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2024-03-29 09:10:12, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001001933            2393 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens LIM homeobox 8 (LHX8), transcript variant 1, mRNA.
ACCESSION   NM_001001933 XM_086344
VERSION     NM_001001933.1  GI:50083286
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2393)
  AUTHORS   Jagarlamudi,K. and Rajkovic,A.
  TITLE     Oogenesis: transcriptional regulators and mouse models
  JOURNAL   Mol. Cell. Endocrinol. 356 (1-2), 31-39 (2012)
   PUBMED   21856374
  REMARK    Review article
REFERENCE   2  (bases 1 to 2393)
  AUTHORS   Paschou P, Stylianopoulou E, Karagiannidis I, Rizzo R, Tarnok Z,
            Wolanczyk T, Hebebrand J, Nothen MM, Lehmkuhl G, Farkas L, Nagy P,
            Szymanska U, Lykidis D, Androutsos C, Tsironi V, Koumoula A, Barta
            C, Klidonas S, Ypsilantis P, Simopoulos C, Skavdis G and Grigoriou
            M.
  CONSRTM   TSGeneSEE Consortium
  TITLE     Evaluation of the LIM homeobox genes LHX6 and LHX8 as candidates
            for Tourette syndrome
  JOURNAL   Genes Brain Behav. 11 (4), 444-451 (2012)
   PUBMED   22435649
  REMARK    GeneRIF: Our tagging-single nucleotide polymorphism (tSNP)-based
            association analysis was negative for Tourette syndrome association
            with LHX8.
REFERENCE   3  (bases 1 to 2393)
  AUTHORS   Nat,R., Salti,A., Suciu,L., Strom,S. and Dechant,G.
  TITLE     Pharmacological modulation of the Hedgehog pathway differentially
            affects dorsal/ventral patterning in mouse and human embryonic stem
            cell models of telencephalic development
  JOURNAL   Stem Cells Dev. 21 (7), 1016-1046 (2012)
   PUBMED   22204396
REFERENCE   4  (bases 1 to 2393)
  AUTHORS   Nikopensius,T., Kempa,I., Ambrozaityte,L., Jagomagi,T., Saag,M.,
            Matuleviciene,A., Utkus,A., Krjutskov,K., Tammekivi,V., Piekuse,L.,
            Akota,I., Barkane,B., Krumina,A., Klovins,J., Lace,B., Kucinskas,V.
            and Metspalu,A.
  TITLE     Variation in FGF1, FOXE1, and TIMP2 genes is associated with
            nonsyndromic cleft lip with or without cleft palate
  JOURNAL   Birth Defects Res. Part A Clin. Mol. Teratol. 91 (4), 218-225
            (2011)
   PUBMED   21462296
REFERENCE   5  (bases 1 to 2393)
  AUTHORS   Kim,J.Y., Jeon,S.H., Park,J.Y., Suh,J.D. and Choung,P.H.
  TITLE     Comparative study of LHX8 expression between odontoma and dental
            tissue-derived stem cells
  JOURNAL   J. Oral Pathol. Med. 40 (3), 250-256 (2011)
   PUBMED   21143530
  REMARK    GeneRIF: LHX8 might play an important role in odontoma formation.
            This is 1st report on comparison of LHX8 expression between human
            odontoma-derived mesenchymal cells and normal adult dental
            mesenchymal stem cells and its overexpression in human samples.
REFERENCE   6  (bases 1 to 2393)
  AUTHORS   Qin,Y., Zhao,H., Kovanci,E., Simpson,J.L., Chen,Z.J. and
            Rajkovic,A.
  TITLE     Analysis of LHX8 mutation in premature ovarian failure
  JOURNAL   Fertil. Steril. 89 (4), 1012-1014 (2008)
   PUBMED   17624344
  REMARK    GeneRIF: Mutations in the LHX8 exons are uncommon in Caucasian
            women with premature ovarian failure.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2393)
  AUTHORS   Suzumori,N., Pangas,S.A. and Rajkovic,A.
  TITLE     Candidate genes for premature ovarian failure
  JOURNAL   Curr. Med. Chem. 14 (3), 353-357 (2007)
   PUBMED   17305537
  REMARK    Review article
REFERENCE   8  (bases 1 to 2393)
  AUTHORS   Pangas,S.A., Choi,Y., Ballow,D.J., Zhao,Y., Westphal,H.,
            Matzuk,M.M. and Rajkovic,A.
