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2019-03-21 17:19:04, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_000693               3510 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens aldehyde dehydrogenase 1 family, member A3 (ALDH1A3),
            mRNA.
ACCESSION   NM_000693
VERSION     NM_000693.2  GI:153266821
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3510)
  AUTHORS   Fares-Taie,L., Gerber,S., Chassaing,N., Clayton-Smith,J.,
            Hanein,S., Silva,E., Serey,M., Serre,V., Gerard,X., Baumann,C.,
            Plessis,G., Demeer,B., Bretillon,L., Bole,C., Nitschke,P.,
            Munnich,A., Lyonnet,S., Calvas,P., Kaplan,J., Ragge,N. and
            Rozet,J.M.
  TITLE     ALDH1A3 mutations cause recessive anophthalmia and microphthalmia
  JOURNAL   Am. J. Hum. Genet. 92 (2), 265-270 (2013)
   PUBMED   23312594
  REMARK    GeneRIF: Homozygosity for one splice-site and two missense
            mutations in the gene encoding the A3 isoform of the aldehyde
            dehydrogenase 1 (ALDH1A3) in three consanguineous families, is
            reported.
REFERENCE   2  (bases 1 to 3510)
  AUTHORS   Eirew,P., Kannan,N., Knapp,D.J., Vaillant,F., Emerman,J.T.,
            Lindeman,G.J., Visvader,J.E. and Eaves,C.J.
  TITLE     Aldehyde dehydrogenase activity is a biomarker of primitive normal
            human mammary luminal cells
  JOURNAL   Stem Cells 30 (2), 344-348 (2012)
   PUBMED   22131125
  REMARK    GeneRIF: ALDH1A3 transcripts are detected at high levels in luminal
            progenitor-enriched fractions obtained from short-term adherent
            cultures of freshly isolated normal human mammary cells.
REFERENCE   3  (bases 1 to 3510)
  AUTHORS   Marcato,P., Dean,C.A., Pan,D., Araslanova,R., Gillis,M., Joshi,M.,
            Helyer,L., Pan,L., Leidal,A., Gujar,S., Giacomantonio,C.A. and
            Lee,P.W.
  TITLE     Aldehyde dehydrogenase activity of breast cancer stem cells is
            primarily due to isoform ALDH1A3 and its expression is predictive
            of metastasis
  JOURNAL   Stem Cells 29 (1), 32-45 (2011)
   PUBMED   21280157
  REMARK    GeneRIF: ALDH1A3 expression in patient breast tumors correlates
            significantly with tumor grade, metastasis, and cancer stage
REFERENCE   4  (bases 1 to 3510)
  AUTHORS   Koenig,U., Amatschek,S., Mildner,M., Eckhart,L. and Tschachler,E.
  TITLE     Aldehyde dehydrogenase 1A3 is transcriptionally activated by
            all-trans-retinoic acid in human epidermal keratinocytes
  JOURNAL   Biochem. Biophys. Res. Commun. 400 (2), 207-211 (2010)
   PUBMED   20709019
  REMARK    GeneRIF: these results indicate that the regulation of the retinoic
            acid metabolism in the epidermis involves transcriptional
            activation of ALDH1A3, possibly representing a positive feedback
            loop, which enhances the effect of exogenous retinoic acid.
REFERENCE   5  (bases 1 to 3510)
  AUTHORS   Wan,C., Shi,Y., Zhao,X., Tang,W., Zhang,M., Ji,B., Zhu,H., Xu,Y.,
            Li,H., Feng,G. and He,L.
  TITLE     Positive association between ALDH1A2 and schizophrenia in the
            Chinese population
  JOURNAL   Prog. Neuropsychopharmacol. Biol. Psychiatry 33 (8), 1491-1495
            (2009)
   PUBMED   19703508
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   6  (bases 1 to 3510)
  AUTHORS   Saito,A., Kawamoto,M. and Kamatani,N.
  TITLE     Association study between single-nucleotide polymorphisms in 199
            drug-related genes and commonly measured quantitative traits of 752
            healthy Japanese subjects
  JOURNAL   J. Hum. Genet. 54 (6), 317-323 (2009)
   PUBMED   19343046
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3510)
  AUTHORS   Nishimura,M., Yoshitsugu,H., Naito,S. and Hiraoka,I.
