURNAL   Biochim. Biophys. Acta 1173 (3), 273-282 (1993)
   PUBMED   8318536
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BG687415.1 and BC015405.1.
            On Jul 26, 2005 this sequence version replaced gi:13904869.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 40S subunit. The protein belongs
            to the S7P family of ribosomal proteins. It is located in the
            cytoplasm. Variable expression of this gene in colorectal cancers
            compared to adjacent normal tissues has been observed, although no
            correlation between the level of expression and the severity of the
            disease has been found. As is typical for genes encoding ribosomal
            proteins, there are multiple processed pseudogenes of this gene
            dispersed through the genome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD175688.1, CD176164.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BG687415.1         1-39
            40-755              BC015405.1         28-743
FEATURES             Location/Qualifiers
     source          1..755
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.4"
     gene            1..755
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /note="ribosomal protein S5"
                     /db_xref="GeneID:6193"
                     /db_xref="HGNC:10426"
                     /db_xref="HPRD:04695"
                     /db_xref="MIM:603630"
     exon            1..71
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    1
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /note="predominant transcription initiation site"
     variation       3
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371476239"
     variation       7
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:112583937"
     variation       9
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:111847582"
     variation       15
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114515295"
     variation       39
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:111590146"
     misc_feature    43..45
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /note="upstream in-frame stop codon"
     exon            72..180
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /inference="alignment:Splign:1.39.8"
     CDS             73..687
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /codon_start=1
                     /product="40S ribosomal protein S5"
                     /protein_id="NP_001000.2"
                     /db_xref="GI:13904870"
                     /db_xref="CCDS:CCDS12978.1"
                     /db_xref="GeneID:6193"
                     /db_xref="HGNC:10426"
                     /db_xref="HPRD:04695"
                     /db_xref="MIM:603630"
                     /translation="
MTEWETAAPAVAETPDIKLFGKWSTDDVQINDISLQDYIAVKEKYAKYLPHSAGRYAAKRFRKAQCPIVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVNAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR
"
     misc_feature    73..75
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N-acetylmethionine, in 40S ribosomal protein S5,
                     alternate; propagated from UniProtKB/Swiss-Prot
                     (P46782.4); acetylation site"
     misc_feature    76..78
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N-acetylthreonine, in 40S ribosomal protein S5,
                     N-terminally processed; propagated from
                     UniProtKB/Swiss-Prot (P46782.4); acetylation site"
     misc_feature    112..684
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /note="40S ribosomal protein S5; Provisional; Region:
                     PTZ00091"
                     /db_xref="CDD:185439"
     misc_feature    211..213
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P46782.4); acetylation site"
     variation       77
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143571102"
     variation       78
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148033938"
     variation       85
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11545064"
     variation       102
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142305058"
     variation       119
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:373895128"
     variation       124
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200088071"
     variation       153
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199912104"
     variation       159
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146125110"
     exon            181..390
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /inference="alignment:Splign:1.39.8"
     variation       231
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113669389"
     variation       234
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:10853905"
     variation       255
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11545062"
     variation       276
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367711986"
     variation       288
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201177783"
     variation       311
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370061857"
     variation       315
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200602413"
     variation       321
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374641510"
     variation       339
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368930275"
     variation       348
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:61731810"
     variation       349
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112637700"
     variation       369
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149481790"
     exon            391..519
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /inference="alignment:Splign:1.39.8"
     variation       446
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1802696"
     variation       475
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11545063"
     exon            520..618
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /inference="alignment:Splign:1.39.8"
     variation       523
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368894713"
     variation       543
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144800741"
     variation       549
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:142861639"
     STS             561..660
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /standard_name="A009W25"
                     /db_xref="UniSTS:26278"
     variation       578
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376539628"
     variation       603
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11545070"
     exon            619..741
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /inference="alignment:Splign:1.39.8"
     variation       630
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369384066"
     variation       645
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3193532"
     variation       654
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144955468"
     variation       693
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:202151690"
     polyA_signal    706..711
                     /gene="RPS5"
                     /gene_synonym="S5"
     variation       707
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182905998"
     variation       712
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:115824630"
     variation       733
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2241787"
     variation       739
                     /gene="RPS5"
                     /gene_synonym="S5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3178234"
     polyA_site      741
                     /gene="RPS5"
                     /gene_synonym="S5"
ORIGIN      
ctcttcctgtctgtaccagggcggcgcgtggtctacgccgagtgacagagacgctcaggctgtgttctcaggatgaccgagtgggagacagcagcaccagcggtggcagagaccccagacatcaagctctttgggaagtggagcaccgatgatgtgcagatcaatgacatttccctgcaggattacattgcagtgaaggagaagtatgccaagtacctgcctcacagtgcagggcggtatgccgccaaacgcttccgcaaagctcagtgtcccattgtggagcgcctcactaactccatgatgatgcacggccgcaacaacggcaagaagctcatgactgtgcgcatcgtcaagcatgccttcgagatcatacacctgctcacaggcgagaaccctctgcaggtcctggtgaacgccatcatcaacagtggtccccgggaggactccacacgcattgggcgcgccgggactgtgagacgacaggctgtggatgtgtcccccctgcgccgtgtgaaccaggccatctggctgctgtgcacaggcgctcgtgaggctgccttccggaacattaagaccattgctgagtgcctggcagatgagctcatcaatgctgccaagggctcctcgaactcctatgccattaagaagaaggacgagctggagcgtgtggccaagtccaaccgctgattttcccagctgctgcccaataaacctgtctgccctttggggcagtcccagccaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:6193 -> Molecular function: GO:0003723 [RNA binding] evidence: NAS
            GeneID:6193 -> Molecular function: GO:0003729 [mRNA binding] evidence: IDA
            GeneID:6193 -> Molecular function: GO:0003735 [structural constituent of ribosome] evidence: IDA
            GeneID:6193 -> Biological process: GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] evidence: TAS
            GeneID:6193 -> Biological process: GO:0006412 [translation] evidence: IC
            GeneID:6193 -> Biological process: GO:0006412 [translation] evidence: IGI
            GeneID:6193 -> Biological process: GO:0006412 [translation] evidence: NAS
            GeneID:6193 -> Biological process: GO:0006412 [translation] evidence: TAS
            GeneID:6193 -> Biological process: GO:0006413 [translational initiation] evidence: IC
            GeneID:6193 -> Biological process: GO:0006413 [translational initiation] evidence: TAS
            GeneID:6193 -> Biological process: GO:0006414 [translational elongation] evidence: TAS
            GeneID:6193 -> Biological process: GO:0006415 [translational termination] evidence: TAS
            GeneID:6193 -> Biological process: GO:0006450 [regulation of translational fidelity] evidence: IGI
            GeneID:6193 -> Biological process: GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] evidence: TAS
            GeneID:6193 -> Biological process: GO:0010467 [gene expression] evidence: TAS
            GeneID:6193 -> Biological process: GO:0016032 [viral process] evidence: TAS
            GeneID:6193 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
            GeneID:6193 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
            GeneID:6193 -> Biological process: GO:0019058 [viral infectious cycle] evidence: TAS
            GeneID:6193 -> Biological process: GO:0019083 [viral transcription] evidence: TAS
            GeneID:6193 -> Biological process: GO:0044267 [cellular protein metabolic process] evidence: TAS
            GeneID:6193 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:6193 -> Cellular component: GO:0022627 [cytosolic small ribosomal subunit] evidence: IDA
            GeneID:6193 -> Cellular component: GO:0030529 [ribonucleoprotein complex] evidence: IDA

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