  TITLE     Oogenesis requires germ cell-specific transcriptional regulators
            Sohlh1 and Lhx8
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 103 (21), 8090-8095 (2006)
   PUBMED   16690745
  REMARK    GeneRIF: Sohlh1 and Lhx8 are two germ cell-specific, critical
            regulators of oogenesis
REFERENCE   9  (bases 1 to 2393)
  AUTHORS   Vieira,A.R., Avila,J.R., Daack-Hirsch,S., Dragan,E., Felix,T.M.,
            Rahimov,F., Harrington,J., Schultz,R.R., Watanabe,Y., Johnson,M.,
            Fang,J., O'Brien,S.E., Orioli,I.M., Castilla,E.E.,
            Fitzpatrick,D.R., Jiang,R., Marazita,M.L. and Murray,J.C.
  TITLE     Medical sequencing of candidate genes for nonsyndromic cleft lip
            and palate
  JOURNAL   PLoS Genet. 1 (6), E64 (2005)
   PUBMED   16327884
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 2393)
  AUTHORS   Zhao,Y., Guo,Y.J., Tomac,A.C., Taylor,N.R., Grinberg,A., Lee,E.J.,
            Huang,S. and Westphal,H.
  TITLE     Isolated cleft palate in mice with a targeted mutation of the LIM
            homeobox gene lhx8
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 96 (26), 15002-15006 (1999)
   PUBMED   10611327
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC099786.2 and BC040321.1.
            On Aug 30, 2004 this sequence version replaced gi:51458577.
            
            Summary: The protein encoded by this gene is a member of the LIM
            homeobox family of proteins, which are involved in patterning and
            differentiation of various tissue types. These proteins contain two
            tandemly repeated cysteine-rich double-zinc finger motifs known as
            LIM domains, in addition to a DNA-binding homeodomain. This family
            member is a transcription factor that plays a role in tooth
            morphogenesis. It is also involved in oogenesis and in neuronal
            differentiation. This gene is a candidate gene for cleft palate,
            and it is also associated with odontoma formation. Alternative
            splicing of this gene results in multiple transcript variants.
            [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040321.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025085 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC099786.2         137235-137237
            4-515               BC040321.1         4-515
            516-516             AC099786.2         139367-139367
            517-1553            BC040321.1         517-1553
            1554-1554           AC099786.2         165773-165773
            1555-2393           BC040321.1         1555-2393
FEATURES             Location/Qualifiers
     source          1..2393
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..2393
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /note="LIM homeobox 8"
                     /db_xref="GeneID:431707"
                     /db_xref="HGNC:28838"
                     /db_xref="HPRD:17275"
                     /db_xref="MIM:604425"
     exon            1..175
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /inference="alignment:Splign:1.39.8"
     variation       36
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:41289228"
     variation       71
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:182226067"
     exon            176..682
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /inference="alignment:Splign:1.39.8"
     variation       194
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:142466848"
     variation       223
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:192939997"
     variation       241
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:41289230"
     variation       433
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111227275"
     variation       504
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375399829"
     variation       595
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41289232"
     variation       635
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200867886"
     variation       646
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200115972"
     variation       649
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191646269"
     variation       653
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:41289234"
     misc_feature    656..658
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /note="upstream in-frame stop codon"
     CDS             665..1735
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     LIM-homeodomain protein Lhx8; LIM/homeobox protein Lhx8"
                     /codon_start=1
                     /product="LIM/homeobox protein Lhx8 isoform 1"
                     /protein_id="NP_001001933.1"
                     /db_xref="GI:50083287"
                     /db_xref="CCDS:CCDS30756.1"
                     /db_xref="GeneID:431707"
                     /db_xref="HGNC:28838"
                     /db_xref="HPRD:17275"
                     /db_xref="MIM:604425"
                     /translation="
MQILSRCQGLMSEECGRTTALAAGRTRKGAGEEGLVSPEGAGDEDSCSSSAPLSPSSSPRSMASGSGCPPGKCVCNSCGLEIVDKYLLKVNDLCWHVRCLSCSVCRTSLGRHTSCYIKDKDIFCKLDYFRRYGTRCSRCGRHIHSTDWVRRAKGNVYHLACFACFSCKRQLSTGEEFALVEEKVLCRVHYDCMLDNLKREVENGNGISVEGALLTEQDVNHPKPAKRARTSFTADQLQVMQAQFAQDNNPDAQTLQKLAERTGLSRRVIQVWFQNCRARHKKHVSPNHSSSTPVTAVPPSRLSPPMLEEMAYSAYVPQDGTMLTALHSYMDAHSPTTLGLQPLLPHSMTQLPISHT
