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2024-04-20 22:34:54, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_000927 4718 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1
(ABCB1), mRNA.
ACCESSION NM_000927
VERSION NM_000927.4 GI:318037598
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4718)
AUTHORS Hirooka-Masui,K., Lesmana,R., Iwasaki,T., Xu,M., Hayasaka,K.,
Haraguchi,M., Takeshita,A., Shimokawa,N., Yamamoto,K. and
Koibuchi,N.
TITLE Interaction of silencing mediator for retinoid and thyroid
receptors with steroid and xenobiotic receptor on multidrug
resistance 1 promoter
JOURNAL Life Sci. 92 (17-19), 911-915 (2013)
PUBMED 23562850
REMARK GeneRIF: silencing mediator for retinoid and thyroid receptors
(SMRT) may affect steroid and xenobiotic receptor(SXR)-mediated
transcription on xenobiotic-response enhancer module (XREM) of MDR1
promoter even in the presence of rifampicin
REFERENCE 2 (bases 1 to 4718)
AUTHORS Kim,K.M., Kim,H.S., Lim,S.H., Cheong,S.H., Choi,E.J., Kang,H.,
Choi,H.R., Jeon,J.W., Yon,J.H., Oh,M. and Shin,J.G.
TITLE Effects of genetic polymorphisms of OPRM1, ABCB1, CYP3A4/5 on
postoperative fentanyl consumption in Korean gynecologic patients
JOURNAL Int J Clin Pharmacol Ther 51 (5), 383-392 (2013)
PUBMED 23557865
REMARK GeneRIF: In Korean gynecologic patients, no association was found
between ABCB1 genetic polymorphisms and postoperative fentanyl
consumption.
REFERENCE 3 (bases 1 to 4718)
AUTHORS Oros,M.M.
TITLE [Pharmacogenetic criteria of drug-resistant epilepsy]
JOURNAL Lik. Sprava 8, 71-74 (2012)
PUBMED 23786015
REMARK GeneRIF: Single nucleotide polymorphisms in ABCB1 and SCN1A genes
significantly correlate with drug resistance to antiepileptic
agents in patients with epilepsy.
REFERENCE 4 (bases 1 to 4718)
AUTHORS Kitada,K. and Yamasaki,T.
TITLE The MDR1/ABCB1 regional amplification in large inverted repeats
with asymmetric sequences and microhomologies at the junction sites
JOURNAL Cancer Genet. Cytogenet. 178 (2), 120-127 (2007)
PUBMED 17954267
REMARK GeneRIF: Treatment with the anti-cancer drug paclitaxel have an
increased copy number in the 7q21.12 region including the
MDR1/ABCB1 gene.
REFERENCE 5 (bases 1 to 4718)
AUTHORS Kioka,N., Yamano,Y., Komano,T. and Ueda,K.
TITLE Heat-shock responsive elements in the induction of the multidrug
resistance gene (MDR1)
JOURNAL FEBS Lett. 301 (1), 37-40 (1992)
PUBMED 1360409
REFERENCE 6 (bases 1 to 4718)
AUTHORS Safa,A.R., Stern,R.K., Choi,K., Agresti,M., Tamai,I., Mehta,N.D.
and Roninson,I.B.
TITLE Molecular basis of preferential resistance to colchicine in
multidrug-resistant human cells conferred by Gly-185----Val-185
substitution in P-glycoprotein
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (18), 7225-7229 (1990)
PUBMED 1976255
REFERENCE 7 (bases 1 to 4718)
AUTHORS Gekeler,V., Weger,S. and Probst,H.
TITLE mdr1/P-glycoprotein gene segments analyzed from various human
leukemic cell lines exhibiting different multidrug resistance
profiles
JOURNAL Biochem. Biophys. Res. Commun. 169 (2), 796-802 (1990)
PUBMED 1972623
REFERENCE 8 (bases 1 to 4718)
AUTHORS Chen,C.J., Clark,D., Ueda,K., Pastan,I., Gottesman,M.M. and
Roninson,I.B.
TITLE Genomic organization of the human multidrug resistance (MDR1) gene
and origin of P-glycoproteins
JOURNAL J. Biol. Chem. 265 (1), 506-514 (1990)
PUBMED 1967175
REFERENCE 9 (bases 1 to 4718)
AUTHORS Kioka,N., Tsubota,J., Kakehi,Y., Komano,T., Gottesman,M.M.,
Pastan,I. and Ueda,K.
