LOCUS       NM_001002026            3350 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens claudin 18 (CLDN18), transcript variant 2, mRNA.
ACCESSION   NM_001002026
VERSION     NM_001002026.2  GI:60115825
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3350)
  AUTHORS   Tanaka,M., Shibahara,J., Fukushima,N., Shinozaki,A., Umeda,M.,
            Ishikawa,S., Kokudo,N. and Fukayama,M.
  TITLE     Claudin-18 is an early-stage marker of pancreatic carcinogenesis
  JOURNAL   J. Histochem. Cytochem. 59 (10), 942-952 (2011)
   PUBMED   21832145
  REMARK    GeneRIF: Claudin 18 (a marker for early carcinogenesis) is commonly
            expressed in precursor lesions of pancreatic ductal
            adenocarcinomas. Activation of the protein kinase C pathway might
            be involved in claudin 18 expression associated with
            carcinogenesis.
REFERENCE   2  (bases 1 to 3350)
  AUTHORS   Shinozaki,A., Shibahara,J., Noda,N., Tanaka,M., Aoki,T., Kokudo,N.
            and Fukayama,M.
  TITLE     Claudin-18 in biliary neoplasms. Its significance in the
            classification of intrahepatic cholangiocarcinoma
  JOURNAL   Virchows Arch. 459 (1), 73-80 (2011)
   PUBMED   21607649
  REMARK    GeneRIF: These results suggest that CLDN18 may play an important
            role in biliary carcinogenesis.
REFERENCE   3  (bases 1 to 3350)
  AUTHORS   Ito,T., Kojima,T., Yamaguchi,H., Kyuno,D., Kimura,Y., Imamura,M.,
            Takasawa,A., Murata,M., Tanaka,S., Hirata,K. and Sawada,N.
  TITLE     Transcriptional regulation of claudin-18 via specific protein
            kinase C signaling pathways and modification of DNA methylation in
            human pancreatic cancer cells
  JOURNAL   J. Cell. Biochem. 112 (7), 1761-1772 (2011)
   PUBMED   21381080
  REMARK    GeneRIF: Cldn18 is primarily regulated at the transcriptional level
            via specific protein kinase C signaling pathways and modified by
            DNA methylation
REFERENCE   4  (bases 1 to 3350)
  AUTHORS   Lee,J.H., Kim,K.S., Kim,T.J., Hong,S.P., Song,S.Y., Chung,J.B. and
            Park,S.W.
  TITLE     Immunohistochemical analysis of claudin expression in pancreatic
            cystic tumors
  JOURNAL   Oncol. Rep. 25 (4), 971-978 (2011)
   PUBMED   21206985
  REMARK    GeneRIF: High claudin 18 is associated with intraductal papillary
            mucinous neoplasms of the pancreas.
REFERENCE   5  (bases 1 to 3350)
  AUTHORS   Merikallio,H., Paakko,P., Harju,T. and Soini,Y.
  TITLE     Claudins 10 and 18 are predominantly expressed in lung
            adenocarcinomas and in tumors of nonsmokers
  JOURNAL   Int J Clin Exp Pathol 4 (7), 667-673 (2011)
   PUBMED   22076167
  REMARK    GeneRIF: Claudin 10/18 are most commonly expressed in lung
            adenocarcinomas. Female patients and non-smokers express these
            claudins more commonly suggesting that they may play a part in the
            carcinogenesis of tobacco unrelated carcinoma.
REFERENCE   6  (bases 1 to 3350)
  AUTHORS   Tsukita,S. and Furuse,M.
  TITLE     Claudin-based barrier in simple and stratified cellular sheets
  JOURNAL   Curr. Opin. Cell Biol. 14 (5), 531-536 (2002)
   PUBMED   12231346
  REMARK    Review article
REFERENCE   7  (bases 1 to 3350)
  AUTHORS   Niimi,T., Nagashima,K., Ward,J.M., Minoo,P., Zimonjic,D.B.,
            Popescu,N.C. and Kimura,S.
  TITLE     claudin-18, a novel downstream target gene for the T/EBP/NKX2.1
            homeodomain transcription factor, encodes lung- and
            stomach-specific isoforms through alternative splicing
  JOURNAL   Mol. Cell. Biol. 21 (21), 7380-7390 (2001)
   PUBMED   11585919
REFERENCE   8  (bases 1 to 3350)
  AUTHORS   Tsukita,S., Furuse,M. and Itoh,M.
