Home |
Help |
Advanced search
2024-04-19 18:17:17, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_000945 3111 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens protein phosphatase 3, regulatory subunit B, alpha
(PPP3R1), mRNA.
ACCESSION NM_000945
VERSION NM_000945.3 GI:45238847
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3111)
AUTHORS Goodyer,W.R., Gu,X., Liu,Y., Bottino,R., Crabtree,G.R. and Kim,S.K.
TITLE Neonatal beta cell development in mice and humans is regulated by
calcineurin/NFAT
JOURNAL Dev. Cell 23 (1), 21-34 (2012)
PUBMED 22814600
REMARK GeneRIF: Pancreatic beta cells lacking Cnb1 fail to express genes
revealed to be direct NFAT targets required for replication,
insulin storage, and secretion.
REFERENCE 2 (bases 1 to 3111)
AUTHORS Su,Z., Xin,S., Xu,L., Cheng,J., Guo,J., Li,L. and Wei,Q.
TITLE The calcineurin B subunit induces TNF-related apoptosis-inducing
ligand (TRAIL) expression via CD11b-NF-kappaB pathway in RAW264.7
macrophages
JOURNAL Biochem. Biophys. Res. Commun. 417 (2), 777-783 (2012)
PUBMED 22197822
REMARK GeneRIF: These findings reveal a novel signaling pathway
(CnB-CD11b-NF-kappaB-TRAIL) regulating TRAIL expression and may
help to understand the roles of the calcineurin B subunit in the
regulation of innate immunity.
REFERENCE 3 (bases 1 to 3111)
AUTHORS Li,J., Hu,M., Guo,J., Su,Z. and Wei,Q.
TITLE Calcineurin subunit B is an immunostimulatory protein and acts as a
vaccine adjuvant inducing protective cellular and humoral responses
against pneumococcal infection
JOURNAL Immunol. Lett. 140 (1-2), 52-58 (2011)
PUBMED 21722668
REMARK GeneRIF: immunostimulatory protein and acts as a vaccine adjuvant
inducing protective cellular and humoral responses against
pneumococcal infection
REFERENCE 4 (bases 1 to 3111)
AUTHORS Cheng,J., Tang,W., Su,Z. and Wei,Q.
TITLE Mutation of calcineurin subunit B M118 influences the activities of
NF-AT and p53, but not calcineurin expression level
JOURNAL Biochem. Biophys. Res. Commun. 413 (3), 481-486 (2011)
PUBMED 21910968
REMARK GeneRIF: CnB M118K fails to enhance the activities of NF-AT and p53
induced by CnA in HeLa-s cells.
REFERENCE 5 (bases 1 to 3111)
AUTHORS Frischbutter,S., Gabriel,C., Bendfeldt,H., Radbruch,A. and
Baumgrass,R.
TITLE Dephosphorylation of Bcl-10 by calcineurin is essential for
canonical NF-kappaB activation in Th cells
JOURNAL Eur. J. Immunol. 41 (8), 2349-2357 (2011)
PUBMED 21674474
REMARK GeneRIF: Findings demonstrate that CaN functions as a critical
signaling molecule during Th cell activation, regulating Bcl-10
phosphorylation and NF-kappaB activation.
REFERENCE 6 (bases 1 to 3111)
AUTHORS Wang,M.G., Yi,H., Guerini,D., Klee,C.B. and McBride,O.W.
TITLE Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and
calcineurin B (PPP3R1) are located on human chromosomes 4,
10q21-->q22 and 2p16-->p15 respectively
JOURNAL Cytogenet. Cell Genet. 72 (2-3), 236-241 (1996)
PUBMED 8978785
REFERENCE 7 (bases 1 to 3111)
AUTHORS Kissinger,C.R., Parge,H.E., Knighton,D.R., Lewis,C.T.,
Pelletier,L.A., Tempczyk,A., Kalish,V.J., Tucker,K.D.,
Showalter,R.E., Moomaw,E.W. et al.
TITLE Crystal structures of human calcineurin and the human
FKBP12-FK506-calcineurin complex
JOURNAL Nature 378 (6557), 641-644 (1995)
PUBMED 8524402
REFERENCE 8 (bases 1 to 3111)
AUTHORS Kawamura,A. and Su,M.S.
