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2019-03-25 15:11:49, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_000845               3572 bp    mRNA    linear   PRI 02-JUN-2013
DEFINITION  Homo sapiens glutamate receptor, metabotropic 8 (GRM8), transcript
            variant 1, mRNA.
ACCESSION   NM_000845
VERSION     NM_000845.2  GI:187960066
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3572)
  AUTHORS   Yanagawa,M., Yamashita,T. and Shichida,Y.
  TITLE     Glutamate acts as a partial inverse agonist to metabotropic
            glutamate receptor with a single amino acid mutation in the
            transmembrane domain
  JOURNAL   J. Biol. Chem. 288 (14), 9593-9601 (2013)
   PUBMED   23420844
  REMARK    GeneRIF: Glutamate acts as a partial inverse agonist to
            metabotropic glutamate receptor with a single amino acid mutation
            in the transmembrane domain
REFERENCE   2  (bases 1 to 3572)
  AUTHORS   Girotto,G., Pirastu,N., Sorice,R., Biino,G., Campbell,H.,
            d'Adamo,A.P., Hastie,N.D., Nutile,T., Polasek,O., Portas,L.,
            Rudan,I., Ulivi,S., Zemunik,T., Wright,A.F., Ciullo,M., Hayward,C.,
            Pirastu,M. and Gasparini,P.
  TITLE     Hearing function and thresholds: a genome-wide association study in
            European isolated populations identifies new loci and pathways
  JOURNAL   J. Med. Genet. 48 (6), 369-374 (2011)
   PUBMED   21493956
  REMARK    GeneRIF: Eight suggestive significant loci were detected with a
            series of genes expressed within the inner ear that underlie the
            auditory function, such as: DCLK1, PTPRD, GRM8, CMIP.
REFERENCE   3  (bases 1 to 3572)
  AUTHORS   Terracciano,A., Tanaka,T., Sutin,A.R., Sanna,S., Deiana,B., Lai,S.,
            Uda,M., Schlessinger,D., Abecasis,G.R., Ferrucci,L. and Costa,P.T.
            Jr.
  TITLE     Genome-wide association scan of trait depression
  JOURNAL   Biol. Psychiatry 68 (9), 811-817 (2010)
   PUBMED   20800221
REFERENCE   4  (bases 1 to 3572)
  AUTHORS   Saus,E., Brunet,A., Armengol,L., Alonso,P., Crespo,J.M.,
            Fernandez-Aranda,F., Guitart,M., Martin-Santos,R., Menchon,J.M.,
            Navines,R., Soria,V., Torrens,M., Urretavizcaya,M., Valles,V.,
            Gratacos,M. and Estivill,X.
  TITLE     Comprehensive copy number variant (CNV) analysis of neuronal
            pathways genes in psychiatric disorders identifies rare variants
            within patients
  JOURNAL   J Psychiatr Res 44 (14), 971-978 (2010)
   PUBMED   20398908
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 3572)
  AUTHORS   Fonseca,F., Gratacos,M., Escaramis,G., De Cid,R., Martin-Santos,R.,
            Fernandez-Espejo,E., Estivill,X. and Torrens,M.
  TITLE     Response to methadone maintenance treatment is associated with the
            MYOCD and GRM6 genes
  JOURNAL   Mol Diagn Ther 14 (3), 171-178 (2010)
   PUBMED   20560679
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 3572)
  AUTHORS   Thomas,N.K., Wright,R.A., Howson,P.A., Kingston,A.E., Schoepp,D.D.
            and Jane,D.E.
  TITLE     (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist,
            activates metabotropic glutamate receptors on primary afferent
            terminals in the neonatal rat spinal cord
  JOURNAL   Neuropharmacology 40 (3), 311-318 (2001)
   PUBMED   11166323
REFERENCE   7  (bases 1 to 3572)
  AUTHORS   Malherbe,P., Kratzeisen,C., Lundstrom,K., Richards,J.G., Faull,R.L.
            and Mutel,V.
  TITLE     Cloning and functional expression of alternative spliced variants
            of the human metabotropic glutamate receptor 8
  JOURNAL   Brain Res. Mol. Brain Res. 67 (2), 201-210 (1999)
   PUBMED   10216218
REFERENCE   8  (bases 1 to 3572)
  AUTHORS   Wu,S., Wright,R.A., Rockey,P.K., Burgett,S.G., Arnold,J.S.,
            Rosteck,P.R. Jr., Johnson,B.G., Schoepp,D.D. and Belagaje,R.M.