  TITLE     Multifunctional strands in tight junctions
  JOURNAL   Nat. Rev. Mol. Cell Biol. 2 (4), 285-293 (2001)
   PUBMED   11283726
  REMARK    Review article
REFERENCE   9  (bases 1 to 3350)
  AUTHORS   Heiskala,M., Peterson,P.A. and Yang,Y.
  TITLE     The roles of claudin superfamily proteins in paracellular transport
  JOURNAL   Traffic 2 (2), 93-98 (2001)
   PUBMED   11247307
  REMARK    Review article
REFERENCE   10 (bases 1 to 3350)
  AUTHORS   Kniesel,U. and Wolburg,H.
  TITLE     Tight junctions of the blood-brain barrier
  JOURNAL   Cell. Mol. Neurobiol. 20 (1), 57-76 (2000)
   PUBMED   10690502
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK098474.1, BM785703.1 and AY102073.1.
            On Feb 23, 2005 this sequence version replaced gi:50345278.
            
            Summary: This gene encodes a member of the claudin family. Claudins
            are integral membrane proteins and components of tight junction
            strands. Tight junction strands serve as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space between epithelial or endothelial cell sheets,
            and also play critical roles in maintaining cell polarity and
            signal transductions. This gene is upregulated in patients with
            ulcerative colitis and highly overexpressed in infiltrating ductal
            adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated
            protein kinase/activator protein-1) dependent pathway regulates the
            expression of this gene in gastric cells. Alternatively spliced
            transcript variants encoding different isoforms have been
            identified. [provided by RefSeq, Jun 2010].
            
            Transcript Variant: This variant (2) has an alternate 5' exon, as
            compared to variant 1. It encodes isoform 2, also known as isoform
            A2, which is of the same size but has a different N-terminus, as
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK098474.1, AF349452.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1855              AK098474.1         1-1855
            1856-2298           BM785703.1         143-585
            2299-2859           AK098474.1         2297-2857
            2860-3350           AY102073.1         394-884
FEATURES             Location/Qualifiers
     source          1..3350
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.3"
     gene            1..3350
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /note="claudin 18"
                     /db_xref="GeneID:51208"
                     /db_xref="HGNC:2039"
                     /db_xref="HPRD:13066"
                     /db_xref="MIM:609210"
     exon            1..273
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /inference="alignment:Splign:1.39.8"
     variation       30
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376871875"
     variation       31
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:182591960"
     variation       38
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372769842"
     CDS             54..839
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /note="isoform 2 is encoded by transcript variant 2;
                     surfactant associated 5; surfactant associated protein J;
                     surfactant, pulmonary associated protein J; claudin-18"
                     /codon_start=1
                     /product="claudin-18 isoform 2"
                     /protein_id="NP_001002026.1"
                     /db_xref="GI:50345279"
                     /db_xref="CCDS:CCDS33862.1"
                     /db_xref="GeneID:51208"
                     /db_xref="HGNC:2039"
                     /db_xref="HPRD:13066"
                     /db_xref="MIM:609210"
                     /translation="

MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV

"
     misc_feature    78..626
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl15797"
                     /db_xref="CDD:210197"
     variation       54
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138856042"
     variation       74
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375931549"
     variation       87
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41265445"
     variation       92
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369997981"
     variation       110
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:76095412"
     variation       135
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377095171"
     variation       171
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369029508"
     variation       180
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372993807"
     variation       205
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139388349"
     exon            274..438
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /inference="alignment:Splign:1.39.8"
     variation       296
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199724224"
     variation       307
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139920646"
     variation       315
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114998965"
     variation       317
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:144886047"
     variation       332
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377074436"
     variation       366
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369712344"
     variation       367
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200466463"
     variation       392
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:151166278"
     exon            439..556
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /inference="alignment:Splign:1.39.8"
     variation       448