  TITLE     Evaluation of gene induction of drug-metabolizing enzymes and
            transporters in primary culture of human hepatocytes using
            high-sensitivity real-time reverse transcription PCR
  JOURNAL   Yakugaku Zasshi 122 (5), 339-361 (2002)
   PUBMED   12040753
REFERENCE   8  (bases 1 to 3510)
  AUTHORS   Rexer,B.N., Zheng,W.L. and Ong,D.E.
  TITLE     Retinoic acid biosynthesis by normal human breast epithelium is via
            aldehyde dehydrogenase 6, absent in MCF-7 cells
  JOURNAL   Cancer Res. 61 (19), 7065-7070 (2001)
   PUBMED   11585737
REFERENCE   9  (bases 1 to 3510)
  AUTHORS   Yoshida,A., Rzhetsky,A., Hsu,L.C. and Chang,C.
  TITLE     Human aldehyde dehydrogenase gene family
  JOURNAL   Eur. J. Biochem. 251 (3), 549-557 (1998)
   PUBMED   9490025
  REMARK    Review article
REFERENCE   10 (bases 1 to 3510)
  AUTHORS   Hsu,L.C., Chang,W.C., Hiraoka,L. and Hsieh,C.L.
  TITLE     Molecular cloning, genomic organization, and chromosomal
            localization of an additional human aldehyde dehydrogenase gene,
            ALDH6
  JOURNAL   Genomics 24 (2), 333-341 (1994)
   PUBMED   7698756
  REMARK    GeneRIF: play a major role in the detoxification of aldehydes
            generated by alcohol metabolism and lipid peroxidation.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB480234.1 and BC069274.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Jul 24, 2007 this sequence version replaced gi:4502040.
            
            Summary: Aldehyde dehydrogenase isozymes are thought to play a
            major role in the detoxification of aldehydes generated by alcohol
            metabolism and lipid peroxidation. The enzyme encoded by this gene
            uses retinal as a substrate, either in a free or cellular
            retinol-binding protein form. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069274.1, U07919.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025083 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                DB480234.1         113-160
            49-3510             BC069274.1         1-3462
FEATURES             Location/Qualifiers
     source          1..3510
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.3"
     gene            1..3510
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /note="aldehyde dehydrogenase 1 family, member A3"
                     /db_xref="GeneID:220"
                     /db_xref="HGNC:409"
                     /db_xref="MIM:600463"
     exon            1..203
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /inference="alignment:Splign:1.39.8"
     variation       13
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375470805"
     CDS             105..1643
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /EC_number="1.2.1.5"
                     /note="aldehyde dehydrogenase 6; retinaldehyde
                     dehydrogenase 3; acetaldehyde dehydrogenase 6; RALDH-3"
                     /codon_start=1
                     /product="aldehyde dehydrogenase family 1 member A3"
                     /protein_id="NP_000684.2"
                     /db_xref="GI:153266822"
                     /db_xref="CCDS:CCDS10389.1"
                     /db_xref="GeneID:220"
                     /db_xref="HGNC:409"
                     /db_xref="MIM:600463"
                     /translation="
MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKLGDKNP
"
     misc_feature    108..110
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N-acetylalanine; propagated from
                     UniProtKB/Swiss-Prot (P47895.2); acetylation site"
     misc_feature    180..1622
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /note="NAD+-dependent retinal dehydrogenase 1, ALDH
                     families 1A, 1B, and 2-like; Region: ALDH_F1AB_F2_RALDH1;
                     cd07141"
                     /db_xref="CDD:143459"
     misc_feature    222..1613
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /note="Aldehyde dehydrogenase family; Region: Aldedh;
                     pfam00171"
                     /db_xref="CDD:201055"
     misc_feature    order(354..359,369..371,378..380,384..386,396..398,
                     519..521,528..533,543..545,549..554,561..575,579..584,
                     591..614,891..893,900..902,909..914,921..926,930..932,
                     945..947,1440..1442,1446..1448,1467..1469,1476..1478,
                     1482..1505,1524..1532,1539..1550,1554..1556,1563..1565,
                     1578..1580,1599..1616,1620..1622)
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /note="homotetrameric interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143459"
     misc_feature    order(633..644,714..716,723..725,813..815,825..830,
                     867..869,876..878,885..887,945..950,1044..1046,1185..1187,
                     1194..1196,1335..1337)
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /note="NAD binding site [chemical binding]; other site"
                     /db_xref="CDD:143459"
     misc_feature    order(645..647,942..944,1035..1037,1044..1046)
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:143459"
     misc_feature    645..647
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="Transition state stabilizer (By similarity);
                     propagated from UniProtKB/Swiss-Prot (P47895.2); other
                     site"
     variation       137
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368010822"
     variation       147
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1130737"
     STS             203..1552
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /standard_name="Aldh1a3"
                     /db_xref="UniSTS:547583"
     exon            204..308
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /inference="alignment:Splign:1.39.8"
     variation       227
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2229182"
     variation       229
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:182607536"
     variation       245
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138741497"
