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2024-04-18 20:26:11, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_000845 3572 bp mRNA linear PRI 02-JUN-2013
DEFINITION Homo sapiens glutamate receptor, metabotropic 8 (GRM8), transcript
variant 1, mRNA.
ACCESSION NM_000845
VERSION NM_000845.2 GI:187960066
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3572)
AUTHORS Yanagawa,M., Yamashita,T. and Shichida,Y.
TITLE Glutamate acts as a partial inverse agonist to metabotropic
glutamate receptor with a single amino acid mutation in the
transmembrane domain
JOURNAL J. Biol. Chem. 288 (14), 9593-9601 (2013)
PUBMED 23420844
REMARK GeneRIF: Glutamate acts as a partial inverse agonist to
metabotropic glutamate receptor with a single amino acid mutation
in the transmembrane domain
REFERENCE 2 (bases 1 to 3572)
AUTHORS Girotto,G., Pirastu,N., Sorice,R., Biino,G., Campbell,H.,
d'Adamo,A.P., Hastie,N.D., Nutile,T., Polasek,O., Portas,L.,
Rudan,I., Ulivi,S., Zemunik,T., Wright,A.F., Ciullo,M., Hayward,C.,
Pirastu,M. and Gasparini,P.
TITLE Hearing function and thresholds: a genome-wide association study in
European isolated populations identifies new loci and pathways
JOURNAL J. Med. Genet. 48 (6), 369-374 (2011)
PUBMED 21493956
REMARK GeneRIF: Eight suggestive significant loci were detected with a
series of genes expressed within the inner ear that underlie the
auditory function, such as: DCLK1, PTPRD, GRM8, CMIP.
REFERENCE 3 (bases 1 to 3572)
AUTHORS Terracciano,A., Tanaka,T., Sutin,A.R., Sanna,S., Deiana,B., Lai,S.,
Uda,M., Schlessinger,D., Abecasis,G.R., Ferrucci,L. and Costa,P.T.
Jr.
TITLE Genome-wide association scan of trait depression
JOURNAL Biol. Psychiatry 68 (9), 811-817 (2010)
PUBMED 20800221
REFERENCE 4 (bases 1 to 3572)
AUTHORS Saus,E., Brunet,A., Armengol,L., Alonso,P., Crespo,J.M.,
Fernandez-Aranda,F., Guitart,M., Martin-Santos,R., Menchon,J.M.,
Navines,R., Soria,V., Torrens,M., Urretavizcaya,M., Valles,V.,
Gratacos,M. and Estivill,X.
TITLE Comprehensive copy number variant (CNV) analysis of neuronal
pathways genes in psychiatric disorders identifies rare variants
within patients
JOURNAL J Psychiatr Res 44 (14), 971-978 (2010)
PUBMED 20398908
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 5 (bases 1 to 3572)
AUTHORS Fonseca,F., Gratacos,M., Escaramis,G., De Cid,R., Martin-Santos,R.,
Fernandez-Espejo,E., Estivill,X. and Torrens,M.
TITLE Response to methadone maintenance treatment is associated with the
MYOCD and GRM6 genes
JOURNAL Mol Diagn Ther 14 (3), 171-178 (2010)
PUBMED 20560679
REMARK GeneRIF: Observational study of gene-disease association,
gene-environment interaction, and pharmacogenomic / toxicogenomic.
(HuGE Navigator)
REFERENCE 6 (bases 1 to 3572)
AUTHORS Thomas,N.K., Wright,R.A., Howson,P.A., Kingston,A.E., Schoepp,D.D.
and Jane,D.E.
TITLE (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist,
activates metabotropic glutamate receptors on primary afferent
terminals in the neonatal rat spinal cord
JOURNAL Neuropharmacology 40 (3), 311-318 (2001)
PUBMED 11166323
REFERENCE 7 (bases 1 to 3572)
AUTHORS Malherbe,P., Kratzeisen,C., Lundstrom,K., Richards,J.G., Faull,R.L.
and Mutel,V.
TITLE Cloning and functional expression of alternative spliced variants
of the human metabotropic glutamate receptor 8
JOURNAL Brain Res. Mol. Brain Res. 67 (2), 201-210 (1999)
PUBMED 10216218
REFERENCE 8 (bases 1 to 3572)
AUTHORS Wu,S., Wright,R.A., Rockey,P.K., Burgett,S.G., Arnold,J.S.,
Rosteck,P.R. Jr., Johnson,B.G., Schoepp,D.D. and Belagaje,R.M.