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149872077"
     variation       450
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113915562"
     variation       498
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:17204075"
     variation       529
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147117084"
     exon            557..667
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /inference="alignment:Splign:1.39.8"
     variation       581
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376466507"
     variation       602
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201712712"
     variation       618
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201345180"
     variation       630
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370938675"
     variation       636
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138443095"
     variation       638
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:142534874"
     variation       643
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143363724"
     variation       663
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200763024"
     exon            668..3350
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /inference="alignment:Splign:1.39.8"
     variation       678
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:180927693"
     variation       688
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376205087"
     variation       695
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:16847742"
     variation       742
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375252888"
     variation       777
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141484279"
     variation       781
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376386414"
     variation       800
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370767483"
     variation       809
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150815158"
     variation       821
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374671741"
     variation       823
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138222227"
     variation       843
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200380058"
     variation       864
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199985015"
     variation       865
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372664208"
     variation       875
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201892247"
     variation       878
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374979503"
     variation       912
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:55923693"
     variation       1052
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:75363623"
     STS             1064..1830
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /standard_name="CLDN18_8037"
                     /db_xref="UniSTS:467609"
     variation       1076
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369925737"
     variation       1131..1132
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace=""
                     /replace="tc"
                     /db_xref="dbSNP:368788455"
     variation       1178
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186179451"
     variation       1258
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:150050712"
     variation       1287
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191425190"
     variation       1315
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145407892"
     variation       1346
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373078185"
     variation       1406
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:181450586"
     variation       1417
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116559189"
     variation       1420
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:76261706"
     variation       1442
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11707127"
     variation       1528
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11707222"
     variation       1596
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:186923182"
     variation       1639
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372249046"
     variation       1694
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374546679"
     variation       1738
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11707988"
     variation       1763
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:191710814"
     variation       1793
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148762227"
     variation       1856
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:6804932"
     variation       1876
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:143810887"
     variation       1980
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1141890"
     variation       1992
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:6804883"
     variation       2116
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372621582"
     variation       2186..2187
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:200226240"
     variation       2208
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:74535985"
     variation       2225
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376231633"
     variation       2276
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:9858250"
     variation       2304
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:183153196"
     variation       2425
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146812070"
     variation       2487
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140627353"
     variation       2673
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:76613552"