     variation       259
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370256420"
     variation       274
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141876599"
     exon            309..449
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /inference="alignment:Splign:1.39.8"
     variation       354
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369355060"
     variation       362
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368918536"
     variation       396
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199537142"
     variation       431
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146169888"
     variation       438
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370671214"
     exon            450..579
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /inference="alignment:Splign:1.39.8"
     variation       491
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139132913"
     variation       498
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142560469"
     variation       507
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373337351"
     variation       535
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200486213"
     variation       568
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201931276"
     variation       570
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113686214"
     exon            580..641
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /inference="alignment:Splign:1.39.8"
     variation       585
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113869203"
     variation       591
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150542846"
     exon            642..770
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /inference="alignment:Splign:1.39.8"
     variation       665
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:139865715"
     variation       686
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:371899693"
     variation       696
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374423113"
     variation       722
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367965632"
     variation       740
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149815923"
     variation       741
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371736673"
     variation       752
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368919800"
     variation       753
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371815578"
     exon            771..884
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /inference="alignment:Splign:1.39.8"
     variation       774
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377673187"
     variation       794
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61757679"
     variation       812
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141807607"
     variation       830
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369627319"
     variation       854
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373589695"
     exon            885..987
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /inference="alignment:Splign:1.39.8"
     variation       911
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141536472"
     variation       916
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147665432"
     variation       947
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:142377552"
     variation       977
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143278553"
     exon            988..1172
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /inference="alignment:Splign:1.39.8"
     variation       1011
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373643477"
     variation       1049
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2229183"
     variation       1071
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:61624077"
     variation       1085
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140508229"
     variation       1091
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146381363"
     variation       1106
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377179870"
     variation       1130
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138675893"
     exon            1173..1337
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /inference="alignment:Splign:1.39.8"
     variation       1190
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187280010"
     variation       1191
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141839784"
     variation       1211
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3803431"
     variation       1212
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146286322"
     variation       1238
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112582857"
     variation       1247
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:113661159"
     variation       1260
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3803430"
     variation       1269
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376953636"
     exon            1338..1495
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /inference="alignment:Splign:1.39.8"
     variation       1358
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113241774"
     variation       1371
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201386727"
     variation       1399
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375918217"
     variation       1406
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143880265"
     variation       1410
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145630728"
     variation       1414
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369860247"
     variation       1448
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146643806"
     variation       1449
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188694308"
     variation       1453
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142115253"