TITLE Group III human metabotropic glutamate receptors 4, 7 and 8:
molecular cloning, functional expression, and comparison of
pharmacological properties in RGT cells
JOURNAL Brain Res. Mol. Brain Res. 53 (1-2), 88-97 (1998)
PUBMED 9473604
REFERENCE 9 (bases 1 to 3572)
AUTHORS Scherer,S.W., Soder,S., Duvoisin,R.M., Huizenga,J.J. and Tsui,L.C.
TITLE The human metabotropic glutamate receptor 8 (GRM8) gene: a
disproportionately large gene located at 7q31.3-q32.1
JOURNAL Genomics 44 (2), 232-236 (1997)
PUBMED 9299241
REFERENCE 10 (bases 1 to 3572)
AUTHORS Scherer,S.W., Duvoisin,R.M., Kuhn,R., Heng,H.H., Belloni,E. and
Tsui,L.C.
TITLE Localization of two metabotropic glutamate receptor genes, GRM3 and
GRM8, to human chromosome 7q
JOURNAL Genomics 31 (2), 230-233 (1996)
PUBMED 8824806
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK315203.1, BC093725.1,
BG202742.1 and BG211606.1.
On May 13, 2008 this sequence version replaced gi:4504148.
Summary: L-glutamate is the major excitatory neurotransmitter in
the central nervous system and activates both ionotropic and
metabotropic glutamate receptors. Glutamatergic neurotransmission
is involved in most aspects of normal brain function and can be
perturbed in many neuropathologic conditions. The metabotropic
glutamate receptors are a family of G protein-coupled receptors,
that have been divided into 3 groups on the basis of sequence
homology, putative signal transduction mechanisms, and
pharmacologic properties. Group I includes GRM1 and GRM5 and these
receptors have been shown to activate phospholipase C. Group II
includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7
and GRM8. Group II and III receptors are linked to the inhibition
of the cyclic AMP cascade but differ in their agonist
selectivities. Alternatively spliced transcript variants encoding
different isoforms have been described for this gene. [provided by
RefSeq, Jul 2008].
Transcript Variant: This variant (1) encodes isoform a.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: U92459.1, BC093725.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025082, ERS025084 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-2092 AK315203.1 247-2338
2093-3066 BC093725.1 1808-2781
3067-3555 BG202742.1 82-570
3556-3572 BG211606.1 558-574
FEATURES Location/Qualifiers
source 1..3572
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q31.3-q32.1"
gene 1..3572
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/note="glutamate receptor, metabotropic 8"
/db_xref="GeneID:2918"
/db_xref="HGNC:4600"
/db_xref="MIM:601116"
exon 1..821
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
STS 131..390
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/standard_name="REN114199"
/db_xref="UniSTS:438994"
variation 137
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="g"
/replace="t"
/db_xref="dbSNP:76817979"
misc_feature 219..221
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/note="upstream in-frame stop codon"
variation 219
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="t"
/db_xref="dbSNP:75009171"
CDS 312..3038
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/note="isoform a precursor is encoded by transcript
variant 1"
/codon_start=1
/product="metabotropic glutamate receptor 8 isoform a
precursor"
/protein_id="NP_000836.2"
/db_xref="GI:187960067"
/db_xref="CCDS:CCDS5794.1"
/db_xref="GeneID:2918"
/db_xref="HGNC:4600"
/db_xref="MIM:601116"
/translation="
MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI
"
sig_peptide 312..410
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
mat_peptide 411..3035
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/product="metabotropic glutamate receptor 8 isoform a"
misc_feature 441..1823
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/note="Ligand-binding domain of the group III metabotropic
glutamate receptor; Region: PBP1_mGluR_groupIII; cd06376"
/db_xref="CDD:107371"
misc_feature order(522..524,777..779,840..848,990..992,1236..1238,
1512..1514)
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/note="ligand-binding site [chemical binding]; other site"
/db_xref="CDD:107371"
misc_feature 531..1745
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/note="Receptor family ligand binding region; Region:
ANF_receptor; pfam01094"
/db_xref="CDD:201592"
misc_feature order(639..641,648..650,792..794,801..803,870..872,
1065..1067)
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/note="dimerization interface [polypeptide binding]; other
site"
/db_xref="CDD:107371"
misc_feature 1845..1997