TITLE Interaction of FKBP12-FK506 with calcineurin A at the B
subunit-binding domain
JOURNAL J. Biol. Chem. 270 (26), 15463-15466 (1995)
PUBMED 7541044
REFERENCE 9 (bases 1 to 3111)
AUTHORS Guerini,D., Krinks,M.H., Sikela,J.M., Hahn,W.E. and Klee,C.B.
TITLE Isolation and sequence of a cDNA clone for human calcineurin B, the
Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein
phosphatase
JOURNAL DNA 8 (9), 675-682 (1989)
PUBMED 2558868
REFERENCE 10 (bases 1 to 3111)
AUTHORS King,M.M., Huang,C.Y., Chock,P.B., Nairn,A.C., Hemmings,H.C. Jr.,
Chan,K.F. and Greengard,P.
TITLE Mammalian brain phosphoproteins as substrates for calcineurin
JOURNAL J. Biol. Chem. 259 (13), 8080-8083 (1984)
PUBMED 6330098
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BM468705.1, BC027913.1 and BQ228635.1.
On Mar 8, 2004 this sequence version replaced gi:24431941.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC027913.1, AL528885.3 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025098 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-368 BM468705.1 31-398
369-2709 BC027913.1 365-2705
2710-2720 BQ228635.1 732-742
2721-3111 BC027913.1 2716-3106
FEATURES Location/Qualifiers
source 1..3111
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p15"
gene 1..3111
/gene="PPP3R1"
/gene_synonym="CALNB1; CNB; CNB1"
/note="protein phosphatase 3, regulatory subunit B, alpha"
/db_xref="GeneID:5534"
/db_xref="HGNC:9317"
/db_xref="HPRD:03195"
/db_xref="MIM:601302"
exon 1..395
/gene="PPP3R1"
/gene_synonym="CALNB1; CNB; CNB1"
/inference="alignment:Splign:1.39.8"
misc_feature 336..338
/gene="PPP3R1"
/gene_synonym="CALNB1; CNB; CNB1"
/note="upstream in-frame stop codon"
CDS 393..905
/gene="PPP3R1"
/gene_synonym="CALNB1; CNB; CNB1"
/EC_number="3.1.3.16"
/note="protein phosphatase 2B regulatory subunit B alpha;
protein phosphatase 3 (formerly 2B), regulatory subunit B
(19kD), alpha isoform (calcineurin B, type I); protein
phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa,
alpha isoform (calcineurin B, type I); protein phosphatase
3 (formerly 2B), regulatory subunit B, alpha isoform;
calcineurin B, type I (19kDa); protein phosphatase 2B
regulatory subunit 1"
/codon_start=1
/product="calcineurin subunit B type 1"
/protein_id="NP_000936.1"
/db_xref="GI:4506025"
/db_xref="CCDS:CCDS46310.1"
/db_xref="GeneID:5534"
/db_xref="HGNC:9317"
/db_xref="HPRD:03195"
/db_xref="MIM:601302"
/translation="
MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDV
"
misc_feature 444..854
/gene="PPP3R1"
/gene_synonym="CALNB1; CNB; CNB1"
/note="calmodulin; Provisional; Region: PTZ00184"
/db_xref="CDD:185504"
misc_feature 465..632
/gene="PPP3R1"
/gene_synonym="CALNB1; CNB; CNB1"
/note="EF-hand, calcium binding motif; A diverse
superfamily of calcium sensors and calcium signal
modulators; most examples in this alignment model have 2
active canonical EF hands. Ca2+ binding induces a
conformational change in the EF-hand motif, leading to...;
Region: EFh; cd00051"
/db_xref="CDD:238008"
misc_feature order(483..485,489..491,495..497,516..518,579..581,
585..587,591..593,612..614)
/gene="PPP3R1"
/gene_synonym="CALNB1; CNB; CNB1"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:238008"