     variation       1478
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372614738"
     variation       1479
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147498604"
     variation       1489
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377271890"
     variation       1490
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140128387"
     exon            1496..1570
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /inference="alignment:Splign:1.39.8"
     variation       1511
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145659258"
     variation       1512
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147752643"
     variation       1562
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200617229"
     variation       1569
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201444877"
     exon            1571..3496
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /inference="alignment:Splign:1.39.8"
     variation       1580
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139684559"
     variation       1589
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367983812"
     variation       1631
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370866811"
     variation       1637
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199747569"
     variation       1638
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374029874"
     variation       1646
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111325102"
     variation       1653
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201216253"
     variation       1674
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:4646690"
     variation       1677
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:371987999"
     variation       1678
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:79203665"
     variation       1695
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:185395342"
     variation       1746
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:77734193"
     variation       1767
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:79145783"
     STS             1770..1982
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /standard_name="D15S1345"
                     /db_xref="UniSTS:45142"
     variation       1797
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:376179481"
     variation       1817
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:7182089"
     variation       1827
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142489050"
     variation       1833
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:7161860"
     variation       1849
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370594639"
     variation       1850
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146962709"
     variation       1851
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3803426"
     variation       1934
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:137974961"
     variation       1990
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189703242"
     variation       2095
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3803425"
     variation       2106
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369311482"
     variation       2125..2126
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:35300460"
     variation       2151
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:141992762"
     variation       2170
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:28760343"
     variation       2176
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3803424"
     variation       2291
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148285612"
     variation       2358
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74696748"
     variation       2429
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181212672"
     variation       2438
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111843183"
     variation       2505
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1130738"
     variation       2519
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186663531"
     variation       2521
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:141341015"
     variation       2661
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:371268481"
     variation       2665
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367691717"
     variation       2673
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191555726"
     variation       2696
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:4288979"
     variation       2701
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150787850"
     variation       2788
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:78763805"
     variation       2833..2834
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:34302490"
     variation       2867
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1802602"
     variation       2871
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:183038230"
     variation       2882
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116457012"
     variation       2914
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368194028"
     variation       2982
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:14226"
     variation       2991
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186109171"
     variation       3046
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:190912866"
     variation       3069
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:182115449"
     variation       3167
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:186713906"
     variation       3176
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:192785797"
     variation       3177
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:142533835"
     variation       3223
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:371823276"
     variation       3259
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:75072374"
     variation       3332