"
     misc_feature    884..1051
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /note="The first LIM domain of Lhx7 and Lhx8; Region:
                     LIM1_Lhx7_Lhx8; cd09381"
                     /db_xref="CDD:188767"
     misc_feature    order(887..889,896..898,950..952,959..961,968..970,
                     977..979,1034..1036,1043..1045)
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188767"
     misc_feature    1070..1234
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /note="The second LIM domain of Lhx7 and Lhx8; Region:
                     LIM2_Lhx7_Lhx8; cd09383"
                     /db_xref="CDD:188769"
     misc_feature    order(1070..1072,1079..1081,1136..1138,1145..1147,
                     1154..1156,1163..1165,1220..1222,1229..1231)
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188769"
     misc_feature    1340..1513
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(1340..1354,1358..1360,1409..1411,1427..1429,
                     1466..1468,1472..1477,1484..1489,1493..1501,1505..1510)
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(1346..1348,1355..1357,1475..1477,1484..1489,
                     1496..1498)
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     variation       675
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202103118"
     exon            683..769
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /inference="alignment:Splign:1.39.8"
     variation       695
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:116590034"
     variation       713
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376772505"
     variation       744
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:143612358"
     variation       754
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140847718"
     variation       765
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369761078"
     exon            770..931
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /inference="alignment:Splign:1.39.8"
     variation       775
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369347146"
     variation       786
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141641179"
     variation       792
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373338242"
     variation       811
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371247581"
     variation       814
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:145195318"
     variation       817
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371111953"
     variation       842
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376300206"
     variation       907
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149422695"
     exon            932..1053
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /inference="alignment:Splign:1.39.8"
     variation       936
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:373880349"
     variation       1001
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199843823"
     exon            1054..1274
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /inference="alignment:Splign:1.39.8"
     variation       1068
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367958622"
     variation       1084
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148556375"
     variation       1090
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376834338"
     variation       1100
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371719492"
     variation       1105
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12084309"
     variation       1108
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:374741343"
     variation       1264
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372110957"
     exon            1275..1378
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /inference="alignment:Splign:1.39.8"
     variation       1276
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376728766"
     variation       1300
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147867930"
     exon            1379..1474
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /inference="alignment:Splign:1.39.8"
     exon            1475..1658
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /inference="alignment:Splign:1.39.8"
     variation       1477
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:79714503"
     variation       1513
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:941032"
     variation       1521
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200810970"
     variation       1559
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201945188"
     variation       1564
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144728419"
     variation       1567
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375095039"
     variation       1591
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:368509617"
     variation       1609
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370428970"
     variation       1610