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/note="Nine Cysteines Domain of family 3 GPCR; Region:
NCD3G; pfam07562"
/db_xref="CDD:191786"
misc_feature 2061..2135
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O00222.2);
transmembrane region"
misc_feature 2088..2834
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/note="7 transmembrane sweet-taste receptor of 3 GCPR;
Region: 7tm_3; pfam00003"
/db_xref="CDD:200920"
misc_feature 2172..2234
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O00222.2);
transmembrane region"
misc_feature 2253..2315
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O00222.2);
transmembrane region"
misc_feature 2397..2459
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O00222.2);
transmembrane region"
misc_feature 2550..2615
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O00222.2);
transmembrane region"
misc_feature 2655..2720
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O00222.2);
transmembrane region"
misc_feature 2766..2840
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O00222.2);
transmembrane region"
variation 340
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="g"
/db_xref="dbSNP:769194"
variation 373
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="g"
/replace="t"
/db_xref="dbSNP:769202"
STS 386..653
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/standard_name="REN114198"
/db_xref="UniSTS:438993"
variation 668
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="t"
/db_xref="dbSNP:769200"
exon 822..1038
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
exon 1039..1174
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
variation 1055
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="t"
/db_xref="dbSNP:1131702"
variation 1075
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="a"
/replace="g"
/db_xref="dbSNP:78266043"
variation 1105..1106
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="t"
/db_xref="dbSNP:2234945"
variation 1105
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="t"
/db_xref="dbSNP:17150343"
exon 1175..1329
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
exon 1330..1467
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
variation 1396
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="a"
/replace="t"
/db_xref="dbSNP:78124913"
variation 1414
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="a"
/replace="g"
/db_xref="dbSNP:78947184"
exon 1468..1668
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
variation 1486
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="a"
/replace="g"
/db_xref="dbSNP:2234947"
variation 1599
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="t"
/db_xref="dbSNP:75863532"
exon 1669..1805
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
variation 1775
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="t"
/db_xref="dbSNP:769198"
exon 1806..2741
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
variation 1954
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="g"
/replace="t"
/db_xref="dbSNP:2234948"
STS 1983..2247
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/standard_name="REN111151"
/db_xref="UniSTS:435947"
STS 2221..2446
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/standard_name="REN111150"
/db_xref="UniSTS:435946"
variation 2333
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="a"
/replace="c"
/db_xref="dbSNP:77222071"
STS 2439..2691
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/standard_name="REN111149"
/db_xref="UniSTS:435945"
variation 2468
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="g"
/db_xref="dbSNP:769201"
variation 2614
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="a"
/replace="t"
/db_xref="dbSNP:1051433"
exon 2742..2988
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
exon 2989..3559
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
variation 3067
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="t"
/db_xref="dbSNP:712723"
STS 3085..3463
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/standard_name="stSG612933"
/db_xref="UniSTS:451074"
STS 3173..3398
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/standard_name="REN110736"
/db_xref="UniSTS:435532"
polyA_signal 3337..3342
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
polyA_site 3357
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
polyA_signal 3480..3485
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
polyA_signal 3535..3540
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
polyA_site 3559