     variation       2752
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:62280604"
     variation       2767
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:9825593"
     variation       2794
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187828330"
     variation       2795
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:189567724"
     variation       2860
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2589258"
     variation       3007
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:182214462"
     STS             3064..3183
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /standard_name="RH18207"
                     /db_xref="UniSTS:2978"
     variation       3068
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151047753"
     variation       3101
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187774253"
     variation       3113
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:140941500"
     variation       3132
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376101110"
     variation       3181
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150154800"
     variation       3204
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115125952"
     variation       3274
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:76203754"
     variation       3281
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:59733755"
     variation       3283
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:73867007"
ORIGIN      

agaattgcgctgtccacttgtcgtgtggctctgtgtcgacactgtgcgccaccatggccgtgactgcctgtcagggcttggggttcgtggtttcactgattgggattgcgggcatcattgctgccacctgcatggaccagtggagcacccaagacttgtacaacaaccccgtaacagctgttttcaactaccaggggctgtggcgctcctgtgtccgagagagctctggcttcaccgagtgccggggctacttcaccctgctggggctgccagccatgctgcaggcagtgcgagccctgatgatcgtaggcatcgtcctgggtgccattggcctcctggtatccatctttgccctgaaatgcatccgcattggcagcatggaggactctgccaaagccaacatgacactgacctccgggatcatgttcattgtctcaggtctttgtgcaattgctggagtgtctgtgtttgccaacatgctggtgactaacttctggatgtccacagctaacatgtacaccggcatgggtgggatggtgcagactgttcagaccaggtacacatttggtgcggctctgttcgtgggctgggtcgctggaggcctcacactaattgggggtgtgatgatgtgcatcgcctgccggggcctggcaccagaagaaaccaactacaaagccgtttcttatcatgcctcaggccacagtgttgcctacaagcctggaggcttcaaggccagcactggctttgggtccaacaccaaaaacaagaagatatacgatggaggtgcccgcacagaggacgaggtacaatcttatccttccaagcacgactatgtgtaatgctctaagacctctcagcacgggcggaagaaactcccggagagctcacccaaaaaacaaggagatcccatctagatttcttcttgcttttgactcacagctggaagttagaaaagcctcgatttcatctttggagaggccaaatggtcttagcctcagtctctgtctctaaatattccaccataaaacagctgagttatttatgaattagaggctatagctcacattttcaatcctctatttctttttttaaatataactttctactctgatgagagaatgtggttttaatctctctctcacattttgatgatttagacagactccccctcttcctcctagtcaataaacccattgatgatctatttcccagcttatccccaagaaaacttttgaaaggaaagagtagacccaaagatgttattttctgctgtttgaattttgtctccccacccccaacttggctagtaataaacacttactgaagaagaagcaataagagaaagatatttgtaatctctccagcccatgatctcggttttcttacactgtgatcttaaaagttaccaaaccaaagtcattttcagtttgaggcaaccaaacctttctactgctgttgacatcttcttattacagcaacaccattctaggagtttcctgagctctccactggagtcctctttctgtcgcgggtcagaaattgtccctagatgaatgagaaaattattttttttaatttaagtcctaaatatagttaaaataaataatgttttagtaaaatgatacactatctctgtgaaatagcctcacccctacatgtggatagaaggaaatgaaaaaataattgctttgacattgtctatatggtactttgtaaagtcatgcttaagtacaaattccatgaaaagctcactgatcctaattctttccctttgaggtctctatggctctgattgtacatgatagtaagtgtaagccatgtaaaaagtaaataatgtctgggcacagtggctcacgcctgtaatcctagcactttgggaggctgaggaggaaggatcacttgagcccagaagttcgagactagcctgggcaacatggagaagccctgtctctacaaaatacagagagaaaaaatcagccagtcatggtggcctacacctgtagtcccagcattccgggaggctgaggtgggaggatcacttgagcccagggaggttggggctgcagtgagccatgatcacaccactgcactccagccaggtgacatagcgagatcctgtctaaaaaaataaaaaataaataatggaacacagcaagtcctaggaagtaggttaaaactaattctttaaaaaaaaaaaaaagttgagcctgaattaaatgtaatgtttccaagtgacaggtatccacatttgcatggttacaagccactgccagttagcagtagcactttcctggcactgtggtcggttttgttttgttttgctttgtttagagacggggtctcactttccaggctggcctcaaactcctgcactcaagcaattcttctaccctggcctcccaagtagctggaattacaggtgtgcgccatcacaactagctggtggtcagttttgttactctgagagctgttcacttctctgaattcacctagagtggttggaccatcagatgtttgggcaaaactgaaagctctttgcaaccacacaccttccctgagcttacatcactgcccttttgagcagaaagtctaaattccttccaagacagtagaattccatcccagtaccaaagccagataggccccctaggaaactgaggtaagagcagtctctaaaaactacccacagcagcattggtgcaggggaacttggccattaggttattatttgagaggaaagtcctcacatcaatagtacatatgaaagtgacctccaaggggattggtgaatactcataaggatcttcaggctgaacagactatgtctggggaaagaacggattatgccccattaaataacaagttgtgttcaagagtcagagcagtgagctcagaggcccttctcactgagacagcaacatttaaaccaaaccagaggaagtatttgtggaactcactgcctcagtttgggtaaaggatgagcagacaagtcaactaaagaaaaaagaaaagcaaggaggagggttgagcaatctagagcatggagtttgttaagtgctctctggatttgagttgaagagcatccatttgagttgaaggccacagggcacaatgagctctcccttctaccaccagaaagtccctggtcaggtctcaggtagtgcggtgtggctcagctgggtttttaattagcgcattctctatccaacatttaattgtttgaaagcctccatatagttagattgtgctttgtaattttgttgttgttgctctatcttattgtatatgcattgagtattaacctgaatgttttgttacttaaatattaaaaacactgttatcctacagtt

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:51208 -> Molecular function: GO:0005198 [structural molecule activity] evidence: IEA
            GeneID:51208 -> Molecular function: GO:0042802 [identical protein binding] evidence: ISS
            GeneID:51208 -> Biological process: GO:0016338 [calcium-independent cell-cell adhesion] evidence: ISS
            GeneID:51208 -> Biological process: GO:0034329 [cell junction assembly] evidence: TAS
            GeneID:51208 -> Biological process: GO:0045216 [cell-cell junction organization] evidence: TAS
            GeneID:51208 -> Biological process: GO:0070830 [tight junction assembly] evidence: TAS
            GeneID:51208 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
            GeneID:51208 -> Cellular component: GO:0005923 [tight junction] evidence: ISS
            GeneID:51208 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA