2024-04-26 07:51:33, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_000771 1876 bp mRNA linear PRI 07-JUL-2013 DEFINITION Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 (CYP2C9), mRNA. ACCESSION NM_000771 VERSION NM_000771.3 GI:189242609 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1876) AUTHORS Zhou,Q., Chen,Q.X., Ruan,Z.R., Yuan,H., Xu,H.M. and Zeng,S. TITLE CYP2C9*3(1075A > C), ABCB1 and SLCO1B1 genetic polymorphisms and gender are determinants of inter-subject variability in pitavastatin pharmacokinetics JOURNAL Pharmazie 68 (3), 187-194 (2013) PUBMED 23556337 REMARK GeneRIF: Compared to CYP2C9*1/*1 carriers, CYP2C9*1/*3 carriers had higher AUC and peak plasma concentration of pitavastatin acid and AUC of pitavastatin lactone REFERENCE 2 (bases 1 to 1876) AUTHORS Reynald,R.L., Sansen,S., Stout,C.D. and Johnson,E.F. TITLE Structural characterization of human cytochrome P450 2C19: active site differences between P450s 2C8, 2C9, and 2C19 JOURNAL J. Biol. Chem. 287 (53), 44581-44591 (2012) PUBMED 23118231 REMARK GeneRIF: The substrate-binding cavity of P450 2C8 is much larger than that of P450 2C19 and P450 2C9. REFERENCE 3 (bases 1 to 1876) AUTHORS Sychev,D.V., Ignatyev,I.V., Emelyanov,N.V., Milovanova,V.V., Kossovskaya,A.V., Kukes,I.V., Tashenova,A.I. and Kukes,V.G. TITLE CYP2C9 and VKORC1 gene polymorphism is inessential for bleeding development under conditions of oral application of anticoagulant acenocoumarol in Russian patients at high risk of thromboembolic complications JOURNAL Bull. Exp. Biol. Med. 153 (6), 886-888 (2012) PUBMED 23113310 REMARK GeneRIF: CYP2C9 and VKORC1 gene polymorphisms are not essential for bleeding development under conditions of oral application of anticoagulant acenocoumarol in Russian patients at high risk of thromboembolic complications. REFERENCE 4 (bases 1 to 1876) AUTHORS Liang,S., Hu,J., Cao,W. and Cai,S. TITLE Meta-analysis of cytochrome P-450 2C9 polymorphism and colorectal cancer risk JOURNAL PLoS ONE 7 (11), E49134 (2012) PUBMED 23145098 REMARK GeneRIF: CYP2C9 may not be associated with colorectal cancer development Erratum:[PLoS One. 2013;8(5). doi:10.1371/annotation/405a8737-be71-4ff1-8755-a3ccf11cb67f. Hu, Jingsong [corrected to Hu, Jinsong]] REFERENCE 5 (bases 1 to 1876) AUTHORS Guo,Y., Hu,C., He,X., Qiu,F. and Zhao,L. TITLE Effects of UGT1A6, UGT2B7, and CYP2C9 genotypes on plasma concentrations of valproic acid in Chinese children with epilepsy JOURNAL Drug Metab. Pharmacokinet. 27 (5), 536-542 (2012) PUBMED 23099353 REMARK GeneRIF: There were no differences in VPA dose or adjusted plasma VPA concentrations among the UGT2B7*2 or CYP2C9*3 genotypic groups. REFERENCE 6 (bases 1 to 1876) AUTHORS Nelson,D.R., Zeldin,D.C., Hoffman,S.M., Maltais,L.J., Wain,H.M. and Nebert,D.W. TITLE Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants JOURNAL Pharmacogenetics 14 (1), 1-18 (2004) PUBMED 15128046 REMARK Review article REFERENCE 7 (bases 1 to 1876) AUTHORS Ohgiya,S., Komori,M., Ohi,H., Shiramatsu,K., Shinriki,N. and Kamataki,T. TITLE Six-base deletion occurring in messages of human cytochrome P-450 in the CYP2C subfamily results in reduction of tolbutamide hydroxylase activity JOURNAL Biochem. Int. 27 (6), 1073-1081 (1992) PUBMED 1445376 REFERENCE 8 (bases 1 to 1876) AUTHORS Srivastava,P.K., Yun,C.H., Beaune,P.H., Ged,C. and Guengerich,F.P. TITLE Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes JOURNAL Mol. Pharmacol. 40 (1), 69-79 (1991) PUBMED 1857342 REFERENCE 9 (bases 1 to 1876) AUTHORS Romkes,M., Faletto,M.B., Blaisdell,J.A., Raucy,J.L. and Goldstein,J.A. TITLE Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily JOURNAL Biochemistry 30 (13), 3247-3255 (1991) PUBMED 2009263 REMARK Erratum:[Biochemistry. 1993 Feb 9;32(5):1390. PMID: 8095407] REFERENCE 10 (bases 1 to 1876) AUTHORS Veronese,M.E., Mackenzie,P.I., Doecke,C.J., McManus,M.E., Miners,J.O. and Birkett,D.J. TITLE Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9 JOURNAL Biochem. Biophys. Res. Commun. 175 (3), 1112-1118 (1991) PUBMED 2025243 REMARK Erratum:[Biochem Biophys Res Commun 1991 Nov 14;180(3);1527] COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BJ993098.1, BC125054.1 and S46963.1. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2008 this sequence version replaced gi:13699817. Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK289420.1, M61857.