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374046822"
     variation       1627
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145367581"
     variation       1638
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34889650"
     exon            1659..2373
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /inference="alignment:Splign:1.39.8"
     variation       1706
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368782371"
     variation       1714
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:377005651"
     variation       1769
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:41306167"
     variation       1784
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199821156"
     variation       1786
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41301265"
     variation       1833
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184821578"
     variation       1930
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:187614610"
     variation       2008
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374351080"
     variation       2045
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:192190181"
     variation       2099
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142785057"
     variation       2152
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184182933"
     variation       2213
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147403016"
     variation       2299
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190197837"
     variation       2311
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4949795"
     polyA_signal    2341..2346
                     /gene="LHX8"
                     /gene_synonym="LHX7"
     variation       2352
                     /gene="LHX8"
                     /gene_synonym="LHX7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377666437"
     polyA_site      2373
                     /gene="LHX8"
                     /gene_synonym="LHX7"
ORIGIN      
agaggcaagaggctagcggctggaccacttgtgctggagtggtaaagaactatcatgaatccatttactgaaagtgtccatttctgaactcaccctaaagaggacaaacaccgcaaagtagttaaaagtcaggcattcgcgtcggacgtctgggtttgaattctgccctggcttgactggaaacgcttcccctatttcttccgtagcggaccgggagagcttactggcgctctgcgaaccggctggaaagaaacaccgagtcactcgtacagactcttggtcgcagaacttggctttccgctattggtcctccagaaccgcttgaaacaactggccccagctggcgcatcagaccgcagtgaggaatgccgcggggcgggtggcgaaggcagggtctgcccgccagtggattcccgggtgtcccgcgtggagcaggcttgcccagctgggaagcccatcaaacctcagtcttggcccacagtgggagagagaccagtgggtcccagacggaggccctcgcccgcttttggcgacctccactggcgtgaataaaagcacccctctcttaccctcagaaactgtgggtagcaaggtataaaacggagtctgggaccggtaagtcccaaggtgagcccgtatacagctctgccatctctgaggggttatgcagattctgagcaggtgtcaggggctcatgtcagaggagtgcgggcggactacagccctggcggccgggaggactcgcaaaggcgccggggaagagggactggtgagccccgagggagcgggggacgaggactcgtgctcctcctcggccccgctgtccccgtcgtcctcgccccggtccatggcctcgggctccggctgccctcctggcaagtgtgtgtgcaacagttgcggcctggagatcgtggacaaataccttctcaaggtgaatgacctatgctggcatgtccggtgtctctcctgcagtgtttgcagaacctccctaggaaggcacaccagctgttatattaaagacaaagacattttctgcaaacttgattatttcagaaggtatggaactcgctgctctcgatgtgggagacacatccattctactgactgggtccggagagccaaggggaatgtctatcacttggcatgctttgcctgcttttcctgcaaaaggcaactttccacaggagaggagtttgctttggtggaagagaaagtcctctgcagagtacattatgactgcatgctggataatttaaaaagagaagtagaaaatgggaatgggattagtgtggaaggtgccctcctcacagagcaagatgttaaccatccaaaaccagcaaaaagagctcggaccagctttacagcagatcagcttcaggttatgcaagcacaatttgctcaggacaacaacccagatgcacagacactccagaaattggcagaaaggacaggcttgagcagacgtgtgatacaggtgtggtttcagaattgtagagcacgccacaagaaacacgtcagtcctaatcactcatcctccaccccagtcacagcagtcccaccctccaggctgtctccacccatgttagaagaaatggcttattctgcctacgtgccccaagatggaacgatgttaactgcgctgcatagttatatggatgctcattcaccaacaactcttggactccagcccttgttaccccattcaatgacacaactgccaataagtcatacctaattcttttttcagggatagacttgattaaggatataaatttgtcatttattatgtataaaataccattgaaaagatattactgttaattttttatttaacacctaaagcatttccaacatcactttgctgcccaggtatgtatctatagttggcctgcaagacacttttattaattcttcattttttgtaaaacttatgtttacaagaagaaaacaaatcaaaacattttttgtattgtctggaaatagttcactctagtgtgtatctgttaatttatttgtcatcaaaagagcactttgcctaaaagaaaggactgacaagtgtgcaaaatgtttacaatcttttgtgaaattgtagtttatcattagtttgtatctgtaagttattgtaataaatattacctgtattttttgttatatacaactttatactttgaagcttgtatctgtgaatttgcaactgaaatttattttgccaatgttttctgaatgaactgaataaagcttctgttgtagcatgccatgcaaacacattattgtgtttgtggttgatgaattatggctgtaaataacactatagtttaataagcccaccattctgagtttattaaacattttccattcttgtgaaaatttcaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:431707 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:431707 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
            GeneID:431707 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:431707 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:431707 -> Biological process: GO:0007611 [learning or memory] evidence: IEA
            GeneID:431707 -> Biological process: GO:0008585 [female gonad development] evidence: IEA
            GeneID:431707 -> Biological process: GO:0021884 [forebrain neuron development] evidence: IEA
            GeneID:431707 -> Biological process: GO:0042475 [odontogenesis of dentin-containing tooth] evidence: IEA
            GeneID:431707 -> Cellular component: GO:0005634 [nucleus] evidence: IEA

by @meso_cacase at DBCLS
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