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2024-04-25 13:43:20, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_000737                933 bp    mRNA    linear   PRI 24-JUN-2013
DEFINITION  Homo sapiens chorionic gonadotropin, beta polypeptide (CGB), mRNA.
ACCESSION   NM_000737
VERSION     NM_000737.3  GI:356874799
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 933)
  AUTHORS   Schumacher,A., Heinze,K., Witte,J., Poloski,E., Linzke,N.,
            Woidacki,K. and Zenclussen,A.C.
  TITLE     Human chorionic gonadotropin as a central regulator of pregnancy
            immune tolerance
  JOURNAL   J. Immunol. 190 (6), 2650-2658 (2013)
   PUBMED   23396945
  REMARK    GeneRIF: Human CG not only acts as a chemoattractant of regulatory
            T (Treg) cells but also plays a central role in pregnancy-induced
            immune tolerance.
REFERENCE   2  (bases 1 to 933)
  AUTHORS   Turgut,E.N., Celik,E., Celik,S., Arikan,D.C., Altuntas,H.,
            Leblebici,C., Purisa,S. and Dansuk,R.
  TITLE     Could serum beta-hCG levels and gestational age be the indicative
            factors for the prediction of the degree of trophoblastic invasion
            into tubal wall in unruptured ampullary pregnancies?
  JOURNAL   Arch. Gynecol. Obstet. 287 (2), 323-328 (2013)
   PUBMED   23011731
  REMARK    GeneRIF: The depth of trophoblastic tissue infiltration into tubal
            wall in ampullary pregnancies is correlated with serum beta-hCG
            levels, but not with gestational age.
REFERENCE   3  (bases 1 to 933)
  AUTHORS   Nitta,S., Kawai,K., Onozawa,M., Ando,S., Miyazaki,J., Nagata,C.,
            Noguchi,M., Yamasaki,K., Uchida,K., Iwamoto,T. and Nishiyama,H.
  TITLE     Intratubular trophoblasts in the contralateral testis caused
            elevation of serum human chorionic gonadotropin following complete
            remission of stage II testicular tumor: a case report
  JOURNAL   Jpn. J. Clin. Oncol. 43 (1), 83-86 (2013)
   PUBMED   23136239
  REMARK    GeneRIF: Elevation of serum human chorionic gonadotropin is
            associated with intratubular trophoblasts in the contralateral
            testis.
REFERENCE   4  (bases 1 to 933)
  AUTHORS   Cocquebert,M., Berndt,S., Segond,N., Guibourdenche,J., Murthi,P.,
            Aldaz-Carroll,L., Evain-Brion,D. and Fournier,T.
  TITLE     Comparative expression of hCG beta-genes in human trophoblast from
            early and late first-trimester placentas
  JOURNAL   Am. J. Physiol. Endocrinol. Metab. 303 (8), E950-E958 (2012)
   PUBMED   22811468
  REMARK    GeneRIF: we showed that type 1 and type 2 beta-hCG are highly
            expressed by villous mononucleated cytotrophoblasts in the early
            first trimester
REFERENCE   5  (bases 1 to 933)
  AUTHORS   Dukic-Stefanovic,S., Walther,J., Wosch,S., Zimmermann,G.,
            Wiedemann,P., Alexander,H. and Claudepierre,T.
  TITLE     Chorionic gonadotropin and its receptor are both expressed in human
            retina, possible implications in normal and pathological conditions
  JOURNAL   PLoS ONE 7 (12), E52567 (2012)
   PUBMED   23285091
  REMARK    GeneRIF: A complex neuroendocrine circuit exists in the retina,
            involving hCG secreting cells, hCG targets and hCG-release
            controlling cells.
REFERENCE   6  (bases 1 to 933)
  AUTHORS   Rothman,P.A., Chao,V.A., Taylor,M.R., Kuhn,R.W., Jaffe,R.B. and
            Taylor,R.N.
  TITLE     Extraplacental human fetal tissues express mRNA transcripts
            encoding the human chorionic gonadotropin-beta subunit protein
  JOURNAL   Mol. Reprod. Dev. 33 (1), 1-6 (1992)
   PUBMED   1510839
REFERENCE   7  (bases 1 to 933)
  AUTHORS   Maruo,T., Ladines-Llave,C.A., Matsuo,H., Manalo,A.S. and
            Mochizuki,M.
  TITLE     A novel change in cytologic localization of human chorionic
            gonadotropin and human placental lactogen in first-trimester
            placenta in the course of gestation
  JOURNAL   Am. J. Obstet. Gynecol. 167 (1), 217-222 (1992)
   PUBMED   1442929
REFERENCE   8  (bases 1 to 933)
  AUTHORS   Bo,M. and Boime,I.
