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2024-03-29 15:23:32, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_000924               3463 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens phosphodiesterase 1B, calmodulin-dependent (PDE1B),
            transcript variant 1, mRNA.
ACCESSION   NM_000924
VERSION     NM_000924.3  GI:260436978
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3463)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   2  (bases 1 to 3463)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am. J. Hum. Genet. 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 3463)
  AUTHORS   Vandeput,F., Wolda,S.L., Krall,J., Hambleton,R., Uher,L.,
            McCaw,K.N., Radwanski,P.B., Florio,V. and Movsesian,M.A.
  TITLE     Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac
            myocytes
  JOURNAL   J. Biol. Chem. 282 (45), 32749-32757 (2007)
   PUBMED   17726023
REFERENCE   4  (bases 1 to 3463)
  AUTHORS   Bender,A.T. and Beavo,J.A.
  TITLE     PDE1B2 regulates cGMP and a subset of the phenotypic
            characteristics acquired upon macrophage differentiation from a
            monocyte
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 103 (2), 460-465 (2006)
   PUBMED   16407168
  REMARK    GeneRIF: PDE1B2 regulates a subset of phenotypic changes that occur
            upon phorbol-12-myristate-13-acetate-induced differentiation and
            likely also plays a role in differentiated macrophages by
            regulating agonist-stimulated cGMP levels
REFERENCE   5  (bases 1 to 3463)
  AUTHORS   Bender,A.T., Ostenson,C.L., Wang,E.H. and Beavo,J.A.
  TITLE     Selective up-regulation of PDE1B2 upon monocyte-to-macrophage
            differentiation
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 102 (2), 497-502 (2005)
   PUBMED   15625104
  REMARK    GeneRIF: Selective up-regulation of PDE1B2 upon
            monocyte-to-macrophage differentiation.
REFERENCE   6  (bases 1 to 3463)
  AUTHORS   Yu,J., Wolda,S.L., Frazier,A.L., Florio,V.A., Martins,T.J.,
            Snyder,P.B., Harris,E.A., McCaw,K.N., Farrell,C.A., Steiner,B.,
            Bentley,J.K., Beavo,J.A., Ferguson,K. and Gelinas,R.
  TITLE     Identification and characterisation of a human
            calmodulin-stimulated phosphodiesterase PDE1B1
  JOURNAL   Cell. Signal. 9 (7), 519-529 (1997)
   PUBMED   9419816
REFERENCE   7  (bases 1 to 3463)
  AUTHORS   Spence,S., Rena,G., Sullivan,M., Erdogan,S. and Houslay,M.D.
  TITLE     Receptor-mediated stimulation of lipid signalling pathways in CHO
            cells elicits the rapid transient induction of the PDE1B isoform of
            Ca2+/calmodulin-stimulated cAMP phosphodiesterase
  JOURNAL   Biochem. J. 321 (PT 1), 157-163 (1997)
   PUBMED   9003415
REFERENCE   8  (bases 1 to 3463)
  AUTHORS   Jiang,X., Li,J., Paskind,M. and Epstein,P.M.
  TITLE     Inhibition of calmodulin-dependent phosphodiesterase induces
            apoptosis in human leukemic cells
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 93 (20), 11236-11241 (1996)
   PUBMED   8855339
REFERENCE   9  (bases 1 to 3463)
  AUTHORS   Loughney,K., Martins,T.J., Harris,E.A., Sadhu,K., Hicks,J.B.,
            Sonnenburg,W.K., Beavo,J.A. and Ferguson,K.
  TITLE     Isolation and characterization of cDNAs corresponding to two human
            calcium, calmodulin-regulated, 3',5'-cyclic nucleotide
            phosphodiesterases
  JOURNAL   J. Biol. Chem. 271 (2), 796-806 (1996)
   PUBMED   8557689
REFERENCE   10 (bases 1 to 3463)
  AUTHORS   Repaske,D.R., Swinnen,J.V., Jin,S.L., Van Wyk,J.J. and Conti,M.
  TITLE     A polymerase chain reaction strategy to identify and clone cyclic
            nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA
            encoding the 63-kDa calmodulin-dependent phosphodiesterase
  JOURNAL   J. Biol. Chem. 267 (26), 18683-18688 (1992)
   PUBMED   1326532
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA254686.1, BC032226.1 and
            AC079310.20.
            This sequence is a reference standard in the RefSeqGene project.
            On Oct 3, 2009 this sequence version replaced gi:24431942.
            
            Summary: The protein encoded by this gene belongs to the cyclic
            nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily.
            Members of the PDE1 family are calmodulin-dependent PDEs that are
            stimulated by a calcium-calmodulin complex. This PDE has
            dual-specificity for the second messengers, cAMP and cGMP, with a
            preference for cGMP as a substrate. cAMP and cGMP function as key
            regulators of many important physiological processes. Alternatively
            spliced transcript variants encoding different isoforms have been
            described for this gene.[provided by RefSeq, Jul 2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032226.1, U86078.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025082, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               DA254686.1         1-227
            228-2571            BC032226.1         1-2344
            2572-2572           AC079310.20        16403-16403
            2573-3463           BC032226.1         2346-3236
FEATURES             Location/Qualifiers
     source          1..3463
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13"
     gene            1..3463
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /note="phosphodiesterase 1B, calmodulin-dependent"
                     /db_xref="GeneID:5153"
                     /db_xref="HGNC:8775"
                     /db_xref="HPRD:01388"
                     /db_xref="MIM:171891"
     exon            1..380
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /inference="alignment:Splign:1.39.8"
     variation       87
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:371875628"
     variation       88
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:112140800"
     misc_feature    130..132
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /note="upstream in-frame stop codon"
     variation       134
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:12814787"
     variation       304
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:115589692"
     exon            381..506
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /inference="alignment:Splign:1.39.8"
     CDS             394..2004
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /EC_number="3.1.4.17"
                     /note="isoform 1 is encoded by transcript variant 1;
                     calcium/calmodulin-dependent 3',5'-cyclic nucleotide
                     phosphodiesterase 1B; calcium/calmodulin-stimulated cyclic
                     nucleotide phosphodiesterase; presumed 63kDa form of the
                     type 1 cyclic nucleotide phosphodiesterase family known as
                     PDE1B; calmodulin-stimulated phosphodiesterase PDE1B1;
                     cam-PDE 1B; 63 kDa Cam-PDE"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent 3',5'-cyclic
                     nucleotide phosphodiesterase 1B isoform 1"
                     /protein_id="NP_000915.1"
                     /db_xref="GI:4505677"
                     /db_xref="CCDS:CCDS8882.1"
                     /db_xref="GeneID:5153"
                     /db_xref="HGNC:8775"
                     /db_xref="HPRD:01388"
                     /db_xref="MIM:171891"
                     /translation="
MELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKNLEYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKPKFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPKALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVVSFRSTWVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD
"
     misc_feature    472..534
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01064.2);
                     Region: Calmodulin-binding (Potential)"
     misc_feature    622..804
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /note="3'5'-cyclic nucleotide phosphodiesterase
                     N-terminal; Region: PDEase_I_N; pfam08499"
                     /db_xref="CDD:203961"
     misc_feature    982..1881
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01064.2);
                     Region: Catalytic (By similarity)"
     misc_feature    1057..1752
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /note="3'5'-cyclic nucleotide phosphodiesterase; Region:
                     PDEase_I; pfam00233"
                     /db_xref="CDD:109297"
     misc_feature    1789..1791
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     variation       405
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148928407"
     variation       419
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149630948"
     variation       453
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201786340"
     variation       457
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200545087"
     variation       492
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:140895636"
     variation       496
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:144754384"
     exon            507..620
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /inference="alignment:Splign:1.39.8"
     variation       511
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147900601"
     variation       512
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374027304"
     variation       514
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61733023"
     variation       517
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139920915"
     variation       544
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376974140"
     variation       585
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:2887906"
     variation       601
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200096201"
     variation       619
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373781937"
     exon            621..803
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /inference="alignment:Splign:1.39.8"
     variation       635
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371717266"
     variation       686
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142799171"
     variation       687
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372746803"
     variation       733
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374242340"
     variation       746
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:377170220"
     variation       795
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151025806"
     exon            804..870
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /inference="alignment:Splign:1.39.8"
     variation       812
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376631753"
     variation       852
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369117826"
     variation       863
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373914778"
     variation       870
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140892078"
     exon            871..987
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /inference="alignment:Splign:1.39.8"
     variation       877
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112699956"
     variation       908
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11615709"
     variation       978
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377445884"
     exon            988..1128
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /inference="alignment:Splign:1.39.8"
     STS             1018..1208
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /standard_name="MARC_21181-21182:1027091922:1"
                     /db_xref="UniSTS:268504"
     variation       1054
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:150159795"
     variation       1059
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146735076"
     variation       1074
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115951482"
     variation       1088
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200815928"
     variation       1114
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145391059"
     exon            1129..1229
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /inference="alignment:Splign:1.39.8"
     variation       1139
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:137936270"
     variation       1140
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113265707"
     variation       1145
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373565313"
     variation       1162
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:143034173"
     variation       1167
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376805586"
     variation       1185
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148185581"
     variation       1197
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:115481291"
     exon            1230..1355
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /inference="alignment:Splign:1.39.8"
     variation       1244
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:375085069"
     variation       1272
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12812036"
     variation       1274
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:12811532"
     variation       1330
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201756814"
     variation       1332
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150688398"
     variation       1339
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12811737"
     exon            1356..1457
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /inference="alignment:Splign:1.39.8"
     variation       1416
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:139284651"
     variation       1441
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200839405"
     variation       1443
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199536319"
     exon            1458..1578
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /inference="alignment:Splign:1.39.8"
     variation       1574
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:143206355"
     exon            1579..1660
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /inference="alignment:Splign:1.39.8"
     exon            1661..1769
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /inference="alignment:Splign:1.39.8"
     variation       1662
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:147497085"
     variation       1669
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372439210"
     variation       1720
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376262595"
     variation       1736
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147477377"
     variation       1752
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:150000693"
     variation       1755
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:148673155"
     exon            1770..1900
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /inference="alignment:Splign:1.39.8"
     variation       1781
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148711763"
     variation       1799
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:142239113"
     variation       1838
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202001120"
     variation       1869
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1249950"
     variation       1885
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140368041"
     variation       1896
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200779298"
     exon            1901..2021
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /inference="alignment:Splign:1.39.8"
     variation       1904
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:183676395"
     variation       1907
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:144100250"
     variation       1911
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146475493"
     variation       1937
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371822951"
     variation       1948
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140787002"
     variation       1968
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150107941"
     exon            2022..3401
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /inference="alignment:Splign:1.39.8"
     STS             2022..2860
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /standard_name="PDE1B_3295"
                     /db_xref="UniSTS:462390"
     variation       2198..2199
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:35108378"
     variation       2202
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372424493"
     variation       2233..2234
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:34320482"
     variation       2252
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376600771"
     variation       2363
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143775746"
     STS             2373..2659
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /standard_name="SHGC-148605"
                     /db_xref="UniSTS:176493"
     variation       2572
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11170978"
     variation       2587
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:5798310"
     variation       2655
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371896018"
     variation       2677
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:884510"
     variation       2904
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191560225"
     variation       2943
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:76676851"
     variation       2977
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1249499"
     variation       2985
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148127859"
     variation       3000
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:183626030"
     variation       3014
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1144996"
     STS             3052..3239
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /standard_name="RH78688"
                     /db_xref="UniSTS:48654"
     variation       3058
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111571643"
     STS             3194..3383
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /standard_name="A007D03"
                     /db_xref="UniSTS:80815"
     variation       3220
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144107699"
     variation       3221
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:10783631"
     variation       3296..3297
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:71444859"
     variation       3326
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189001857"
     variation       3370
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3825195"
     polyA_signal    3382..3387
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
     polyA_site      3401
                     /gene="PDE1B"
                     /gene_synonym="PDE1B1; PDES1B"
ORIGIN      
actcgtccccggcgcctgtgtgcgtgcgctcgcccttgggcgcttctgtctgtgtgtgcccccggcttccaatcgttcctttgggagggggaggagtggctgtgaggagtgagagactggcgggcaggctgaggagaagggagggagagcagagggaggggggaacccggccgggggaggaggagagaggcgaggaggcggctctggcagcgcgcggcggcggcggcggtagcggcagcagcagcggcggtgcggagagcttggactgggagcccaaagctcggctgggcagcgggagaggaggagccgcaggagctgcagctctgccagcttgggccgagcctagagacaccggcctggctggtccacgccagccgcagaccgtggctgagcatggagctgtccccccgcagtcctccggagatgctggaggagtcggattgcccgtcacccctggagctgaagtcagcccccagcaagaagatgtggattaagcttcggtctctgctgcgctacatggtgaagcagttggagaatggggagataaacattgaggagctgaagaaaaatctggagtacacagcttctctgctggaagccgtctacatagatgagacacggcaaatcttggacacggaggacgagctgcaggagctgcggtcagatgccgtgccttcggaggtgcgggactggctggcctccaccttcacccagcaggcccgggccaaaggccgccgagcagaggagaagcccaagttccgaagcattgtgcacgctgtgcaggctgggatcttcgtggaacggatgttccggagaacatacacctctgtgggccccacttactctactgcggttctcaactgtctcaagaacctggatctctggtgctttgatgtcttttccttgaaccaggcagcagatgaccatgccctgaggaccattgtttttgagttgctgactcggcataacctcatcagccgcttcaagattcccactgtgtttttgatgagtttcctggatgccttggagacaggctatgggaagtacaagaatccttaccacaaccagatccacgcagccgatgttacccagacagtccattgcttcttgctccgcacagggatggtgcactgcctgtcggagattgagctcctggccatcatctttgctgcagctatccatgattatgagcacacgggcactaccaacagcttccacatccagaccaagtcagaatgtgccatcgtgtacaatgatcgttcagtgctggagaatcaccacatcagctctgttttccgattgatgcaggatgatgagatgaacattttcatcaacctcaccaaggatgagtttgtagaactccgagccctggtcattgagatggtgttggccacagacatgtcctgccatttccagcaagtgaagaccatgaagacagccttgcaacagctggagaggattgacaagcccaaggccctgtctctactgctccatgctgctgacatcagccacccaaccaagcagtggttggtccacagccgttggaccaaggccctcatggaggaattcttccgtcagggtgacaaggaggcagagttgggcctgcccttttctccactctgtgaccgcacttccactctagtggcacagtctcagatagggttcatcgacttcattgtggagcccacattctctgtgctgactgacgtggcagagaagagtgttcagcccctggcggatgaggactccaagtctaaaaaccagcccagctttcagtggcgccagccctctctggatgtggaagtgggagaccccaaccctgatgtggtcagctttcgttccacctgggtcaagcgcattcaggagaataagcagaaatggaaggaacgggcagcaagtggcatcaccaaccagatgtccattgacgagctgtccccctgtgaagaagaggcccccccatcccctgccgaagatgaacacaaccagaatgggaatctggattagccctggggctggcccaggtcttcattgagtccaaagtgtttgatgtcatcagcaccatccatcaggactggctcccccatctgctccaagggagcgtggtcgtggaagaaacaacccacctgaaggccaaatgccagagatttggggttggggaaagggcccctccccacctgacacccactggggtgcactttaatgttccggcagcaagactggggaacttcaggctcccagtggtcactgtgcccatccctcagcctctggattctcttcatggccaggtggctgccagggagcggggagcttcctggaggcttcccagggccttggggaagggtcagagatgccagccccctgggacctcccccatcctttttgcctccaagtttctaagcaatacattttgggggttccctcagccccccaccccagatcttagctggcaggtctgggtgccccttttcctcccctgggaagggctggaataggatagaaagctgggggttttcagagccctatgtgtggggaggggagtggattccttcagggcatggtacctttctaggacctgggaatggggtggagaggacatcctcttcaccccagaattgcgctgcttcagccccatctccagcctgatcctctgaatcttccttccctccctttctgatacagtgactggggcaaaaggagccattgtgaccaggggctgcgggaggcctttcctgggaccttccttgggactggtctgggcccctggggcttgtcgcctgccctgagtccggagccctttgcctccttcctctcccctggggctgggaggctccatccgaccaatgtctgtaaagtgctttgaggatctccccagcaaagcaccttcagaatgtatcgacaccagctgggttagggtcaagggtgcctggggagggtgagtaatcctgcattgctaaaagagagggtctgtcccctcctctccacgtcccagaactggcccagctgcaggcactaagaagctcctcccctgagacaagtgaggggtagtcggtgaaaggcagatggacaaggggctcagggctgctgccttcctgtcctctggagagaacccagccaggcgcggtgccccttcctctcctcaggctcctccttgcccccaccttgccccaggaaaggccaaagtccaggtgactgccctccttctttcttgtaaataccaaccatgcatttgtacagtgggccctgttcatgcgaaatccacatccatggtctcctagacctgctaccctggtacttccaccctaccccaccccgagaagggcagagacgcatgtgactcacccctgcccttggtttcccagacccctgctatagccagagaacaataaagaagggagaccaggaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5153 -> Molecular function: GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] evidence: IEA
            GeneID:5153 -> Molecular function: GO:0004117 [calmodulin-dependent cyclic-nucleotide phosphodiesterase activity] evidence: TAS
            GeneID:5153 -> Molecular function: GO:0005516 [calmodulin binding] evidence: IEA
            GeneID:5153 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
            GeneID:5153 -> Molecular function: GO:0048101 [calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity] evidence: IEA
            GeneID:5153 -> Biological process: GO:0001505 [regulation of neurotransmitter levels] evidence: IEA
            GeneID:5153 -> Biological process: GO:0001975 [response to amphetamine] evidence: IEA
            GeneID:5153 -> Biological process: GO:0006198 [cAMP catabolic process] evidence: IDA
            GeneID:5153 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:5153 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
            GeneID:5153 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS
            GeneID:5153 -> Biological process: GO:0007202 [activation of phospholipase C activity] evidence: TAS
            GeneID:5153 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
            GeneID:5153 -> Biological process: GO:0007626 [locomotory behavior] evidence: IEA
            GeneID:5153 -> Biological process: GO:0008542 [visual learning] evidence: IEA
            GeneID:5153 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: TAS
            GeneID:5153 -> Biological process: GO:0030224 [monocyte differentiation] evidence: IEP
            GeneID:5153 -> Biological process: GO:0036006 [cellular response to macrophage colony-stimulating factor stimulus] evidence: IDA
            GeneID:5153 -> Biological process: GO:0042053 [regulation of dopamine metabolic process] evidence: IEA
            GeneID:5153 -> Biological process: GO:0042428 [serotonin metabolic process] evidence: IEA
            GeneID:5153 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:5153 -> Biological process: GO:0046069 [cGMP catabolic process] evidence: IDA
            GeneID:5153 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
            GeneID:5153 -> Biological process: GO:0097011 [cellular response to granulocyte macrophage colony-stimulating factor stimulus] evidence: IDA
            GeneID:5153 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:5153 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
            GeneID:5153 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:5153 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:5153 -> Cellular component: GO:0043025 [neuronal cell body] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_000915 -> EC 3.1.4.17

by @meso_cacase at DBCLS
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