misc_feature 663..863
/gene="PPP3R1"
/gene_synonym="CALNB1; CNB; CNB1"
/note="EF-hand, calcium binding motif; A diverse
superfamily of calcium sensors and calcium signal
modulators; most examples in this alignment model have 2
active canonical EF hands. Ca2+ binding induces a
conformational change in the EF-hand motif, leading to...;
Region: EFh; cd00051"
/db_xref="CDD:238008"
misc_feature order(690..692,696..698,702..704,723..725,813..815,
819..821,825..827,846..848)
/gene="PPP3R1"
/gene_synonym="CALNB1; CNB; CNB1"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:238008"
exon 396..435
/gene="PPP3R1"
/gene_synonym="CALNB1; CNB; CNB1"
/inference="alignment:Splign:1.39.8"
exon 436..612
/gene="PPP3R1"
/gene_synonym="CALNB1; CNB; CNB1"
/inference="alignment:Splign:1.39.8"
STS 462..611
/gene="PPP3R1"
/gene_synonym="CALNB1; CNB; CNB1"
/standard_name="G44336"
/db_xref="UniSTS:95123"
variation 491
/gene="PPP3R1"
/gene_synonym="CALNB1; CNB; CNB1"
/replace="c"
/replace="t"
/db_xref="dbSNP:687"
exon 613..672
/gene="PPP3R1"
/gene_synonym="CALNB1; CNB; CNB1"
/inference="alignment:Splign:1.39.8"
exon 673..857
/gene="PPP3R1"
/gene_synonym="CALNB1; CNB; CNB1"
/inference="alignment:Splign:1.39.8"
exon 858..3011
/gene="PPP3R1"
/gene_synonym="CALNB1; CNB; CNB1"
/inference="alignment:Splign:1.39.8"
STS 1016..1340
/gene="PPP3R1"
/gene_synonym="CALNB1; CNB; CNB1"
/standard_name="D2S2724"
/db_xref="UniSTS:75166"
variation 1074
/gene="PPP3R1"
/gene_synonym="CALNB1; CNB; CNB1"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:875"
variation 1107
/gene="PPP3R1"
/gene_synonym="CALNB1; CNB; CNB1"
/replace="a"
/replace="c"
/db_xref="dbSNP:3730336"
variation 1323
/gene="PPP3R1"
/gene_synonym="CALNB1; CNB; CNB1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3770643"
STS 1539..2294
/gene="PPP3R1"
/gene_synonym="CALNB1; CNB; CNB1"
/standard_name="PPP3R1_8560"
/db_xref="UniSTS:467841"
STS 1768..2060
/gene="PPP3R1"
/gene_synonym="CALNB1; CNB; CNB1"
/standard_name="G60033"
/db_xref="UniSTS:137299"
STS 1768..1941
/gene="PPP3R1"
/gene_synonym="CALNB1; CNB; CNB1"
/standard_name="RH120881"
/db_xref="UniSTS:25450"
ORIGIN
gcgggtcagcgcgagccgctgcagtgagtccgtcacggctccggcgcgagcgcgaggctgcagcccccgagtttcccggccgtcttcgccccctctccccctcctttcttcttctctgcctctcctgcctctcgccgctgctcctcccgcgctctccggctctgaatctcgaccttaatttatttccccctaccctgcccgctccctcgcgtgcccaatcgcccggccggcgcgggccccgcggcgccgcctcccctcccccacgcgcgccccctccccgccggcgacccgagggccgcagctgggccgccgccgccgtttcctgcgagccagcctgagcgcaacacttctccgagccagcgagccagcgagccgccgacccgccgagcaaaatgggaaatgaggcaagttatcctttggaaatgtgctcacactttgatgcggatgaaattaaaaggctaggaaagagatttaagaagcttgatttggacaattctggttctttgagtgtggaagagttcatgtctctgcctgagttacaacagaatcctttagtacagcgagtaatagatatattcgacacagatgggaatggagaagtagactttaaagaattcattgagggcgtctctcagttcagtgtcaaaggagataaggagcagaaattgaggtttgctttccgtatctatgacatggataaagatggctatatttccaatggggaactcttccaggtattgaagatgatggtggggaacaatctgaaagatacacagttacagcaaattgtagacaaaaccataataaatgcagataaggatggagatggaagaatatcctttgaagaattctgtgctgttgtaggtggcctagatatccacaaaaagatggtggtagatgtgtgactcttatcagagagtaccacccaacacttttgctttcttctccatctctgaagatctgctcaagacgtccagcaatgctctctgtgtatttaaatggaagtatttttctctgtgaagccacattttccaacatgagcctcatgaagccaactaagtgttattgaactgtaattctctcaataactcagtgtagcactttaaagtctgaaggacagcaacatgaaaagagcatatcaatgtggtggagaaagggaaggggttggctttttaatttatttttcttcatcttttataacaagaaagtatctatatatacatatgtaaatatttatatatagatatatgtagctttctatatatgtagtaggttggctttaatttaatatacttgattcagaaacaaaacaatagagtacaaaagtgccaagcagaacataaaacatccttacttttatttcacacagttttatatatagatagaagactgtacaatttgagccgggtgttaggccagctattttccttttcctgtgctttctcctttgagagattgacaaagcatttgttaacgtcctattatttaccttaattacatttttgtaacaaaggagtctgtaactttatttatacttatgaatatatccagggactacttctcattgctgagcagcttttaatacacctctgcttgaggagaaagtctagttcattgctactgccaagagctagttcttgtgttcatatagtaactgcacagggcttatagctgcttcattctgctactttgtaactaggagccattgcatttattaaatgtccctcagtaacgttaagtgctagttgtgattttatacataaaggccagaagctgtctgaggcaatcatgattgattgtatgtatcacttactgaagaatacctgaagtgatcatgtaactacttataagggatatccatttgtttgattacatgggtaaataatttgtcattaaacttgtgtttgaatcatgaattcccttgtttcaaaagacttgcagctaatctaaaaaactggtgatatttaatatgcatgtatgtatctaaacacccacatatatttgtggtttaagtgtgagaaatcttgctaatctatatgccacagaagagcaaaattgtatccaaatttatgccacttaaatttctttaccacgagggatagagcatgcatactggtttttttttcttgatttgcccatataattggtaatggataacttaataaatttgtgtgatataaaagtagtgtatcatgttctactgtttgatcttatcccttcccatttctgcaaaggtactgttagctggaagaaaaacattttggttagctttgtatgacagtagtctttccctttatagtttctctataaaaactggttttaaaatcagtggaaaagggcaggttgaatcaaggtgaatcaatctgaaattgagcacacctgcctgccatcgctgttccttcaactgagtgctgcacatcatgggctctgtctgtgagagaaaaatcccggtgcttggtgtccttgcatgacatggagttttgcatgtagatcaatttaaaatgtacctcttgtttacataatttgcataattttaaaagataatgttgccaaactttggaaatgttaatgttcagactgaaaatctccactacatgtaactttcttcctctggatcagtggcatggcttataatcccagccagtggtttgaactgttccagtgtcaactgccatgtgctctgcttcaagggggaactagccttttgtgaattttttgtacataagtatttgttacaaatattttagcaaatgctttctatttctcttgcttgtgcatatcttggctggcgttacagaaaaatagtgtaaacattatttccttaccggggaatgagggttttttctttttctttttttttttttttttttttagtttgtgtgtgggggtgggtaagggaggggatggtttatgttgaatgtttagtttttcttctgcatgatacgtcatgttgtgggatctttagaaaacttcatactgtatgaataagaaaataaaatatttgaaacttgaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5534 -> Molecular function: GO:0004723 [calcium-dependent protein serine/threonine phosphatase activity] evidence: NAS
GeneID:5534 -> Molecular function: GO:0005509 [calcium ion binding] evidence: NAS
GeneID:5534 -> Molecular function: GO:0005516 [calmodulin binding] evidence: NAS
GeneID:5534 -> Molecular function: GO:0019904 [protein domain specific binding] evidence: IPI
GeneID:5534 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:5534 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
GeneID:5534 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:5534 -> Biological process: GO:0097193 [intrinsic apoptotic signaling pathway] evidence: TAS
GeneID:5534 -> Biological process: GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] evidence: TAS
GeneID:5534 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:5534 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:5534 -> Cellular component: GO:0005955 [calcineurin complex] evidence: NAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_000936 -> EC 3.1.3.16
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.