  TITLE     Group III human metabotropic glutamate receptors 4, 7 and 8:
            molecular cloning, functional expression, and comparison of
            pharmacological properties in RGT cells
  JOURNAL   Brain Res. Mol. Brain Res. 53 (1-2), 88-97 (1998)
   PUBMED   9473604
REFERENCE   9  (bases 1 to 3572)
  AUTHORS   Scherer,S.W., Soder,S., Duvoisin,R.M., Huizenga,J.J. and Tsui,L.C.
  TITLE     The human metabotropic glutamate receptor 8 (GRM8) gene: a
            disproportionately large gene located at 7q31.3-q32.1
  JOURNAL   Genomics 44 (2), 232-236 (1997)
   PUBMED   9299241
REFERENCE   10 (bases 1 to 3572)
  AUTHORS   Scherer,S.W., Duvoisin,R.M., Kuhn,R., Heng,H.H., Belloni,E. and
            Tsui,L.C.
  TITLE     Localization of two metabotropic glutamate receptor genes, GRM3 and
            GRM8, to human chromosome 7q
  JOURNAL   Genomics 31 (2), 230-233 (1996)
   PUBMED   8824806
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK315203.1, BC093725.1,
            BG202742.1 and BG211606.1.
            On May 13, 2008 this sequence version replaced gi:4504148.
            
            Summary: L-glutamate is the major excitatory neurotransmitter in
            the central nervous system and activates both ionotropic and
            metabotropic glutamate receptors. Glutamatergic neurotransmission
            is involved in most aspects of normal brain function and can be
            perturbed in many neuropathologic conditions. The metabotropic
            glutamate receptors are a family of G protein-coupled receptors,
            that have been divided into 3 groups on the basis of sequence
            homology, putative signal transduction mechanisms, and
            pharmacologic properties. Group I includes GRM1 and GRM5 and these
            receptors have been shown to activate phospholipase C. Group II
            includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7
            and GRM8. Group II and III receptors are linked to the inhibition
            of the cyclic AMP cascade but differ in their agonist
            selectivities. Alternatively spliced transcript variants encoding
            different isoforms have been described for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U92459.1, BC093725.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025082, ERS025084 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2092              AK315203.1         247-2338
            2093-3066           BC093725.1         1808-2781
            3067-3555           BG202742.1         82-570
            3556-3572           BG211606.1         558-574
FEATURES             Location/Qualifiers
     source          1..3572
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.3-q32.1"
     gene            1..3572
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /note="glutamate receptor, metabotropic 8"
                     /db_xref="GeneID:2918"
                     /db_xref="HGNC:4600"
                     /db_xref="MIM:601116"
     exon            1..821
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:1.39.8"
     STS             131..390
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /standard_name="REN114199"
                     /db_xref="UniSTS:438994"
     variation       137
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:76817979"
     misc_feature    219..221
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /note="upstream in-frame stop codon"
     variation       219
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:75009171"
     CDS             312..3038
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="metabotropic glutamate receptor 8 isoform a
                     precursor"
                     /protein_id="NP_000836.2"
                     /db_xref="GI:187960067"
                     /db_xref="CCDS:CCDS5794.1"
                     /db_xref="GeneID:2918"
                     /db_xref="HGNC:4600"
                     /db_xref="MIM:601116"
                     /translation="
MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI
"
     sig_peptide     312..410
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
     mat_peptide     411..3035
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /product="metabotropic glutamate receptor 8 isoform a"
     misc_feature    441..1823
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /note="Ligand-binding domain of the group III metabotropic
                     glutamate receptor; Region: PBP1_mGluR_groupIII; cd06376"
                     /db_xref="CDD:107371"
     misc_feature    order(522..524,777..779,840..848,990..992,1236..1238,
                     1512..1514)
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /note="ligand-binding site [chemical binding]; other site"
                     /db_xref="CDD:107371"
     misc_feature    531..1745
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /note="Receptor family ligand binding region; Region:
                     ANF_receptor; pfam01094"
                     /db_xref="CDD:201592"
     misc_feature    order(639..641,648..650,792..794,801..803,870..872,
                     1065..1067)
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:107371"
     misc_feature    1845..1997
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:191786"
     misc_feature    2061..2135
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O00222.2);
                     transmembrane region"
     misc_feature    2088..2834
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /note="7 transmembrane sweet-taste receptor of 3 GCPR;
                     Region: 7tm_3; pfam00003"
                     /db_xref="CDD:200920"
     misc_feature    2172..2234
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O00222.2);
                     transmembrane region"
     misc_feature    2253..2315
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O00222.2);
                     transmembrane region"
     misc_feature    2397..2459
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O00222.2);
                     transmembrane region"
     misc_feature    2550..2615
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O00222.2);
                     transmembrane region"
     misc_feature    2655..2720
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O00222.2);
                     transmembrane region"
     misc_feature    2766..2840
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O00222.2);
                     transmembrane region"
     variation       340
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:769194"
     variation       373
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:769202"
     STS             386..653
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /standard_name="REN114198"
                     /db_xref="UniSTS:438993"
     variation       668
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:769200"
     exon            822..1038
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:1.39.8"
     exon            1039..1174
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:1.39.8"
     variation       1055
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1131702"
     variation       1075
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:78266043"
     variation       1105..1106
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2234945"
     variation       1105
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17150343"
     exon            1175..1329
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:1.39.8"
     exon            1330..1467
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:1.39.8"
     variation       1396
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:78124913"
     variation       1414
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:78947184"
     exon            1468..1668
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:1.39.8"
     variation       1486
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2234947"
     variation       1599
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:75863532"
     exon            1669..1805
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:1.39.8"
     variation       1775
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:769198"
     exon            1806..2741
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:1.39.8"
     variation       1954
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2234948"
     STS             1983..2247
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /standard_name="REN111151"
                     /db_xref="UniSTS:435947"
     STS             2221..2446
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /standard_name="REN111150"
                     /db_xref="UniSTS:435946"
     variation       2333
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:77222071"
     STS             2439..2691
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /standard_name="REN111149"
                     /db_xref="UniSTS:435945"
     variation       2468
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:769201"
     variation       2614
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1051433"
     exon            2742..2988
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:1.39.8"
     exon            2989..3559
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:1.39.8"
     variation       3067
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:712723"
     STS             3085..3463
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /standard_name="stSG612933"
                     /db_xref="UniSTS:451074"
     STS             3173..3398
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /standard_name="REN110736"
                     /db_xref="UniSTS:435532"
     polyA_signal    3337..3342
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