TITLE P-glycoprotein gene (MDR1) cDNA from human adrenal: normal
P-glycoprotein carries Gly185 with an altered pattern of multidrug
resistance
JOURNAL Biochem. Biophys. Res. Commun. 162 (1), 224-231 (1989)
PUBMED 2568832
REFERENCE 10 (bases 1 to 4718)
AUTHORS Chen,C.J., Chin,J.E., Ueda,K., Clark,D.P., Pastan,I.,
Gottesman,M.M. and Roninson,I.B.
TITLE Internal duplication and homology with bacterial transport proteins
in the mdr1 (P-glycoprotein) gene from multidrug-resistant human
cells
JOURNAL Cell 47 (3), 381-389 (1986)
PUBMED 2876781
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK290159.1, AC002457.2 and
AA776371.1.
This sequence is a reference standard in the RefSeqGene project.
On Jan 13, 2011 this sequence version replaced gi:42741658.
Summary: The membrane-associated protein encoded by this gene is a
member of the superfamily of ATP-binding cassette (ABC)
transporters. ABC proteins transport various molecules across
extra- and intra-cellular membranes. ABC genes are divided into
seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
White). This protein is a member of the MDR/TAP subfamily. Members
of the MDR/TAP subfamily are involved in multidrug resistance. The
protein encoded by this gene is an ATP-dependent drug efflux pump
for xenobiotic compounds with broad substrate specificity. It is
responsible for decreased drug accumulation in multidrug-resistant
cells and often mediates the development of resistance to
anticancer drugs. This protein also functions as a transporter in
the blood-brain barrier. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK290159.1, M14758.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-492 AK290159.1 2-493
493-493 AC002457.2 35852-35852 c
494-553 AK290159.1 495-554
554-554 AC002457.2 35791-35791 c
555-4338 AK290159.1 556-4339
4339-4718 AA776371.1 1-380 c
FEATURES Location/Qualifiers
source 1..4718
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q21.12"
gene 1..4718
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/note="ATP-binding cassette, sub-family B (MDR/TAP),
member 1"
/db_xref="GeneID:5243"
/db_xref="HGNC:40"
/db_xref="HPRD:01370"
/db_xref="MIM:171050"
exon 1..163
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
variation 54
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="c"
/replace="t"
/db_xref="dbSNP:3747802"
exon 164..487
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
STS 172..351
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/standard_name="PGY1"
/db_xref="UniSTS:3185"
variation 253
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:35265821"
variation 349
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="c"
/replace="g"
/db_xref="dbSNP:34976462"
misc_feature 365..367
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/note="upstream in-frame stop codon"
variation 365
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="c"
/replace="t"
/db_xref="dbSNP:3213619"
variation 450
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:59318075"
variation 451
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:28381801"
exon 488..561
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
variation 490
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="c"
/replace="t"
/db_xref="dbSNP:34834348"
variation 492
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:57237390"
variation 493
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2214102"
CDS 494..4336
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/EC_number="3.6.3.44"
/note="colchicin sensitivity; doxorubicin resistance;
P-glycoprotein 1"
/codon_start=1
/product="multidrug resistance protein 1"
/protein_id="NP_000918.2"
/db_xref="GI:42741659"
/db_xref="CCDS:CCDS5608.1"
/db_xref="GeneID:5243"
/db_xref="HGNC:40"
/db_xref="HPRD:01370"
/db_xref="MIM:171050"
/translation="
MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTKRQ
"
misc_feature 626..694
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P08183.3);
transmembrane region"
misc_feature 650..4294
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/note="multidrug resistance protein (mdr1); Provisional;
Region: PTZ00265"
/db_xref="CDD:173501"
misc_feature 701..1528
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/note="ABC transporter transmembrane region; Region:
ABC_membrane; pfam00664"
/db_xref="CDD:201380"
misc_feature 842..904
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P08183.3);
transmembrane region"
misc_feature 1052..1117
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P08183.3);
transmembrane region"
misc_feature 1139..1201
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P08183.3);
transmembrane region"
misc_feature 1370..1441
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P08183.3);
transmembrane region"
misc_feature 1484..1549
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P08183.3);
