GGRNA | NM_001006681.1

LOCUS       NM_001006681            1277 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens spindlin family, member 2B (SPIN2B), transcript
            variant 1, mRNA.
ACCESSION   NM_001006681
VERSION     NM_001006681.1  GI:56682944
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1277)
  AUTHORS   Zhang,B., Abreu,J.G., Zhou,K., Chen,Y., Hu,Y., Zhou,T., He,X. and
            Ma,J.X.
  TITLE     Blocking the Wnt pathway, a unifying mechanism for an angiogenic
            inhibitor in the serine proteinase inhibitor family
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 107 (15), 6900-6905 (2010)
   PUBMED   20351274
  REMARK    GeneRIF: SERPINA3K is a high-affinity, endogenous antagonist of
            LRP6
REFERENCE   2  (bases 1 to 1277)
  AUTHORS   Lamesch,P., Li,N., Milstein,S., Fan,C., Hao,T., Szabo,G., Hu,Z.,
            Venkatesan,K., Bethel,G., Martin,P., Rogers,J., Lawlor,S.,
            McLaren,S., Dricot,A., Borick,H., Cusick,M.E., Vandenhaute,J.,
            Dunham,I., Hill,D.E. and Vidal,M.
  TITLE     hORFeome v3.1: a resource of human open reading frames representing
            over 10,000 human genes
  JOURNAL   Genomics 89 (3), 307-315 (2007)
   PUBMED   17207965
REFERENCE   3  (bases 1 to 1277)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   4  (bases 1 to 1277)
  AUTHORS   Fletcher,B.S., Dragstedt,C., Notterpek,L. and Nolan,G.P.
  TITLE     Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with
            roles in cell cycle progression
  JOURNAL   Leukemia 16 (8), 1507-1518 (2002)
   PUBMED   12145692
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ221120.1 and BC071974.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071974.1, BQ691589.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025082, ERS025083 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                BQ221120.1         13-80
            69-1277             BC071974.1         1-1209
FEATURES             Location/Qualifiers
     source          1..1277
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.1"
     gene            1..1277
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN2_duplicate"
                     /note="spindlin family, member 2B"
                     /db_xref="GeneID:474343"
                     /db_xref="HGNC:33147"
                     /db_xref="HPRD:18662"
                     /db_xref="MIM:300517"
     exon            1..309
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN2_duplicate"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    273..275
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN2_duplicate"
                     /note="upstream in-frame stop codon"
     exon            310..1259
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN2_duplicate"
                     /inference="alignment:Splign:1.39.8"
     CDS             312..1088
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN2_duplicate"
                     /note="telomeric SPIN2 copy; spindlin family, member 2
                     duplicate; SPIN-2B; spindlin-like protein 2B"
                     /codon_start=1
                     /product="spindlin-2B"
                     /protein_id="NP_001006682.1"
                     /db_xref="GI:56682945"
                     /db_xref="CCDS:CCDS35311.1"
                     /db_xref="GeneID:474343"
                     /db_xref="HGNC:33147"
                     /db_xref="HPRD:18662"
                     /db_xref="MIM:300517"
                     /translation="

MKTPNAQEAEGQQTRAAAGRATGSANMTKKKVSQKKQRGRPSSQPRRNIVGCRISHGWKEGDEPITQWKGTVLDQVPINPSLYLVKYDGIDCVYGLELHRDERVLSLKILSDRVASSHISDANLANTIIGKAVEHMFEGEHGSKDEWRGMVLAQAPIMKAWFYITYEKDPVLYMYQLLDDYKEGDLRIMPESSESPPTEREPGGVVDGLIGKHVEYTKEDGSKRIGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKKS

"
     misc_feature    459..605
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN2_duplicate"
                     /note="Spin/Ssty Family; Region: Spin-Ssty; pfam02513"
                     /db_xref="CDD:145577"
     misc_feature    696..842
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN2_duplicate"
                     /note="Spin/Ssty Family; Region: Spin-Ssty; pfam02513"
                     /db_xref="CDD:145577"
     misc_feature    939..1073
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN2_duplicate"
                     /note="Spin/Ssty Family; Region: Spin-Ssty; pfam02513"
                     /db_xref="CDD:145577"
     variation       1245
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN2_duplicate"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1736862"
     variation       1251
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN2_duplicate"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1736863"
     variation       1252
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN2_duplicate"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1736864"
     polyA_site      1259
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN2_duplicate"
ORIGIN

gagactgccgcggcgacagcagggactggtggaatcccgatgtggctgaggggccgccaccgccagcagggaggcggagggctagcgagccaagcggtggggacgccgctgccttcctctttgcctgtctcgccgccctcctagacacgctcctcatctacggatcctaccctccccgctcttgcaagcattcactcggccggtcgcctgctgaccctccttcgccacaggctcgtagcggaggcagcagcgaggtgtccgatttgggcacgtgaggcccgcgatccccggcggtggacgccaggcagggcatgaagacccccaacgcacaggaagccgaagggcaacaaaccagggcagctgcaggacgggccactgggtctgcaaacatgacaaagaaaaaagtctcccaaaagaagcagagaggccgaccttcatcccagccccgcaggaacatcgtgggctgcagaatttctcatggatggaaggaaggagatgagcccatcacgcagtggaaaggaaccgttctggatcaggtgcctataaatccctctctttatctggtgaaatatgatggaattgactgtgtctatggactggaacttcacagagatgaaagggttttgtctcttaaaattctttctgacagggtggcatcatctcacattagtgatgccaaccttgcaaataccataattggcaaagcagtggaacatatgtttgagggagagcatggttctaaggatgaatggagggggatggtcttagctcaagcacctatcatgaaagcctggttttatattacctatgagaaagatcctgtcttgtacatgtaccagcttctagatgattataaggaaggtgacctccgcatcatgccagaatccagtgagtctcctccaacagagagggagccaggaggagttgtagatggcctaataggtaagcatgtggaatataccaaagaagatggctccaaaaggatcggcatggtcattcaccaagtggaagccaaaccctctgtgtatttcatcaagtttgatgatgatttccatatctatgtctacgatttggtgaaaaagtcctaactgttagggtaaaatttggcacatgtgtggaaacaaatgtataatttgtagacatgcaaaaaatgttgcctttcagtgtattgaaagcttatggaatccctgataactaaacatctttgccagcattaactgttgttttgctctaaaaaatacaaacttgtgtgtacatgaaaaaaaaaaaaaaaaaaa

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