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025084, ERS025088 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-25 BJ993098.1 1-25 26-1652 BC125054.1 1-1627 1653-1876 S46963.1 1591-1814 FEATURES Location/Qualifiers source 1..1876 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="10" /map="10q24" gene 1..1876 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /note="cytochrome P450, family 2, subfamily C, polypeptide 9" /db_xref="GeneID:1559" /db_xref="HGNC:2623" /db_xref="HPRD:03084" /db_xref="MIM:601130" exon 1..193 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /inference="alignment:Splign:1.39.8" misc_feature 5..7 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /note="upstream in-frame stop codon" variation 19 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:200634604" CDS 26..1498 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /EC_number="1.14.13.48" /EC_number="1.14.13.49" /EC_number="1.14.13.80" /note="microsomal monooxygenase; xenobiotic monooxygenase; flavoprotein-linked monooxygenase; cytochrome P450 2C9; cytochrome P-450 S-mephenytoin 4-hydroxylase; cytochrome P-450MP; cytochrome P450 PB-1" /codon_start=1 /product="cytochrome P450 2C9 precursor" /protein_id="NP_000762.2" /db_xref="GI:13699818" /db_xref="CCDS:CCDS7437.1" /db_xref="GeneID:1559" /db_xref="HGNC:2623" /db_xref="HPRD:03084" /db_xref="MIM:601130" /translation="
MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPV
" sig_peptide 26..100 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /inference="COORDINATES: ab initio prediction:SignalP:4.0" misc_feature 113..1486 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /note="Cytochrome P450; Region: p450; pfam00067" /db_xref="CDD:200971" misc_feature 116..1435 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /note="Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078" /db_xref="CDD:212625" misc_feature 1328..1330 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /note="heme binding site" variation 26 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:114071557" variation 28 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:150891702" variation 29 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:139414138" variation 39 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:138957855" STS 55..191 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /standard_name="GDB:193845" /db_xref="UniSTS:155761" variation 80 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="c" /db_xref="dbSNP:67807361" variation 114 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:142240658" variation 118 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:146375887" variation 121 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="g" /db_xref="dbSNP:28371673" variation 149 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:111639787" variation 185 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:199724614" exon 194..356 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /inference="alignment:Splign:1.39.8" variation 228 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:370315268" variation 229 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:201050615" variation 233 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="g" /db_xref="dbSNP:371055887" variation 242 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="c" /db_xref="dbSNP:201491545" variation 245 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:111808915" variation 253 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:17847036" variation 254 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:202113950" variation 259 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:371138960" variation 265 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:200794294" variation 288 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:139656048" variation 289 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:144043022" variation 290 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="g" /replace="t" /db_xref="dbSNP:371997605" variation 294 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:72558187" variation 296 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:377542177" variation 315 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="g" /db_xref="dbSNP:374201833" variation 337 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="t" /db_xref="dbSNP:367848139" exon 357..506 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /inference="alignment:Splign:1.39.8" variation 361 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:201856860" variation 387 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="" /replace="agaaatggaa" /db_xref="dbSNP:72558188" variation 396 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /replace="t" /db_xref="dbSNP:12414460" variation 398 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:375805362" variation 399 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:72558189" variation 414 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:200965026" variation 415 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="g" /replace="t" /db_xref="dbSNP:5031019" variation 419 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:199523631" variation 420 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:200183364" variation 431 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:377477630" variation 447 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="t" /db_xref="dbSNP:148615754" variation 454 