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
ORIGIN
gaataattctgctacaaggctgatttcaaggacatgaattgttgacctcatcccaacatcagaacctcagatgttctaatttttgcaccattccaggcaagttgatcttataaggaaataaaattgaaccttaggggtctgatggaaattcactgtgacattcaaatcaagaaaacttgctaatgcccacagagccttttccccatgggccctgatggtagcctccagaaggtgcagcctcaggtggtgccctttcttctgtggcaagaataaactttgggtcttggattgcaataccacctgtggagaaaatggtatgcgagggaaagcgatcagcctcttgcccttgtttcttcctcttgaccgccaagttctactggatcctcacaatgatgcaaagaactcacagccaggagtatgcccattccatacgggtggatggggacattattttggggggtctcttccctgtccacgcaaagggagagagaggggtgccttgtggggagctgaagaaggaaaaggggattcacagactggaggccatgctttatgcaattgaccagattaacaaggaccctgatctcctttccaacatcactctgggtgtccgcatcctcgacacgtgctctagggacacctatgctttggagcagtctctaacattcgtgcaggcattaatagagaaagatgcttcggatgtgaagtgtgctaatggagatccacccattttcaccaagcccgacaagatttctggcgtcataggtgctgcagcaagctccgtgtccatcatggttgctaacattttaagactttttaagatacctcaaatcagctatgcatccacagccccagagctaagtgataacaccaggtatgactttttctctcgagtggttccgcctgactcctaccaagcccaagccatggtggacatcgtgacagcactgggatggaattatgtttcgacactggcttctgaggggaactatggtgagagcggtgtggaggccttcacccagatctcgagggagattggtggtgtttgcattgctcagtcacagaaaatcccacgtgaaccaagacctggagaatttgaaaaaattatcaaacgcctgctagaaacacctaatgctcgagcagtgattatgtttgccaatgaggatgacatcaggaggatattggaagcagcaaaaaaactaaaccaaagtgggcattttctctggattggctcagatagttggggatccaaaatagcacctgtctatcagcaagaggagattgcagaaggggctgtgacaattttgcccaaacgagcatcaattgatggatttgatcgatactttagaagccgaactcttgccaataatcgaagaaatgtgtggtttgcagaattctgggaggagaattttggctgcaagttaggatcacatgggaaaaggaacagtcatataaagaaatgcacagggctggagcgaattgctcgggattcatcttatgaacaggaaggaaaggtccaatttgtaattgatgctgtatattccatggcttacgccctgcacaatatgcacaaagatctctgccctggatacattggcctttgtccacgaatgagtaccattgatgggaaagagctacttggttatattcgggctgtaaattttaatggcagtgctggcactcctgtcacttttaatgaaaacggagatgctcctggacgttatgatatcttccagtatcaaataaccaacaaaagcacagagtacaaagtcatcggccactggaccaatcagcttcatctaaaagtggaagacatgcagtgggctcatagagaacatactcacccggcgtctgtctgcagcctgccgtgtaagccaggggagaggaagaaaacggtgaaaggggtcccttgctgctggcactgtgaacgctgtgaaggttacaactaccaggtggatgagctgtcctgtgaactttgccctctggatcagagacccaacatgaaccgcacaggctgccagcttatccccatcatcaaattggagtggcattctccctgggctgtggtgcctgtgtttgttgcaatattgggaatcatcgccaccacctttgtgatcgtgacctttgtccgctataatgacacacctatcgtgagggcttcaggacgcgaacttagttacgtgctcctaacggggatttttctctgttattcaatcacgtttttaatgattgcagcaccagatacaatcatatgctccttccgacgggtcttcctaggacttggcatgtgtttcagctatgcagcccttctgaccaaaacaaaccgtatccaccgaatatttgagcaggggaagaaatctgtcacagcgcccaagttcattagtccagcatctcagctggtgatcaccttcagcctcatctccgtccagctccttggagtgtttgtctggtttgttgtggatcccccccacatcatcattgactatggagagcagcggacactagatccagagaaggccaggggagtgctcaagtgtgacatttctgatctctcactcatttgttcacttggatacagtatcctcttgatggtcacttgtactgtttatgccattaaaacgagaggtgtcccagagactttcaatgaagccaaacctattggatttaccatgtataccacctgcatcatttggttagctttcatccccatcttttttggtacagcccagtcagcagaaaagatgtacatccagacaacaacacttactgtctccatgagtttaagtgcttcagtatctctgggcatgctctatatgcccaaggtttatattataatttttcatccagaacagaatgttcaaaaacgcaagaggagcttcaaggctgtggtgacagctgccaccatgcaaagcaaactgatccaaaaaggaaatgacagaccaaatggcgaggtgaaaagtgaactctgtgagagtcttgaaaccaacacttcctctaccaagacaacatatatcagttacagcaatcattcaatctgaaacagggaaatggcacaatctgaagagatgtggtatatgatcttaaatgatgaacatgagaccgcaaaaattcactcctggagatctccgtagactacaatcaatcaaatcaatagtcagtcttgtaaggaacaaaaattagccatgagccaaaagtatcaataaacggggagtgaagaaacccgttttatacaataaaaccaatgagtgtcaagctaaagtattgcttattcatgagcagttaaaacaaatcacaaaaggaaaactaatgttagctcgtgaaaaaaaatgctgttgaaataaataatgtctgatgttattcttgtatttttctgtgattgtgagaactcccgttcctgtcccacattgtttaacttgtataagacaatgagtctgtttcttgtaatggctgaccagattgaagccctgggttgtgctaaaaataaatgcaatgattgatgcatgcaattttttatacaaataatttatttctaataataaaggaatgttttgcaaatgttaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:2918 -> Molecular function: GO:0001642 [group III metabotropic glutamate receptor activity] evidence: IEA
GeneID:2918 -> Molecular function: GO:0004930 [G-protein coupled receptor activity] evidence: TAS
GeneID:2918 -> Molecular function: GO:0008066 [glutamate receptor activity] evidence: TAS
GeneID:2918 -> Biological process: GO:0007194 [negative regulation of adenylate cyclase activity] evidence: TAS
GeneID:2918 -> Biological process: GO:0007601 [visual perception] evidence: TAS
GeneID:2918 -> Biological process: GO:0007608 [sensory perception of smell] evidence: IEA
GeneID:2918 -> Biological process: GO:0030818 [negative regulation of cAMP biosynthetic process] evidence: IDA
GeneID:2918 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:2918 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
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