     polyA_site      3357
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
     polyA_signal    3480..3485
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
     polyA_signal    3535..3540
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
     polyA_site      3559
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
ORIGIN      
gaataattctgctacaaggctgatttcaaggacatgaattgttgacctcatcccaacatcagaacctcagatgttctaatttttgcaccattccaggcaagttgatcttataaggaaataaaattgaaccttaggggtctgatggaaattcactgtgacattcaaatcaagaaaacttgctaatgcccacagagccttttccccatgggccctgatggtagcctccagaaggtgcagcctcaggtggtgccctttcttctgtggcaagaataaactttgggtcttggattgcaataccacctgtggagaaaatggtatgcgagggaaagcgatcagcctcttgcccttgtttcttcctcttgaccgccaagttctactggatcctcacaatgatgcaaagaactcacagccaggagtatgcccattccatacgggtggatggggacattattttggggggtctcttccctgtccacgcaaagggagagagaggggtgccttgtggggagctgaagaaggaaaaggggattcacagactggaggccatgctttatgcaattgaccagattaacaaggaccctgatctcctttccaacatcactctgggtgtccgcatcctcgacacgtgctctagggacacctatgctttggagcagtctctaacattcgtgcaggcattaatagagaaagatgcttcggatgtgaagtgtgctaatggagatccacccattttcaccaagcccgacaagatttctggcgtcataggtgctgcagcaagctccgtgtccatcatggttgctaacattttaagactttttaagatacctcaaatcagctatgcatccacagccccagagctaagtgataacaccaggtatgactttttctctcgagtggttccgcctgactcctaccaagcccaagccatggtggacatcgtgacagcactgggatggaattatgtttcgacactggcttctgaggggaactatggtgagagcggtgtggaggccttcacccagatctcgagggagattggtggtgtttgcattgctcagtcacagaaaatcccacgtgaaccaagacctggagaatttgaaaaaattatcaaacgcctgctagaaacacctaatgctcgagcagtgattatgtttgccaatgaggatgacatcaggaggatattggaagcagcaaaaaaactaaaccaaagtgggcattttctctggattggctcagatagttggggatccaaaatagcacctgtctatcagcaagaggagattgcagaaggggctgtgacaattttgcccaaacgagcatcaattgatggatttgatcgatactttagaagccgaactcttgccaataatcgaagaaatgtgtggtttgcagaattctgggaggagaattttggctgcaagttaggatcacatgggaaaaggaacagtcatataaagaaatgcacagggctggagcgaattgctcgggattcatcttatgaacaggaaggaaaggtccaatttgtaattgatgctgtatattccatggcttacgccctgcacaatatgcacaaagatctctgccctggatacattggcctttgtccacgaatgagtaccattgatgggaaagagctacttggttatattcgggctgtaaattttaatggcagtgctggcactcctgtcacttttaatgaaaacggagatgctcctggacgttatgatatcttccagtatcaaataaccaacaaaagcacagagtacaaagtcatcggccactggaccaatcagcttcatctaaaagtggaagacatgcagtgggctcatagagaacatactcacccggcgtctgtctgcagcctgccgtgtaagccaggggagaggaagaaaacggtgaaaggggtcccttgctgctggcactgtgaacgctgtgaaggttacaactaccaggtggatgagctgtcctgtgaactttgccctctggatcagagacccaacatgaaccgcacaggctgccagcttatccccatcatcaaattggagtggcattctccctgggctgtggtgcctgtgtttgttgcaatattgggaatcatcgccaccacctttgtgatcgtgacctttgtccgctataatgacacacctatcgtgagggcttcaggacgcgaacttagttacgtgctcctaacggggatttttctctgttattcaatcacgtttttaatgattgcagcaccagatacaatcatatgctccttccgacgggtcttcctaggacttggcatgtgtttcagctatgcagcccttctgaccaaaacaaaccgtatccaccgaatatttgagcaggggaagaaatctgtcacagcgcccaagttcattagtccagcatctcagctggtgatcaccttcagcctcatctccgtccagctccttggagtgtttgtctggtttgttgtggatcccccccacatcatcattgactatggagagcagcggacactagatccagagaaggccaggggagtgctcaagtgtgacatttctgatctctcactcatttgttcacttggatacagtatcctcttgatggtcacttgtactgtttatgccattaaaacgagaggtgtcccagagactttcaatgaagccaaacctattggatttaccatgtataccacctgcatcatttggttagctttcatccccatcttttttggtacagcccagtcagcagaaaagatgtacatccagacaacaacacttactgtctccatgagtttaagtgcttcagtatctctgggcatgctctatatgcccaaggtttatattataatttttcatccagaacagaatgttcaaaaacgcaagaggagcttcaaggctgtggtgacagctgccaccatgcaaagcaaactgatccaaaaaggaaatgacagaccaaatggcgaggtgaaaagtgaactctgtgagagtcttgaaaccaacacttcctctaccaagacaacatatatcagttacagcaatcattcaatctgaaacagggaaatggcacaatctgaagagatgtggtatatgatcttaaatgatgaacatgagaccgcaaaaattcactcctggagatctccgtagactacaatcaatcaaatcaatagtcagtcttgtaaggaacaaaaattagccatgagccaaaagtatcaataaacggggagtgaagaaacccgttttatacaataaaaccaatgagtgtcaagctaaagtattgcttattcatgagcagttaaaacaaatcacaaaaggaaaactaatgttagctcgtgaaaaaaaatgctgttgaaataaataatgtctgatgttattcttgtatttttctgtgattgtgagaactcccgttcctgtcccacattgtttaacttgtataagacaatgagtctgtttcttgtaatggctgaccagattgaagccctgggttgtgctaaaaataaatgcaatgattgatgcatgcaattttttatacaaataatttatttctaataataaaggaatgttttgcaaatgttaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:2918 -> Molecular function: GO:0001642 [group III metabotropic glutamate receptor activity] evidence: IEA
            GeneID:2918 -> Molecular function: GO:0004930 [G-protein coupled receptor activity] evidence: TAS
            GeneID:2918 -> Molecular function: GO:0008066 [glutamate receptor activity] evidence: TAS
            GeneID:2918 -> Biological process: GO:0007194 [negative regulation of adenylate cyclase activity] evidence: TAS
            GeneID:2918 -> Biological process: GO:0007601 [visual perception] evidence: TAS
            GeneID:2918 -> Biological process: GO:0007608 [sensory perception of smell] evidence: IEA
            GeneID:2918 -> Biological process: GO:0030818 [negative regulation of cAMP biosynthetic process] evidence: IDA
            GeneID:2918 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
            GeneID:2918 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS

by @meso_cacase at DBCLS
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