2024-03-29 15:23:32, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_000924 3463 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens phosphodiesterase 1B, calmodulin-dependent (PDE1B), transcript variant 1, mRNA. ACCESSION NM_000924 VERSION NM_000924.3 GI:260436978 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3463) AUTHORS Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V., Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S. CONSRTM DREAM investigators TITLE Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study JOURNAL Diabetes Care 33 (10), 2250-2253 (2010) PUBMED 20628086 REMARK GeneRIF: Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) REFERENCE 2 (bases 1 to 3463) AUTHORS Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C., Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R., Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A., Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C., Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S., Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N., Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D. CONSRTM ASCOT investigators; NORDIL investigators; BRIGHT Consortium TITLE Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip JOURNAL Am. J. Hum. Genet. 85 (5), 628-642 (2009) PUBMED 19913121 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 3 (bases 1 to 3463) AUTHORS Vandeput,F., Wolda,S.L., Krall,J., Hambleton,R., Uher,L., McCaw,K.N., Radwanski,P.B., Florio,V. and Movsesian,M.A. TITLE Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes JOURNAL J. Biol. Chem. 282 (45), 32749-32757 (2007) PUBMED 17726023 REFERENCE 4 (bases 1 to 3463) AUTHORS Bender,A.T. and Beavo,J.A. TITLE PDE1B2 regulates cGMP and a subset of the phenotypic characteristics acquired upon macrophage differentiation from a monocyte JOURNAL Proc. Natl. Acad. Sci. U.S.A. 103 (2), 460-465 (2006) PUBMED 16407168 REMARK GeneRIF: PDE1B2 regulates a subset of phenotypic changes that occur upon phorbol-12-myristate-13-acetate-induced differentiation and likely also plays a role in differentiated macrophages by regulating agonist-stimulated cGMP levels REFERENCE 5 (bases 1 to 3463) AUTHORS Bender,A.T., Ostenson,C.L., Wang,E.H. and Beavo,J.A. TITLE Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation JOURNAL Proc. Natl. Acad. Sci. U.S.A. 102 (2), 497-502 (2005) PUBMED 15625104 REMARK GeneRIF: Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation. REFERENCE 6 (bases 1 to 3463) AUTHORS Yu,J., Wolda,S.L., Frazier,A.L., Florio,V.A., Martins,T.J., Snyder,P.B., Harris,E.A., McCaw,K.N., Farrell,C.A., Steiner,B., Bentley,J.K., Beavo,J.A., Ferguson,K. and Gelinas,R. TITLE Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1 JOURNAL Cell. Signal. 9 (7), 519-529 (1997) PUBMED 9419816 REFERENCE 7 (bases 1 to 3463) AUTHORS Spence,S., Rena,G., Sullivan,M., Erdogan,S. and Houslay,M.D. TITLE Receptor-mediated stimulation of lipid signalling pathways in CHO cells elicits the rapid transient induction of the PDE1B isoform of Ca2+/calmodulin-stimulated cAMP phosphodiesterase JOURNAL Biochem. J. 321 (PT 1), 157-163 (1997) PUBMED 9003415 REFERENCE 8 (bases 1 to 3463) AUTHORS Jiang,X., Li,J., Paskind,M. and Epstein,P.M. TITLE Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (20), 11236-11241 (1996) PUBMED 8855339 REFERENCE 9 (bases 1 to 3463) AUTHORS Loughney,K., Martins,T.J., Harris,E.A., Sadhu,K., Hicks,J.B., Sonnenburg,W.K., Beavo,J.A. and Ferguson,K. TITLE Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases JOURNAL J. Biol. Chem. 271 (2), 796-806 (1996) PUBMED 8557689 REFERENCE 10 (bases 1 to 3463) AUTHORS Repaske,D.R., Swinnen,J.V., Jin,S.L., Van Wyk,J.J. and Conti,M. TITLE A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase JOURNAL J. Biol. Chem. 267 (26), 18683-18688 (1992) PUBMED 1326532 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA254686.1, BC032226.1 and AC079310.20. This sequence is a reference standard in the RefSeqGene project. On Oct 3, 2009 this sequence version replaced gi:24431942. Summary: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC032226.1, U86078.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025082, ERS025084 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-227 DA254686.1 1-227 228-2571 BC032226.1 1-2344 2572-2572 AC079310.20 16403-16403 2573-3463 BC032226.1 2346-3236 FEATURES Location/Qualifiers source 1..3463 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="12" /map="12q13" gene 1..3463 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /note="phosphodiesterase 1B, calmodulin-dependent" /db_xref="GeneID:5153" /db_xref="HGNC:8775" /db_xref="HPRD:01388" /db_xref="MIM:171891" exon 1..380 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" variation 87 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="g" /replace="t" /db_xref="dbSNP:371875628" variation 88 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="g" /db_xref="dbSNP:112140800" misc_feature 130..132 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /note="upstream in-frame stop codon" variation 134 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="g" /replace="t" /db_xref="dbSNP:12814787" variation 304 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:115589692" exon 381..506 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" CDS 394..2004 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /EC_number="3.1.4.17" /note="isoform 1 is encoded by transcript variant 1; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; presumed 63kDa form of the type 1 cyclic nucleotide phosphodiesterase family known as PDE1B; calmodulin-stimulated phosphodiesterase PDE1B1; cam-PDE 1B; 63 kDa Cam-PDE" /codon_start=1 /product="calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1" /protein_id="NP_000915.1" /db_xref="GI:4505677" /db_xref="CCDS:CCDS8882.1" /db_xref="GeneID:5153" /db_xref="HGNC:8775" /db_xref="HPRD:01388" /db_xref="MIM:171891" /translation="
MELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKNLEYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKPKFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPKALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVVSFRSTWVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD
" misc_feature 472..534 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q01064.2); Region: Calmodulin-binding (Potential)" misc_feature 622..804 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /note="3'5'-cyclic nucleotide phosphodiesterase N-terminal; Region: PDEase_I_N; pfam08499" /db_xref="CDD:203961" misc_feature 982..1881 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q01064.2); Region: Catalytic (By similarity)" misc_feature 1057..1752 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /note="3'5'-cyclic nucleotide phosphodiesterase; Region: PDEase_I; pfam00233" /db_xref="CDD:109297" misc_feature 1789..1791 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" variation 405 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="c" /replace="t" /db_xref="dbSNP:148928407" variation 419 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:149630948" variation 453 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="c" /db_xref="dbSNP:201786340" variation 457 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:200545087" variation 492 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="t" /db_xref="dbSNP:140895636" variation 496 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="g" /db_xref="dbSNP:144754384" exon 507..620 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" variation 511 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:147900601" variation 512 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:374027304" variation 514 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:61733023" variation 517 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:139920915" variation 544 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:376974140" variation 585 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="t" /db_xref="dbSNP:2887906" variation 601 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:200096201" variation 619 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:373781937" exon 621..803 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" variation 635 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:371717266" variation 686 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:142799171" variation 687 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:372746803" variation 733 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:374242340" variation 746 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="t" /db_xref="dbSNP:377170220" variation 795 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:151025806" exon 804..870 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" variation 812 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:376631753" variation 852 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:369117826" variation 863 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:373914778" variation 870 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:140892078" exon 871..987 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" variation 877 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:112699956" variation 908 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="c" /db_xref="dbSNP:11615709" variation 978 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:377445884" exon 988..1128 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" STS 1018..1208 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /standard_name="MARC_21181-21182:1027091922:1" /db_xref="UniSTS:268504" variation 1054 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="c" /db_xref="dbSNP:150159795" variation 1059 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:146735076" variation 1074 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:115951482" variation 1088 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:200815928" variation 1114 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:145391059" exon 1129..1229 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" variation 1139 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:137936270" variation 1140 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:113265707" variation 1145 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:373565313" variation 1162 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="t" /db_xref="dbSNP:143034173" variation 1167 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:376805586" variation 1185 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:148185581" variation 1197 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:115481291" exon 1230..1355 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" variation 1244 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="t" /db_xref="dbSNP:375085069" variation 1272 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:12812036" variation 1274 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="t" /db_xref="dbSNP:12811532" variation 1330 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:201756814" variation 1332 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:150688398" variation 1339 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="c" /replace="t" /db_xref="dbSNP:12811737" exon 1356..1457 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" variation 1416 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="g" /db_xref="dbSNP:139284651" variation 1441 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:200839405" variation 1443 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:199536319" exon 1458..1578 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" variation 1574 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="g" /replace="t" /db_xref="dbSNP:143206355" exon 1579..1660 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" exon 1661..1769 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" variation 1662 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="g" /replace="t" /db_xref="dbSNP:147497085" variation 1669 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:372439210" variation 1720 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="c" /db_xref="dbSNP:376262595" variation 1736 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:147477377" variation 1752 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="g" /db_xref="dbSNP:150000693" variation 1755 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="g" /replace="t" /db_xref="dbSNP:148673155" exon 1770..1900 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" variation 1781 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:148711763" variation 1799 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="g" /replace="t" /db_xref="dbSNP:142239113" variation 1838 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:202001120" variation 1869 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:1249950" variation 1885 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:140368041" variation 1896 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="c" /db_xref="dbSNP:200779298" exon 1901..2021 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" variation 1904 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="t" /db_xref="dbSNP:183676395" variation 1907 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="c" /db_xref="dbSNP:144100250" variation 1911 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:146475493" variation 1937 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="g" /db_xref="dbSNP:371822951" variation 1948 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:140787002" variation 1968 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:150107941" exon 2022..3401 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" STS 2022..2860 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /standard_name="PDE1B_3295" /db_xref="UniSTS:462390" variation 2198..2199 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="" /replace="t" /db_xref="dbSNP:35108378" variation 2202 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:372424493" variation 2233..2234 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="" /replace="t" /db_xref="dbSNP:34320482" variation 2252 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:376600771" variation 2363 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:143775746" STS 2373..2659 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /standard_name="SHGC-148605" /db_xref="UniSTS:176493" variation 2572 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:11170978" variation 2587 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="" /replace="g" /db_xref="dbSNP:5798310" variation 2655 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:371896018" variation 2677 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:884510" variation 2904 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:191560225" variation 2943 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:76676851" variation 2977 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:1249499" variation 2985 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:148127859" variation 3000 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="g" /db_xref="dbSNP:183626030" variation 3014 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:1144996" STS 3052..3239 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /standard_name="RH78688" /db_xref="UniSTS:48654" variation 3058 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:111571643" STS 3194..3383 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /standard_name="A007D03" /db_xref="UniSTS:80815" variation 3220 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:144107699" variation 3221 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:10783631" variation 3296..3297 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="" /replace="c" /db_xref="dbSNP:71444859" variation 3326 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:189001857" variation 3370 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="c" /replace="t" /db_xref="dbSNP:3825195" polyA_signal 3382..3387 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" polyA_site 3401 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" ORIGIN
