GGRNA | NM_001006683.1

LOCUS       NM_001006683            1216 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens spindlin family, member 2B (SPIN2B), transcript
            variant 3, mRNA.
ACCESSION   NM_001006683
VERSION     NM_001006683.1  GI:56682948
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1216)
  AUTHORS   Zhang,B., Abreu,J.G., Zhou,K., Chen,Y., Hu,Y., Zhou,T., He,X. and
            Ma,J.X.
  TITLE     Blocking the Wnt pathway, a unifying mechanism for an angiogenic
            inhibitor in the serine proteinase inhibitor family
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 107 (15), 6900-6905 (2010)
   PUBMED   20351274
  REMARK    GeneRIF: SERPINA3K is a high-affinity, endogenous antagonist of
            LRP6
REFERENCE   2  (bases 1 to 1216)
  AUTHORS   Lamesch,P., Li,N., Milstein,S., Fan,C., Hao,T., Szabo,G., Hu,Z.,
            Venkatesan,K., Bethel,G., Martin,P., Rogers,J., Lawlor,S.,
            McLaren,S., Dricot,A., Borick,H., Cusick,M.E., Vandenhaute,J.,
            Dunham,I., Hill,D.E. and Vidal,M.
  TITLE     hORFeome v3.1: a resource of human open reading frames representing
            over 10,000 human genes
  JOURNAL   Genomics 89 (3), 307-315 (2007)
   PUBMED   17207965
REFERENCE   3  (bases 1 to 1216)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   4  (bases 1 to 1216)
  AUTHORS   Fletcher,B.S., Dragstedt,C., Notterpek,L. and Nolan,G.P.
  TITLE     Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with
            roles in cell cycle progression
  JOURNAL   Leukemia 16 (8), 1507-1518 (2002)
   PUBMED   12145692
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ221120.1 and AF356353.1.
            
            Transcript Variant: This variant (3) lacks an internal segment in
            the 5' UTR, as compared to variant 1. Variants 1, 2 and 3 encode
            the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF356353.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               BQ221120.1         13-140
            129-1216            AF356353.1         1-1088
FEATURES             Location/Qualifiers
     source          1..1216
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.1"
     gene            1..1216
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN2_duplicate"
                     /note="spindlin family, member 2B"
                     /db_xref="GeneID:474343"
                     /db_xref="HGNC:33147"
                     /db_xref="HPRD:18662"
                     /db_xref="MIM:300517"
     exon            1..254
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN2_duplicate"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    236..238
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN2_duplicate"
                     /note="upstream in-frame stop codon"
     exon            255..1204
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN2_duplicate"
                     /inference="alignment:Splign:1.39.8"
     CDS             257..1033
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN2_duplicate"
                     /note="telomeric SPIN2 copy; spindlin family, member 2
                     duplicate; SPIN-2B; spindlin-like protein 2B"
                     /codon_start=1
                     /product="spindlin-2B"
                     /protein_id="NP_001006684.1"
                     /db_xref="GI:56682949"
                     /db_xref="CCDS:CCDS35311.1"
                     /db_xref="GeneID:474343"
                     /db_xref="HGNC:33147"
                     /db_xref="HPRD:18662"
                     /db_xref="MIM:300517"
                     /translation="

MKTPNAQEAEGQQTRAAAGRATGSANMTKKKVSQKKQRGRPSSQPRRNIVGCRISHGWKEGDEPITQWKGTVLDQVPINPSLYLVKYDGIDCVYGLELHRDERVLSLKILSDRVASSHISDANLANTIIGKAVEHMFEGEHGSKDEWRGMVLAQAPIMKAWFYITYEKDPVLYMYQLLDDYKEGDLRIMPESSESPPTEREPGGVVDGLIGKHVEYTKEDGSKRIGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKKS

"
     misc_feature    404..550
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN2_duplicate"
                     /note="Spin/Ssty Family; Region: Spin-Ssty; pfam02513"
                     /db_xref="CDD:145577"
     misc_feature    641..787
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN2_duplicate"
                     /note="Spin/Ssty Family; Region: Spin-Ssty; pfam02513"
                     /db_xref="CDD:145577"
     misc_feature    884..1018
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN2_duplicate"
                     /note="Spin/Ssty Family; Region: Spin-Ssty; pfam02513"
                     /db_xref="CDD:145577"
     variation       1190
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN2_duplicate"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1736862"
     variation       1196
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN2_duplicate"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1736863"
     variation       1197
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN2_duplicate"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1736864"
     polyA_site      1204
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN2_duplicate"
ORIGIN

gagactgccgcggcgacagcagggactggtggaatcccgatgtggctgaggggccgccaccgccagcagggaggcggagggctagcgagccaagcggtggggacgccgctgccttcctctttgcctgtctcgccgccctcctagacacgctcctcatctacggatcctaccctccccgctcttgcaagcattcactcggccggtcgcctgctgaccctccttcgccacaggctcgtagcggaggcagcagcgaggcatgaagacccccaacgcacaggaagccgaagggcaacaaaccagggcagctgcaggacgggccactgggtctgcaaacatgacaaagaaaaaagtctcccaaaagaagcagagaggccgaccttcatcccagccccgcaggaacatcgtgggctgcagaatttctcatggatggaaggaaggagatgagcccatcacgcagtggaaaggaaccgttctggatcaggtgcctataaatccctctctttatctggtgaaatatgatggaattgactgtgtctatggactggaacttcacagagatgaaagggttttgtctcttaaaattctttctgacagggtggcatcatctcacattagtgatgccaaccttgcaaataccataattggcaaagcagtggaacatatgtttgagggagagcatggttctaaggatgaatggagggggatggtcttagctcaagcacctatcatgaaagcctggttttatattacctatgagaaagatcctgtcttgtacatgtaccagcttctagatgattataaggaaggtgacctccgcatcatgccagaatccagtgagtctcctccaacagagagggagccaggaggagttgtagatggcctaataggtaagcatgtggaatataccaaagaagatggctccaaaaggatcggcatggtcattcaccaagtggaagccaaaccctctgtgtatttcatcaagtttgatgatgatttccatatctatgtctacgatttggtgaaaaagtcctaactgttagggtaaaatttggcacatgtgtggaaacaaatgtataatttgtagacatgcaaaaaatgttgcctttcagtgtattgaaagcttatggaatccctgataactaaacatctttgccagcattaactgttgttttgctctaaaaaatacaaacttgtgtgtacatgaaaaaaaaaaaaa

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