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2024-04-19 20:33:20, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_000772 2562 bp mRNA linear PRI 11-MAY-2013
DEFINITION Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 18
(CYP2C18), transcript variant 1, mRNA.
ACCESSION NM_000772
VERSION NM_000772.2 GI:193083146
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2562)
AUTHORS Flachsbart,F., Ufer,M., Kleindorp,R., Nikolaus,S., Schreiber,S. and
Nebel,A.
TITLE Genetic variation in the CYP2C monooxygenase enzyme subfamily shows
no association with longevity in a German population
JOURNAL J. Gerontol. A Biol. Sci. Med. Sci. 66 (11), 1186-1191 (2011)
PUBMED 21798861
REMARK GeneRIF: These results suggest that there is no notable influence
of sequence variation in the CYP2C genes on longevity in the
examined German population
REFERENCE 2 (bases 1 to 2562)
AUTHORS Howard,T.D., Hsu,F.C., Grzywacz,J.G., Chen,H., Quandt,S.A.,
Vallejos,Q.M., Whalley,L.E., Cui,W., Padilla,S. and Arcury,T.A.
TITLE Evaluation of candidate genes for cholinesterase activity in
farmworkers exposed to organophosphorus pesticides: association of
single nucleotide polymorphisms in BCHE
JOURNAL Environ. Health Perspect. 118 (10), 1395-1399 (2010)
PUBMED 20529763
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 3 (bases 1 to 2562)
AUTHORS Liu,C.Y., Wu,M.C., Chen,F., Ter-Minassian,M., Asomaning,K.,
Zhai,R., Wang,Z., Su,L., Heist,R.S., Kulke,M.H., Lin,X., Liu,G. and
Christiani,D.C.
TITLE A Large-scale genetic association study of esophageal
adenocarcinoma risk
JOURNAL Carcinogenesis 31 (7), 1259-1263 (2010)
PUBMED 20453000
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 4 (bases 1 to 2562)
AUTHORS Lee,M.T., Chen,C.H., Chou,C.H., Lu,L.S., Chuang,H.P., Chen,Y.T.,
Saleem,A.N., Wen,M.S., Chen,J.J., Wu,J.Y. and Chen,Y.T.
TITLE Genetic determinants of warfarin dosing in the Han-Chinese
population
JOURNAL Pharmacogenomics 10 (12), 1905-1913 (2009)
PUBMED 19958090
REMARK GeneRIF: Observational study of gene-disease association,
gene-environment interaction, and pharmacogenomic / toxicogenomic.
(HuGE Navigator)
REFERENCE 5 (bases 1 to 2562)
AUTHORS Satyanarayana,C.R., Devendran,A., Jayaraman,M., Mannu,J.,
Mathur,P.P., Gopal,S.D., Rajagopal,K. and Chandrasekaran,A.
TITLE Influence of the genetic polymorphisms in the 5' flanking and
exonic regions of CYP2C19 on proguanil oxidation
JOURNAL Drug Metab. Pharmacokinet. 24 (6), 537-548 (2009)
PUBMED 20045989
REMARK GeneRIF: Observational study of gene-disease association,
gene-environment interaction, and pharmacogenomic / toxicogenomic.
(HuGE Navigator)
REFERENCE 6 (bases 1 to 2562)
AUTHORS Nelson,D.R., Zeldin,D.C., Hoffman,S.M., Maltais,L.J., Wain,H.M. and
Nebert,D.W.
TITLE Comparison of cytochrome P450 (CYP) genes from the mouse and human
genomes, including nomenclature recommendations for genes,
pseudogenes and alternative-splice variants
JOURNAL Pharmacogenetics 14 (1), 1-18 (2004)
PUBMED 15128046
REMARK Review article
REFERENCE 7 (bases 1 to 2562)
AUTHORS Goldstein,J.A. and de Morais,S.M.
TITLE Biochemistry and molecular biology of the human CYP2C subfamily
JOURNAL Pharmacogenetics 4 (6), 285-299 (1994)
PUBMED 7704034
REMARK Review article
REFERENCE 8 (bases 1 to 2562)
AUTHORS Ged,C. and Beaune,P.
TITLE Partial sequence and polymerase chain reaction-mediated analysis of
expression of the human CYP2C18 gene
JOURNAL Pharmacogenetics 2 (3), 109-115 (1992)
PUBMED 1306110
REFERENCE 9 (bases 1 to 2562)
AUTHORS Furuya,H., Meyer,U.A., Gelboin,H.V. and Gonzalez,F.J.
TITLE Polymerase chain reaction-directed identification, cloning, and
quantification of human CYP2C18 mRNA
JOURNAL Mol. Pharmacol. 40 (3), 375-382 (1991)
PUBMED 1896026
REFERENCE 10 (bases 1 to 2562)
AUTHORS Romkes,M., Faletto,M.B., Blaisdell,J.A., Raucy,J.L. and
Goldstein,J.A.