  TITLE     Identification of the transcriptionally active genes of the
            chorionic gonadotropin beta gene cluster in vivo
  JOURNAL   J. Biol. Chem. 267 (5), 3179-3184 (1992)
   PUBMED   1371113
REFERENCE   9  (bases 1 to 933)
  AUTHORS   Weisshaar,G., Hiyama,J. and Renwick,A.G.
  TITLE     Site-specific N-glycosylation of human chorionic
            gonadotrophin--structural analysis of glycopeptides by one- and
            two-dimensional 1H NMR spectroscopy
  JOURNAL   Glycobiology 1 (4), 393-404 (1991)
   PUBMED   1820200
REFERENCE   10 (bases 1 to 933)
  AUTHORS   Beebe,J.S., Mountjoy,K., Krzesicki,R.F., Perini,F. and Ruddon,R.W.
  TITLE     Role of disulfide bond formation in the folding of human chorionic
            gonadotropin beta subunit into an alpha beta dimer
            assembly-competent form
  JOURNAL   J. Biol. Chem. 265 (1), 312-317 (1990)
   PUBMED   1688430
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX334905.2, AK291552.1 and
            BC106059.1.
            On Nov 11, 2011 this sequence version replaced gi:15451751.
            
            Summary: This gene is a member of the glycoprotein hormone beta
            chain family and encodes the beta 3 subunit of chorionic
            gonadotropin (CG). Glycoprotein hormones are heterodimers
            consisting of a common alpha subunit and an unique beta subunit
            which confers biological specificity. CG is produced by the
            trophoblastic cells of the placenta and stimulates the ovaries to
            synthesize the steroids that are essential for the maintenance of
            pregnancy. The beta subunit of CG is encoded by 6 genes which are
            arranged in tandem and inverted pairs on chromosome 19q13.3 and
            contiguous with the luteinizing hormone beta subunit gene.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX334905.2, AK291552.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025085 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                BX334905.2         1-42
            43-902              AK291552.1         1-860
            903-933             BC106059.1         849-879
FEATURES             Location/Qualifiers
     source          1..933
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..933
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /note="chorionic gonadotropin, beta polypeptide"
                     /db_xref="GeneID:1082"
                     /db_xref="HGNC:1886"
                     /db_xref="HPRD:00343"
                     /db_xref="MIM:118860"
     exon            1..419
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(48)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:74174271"
     variation       complement(48)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112003635"
     variation       complement(51)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:74174270"
     variation       complement(51)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:112682393"
     variation       complement(77)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:74174269"
     variation       complement(77)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201091434"
     variation       complement(81)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74174268"
     variation       complement(81)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200207020"
     variation       complement(129)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141557498"
     variation       complement(131)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376973036"
     variation       complement(133)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:71352717"
     variation       complement(137)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369610551"
     variation       complement(162)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112139593"
     variation       complement(196)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375217929"
     variation       complement(220)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201985302"
     variation       complement(225)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201181723"
     variation       complement(261)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:76097816"
     variation       complement(261)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:34236386"
     variation       complement(294)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:72626227"
     variation       complement(294)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74174265"
     variation       complement(294)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34236037"
     variation       complement(316)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368756847"
     variation       complement(328)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:62126028"
     variation       complement(328)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:74174264"
     variation       complement(359)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369725157"
     variation       complement(362)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375631692"
     variation       complement(363)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375297042"
     variation       complement(365)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371959359"
     variation       complement(368)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200375640"
     misc_feature    369..371
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /note="upstream in-frame stop codon"
     variation       complement(370)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202072529"
     variation       complement(378)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372316356"
     variation       complement(384)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201342765"
     STS             396..913
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /db_xref="UniSTS:483811"
     variation       complement(396)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200578663"
     CDS             405..902
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /note="chorionic gonadotropin beta chain; chorionic
                     gonadotropin beta 3 subunit; choriogonadotropin subunit
                     beta; chorionic gonadotropin beta subunit; CG-beta;
                     chorionic gonadotrophin chain beta"
                     /codon_start=1
                     /product="choriogonadotropin subunit beta precursor"
                     /protein_id="NP_000728.1"
                     /db_xref="GI:4502789"
                     /db_xref="CCDS:CCDS12749.1"
                     /db_xref="GeneID:1082"
                     /db_xref="HGNC:1886"