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:142079687" variation 455 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:1799853" variation 456 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:141489852" variation 473 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:17847037" variation 474 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /replace="t" /db_xref="dbSNP:7900194" variation 477 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:369217316" variation 483 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="g" /replace="t" /db_xref="dbSNP:373993395" variation 484 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:199626937" variation 501 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="c" /db_xref="dbSNP:202199847" exon 507..667 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /inference="alignment:Splign:1.39.8" variation 510 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="c" /db_xref="dbSNP:72558190" variation 540 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="g" /db_xref="dbSNP:147617899" variation 542 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:373758696" variation 545 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="g" /db_xref="dbSNP:199539783" variation 557 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:201560188" variation 558 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="g" /replace="t" /db_xref="dbSNP:142123260" variation 563 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:367922573" variation 564 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:200149294" variation 581 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:150435881" variation 593 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:200629270" variation 618 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:371697146" variation 643 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="g" /replace="t" /db_xref="dbSNP:374225039" variation 647 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="g" /replace="t" /db_xref="dbSNP:72558191" variation 649 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="g" /db_xref="dbSNP:368462490" variation 662 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="c" /db_xref="dbSNP:372756508" variation 663 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:376006545" variation 667 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:370100007" exon 668..844 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /inference="alignment:Splign:1.39.8" variation 744 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:369745682" variation 746 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:199841629" variation 777 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:2256871" variation 826 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:149158426" variation 840 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:9332130" variation 841..842 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="" /replace="a" /db_xref="dbSNP:77147375" variation 842 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="" /replace="a" /db_xref="dbSNP:9332131" exon 845..986 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /inference="alignment:Splign:1.39.8" variation 845 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:370407644" variation 855 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:374108919" variation 857 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:200985348" variation 860 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="c" /db_xref="dbSNP:182132442" variation 862 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="c" /replace="g" /db_xref="dbSNP:60520749" variation 865 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="t" /db_xref="dbSNP:1135654" variation 883 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:368456264" variation 884 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="c" /replace="t" /db_xref="dbSNP:111719851" variation 891 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:150071523" variation 920 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:72558192" variation 925 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:187841862" variation 941 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="c" /db_xref="dbSNP:74441467" variation 949 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:370660670" variation 961 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="c" /db_xref="dbSNP:9332173" variation 964 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="g" /replace="t" /db_xref="dbSNP:375193036" exon 987..1174 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /inference="alignment:Splign:1.39.8" variation 1003 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:147665916" variation 1005 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:57505750" variation 1028 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:28371685" variation 1029 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:367826293" variation 1035 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:58368927" variation 1051 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:56718285" variation 1059 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:201055266" variation 1061 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:376725916" variation 1084 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:369488415" variation 1096 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:72544153" variation 1098 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:1057909" variation 1100 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="c" /db_xref="dbSNP:1057910" variation 1101 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="c" /replace="t" /db_xref="dbSNP:56165452" variation 1105 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="g" /db_xref="dbSNP:28371686" variation 1111 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:373048216" variation 1113 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:150663116" variation 1120 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="c" /db_xref="dbSNP:139532088" variation 1162 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:141283168" variation 1163 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:376551924" variation 1165 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="c" /db_xref="dbSNP:60130805" variation 1171 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="g" /db_xref="dbSNP:144464568" exon 1175..1316 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /inference="alignment:Splign:1.39.8" variation 1205 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:139413779" variation 1210 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="t" /db_xref="dbSNP:17847032" variation 1212 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:187793133" variation 1215 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="c" /db_xref="dbSNP:72558193" variation 1263 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:28371687" variation 1295 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:147634562" exon 1317..1861 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /inference="alignment:Splign:1.39.8" variation 1333 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="g" /replace="t" /db_xref="dbSNP:199741616" variation 1345 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:376352385" variation 1348 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:2017319" variation 1349 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:368545396" variation 1359 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:200382419" variation 1361 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:371491081" variation 1366 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="c" /db_xref="dbSNP:59485260" variation 1395 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:202201137" variation 1414 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:112354725" variation 1440 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:376962288" variation 1444 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:151194062" variation 1446 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:141011391" variation 1450 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="t" /db_xref="dbSNP:1057911" variation 1465 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:376114904" variation 1490 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:9332239" variation 1531 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:375918804" variation 1533 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="c" /db_xref="dbSNP:372707224" STS 1553..1837 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /standard_name="SGC35305" /db_xref="UniSTS:73844" variation 1564 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="c" /db_xref="dbSNP:186465817" variation 1565 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:9332240" variation 1586 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:9332241" variation 1606 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="g" /db_xref="dbSNP:9332242" STS 1644..1833 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /standard_name="RH45236" /db_xref="UniSTS:2795" variation 1653 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:9332243" variation 1654 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:74779754" variation 1700 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:59943433" variation 1718 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:9332244" variation 1775 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="c" /replace="t" /db_xref="dbSNP:149476715" variation 1810 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" /replace="a" /replace="g" /db_xref="dbSNP:28969379" polyA_signal 1837..1842 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" polyA_site 1860 /gene="CYP2C9" /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9" ORIGIN