TITLE Cloning and expression of complementary DNAs for multiple members
of the human cytochrome P450IIC subfamily
JOURNAL Biochemistry 30 (13), 3247-3255 (1991)
PUBMED 2009263
REMARK Erratum:[Biochemistry. 1993 Feb 9;32(5):1390. PMID: 8095407]
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BJ993698.1, M61856.1,
BX538127.1 and M61853.1.
This sequence is a reference standard in the RefSeqGene project.
On Jun 27, 2008 this sequence version replaced gi:13699815.
Summary: This gene encodes a member of the cytochrome P450
superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug
metabolism and synthesis of cholesterol, steroids and other lipids.
This protein localizes to the endoplasmic reticulum but its
specific substrate has not yet been determined. The gene is located
within a cluster of cytochrome P450 genes on chromosome 10q24. An
additional gene, CYP2C17, was once thought to exist; however,
CYP2C17 is now considered an artefact based on a chimera of CYP2C18
and CYP2C19. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq, Jul 2008].
Transcript Variant: This variant (1) encodes the longer isoform
(1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: M61853.1, M61856.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-127 BJ993698.1 1-127
128-1863 M61856.1 1-1736
1864-2122 BX538127.1 998-1256
2123-2390 M61853.1 1839-2106
2391-2562 BX538127.1 1525-1696
FEATURES Location/Qualifiers
source 1..2562
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q24"
gene 1..2562
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/note="cytochrome P450, family 2, subfamily C, polypeptide
18"
/db_xref="GeneID:1562"
/db_xref="HGNC:2620"
/db_xref="HPRD:03085"
/db_xref="MIM:601131"
exon 1..494
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/inference="alignment:Splign:1.39.8"
variation 20
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:879406"
variation 28
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="g"
/replace="t"
/db_xref="dbSNP:148696174"
variation 60..62
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace=""
/replace="aac"
/db_xref="dbSNP:376114020"
variation 61..62
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace=""
/replace="caa"
/db_xref="dbSNP:368050072"
variation 164
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="g"
/replace="t"
/db_xref="dbSNP:79340481"
variation 261
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:374585526"
STS 282..1930
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/db_xref="UniSTS:482629"
misc_feature 309..311
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/note="upstream in-frame stop codon"
variation 311
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:201820267"
variation 312
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:201110913"
variation 314
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:142036845"
variation 316
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:374064225"
variation 318
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:377514919"
CDS 327..1799
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/EC_number="1.14.14.1"
/note="isoform 1 precursor is encoded by transcript
variant 1; microsomal monooxygenase; flavoprotein-linked
monooxygenase; cytochrome P450, subfamily IIC (mephenytoin
4-hydroxylase), polypeptide 18; cytochrome P450, subfamily
IIC (mephenytoin 4-hydroxylase), polypeptide 17;
cytochrome P450 2C18; (S)-mephenytoin hydroxylase
associated cytochrome P450; unspecific monooxygenase;
CYPIIC18; cytochrome P450-6B/29C"
/codon_start=1
/product="cytochrome P450 2C18 isoform 1 precursor"
/protein_id="NP_000763.1"
/db_xref="GI:13699816"
/db_xref="CCDS:CCDS7435.1"
/db_xref="GeneID:1562"
/db_xref="HGNC:2620"
/db_xref="HPRD:03085"
/db_xref="MIM:601131"
/translation="
MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQLCFIPV
"
sig_peptide 327..401
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
misc_feature 414..1787
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/note="Cytochrome P450; Region: p450; pfam00067"
/db_xref="CDD:200971"
misc_feature 417..1736
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/note="Cytochrome P450 [Secondary metabolites
biosynthesis, transport, and catabolism]; Region: CypX;
cl12078"
/db_xref="CDD:212625"
misc_feature 621..623
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
variation 360
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="g"
/replace="t"
/db_xref="dbSNP:370987812"
variation 473
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:56113807"
exon 495..657
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/inference="alignment:Splign:1.39.8"
variation 512
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:143341184"
variation 519
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:146239394"
variation 520
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:202113535"
variation 529..530
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace=""
/replace="t"
/db_xref="dbSNP:372279673"
variation 530
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="t"
/db_xref="dbSNP:41291550"
variation 548
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:375505433"
variation 555
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:143695270"
variation 565
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:368264095"
variation 592
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:372444081"
variation 609
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:200398730"
variation 651
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:145731435"
exon 658..807
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/inference="alignment:Splign:1.39.8"
variation 674
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="t"
/db_xref="dbSNP:371597682"
variation 679
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:201048148"
variation 692
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:190647817"
variation 696
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:117111102"
variation 700