actcgtccccggcgcctgtgtgcgtgcgctcgcccttgggcgcttctgtctgtgtgtgcccccggcttccaatcgttcctttgggagggggaggagtggctgtgaggagtgagagactggcgggcaggctgaggagaagggagggagagcagagggaggggggaacccggccgggggaggaggagagaggcgaggaggcggctctggcagcgcgcggcggcggcggcggtagcggcagcagcagcggcggtgcggagagcttggactgggagcccaaagctcggctgggcagcgggagaggaggagccgcaggagctgcagctctgccagcttgggccgagcctagagacaccggcctggctggtccacgccagccgcagaccgtggctgagcatggagctgtccccccgcagtcctccggagatgctggaggagtcggattgcccgtcacccctggagctgaagtcagcccccagcaagaagatgtggattaagcttcggtctctgctgcgctacatggtgaagcagttggagaatggggagataaacattgaggagctgaagaaaaatctggagtacacagcttctctgctggaagccgtctacatagatgagacacggcaaatcttggacacggaggacgagctgcaggagctgcggtcagatgccgtgccttcggaggtgcgggactggctggcctccaccttcacccagcaggcccgggccaaaggccgccgagcagaggagaagcccaagttccgaagcattgtgcacgctgtgcaggctgggatcttcgtggaacggatgttccggagaacatacacctctgtgggccccacttactctactgcggttctcaactgtctcaagaacctggatctctggtgctttgatgtcttttccttgaaccaggcagcagatgaccatgccctgaggaccattgtttttgagttgctgactcggcataacctcatcagccgcttcaagattcccactgtgtttttgatgagtttcctggatgccttggagacaggctatgggaagtacaagaatccttaccacaaccagatccacgcagccgatgttacccagacagtccattgcttcttgctccgcacagggatggtgcactgcctgtcggagattgagctcctggccatcatctttgctgcagctatccatgattatgagcacacgggcactaccaacagcttccacatccagaccaagtcagaatgtgccatcgtgtacaatgatcgttcagtgctggagaatcaccacatcagctctgttttccgattgatgcaggatgatgagatgaacattttcatcaacctcaccaaggatgagtttgtagaactccgagccctggtcattgagatggtgttggccacagacatgtcctgccatttccagcaagtgaagaccatgaagacagccttgcaacagctggagaggattgacaagcccaaggccctgtctctactgctccatgctgctgacatcagccacccaaccaagcagtggttggtccacagccgttggaccaaggccctcatggaggaattcttccgtcagggtgacaaggaggcagagttgggcctgcccttttctccactctgtgaccgcacttccactctagtggcacagtctcagatagggttcatcgacttcattgtggagcccacattctctgtgctgactgacgtggcagagaagagtgttcagcccctggcggatgaggactccaagtctaaaaaccagcccagctttcagtggcgccagccctctctggatgtggaagtgggagaccccaaccctgatgtggtcagctttcgttccacctgggtcaagcgcattcaggagaataagcagaaatggaaggaacgggcagcaagtggcatcaccaaccagatgtccattgacgagctgtccccctgtgaagaagaggcccccccatcccctgccgaagatgaacacaaccagaatgggaatctggattagccctggggctggcccaggtcttcattgagtccaaagtgtttgatgtcatcagcaccatccatcaggactggctcccccatctgctccaagggagcgtggtcgtggaagaaacaacccacctgaaggccaaatgccagagatttggggttggggaaagggcccctccccacctgacacccactggggtgcactttaatgttccggcagcaagactggggaacttcaggctcccagtggtcactgtgcccatccctcagcctctggattctcttcatggccaggtggctgccagggagcggggagcttcctggaggcttcccagggccttggggaagggtcagagatgccagccccctgggacctcccccatcctttttgcctccaagtttctaagcaatacattttgggggttccctcagccccccaccccagatcttagctggcaggtctgggtgccccttttcctcccctgggaagggctggaataggatagaaagctgggggttttcagagccctatgtgtggggaggggagtggattccttcagggcatggtacctttctaggacctgggaatggggtggagaggacatcctcttcaccccagaattgcgctgcttcagccccatctccagcctgatcctctgaatcttccttccctccctttctgatacagtgactggggcaaaaggagccattgtgaccaggggctgcgggaggcctttcctgggaccttccttgggactggtctgggcccctggggcttgtcgcctgccctgagtccggagccctttgcctccttcctctcccctggggctgggaggctccatccgaccaatgtctgtaaagtgctttgaggatctccccagcaaagcaccttcagaatgtatcgacaccagctgggttagggtcaagggtgcctggggagggtgagtaatcctgcattgctaaaagagagggtctgtcccctcctctccacgtcccagaactggcccagctgcaggcactaagaagctcctcccctgagacaagtgaggggtagtcggtgaaaggcagatggacaaggggctcagggctgctgccttcctgtcctctggagagaacccagccaggcgcggtgccccttcctctcctcaggctcctccttgcccccaccttgccccaggaaaggccaaagtccaggtgactgccctccttctttcttgtaaataccaaccatgcatttgtacagtgggccctgttcatgcgaaatccacatccatggtctcctagacctgctaccctggtacttccaccctaccccaccccgagaagggcagagacgcatgtgactcacccctgcccttggtttcccagacccctgctatagccagagaacaataaagaagggagaccaggaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:5153 -> Molecular function: GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] evidence: IEA GeneID:5153 -> Molecular function: GO:0004117 [calmodulin-dependent cyclic-nucleotide phosphodiesterase activity] evidence: TAS GeneID:5153 -> Molecular function: GO:0005516 [calmodulin binding] evidence: IEA GeneID:5153 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA GeneID:5153 -> Molecular function: GO:0048101 [calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity] evidence: IEA GeneID:5153 -> Biological process: GO:0001505 [regulation of neurotransmitter levels] evidence: IEA GeneID:5153 -> Biological process: GO:0001975 [response to amphetamine] evidence: IEA GeneID:5153 -> Biological process: GO:0006198 [cAMP catabolic process] evidence: IDA GeneID:5153 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:5153 -> Biological process: GO:0007165 [signal transduction] evidence: TAS GeneID:5153 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS GeneID:5153 -> Biological process: GO:0007202 [activation of phospholipase C activity] evidence: TAS GeneID:5153 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS GeneID:5153 -> Biological process: GO:0007626 [locomotory behavior] evidence: IEA GeneID:5153 -> Biological process: GO:0008542 [visual learning] evidence: IEA GeneID:5153 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: TAS GeneID:5153 -> Biological process: GO:0030224 [monocyte differentiation] evidence: IEP GeneID:5153 -> Biological process: GO:0036006 [cellular response to macrophage colony-stimulating factor stimulus] evidence: IDA GeneID:5153 -> Biological process: GO:0042053 [regulation of dopamine metabolic process] evidence: IEA GeneID:5153 -> Biological process: GO:0042428 [serotonin metabolic process] evidence: IEA GeneID:5153 -> Biological process: GO:0045087 [innate immune response] evidence: TAS GeneID:5153 -> Biological process: GO:0046069 [cGMP catabolic process] evidence: IDA GeneID:5153 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS GeneID:5153 -> Biological process: GO:0097011 [cellular response to granulocyte macrophage colony-stimulating factor stimulus] evidence: IDA GeneID:5153 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:5153 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA GeneID:5153 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:5153 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:5153 -> Cellular component: GO:0043025 [neuronal cell body] evidence: IEA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_000915 -> EC 3.1.4.17
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.