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1802604"
     variation       3367
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:76952824"
     STS             3378..3461
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /standard_name="RH66397"
                     /db_xref="UniSTS:28838"
     variation       3432
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182899837"
     variation       3448
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:7045"
     variation       3449
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1802603"
     variation       3456
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1130768"
     polyA_signal    3474..3479
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
     polyA_site      3496
                     /gene="ALDH1A3"
                     /gene_synonym="ALDH1A6; ALDH6; MCOP8; RALDH3"
ORIGIN      
aaagcggcggggagctgccaccccgggagcgggctgcgcagtgtccgggccgagccggtgcgccgcagactagggcgcctcgggccagggagcgcggaggagccatggccaccgctaacggggccgtggaaaacgggcagccggacaggaagccgccggccctgccgcgccccatccgcaacctggaggtcaagttcaccaagatatttatcaacaatgaatggcacgaatccaagagtgggaaaaagtttgctacatgtaacccttcaactcgggagcaaatatgtgaagtggaagaaggagataagcccgacgtggacaaggctgtggaggctgcacaggttgccttccagaggggctcgccatggcgccggctggatgccctgagtcgtgggcggctgctgcaccagctggctgacctggtggagagggaccgcgccaccttggccgccctggagacgatggatacagggaagccatttcttcatgcttttttcatcgacctggagggctgtattagaaccctcagatactttgcagggtgggcagacaaaatccagggcaagaccatccccacagatgacaacgtcgtgtgcttcaccaggcatgagcccattggtgtctgtggggccatcactccatggaacttccccctgctgatgctggtgtggaagctggcacccgccctctgctgtgggaacaccatggtcctgaagcctgcggagcagacacctctcaccgccctttatctcggctctctgatcaaagaggccgggttccctccaggagtggtgaacattgtgccaggattcgggcccacagtgggagcagcaatttcttctcaccctcagatcaacaagatcgccttcaccggctccacagaggttggaaaactggttaaagaagctgcgtcccggagcaatctgaagcgggtgacgctggagctgggggggaagaacccctgcatcgtgtgtgcggacgctgacttggacttggcagtggagtgtgcccatcagggagtgttcttcaaccaaggccagtgttgcacggcagcctccagggtgttcgtggaggagcaggtctactctgagtttgtcaggcggagcgtggagtatgccaagaaacggcccgtgggagaccccttcgatgtcaaaacagaacaggggcctcagattgatcaaaagcagttcgacaaaatcttagagctgatcgagagtgggaagaaggaaggggccaagctggaatgcgggggctcagccatggaagacaaggggctcttcatcaaacccactgtcttctcagaagtcacagacaacatgcggattgccaaagaggagattttcgggccagtgcaaccaatactgaagttcaaaagtatcgaagaagtgataaaaagagcgaatagcaccgactatggactcacagcagccgtgttcacaaaaaatctcgacaaagccctgaagttggcttctgccttagagtctggaacggtctggatcaactgctacaacgccctctatgcacaggctccatttggtggctttaaaatgtcaggaaatggcagagaactaggtgaatacgctttggccgaatacacagaagtgaaaactgtcaccatcaaacttggcgacaagaacccctgaaggaaaggcggggctccttcctcaaacatcggacggcggaatgtggcagatgaaatgtgctggaggaaaaaaatgacatttctgaccttcccgggacacattcttctggaggctttacatctactggagttgaatgattgctgttttcctctcactctcctgtttattcaccagactggggatgcctataggttgtctgtgaaatcgcagtcctgcctggggagggagctgttggccatttctgtgtttccctttaaaccagatcctggagacagtgagatactcagggcgttgttaacagggagtggtatttgaagtgtccagcagttgcttgaaatgctttgccgaatctgactccagtaagaatgtgggaaaaccccctgtgtgttctgcaagcagggctcttgcaccagcggtctcctcagggtggacctgcttacagagcaagccacgcctctttccgaggtgaaggtgggaccattccttgggaaaggattcacagtaaggttttttggtttttgttttttgttttcttgtttttaaaaaaaggatttcacagtgagaaagttttggttagtgcataccgtggaagggcgccagggtctttgtggattgcatgttgacattgaccgtgagattcggcttcaaaccaatactgcctttggaatatgacagaatcaatagcccagagagcttagtcaaagacgatatcacggtctaccttaaccaaggcactttcttaagcagaaaatattgttgaggttacctttgctgctaaagatccaatcttctaacgccacaacagcatagcaaatcctaggataattcacctcctcatttgacaaatcagagctgtaattcgctttaacaaattacgcatttctatcacgttcactaacagcttatgataagtctgtgtagtcttccttttctccagttctgttacccaatttagattagtaaagcgtacacaactggaaagactgctgtaataacacagccttgttatttttaagtcctattttgatattaatttctgattagttagtaaataacacctggattctatggaggacctcggtcttcatccaagtggcctgagtatttcactggcaggttgtgaatttttcttttcctctttggggatccaaatgatgatgtgcaatttcatgttttaacttgggaaactgaaagtgttcccatatagcttcaaaaacaaaaacaaatgtgttatccgacggatacttttatggttactaactagtactttcctaattgggaaagtagtgcttaagtttgcaaattaagttggggagggcaataataaaatgagggcccgtaacagaaccagtgtgtgtataacgaaaaccatgtataaaatgggcctatcacccttgtcagagatataaattaccacatttgccttcccttcatcagctaacacttatcacttatactaccaataacttgttaaatcaggatttggcttcatacactgaattttcagtattttatctcaagtagatatagacactaaccttgatagtgatacgttagagggttcctattcttccattgtacgataatgtctttaatatgaaatgctacattatttataattggtagagttattgtatctttttatagttgtaagtacacagaggtggtatatttaaacttctgtaatatactgtatttagaaatggaaatatatatagtgttaggtttcacttcttttaaggtttacccctgtggtgtggtttaaaaatctataggcctgggaattccgatcctagctgcagatcgcatcccacaatgcgagaatgataaaataaaattggatatttgagaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:220 -> Molecular function: GO:0004029 [aldehyde dehydrogenase (NAD) activity] evidence: IEA
            GeneID:220 -> Molecular function: GO:0004030 [aldehyde dehydrogenase [NAD(P)+] activity] evidence: IDA
            GeneID:220 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IDA
            GeneID:220 -> Molecular function: GO:0070324 [thyroid hormone binding] evidence: IEA
            GeneID:220 -> Molecular function: GO:0070403 [NAD+ binding] evidence: IEA
            GeneID:220 -> Biological process: GO:0002072 [optic cup morphogenesis involved in camera-type eye development] evidence: IEA
            GeneID:220 -> Biological process: GO:0002138 [retinoic acid biosynthetic process] evidence: IEA
            GeneID:220 -> Biological process: GO:0021768 [nucleus accumbens development] evidence: IEA
            GeneID:220 -> Biological process: GO:0042572 [retinol metabolic process] evidence: IEA
            GeneID:220 -> Biological process: GO:0042573 [retinoic acid metabolic process] evidence: IDA
            GeneID:220 -> Biological process: GO:0042574 [retinal metabolic process] evidence: IDA
            GeneID:220 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IEA
            GeneID:220 -> Biological process: GO:0048048 [embryonic eye morphogenesis] evidence: ISS
            GeneID:220 -> Biological process: GO:0060166 [olfactory pit development] evidence: IEA
            GeneID:220 -> Biological process: GO:0060324 [face development] evidence: IEA
            GeneID:220 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_000684 -> EC 1.2.1.5

by @meso_cacase at DBCLS
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