                     /db_xref="HPRD:00343"
                     /db_xref="MIM:118860"
                     /translation="
MEMFQGLLLLLLLSMGGTWASKEPLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSYAVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQDSSSSKAPPPSLPSPSRLPGPSDTPILPQ
"
     sig_peptide     405..464
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     mat_peptide     465..899
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /product="Choriogonadotropin subunit beta"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P01233.1)"
     misc_feature    489..773
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /note="Glycoprotein hormone beta chain homologues; Region:
                     GHB_like; cd00069"
                     /db_xref="CDD:200450"
     misc_feature    order(489..491,564..566,576..578,633..635,726..728,
                     732..734)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /note="cysteine knot motif; other site"
                     /db_xref="CDD:200450"
     misc_feature    order(489..491,633..635)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="disulfide bridge bond"
     misc_feature    501..503
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="glycosylation site"
                     /citation=[9]
     misc_feature    order(510..512,519..521,561..602,630..635,741..743,
                     747..749,756..773)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:200450"
     misc_feature    order(531..533,678..680)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="disulfide bridge bond"
     misc_feature    order(540..542,792..794)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="disulfide bridge bond"
     misc_feature    552..554
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="glycosylation site"
                     /citation=[9]
     misc_feature    order(564..566,726..728)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="disulfide bridge bond"
     misc_feature    order(576..578,732..734)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="disulfide bridge bond"
     misc_feature    order(600..602,747..752,759..761,765..773)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /note="receptor binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:200450"
     misc_feature    660..662
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    order(741..743,762..764)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="disulfide bridge bond"
     misc_feature    750..752
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    753..755
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     exon            420..587
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(469)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201575305"
     variation       complement(476)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200749289"
     variation       complement(493)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200012583"
     variation       complement(508)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201780746"
     variation       complement(536)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200899514"
     exon            588..919
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /inference="alignment:Splign:1.39.8"
     STS             621..798
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /standard_name="RH71426"
                     /db_xref="UniSTS:32956"
     STS             699..833
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /standard_name="D19S1130"
                     /db_xref="UniSTS:53128"
     STS             783..917
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /standard_name="STS-J00117"
                     /db_xref="UniSTS:32231"
     variation       complement(814)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200199557"
     variation       complement(827)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:139055053"
     variation       complement(840)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141896729"
     variation       complement(841)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:112003183"
     variation       complement(842)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:17852109"
     variation       complement(854)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:28571120"
     variation       complement(857)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199786416"
     variation       complement(877)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:142522943"
     variation       complement(878)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200571270"
     variation       complement(886)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200570800"
     polyA_signal    898..903
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
     variation       complement(899)
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148118323"
     polyA_site      919
                     /gene="CGB"
                     /gene_synonym="CGB3; CGB5; CGB7; CGB8; hCGB"
ORIGIN      
tgcaggaaagcctcaagtagaggagggttgaggcttcagtccagcacctttctcgggtcacggcctcctcctggctcccaggaccccaccataggcagaggcaggccttcctacaccctactccctgtgcctccagcctcgactagtccctagcactcgacgactgagtctctgaggtcacttcaccgtggtctccgcctcacccttggcgctggaccagtgagaggagagggctggggcgctccgctgagccactcctgcgcccccctggccttgtctacctcttgccccccgaggggttagtgtcgagctcaccccagcatcctatcacctcctggtggccttgccgcccccacaaccccgaggtataaagccaggtacacgaggcaggggacgcaccaaggatggagatgttccaggggctgctgctgttgctgctgctgagcatgggcgggacatgggcatccaaggagccgcttcggccacggtgccgccccatcaatgccaccctggctgtggagaaggagggctgccccgtgtgcatcaccgtcaacaccaccatctgtgccggctactgccccaccatgacccgcgtgctgcagggggtcctgccggccctgcctcaggtggtgtgcaactaccgcgatgtgcgcttcgagtccatccggctccctggctgcccgcgcggcgtgaaccccgtggtctcctacgccgtggctctcagctgtcaatgtgcactctgccgccgcagcaccactgactgcgggggtcccaaggaccaccccttgacctgtgatgacccccgcttccaggactcctcttcctcaaaggcccctccccccagccttccaagcccatcccgactcccggggccctcggacaccccgatcctcccacaataaaggcttctcaatccgcaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:1082 -> Molecular function: GO:0005179 [hormone activity] evidence: IEA
            GeneID:1082 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:1082 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
            GeneID:1082 -> Biological process: GO:0007267 [cell-cell signaling] evidence: TAS
            GeneID:1082 -> Biological process: GO:0007292 [female gamete generation] evidence: TAS
            GeneID:1082 -> Biological process: GO:0016486 [peptide hormone processing] evidence: TAS
            GeneID:1082 -> Biological process: GO:0044267 [cellular protein metabolic process] evidence: TAS
            GeneID:1082 -> Cellular component: GO:0005576 [extracellular region] evidence: TAS

by @meso_cacase at DBCLS
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