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:142985033"
variation 749
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:151106761"
variation 757
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:115091705"
variation 774
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:371910428"
variation 796
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="g"
/db_xref="dbSNP:375267413"
exon 808..968
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/inference="alignment:Splign:1.39.8"
variation 809
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:202163378"
variation 818
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="g"
/replace="t"
/db_xref="dbSNP:373749082"
variation 821
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:116092201"
variation 834
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:11188056"
variation 853
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:139238143"
variation 879
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:376802839"
variation 882
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:141271146"
variation 887
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:200638718"
variation 889
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:41303835"
variation 893
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:374650806"
variation 902
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="g"
/db_xref="dbSNP:115269792"
variation 908..909
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace=""
/replace="t"
/db_xref="dbSNP:72558183"
variation 931
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:137908489"
variation 948
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:11188057"
variation 953
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:149450201"
exon 969..1145
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/inference="alignment:Splign:1.39.8"
variation 995
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:77738774"
variation 996
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="g"
/db_xref="dbSNP:201869881"
variation 1020
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:2296681"
variation 1070
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:368692166"
variation 1077
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="c"
/db_xref="dbSNP:138778808"
variation 1082
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:370229405"
variation 1089
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="c"
/db_xref="dbSNP:373847336"
variation 1107
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:184571563"
variation 1128
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:141829322"
variation 1138
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="t"
/db_xref="dbSNP:371704710"
exon 1146..1287
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/inference="alignment:Splign:1.39.8"
variation 1150
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:117601208"
variation 1151
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="g"
/replace="t"
/db_xref="dbSNP:146257549"
variation 1222
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:60181876"
variation 1227
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:202032764"
variation 1232
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:200741772"
variation 1237
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:201878313"
variation 1241
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:201426134"
variation 1256
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:143695504"
variation 1268
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="g"
/db_xref="dbSNP:375872072"
exon 1288..1475
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/inference="alignment:Splign:1.39.8"
variation 1288
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:191275957"
variation 1314
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="g"
/replace="t"
/db_xref="dbSNP:59636573"
variation 1329
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:140111676"
variation 1330
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:41286880"
variation 1338
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:41286882"
variation 1360
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:200587027"
variation 1374
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="g"
/db_xref="dbSNP:145173626"
variation 1386
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:142667327"
variation 1418
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:76498052"
variation 1420
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:144917969"
variation 1421
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="c"
/db_xref="dbSNP:147932613"
variation 1434
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="g"
/replace="t"
/db_xref="dbSNP:373928015"
variation 1442
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:199696917"
variation 1451
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:141702647"
variation 1460
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:377123025"
variation 1474
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="t"
/db_xref="dbSNP:370873051"
exon 1476..1617
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/inference="alignment:Splign:1.39.8"
variation 1480
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:1126545"
variation 1481
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:114879149"
variation 1494
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:371155124"
variation 1505
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:78319229"
variation 1537
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="g"
/db_xref="dbSNP:201690300"
variation 1544
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:201619531"
variation 1546
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="t"
/db_xref="dbSNP:150095869"
variation 1550
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="g"
/db_xref="dbSNP:367800235"
variation 1583
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:138527038"