transmembrane region"
misc_feature 1667..2380
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/note="MTABC3 (also known as ABCB6) is a mitochondrial
ATP-binding cassette protein involved in iron homeostasis
and one of four ABC transporters expressed in the
mitochondrial inner membrane, the other three being
MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region:
ABC_MTABC3_MDL1_MDL2; cd03249"
/db_xref="CDD:73008"
misc_feature 1772..1795
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/note="Walker A/P-loop; other site"
/db_xref="CDD:73008"
misc_feature order(1781..1786,1790..1798,1916..1918,2156..2161,
2252..2254)
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:73008"
misc_feature 1907..1918
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/note="Q-loop/lid; other site"
/db_xref="CDD:73008"
misc_feature 2084..2113
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/note="ABC transporter signature motif; other site"
/db_xref="CDD:73008"
misc_feature 2144..2161
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/note="Walker B; other site"
/db_xref="CDD:73008"
misc_feature 2168..2179
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/note="D-loop; other site"
/db_xref="CDD:73008"
misc_feature 2240..2260
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/note="H-loop/switch region; other site"
/db_xref="CDD:73008"
misc_feature 2474..2476
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2492..2494
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2504..2506
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2540..2542
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2627..2689
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P08183.3);
transmembrane region"
misc_feature 2636..3466
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/note="ABC transporter transmembrane region; Region:
ABC_membrane; pfam00664"
/db_xref="CDD:201380"
misc_feature 2762..2824
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P08183.3);
transmembrane region"
misc_feature 2990..3052
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P08183.3);
transmembrane region"
misc_feature 3056..3115
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P08183.3);
transmembrane region"
misc_feature 3296..3364
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P08183.3);
transmembrane region"
misc_feature 3413..3478
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P08183.3);
transmembrane region"
misc_feature 3596..4315
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/note="MTABC3 (also known as ABCB6) is a mitochondrial
ATP-binding cassette protein involved in iron homeostasis
and one of four ABC transporters expressed in the
mitochondrial inner membrane, the other three being
MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region:
ABC_MTABC3_MDL1_MDL2; cd03249"
/db_xref="CDD:73008"
misc_feature 3701..3724
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/note="Walker A/P-loop; other site"
/db_xref="CDD:73008"
misc_feature order(3710..3715,3719..3727,3845..3847,4091..4096,
4187..4189)
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:73008"
misc_feature 3836..3847
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/note="Q-loop/lid; other site"
/db_xref="CDD:73008"
misc_feature 4019..4048
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/note="ABC transporter signature motif; other site"
/db_xref="CDD:73008"
misc_feature 4079..4096
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/note="Walker B; other site"
/db_xref="CDD:73008"
misc_feature 4103..4114
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/note="D-loop; other site"
/db_xref="CDD:73008"
misc_feature 4175..4195
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/note="H-loop/switch region; other site"
/db_xref="CDD:73008"
variation 542
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="c"
/replace="t"
/db_xref="dbSNP:28381804"
variation 550..554
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:9332385"
variation 550
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:76199854"
variation 554
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:9282564"
exon 562..610
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
exon 611..779
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
variation 624
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1202183"
variation 731..732
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="c"
/db_xref="dbSNP:76812075"
variation 732
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="c"
/db_xref="dbSNP:9282565"
variation 759
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="c"
/replace="t"
/db_xref="dbSNP:35810889"
exon 780..831
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
exon 832..1023
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
variation 924
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="c"
/replace="t"
/db_xref="dbSNP:61607171"
variation 995
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:61122623"
exon 1024..1195
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
variation 1033
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="c"
/replace="t"
/db_xref="dbSNP:1128500"
variation 1041
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:60419673"
variation 1047..1048
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="t"
/db_xref="dbSNP:1128502"
exon 1196..1320
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
variation 1222
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2235022"
variation 1231
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:28381867"
variation 1274
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:36008564"
exon 1321..1492
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
exon 1493..1606
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
exon 1607..1717
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
variation 1692
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:2229109"
exon 1718..1843
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
variation 1729
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="c"
/replace="t"
/db_xref="dbSNP:1128503"
variation 1801
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:35068177"
exon 1844..2047
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
exon 2048..2218
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
variation 2110
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="c"
/replace="t"
/db_xref="dbSNP:35633772"
variation 2125
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="c"
/replace="t"
/db_xref="dbSNP:60247941"
variation 2155
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="c"
/replace="g"
/db_xref="dbSNP:2235012"
variation 2167
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:56871767"
variation 2188
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="c"
/replace="t"
/db_xref="dbSNP:59697741"
variation 2189
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:28381902"
exon 2219..2380
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
variation 2270
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="c"
/replace="t"
/db_xref="dbSNP:28381914"
variation 2287
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="c"
/replace="t"
/db_xref="dbSNP:28381915"
variation 2288
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2235036"
variation 2330
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="g"
/replace="t"
/db_xref="dbSNP:57001392"
exon 2381..2557
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
variation 2478
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="g"
/replace="t"
/db_xref="dbSNP:35657960"
variation 2498
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="c"
/replace="t"
/db_xref="dbSNP:35023033"
variation 2530
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="c"
/replace="t"
/db_xref="dbSNP:59340265"
exon 2558..2704
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
exon 2705..2812
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
exon 2813..2890
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
exon 2891..2974
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
variation 2894
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2235039"
exon 2975..3178
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
variation 2978
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2032581"
variation 2998
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:28381966"
variation 2999
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:28381967"
variation 3040
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:36105130"
variation 3143
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="c"
/replace="t"
/db_xref="dbSNP:9282563"
variation 3170
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:2032582"
exon 3179..3279
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
exon 3280..3420
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
exon 3421..3577
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
variation 3468
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:56849127"
variation 3577
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2235044"
exon 3578..3775
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
variation 3644
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="c"
/replace="g"
/db_xref="dbSNP:28401798"
variation 3755
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:57521326"
exon 3776..3982
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
variation 3815
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="c"
/replace="t"
/db_xref="dbSNP:35730308"
variation 3889