gtcttaacaagaagagaaggcttcaatggattctcttgtggtccttgtgctctgtctctcatgtttgcttctcctttcactctggagacagagctctgggagaggaaaactccctcctggccccactcctctcccagtgattggaaatatcctacagataggtattaaggacatcagcaaatccttaaccaatctctcaaaggtctatggccctgtgttcactctgtattttggcctgaaacccatagtggtgctgcatggatatgaagcagtgaaggaagccctgattgatcttggagaggagttttctggaagaggcattttcccactggctgaaagagctaacagaggatttggaattgttttcagcaatggaaagaaatggaaggagatccggcgtttctccctcatgacgctgcggaattttgggatggggaagaggagcattgaggaccgtgttcaagaggaagcccgctgccttgtggaggagttgagaaaaaccaaggcctcaccctgtgatcccactttcatcctgggctgtgctccctgcaatgtgatctgctccattattttccataaacgttttgattataaagatcagcaatttcttaacttaatggaaaagttgaatgaaaacatcaagattttgagcagcccctggatccagatctgcaataatttttctcctatcattgattacttcccgggaactcacaacaaattacttaaaaacgttgcttttatgaaaagttatattttggaaaaagtaaaagaacaccaagaatcaatggacatgaacaaccctcaggactttattgattgcttcctgatgaaaatggagaaggaaaagcacaaccaaccatctgaatttactattgaaagcttggaaaacactgcagttgacttgtttggagctgggacagagacgacaagcacaaccctgagatatgctctccttctcctgctgaagcacccagaggtcacagctaaagtccaggaagagattgaacgtgtgattggcagaaaccggagcccctgcatgcaagacaggagccacatgccctacacagatgctgtggtgcacgaggtccagagatacattgaccttctccccaccagcctgccccatgcagtgacctgtgacattaaattcagaaactatctcattcccaagggcacaaccatattaatttccctgacttctgtgctacatgacaacaaagaatttcccaacccagagatgtttgaccctcatcactttctggatgaaggtggcaattttaagaaaagtaaatacttcatgcctttctcagcaggaaaacggatttgtgtgggagaagccctggccggcatggagctgtttttattcctgacctccattttacagaactttaacctgaaatctctggttgacccaaagaaccttgacaccactccagttgtcaatggatttgcctctgtgccgcccttctaccagctgtgcttcattcctgtctgaagaagagcagatggcctggctgctgctgtgcagtccctgcagctctctttcctctggggcattatccatctttcactatctgtaatgccttttctcacctgtcatctcacattttcccttccctgaagatctagtgaacattcgacctccattacggagagtttcctatgtttcactgtgcaaatatatctgctattctccatactctgtaacagttgcattgactgtcacataatgctcatacttatctaatgttgagttattaatatgttattattaaatagagaaatatgatttgtgtattataattcaaaggcatttcttttctgcatgttctaaataaaaagcattattatttgctgaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:1559 -> Molecular function: GO:0004497 [monooxygenase activity] evidence: IDA GeneID:1559 -> Molecular function: GO:0004497 [monooxygenase activity] evidence: NAS GeneID:1559 -> Molecular function: GO:0005506 [iron ion binding] evidence: IEA GeneID:1559 -> Molecular function: GO:0008144 [drug binding] evidence: IDA GeneID:1559 -> Molecular function: GO:0008395 [steroid hydroxylase activity] evidence: IMP GeneID:1559 -> Molecular function: GO:0009055 [electron carrier activity] evidence: IEA GeneID:1559 -> Molecular function: GO:0016491 [oxidoreductase activity] evidence: IDA GeneID:1559 -> Molecular function: GO:0018675 [(S)-limonene 6-monooxygenase activity] evidence: IEA GeneID:1559 -> Molecular function: GO:0018676 [(S)-limonene 7-monooxygenase activity] evidence: IEA GeneID:1559 -> Molecular function: GO:0020037 [heme binding] evidence: IEA GeneID:1559 -> Molecular function: GO:0034875 [caffeine oxidase activity] evidence: IDA GeneID:1559 -> Molecular function: GO:0052741 [(R)-limonene 6-monooxygenase activity] evidence: IEA GeneID:1559 -> Biological process: GO:0006805 [xenobiotic metabolic process] evidence: TAS GeneID:1559 -> Biological process: GO:0008202 [steroid metabolic process] evidence: IMP GeneID:1559 -> Biological process: GO:0016098 [monoterpenoid metabolic process] evidence: IDA GeneID:1559 -> Biological process: GO:0017144 [drug metabolic process] evidence: IDA GeneID:1559 -> Biological process: GO:0017144 [drug metabolic process] evidence: IMP GeneID:1559 -> Biological process: GO:0019369 [arachidonic acid metabolic process] evidence: TAS GeneID:1559 -> Biological process: GO:0019373 [epoxygenase P450 pathway] evidence: TAS GeneID:1559 -> Biological process: GO:0019627 [urea metabolic process] evidence: IDA GeneID:1559 -> Biological process: GO:0032787 [monocarboxylic acid metabolic process] evidence: IDA GeneID:1559 -> Biological process: GO:0042737 [drug catabolic process] evidence: IMP GeneID:1559 -> Biological process: GO:0042738 [exogenous drug catabolic process] evidence: IDA GeneID:1559 -> Biological process: GO:0043603 [cellular amide metabolic process] evidence: IDA GeneID:1559 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS GeneID:1559 -> Biological process: GO:0055114 [oxidation-reduction process] evidence: IDA GeneID:1559 -> Biological process: GO:0070989 [oxidative demethylation] evidence: IDA GeneID:1559 -> Biological process: GO:0097267 [omega-hydroxylase P450 pathway] evidence: TAS GeneID:1559 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: NAS GeneID:1559 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: TAS GeneID:1559 -> Cellular component: GO:0043231 [intracellular membrane-bounded organelle] evidence: IDA GeneID:1559 -> Cellular component: GO:0043231 [intracellular membrane-bounded organelle] evidence: TAS ANNOTATIONS from NCBI Entrez Gene (20130726): NP_000762 -> EC 1.14.13.48 NP_000762 -> EC 1.14.13.49 NP_000762 -> EC 1.14.13.80
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