variation 1597
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:374042569"
variation 1611
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:200735820"
variation 1616
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:145480465"
exon 1618..2545
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/inference="alignment:Splign:1.39.8"
variation 1650
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:79500998"
variation 1651
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:111489446"
variation 1677
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:202042825"
variation 1680
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:201218429"
variation 1715
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="c"
/db_xref="dbSNP:371529582"
variation 1719
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="t"
/db_xref="dbSNP:138045916"
variation 1751
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:149500379"
variation 1759
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:41286884"
variation 1766
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:115308818"
variation 1805
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:184489530"
variation 1830
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:2860840"
variation 1864
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:3740367"
variation 1882
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:1042192"
variation 1909
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:74696697"
variation 2008
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:41291552"
variation 2079
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="c"
/db_xref="dbSNP:190761792"
variation 2082
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="g"
/replace="t"
/db_xref="dbSNP:1042194"
variation 2153
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="g"
/replace="t"
/db_xref="dbSNP:76680226"
variation 2185
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="c"
/db_xref="dbSNP:181997244"
variation 2225
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:41291554"
STS 2242..2379
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/standard_name="RH2"
/db_xref="UniSTS:58153"
variation 2345..2346
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace=""
/replace="a"
/db_xref="dbSNP:140228918"
variation 2391
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="g"
/replace="t"
/db_xref="dbSNP:1326830"
variation 2483
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="g"
/replace="t"
/db_xref="dbSNP:115365853"
polyA_site 2544
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
ORIGIN
gagatcttgccattgcactccagcctgggcaacaagagcgaaactccatctcaaggaaaaacaacaacaacaacaacaaaatcctgggctctgcttcagactagttaaaccagaatctccagggtggggcaccggaaagaacaagaaaaaagaacaccttatttttatcttcttcagtgagccaatgttcattcaaaagagagattaaagtgctttttgctgactagtcacagtcagagtcagaatcacaggtggattagtagggagtgttataaaagccttgaagtgaaagcccgcagttgtcttactaagaagagaagccttcaatggatccagctgtggctctggtgctctgtctctcctgtttgtttctcctttcactctggaggcagagctctggaagagggaggctcccgtctggccccactcctctcccgattattggaaatatcctgcagttagatgttaaggacatgagcaaatccttaaccaatttctcaaaagtctatggccctgtgttcactgtgtattttggcctgaagcccattgtggtgttgcatggatatgaagcagtgaaggaggccctgattgatcatggagaggagttttctggaagaggaagttttccagtggctgaaaaagttaacaaaggacttggaatccttttcagcaatggaaagagatggaaggagatccggcgtttctgcctcatgactctgcggaattttgggatggggaagaggagcatcgaggaccgtgttcaagaggaagcccgctgccttgtggaggagttgagaaaaaccaatgcctcaccctgtgatcccactttcatcctgggctgtgctccctgcaatgtgatctgctctgttattttccatgatcgatttgattataaagatcagaggtttcttaacttgatggaaaaattcaatgaaaacctcaggattctgagctctccatggatccaggtctgcaataatttccctgctctcatcgattatctcccaggaagtcataataaaatagctgaaaattttgcttacattaaaagttatgtattggagagaataaaagaacatcaagaatccctggacatgaacagtgctcgggactttattgattgtttcctgatcaaaatggaacaggaaaagcacaatcaacagtctgaatttactgttgaaagcttgatagccactgtaactgatatgtttggggctggaacagagacaacgagcaccactctgagatatggactcctgctcctgctgaagtacccagaggtcacagctaaagtccaggaagagattgaatgtgtagttggcagaaaccggagcccctgtatgcaggacaggagtcacatgccctacacagatgctgtggtgcacgagatccagagatacattgacctcctccccaccaacctgccccatgcagtgacctgtgatgttaaattcaaaaactacctcatccccaagggcacgaccataataacatccctgacttctgtgctgcacaatgacaaagaattccccaacccagagatgtttgaccctggccactttctggataagagtggcaactttaagaaaagtgactacttcatgcctttctcagcaggaaaacggatgtgtatgggagagggcctggcccgcatggagctgtttttattcctgaccaccattttgcagaactttaacctgaaatctcaggttgacccaaaggatattgacatcacccccattgccaatgcatttggtcgtgtgccacccttgtaccagctctgcttcattcctgtctgaagaagggcagatagtttggctgctcctgtgctgtcacctgcaattctcccttatcagggccattggcctctcccttctctctgtgagggatattttctctgacttgtcaatccacatcttcccattccctcaagatccaatgaacatccaacctccattaaagagagtttcttgggtcacttcctaaatatatctgctattctccatactctgtatcacttgtattgaccaccacatatgctaatacctatctactgctgagttgtcagtatgttatcactagaaaacaaagaaaaatgattaataaatgacaattcagagccatttattctctgcatgctctagataaaaatgattattatttactgggtcagttcttagatttctttcttttgagtaaaatgaaagtaagaaatgaaagaaaatagaatgtgaagaggctgtgctggccctcatagtgttaagcacaaaaagggagaaaggtaagagggtaggaaagctgttttagctaaatgccacctagagttattggaggtctgaatttggaaaaaaaaactatgtccaggagcagctgtaacctgtagggaaatactggaacaatcatccataagagggatgaacattaagtgtttgaattcatgctctgcttttgtgttactgtaaacacaagatcaagatttggataatctttttcctttgtgtttccaacttagatcatgtctaaatatatgctttcatatggctaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:1562 -> Molecular function: GO:0004497 [monooxygenase activity] evidence: TAS
GeneID:1562 -> Molecular function: GO:0005506 [iron ion binding] evidence: IEA
GeneID:1562 -> Molecular function: GO:0009055 [electron carrier activity] evidence: IEA
GeneID:1562 -> Molecular function: GO:0019825 [oxygen binding] evidence: TAS
GeneID:1562 -> Molecular function: GO:0020037 [heme binding] evidence: IEA
GeneID:1562 -> Molecular function: GO:0070330 [aromatase activity] evidence: IEA
GeneID:1562 -> Biological process: GO:0006805 [xenobiotic metabolic process] evidence: TAS
GeneID:1562 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:1562 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_000763 -> EC 1.14.14.1
by
@meso_cacase at
DBCLS
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