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="c"
/replace="t"
/db_xref="dbSNP:34748655"
variation 3914
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="t"
/db_xref="dbSNP:2229107"
variation 3928
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:1045642"
exon 3983..4129
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
variation 3995
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:59241388"
STS 4127..4308
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/standard_name="RH17678"
/db_xref="UniSTS:4896"
exon 4130..4716
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/inference="alignment:Splign:1.39.8"
variation 4240
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="c"
/replace="g"
/db_xref="dbSNP:2235051"
variation 4244
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:28364274"
variation 4260
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="c"
/db_xref="dbSNP:35721439"
variation 4357
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="c"
/replace="t"
/db_xref="dbSNP:28364275"
STS 4385..4692
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/standard_name="D7S2326"
/db_xref="UniSTS:69986"
STS 4395..4646
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/standard_name="SHGC-56130"
/db_xref="UniSTS:63985"
variation 4413
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace=""
/replace="a"
/db_xref="dbSNP:61473597"
variation 4414
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace=""
/replace="c"
/db_xref="dbSNP:61565026"
variation 4415..4418
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace=""
/replace="ttac"
/db_xref="dbSNP:2235052"
variation 4415
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace=""
/replace="t"
/db_xref="dbSNP:57792825"
variation 4425
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="t"
/db_xref="dbSNP:17064"
STS 4449..4641
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/standard_name="G60182"
/db_xref="UniSTS:137441"
variation 4482
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:28364277"
variation 4505..4506
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace=""
/replace="acagagag"
/db_xref="dbSNP:56794014"
variation 4508..4509
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace=""
/replace="gagagaca"
/db_xref="dbSNP:28364278"
variation 4529
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3842"
variation 4538
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:41297363"
variation 4555
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:41296639"
polyA_signal 4563..4568
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
polyA_site 4588
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
variation 4588
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="c"
/db_xref="dbSNP:28364279"
variation 4652
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="a"
/replace="g"
/db_xref="dbSNP:28364280"
variation 4691
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
/replace="c"
/replace="t"
/db_xref="dbSNP:57126620"
polyA_signal 4694..4699
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
polyA_site 4716
/gene="ABCB1"
/gene_synonym="ABC20; CD243; CLCS; GP170; MDR1; P-GP;
PGY1"
ORIGIN
aaacacttgtattaccattttaaaggctatcattactctttacctgtgaagagtagaacatgaagaaatctactttattcagatattctccagattcctaaagattagagatcatttctcattctcctaggagtactcacttcaggaagcaaccagataaaagagaggtgcaacggaagccagaacattcctcctggaaattcaacctgtttcgcagtttctcgaggaatcagcattcagtcaatccgggccgggagcagtcatctgtggtgaggctgattggctgggcaggaacagcgccggggcgtgggctgagcacagccgcttcgctctctttgccacaggaagcctgagctcattcgagtagcggctcttccaagctcaaagaagcagaggccgctgttcgtttcctttaggtctttccactaaagtcggagtatcttcttccaaaatttcacgtcttggtggccgttccaaggagcgcgaggtcggaatggatcttgaaggggaccgcaatggaggagcaaagaagaagaacttttttaaactgaacaataaaagtgaaaaagataagaaggaaaagaaaccaactgtcagtgtattttcaatgtttcgctattcaaattggcttgacaagttgtatatggtggtgggaactttggctgccatcatccatggggctggacttcctctcatgatgctggtgtttggagaaatgacagatatctttgcaaatgcaggaaatttagaagatctgatgtcaaacatcactaatagaagtgatatcaatgatacagggttcttcatgaatctggaggaagacatgaccaggtatgcctattattacagtggaattggtgctggggtgctggttgctgcttacattcaggtttcattttggtgcctggcagctggaagacaaatacacaaaattagaaaacagttttttcatgctataatgcgacaggagataggctggtttgatgtgcacgatgttggggagcttaacacccgacttacagatgatgtctccaagattaatgaaggaattggtgacaaaattggaatgttctttcagtcaatggcaacatttttcactgggtttatagtaggatttacacgtggttggaagctaacccttgtgattttggccatcagtcctgttcttggactgtcagctgctgtctgggcaaagatactatcttcatttactgataaagaactcttagcgtatgcaaaagctggagcagtagctgaagaggtcttggcagcaattagaactgtgattgcatttggaggacaaaagaaagaacttgaaaggtacaacaaaaatttagaagaagctaaaagaattgggataaagaaagctattacagccaatatttctataggtgctgctttcctgctgatctatgcatcttatgctctggccttctggtatgggaccaccttggtcctctcaggggaatattctattggacaagtactcactgtattcttttctgtattaattggggcttttagtgttggacaggcatctccaagcattgaagcatttgcaaatgcaagaggagcagcttatgaaatcttcaagataattgataataagccaagtattgacagctattcgaagagtgggcacaaaccagataatattaagggaaatttggaattcagaaatgttcacttcagttacccatctcgaaaagaagttaagatcttgaagggtctgaacctgaaggtgcagagtgggcagacggtggccctggttggaaacagtggctgtgggaagagcacaacagtccagctgatgcagaggctctatgaccccacagaggggatggtcagtgttgatggacaggatattaggaccataaatgtaaggtttctacgggaaatcattggtgtggtgagtcaggaacctgtattgtttgccaccacgatagctgaaaacattcgctatggccgtgaaaatgtcaccatggatgagattgagaaagctgtcaaggaagccaatgcctatgactttatcatgaaactgcctcataaatttgacaccctggttggagagagaggggcccagttgagtggtgggcagaagcagaggatcgccattgcacgtgccctggttcgcaaccccaagatcctcctgctggatgaggccacgtcagccttggacacagaaagcgaagcagtggttcaggtggctctggataaggccagaaaaggtcggaccaccattgtgatagctcatcgtttgtctacagttcgtaatgctgacgtcatcgctggtttcgatgatggagtcattgtggagaaaggaaatcatgatgaactcatgaaagagaaaggcatttacttcaaacttgtcacaatgcagacagcaggaaatgaagttgaattagaaaatgcagctgatgaatccaaaagtgaaattgatgccttggaaatgtcttcaaatgattcaagatccagtctaataagaaaaagatcaactcgtaggagtgtccgtggatcacaagcccaagacagaaagcttagtaccaaagaggctctggatgaaagtatacctccagtttccttttggaggattatgaagctaaatttaactgaatggccttattttgttgttggtgtattttgtgccattataaatggaggcctgcaaccagcatttgcaataatattttcaaagattataggggtttttacaagaattgatgatcctgaaacaaaacgacagaatagtaacttgttttcactattgtttctagcccttggaattatttcttttattacatttttccttcagggtttcacatttggcaaagctggagagatcctcaccaagcggctccgatacatggttttccgatccatgctcagacaggatgtgagttggtttgatgaccctaaaaacaccactggagcattgactaccaggctcgccaatgatgctgctcaagttaaaggggctataggttccaggcttgctgtaattacccagaatatagcaaatcttgggacaggaataattatatccttcatctatggttggcaactaacactgttactcttagcaattgtacccatcattgcaatagcaggagttgttgaaatgaaaatgttgtctggacaagcactgaaagataagaaagaactagaaggttctgggaagatcgctactgaagcaatagaaaacttccgaaccgttgtttctttgactcaggagcagaagtttgaacatatgtatgctcagagtttgcaggtaccatacagaaactctttgaggaaagcacacatctttggaattacattttccttcacccaggcaatgatgtatttttcctatgctggatgtttccggtttggagcctacttggtggcacataaactcatgagctttgaggatgttctgttagtattttcagctgttgtctttggtgccatggccgtggggcaagtcagttcatttgctcctgactatgccaaagccaaaatatcagcagcccacatcatcatgatcattgaaaaaacccctttgattgacagctacagcacggaaggcctaatgccgaacacattggaaggaaatgtcacatttggtgaagttgtattcaactatcccacccgaccggacatcccagtgcttcagggactgagcctggaggtgaagaagggccagacgctggctctggtgggcagcagtggctgtgggaagagcacagtggtccagctcctggagcggttctacgaccccttggcagggaaagtgctgcttgatggcaaagaaataaagcgactgaatgttcagtggctccgagcacacctgggcatcgtgtcccaggagcccatcctgtttgactgcagcattgctgagaacattgcctatggagacaacagccgggtggtgtcacaggaagagattgtgagggcagcaaaggaggccaacatacatgccttcatcgagtcactgcctaataaatatagcactaaagtaggagacaaaggaactcagctctctggtggccagaaacaacgcattgccatagctcgtgcccttgttagacagcctcatattttgcttttggatgaagccacgtcagctctggatacagaaagtgaaaaggttgtccaagaagccctggacaaagccagagaaggccgcacctgcattgtgattgctcaccgcctgtccaccatccagaatgcagacttaatagtggtgtttcagaatggcagagtcaaggagcatggcacgcatcagcagctgctggcacagaaaggcatctatttttcaatggtcagtgtccaggctggaacaaagcgccagtgaactctgactgtatgagatgttaaatactttttaatatttgtttagatatgacatttattcaaagttaaaagcaaacacttacagaattatgaagaggtatctgtttaacatttcctcagtcaagttcagagtcttcagagacttcgtaattaaaggaacagagtgagagacatcatcaagtggagagaaatcatagtttaaactgcattataaattttataacagaattaaagtagattttaaaagataaaatgtgtaattttgtttatattttcccatttggactgtaactgactgccttgctaaaagattatagaagtagcaaaaagtattgaaatgtttgcataaagtgtctataataaaactaaactttcatgtgaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5243 -> Molecular function: GO:0005215 [transporter activity] evidence: TAS
GeneID:5243 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5243 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:5243 -> Molecular function: GO:0008559 [xenobiotic-transporting ATPase activity] evidence: IEA
GeneID:5243 -> Molecular function: GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] evidence: IBA
GeneID:5243 -> Biological process: GO:0000086 [G2/M transition of mitotic cell cycle] evidence: IDA
GeneID:5243 -> Biological process: GO:0006810 [transport] evidence: TAS
GeneID:5243 -> Biological process: GO:0006855 [drug transmembrane transport] evidence: TAS
GeneID:5243 -> Biological process: GO:0042493 [response to drug] evidence: TAS
GeneID:5243 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:5243 -> Biological process: GO:0055085 [transmembrane transport] evidence: IBA
GeneID:5243 -> Biological process: GO:0055085 [transmembrane transport] evidence: TAS
GeneID:5243 -> Biological process: GO:0072089 [stem cell proliferation] evidence: IMP
GeneID:5243 -> Cellular component: GO:0000139 [Golgi membrane] evidence: IBA
GeneID:5243 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:5243 -> Cellular component: GO:0009986 [cell surface] evidence: IDA
GeneID:5243 -> Cellular component: GO:0016020 [membrane] evidence: TAS
GeneID:5243 -> Cellular component: GO:0016021 [integral to membrane] evidence: IBA
GeneID:5243 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: IBA
GeneID:5243 -> Cellular component: GO:0046581 [intercellular canaliculus] evidence: IBA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_000918 -> EC 3.6.3.44
by
@meso_cacase at
DBCLS
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