2024-03-29 01:11:31, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_000684 2862 bp mRNA linear PRI 07-JUL-2013 DEFINITION Homo sapiens adrenoceptor beta 1 (ADRB1), mRNA. ACCESSION NM_000684 VERSION NM_000684.2 GI:110349783 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2862) AUTHORS Meitzen,J., Perry,A.N., Westenbroek,C., Hedges,V.L., Becker,J.B. and Mermelstein,P.G. TITLE Enhanced striatal beta1-adrenergic receptor expression following hormone loss in adulthood is programmed by both early sexual differentiation and puberty: a study of humans and rats JOURNAL Endocrinology 154 (5), 1820-1831 (2013) PUBMED 23533220 REMARK GeneRIF: Up-regulation of beta1AR action was eliminated with 17beta-estradiol addition to the media, directly implicating this hormone as a regulator of beta1AR expression. REFERENCE 2 (bases 1 to 2862) AUTHORS Cotarlan,V., Brofferio,A., Gerhard,G.S., Chu,X. and Shirani,J. TITLE Impact of beta(1)- and beta(2)-adrenergic receptor gene single nucleotide polymorphisms on heart rate response to metoprolol prior to coronary computed tomographic angiography JOURNAL Am. J. Cardiol. 111 (5), 661-666 (2013) PUBMED 23261005 REMARK GeneRIF: the selected SNPs of beta(1)-AR and beta(2)-AR genes influence HR response to metoprolol in patients who undergo coronary computed tomographic angiography. REFERENCE 3 (bases 1 to 2862) AUTHORS Moretti,S., Massi,D., Farini,V., Baroni,G., Parri,M., Innocenti,S., Cecchi,R. and Chiarugi,P. TITLE beta-adrenoceptors are upregulated in human melanoma and their activation releases pro-tumorigenic cytokines and metalloproteases in melanoma cell lines JOURNAL Lab. Invest. 93 (3), 279-290 (2013) PUBMED 23318885 REMARK GeneRIF: beta-adrenoceptors are upregulated in human melanoma and their activation releases pro-tumorigenic cytokines and metalloproteases in melanoma cell lines. REFERENCE 4 (bases 1 to 2862) AUTHORS Aleong,R.G., Sauer,W.H., Robertson,A.D., Liggett,S.B. and Bristow,M.R. TITLE Adrenergic receptor polymorphisms and prevention of ventricular arrhythmias with bucindolol in patients with chronic heart failure JOURNAL Circ Arrhythm Electrophysiol 6 (1), 137-143 (2013) PUBMED 23275278 REMARK GeneRIF: Bucindolol prevents ventricular arrhythmias in subjects with heart failure and reduced left ventricular ejection fractions, and this effect is modulated by adrenergic beta(1) receptor polymorphisms. REFERENCE 5 (bases 1 to 2862) AUTHORS Horikoshi M, Yaghootkar H, Mook-Kanamori DO, Sovio U, Taal HR, Hennig BJ, Bradfield JP, St Pourcain B, Evans DM, Charoen P, Kaakinen M, Cousminer DL, Lehtimaki T, Kreiner-Moller E, Warrington NM, Bustamante M, Feenstra B, Berry DJ, Thiering E, Pfab T, Barton SJ, Shields BM, Kerkhof M, van Leeuwen EM, Fulford AJ, Kutalik Z, Zhao JH, den Hoed M, Mahajan A, Lindi V, Goh LK, Hottenga JJ, Wu Y, Raitakari OT, Harder MN, Meirhaeghe A, Ntalla I, Salem RM, Jameson KA, Zhou K, Monies DM, Lagou V, Kirin M, Heikkinen J, Adair LS, Alkuraya FS, Al-Odaib A, Amouyel P, Andersson EA, Bennett AJ, Blakemore AI, Buxton JL, Dallongeville J, Das S, de Geus EJ, Estivill X, Flexeder C, Froguel P, Geller F, Godfrey KM, Gottrand F, Groves CJ, Hansen T, Hirschhorn JN, Hofman A, Hollegaard MV, Hougaard DM, Hypponen E, Inskip HM, Isaacs A, Jorgensen T, Kanaka-Gantenbein C, Kemp JP, Kiess W, Kilpelainen TO, Klopp N, Knight BA, Kuzawa CW, McMahon G, Newnham JP, Niinikoski H, Oostra BA, Pedersen L, Postma DS, Ring SM, Rivadeneira F, Robertson NR, Sebert S, Simell O, Slowinski T, Tiesler CM, Tonjes A, Vaag A, Viikari JS, Vink JM, Vissing NH, Wareham NJ, Willemsen G, Witte DR, Zhang H, Zhao J, Wilson JF, Stumvoll M, Prentice AM, Meyer BF, Pearson ER, Boreham CA, Cooper C, Gillman MW, Dedoussis GV, Moreno LA, Pedersen O, Saarinen M, Mohlke KL, Boomsma DI, Saw SM, Lakka TA, Korner A, Loos RJ, Ong KK, Vollenweider P, van Duijn CM, Koppelman GH, Hattersley AT, Holloway JW, Hocher B, Heinrich J, Power C, Melbye M, Guxens M, Pennell CE, Bonnelykke K, Bisgaard H, Eriksson JG, Widen E, Hakonarson H, Uitterlinden AG, Pouta A, Lawlor DA, Smith GD, Frayling TM, McCarthy MI, Grant SF, Jaddoe VW, Jarvelin MR, Timpson NJ, Prokopenko I and Freathy RM. CONSRTM Meta-Analyses of Glucose- and Insulin-related traits Consortium (MAGIC); Early Growth Genetics (EGG) Consortium TITLE New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism JOURNAL Nat. Genet. 45 (1), 76-82 (2013) PUBMED 23202124 REFERENCE 6 (bases 1 to 2862) AUTHORS Yang-Feng,T.L., Xue,F.Y., Zhong,W.W., Cotecchia,S., Frielle,T., Caron,M.G., Lefkowitz,R.J. and Francke,U. TITLE Chromosomal organization of adrenergic receptor genes JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (4), 1516-1520 (1990) PUBMED 2154750 REFERENCE 7 (bases 1 to 2862) AUTHORS Forse,R.A., Leibel,R. and Gagner,M. TITLE The effect of Escherichia coli endotoxin on the adrenergic control of lipolysis in the human adipocyte JOURNAL J. Surg. Res. 46 (1), 41-48 (1989) PUBMED 2536864 REFERENCE 8 (bases 1 to 2862) AUTHORS Frielle,T., Kobilka,B., Lefkowitz,R.J. and Caron,M.G. TITLE Human beta 1- and beta 2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes JOURNAL Trends Neurosci. 11 (7), 321-324 (1988) PUBMED 2465637 REMARK Review article REFERENCE 9 (bases 1 to 2862) AUTHORS Frielle,T., Collins,S., Daniel,K.W., Caron,M.G., Lefkowitz,R.J. and Kobilka,B.K. TITLE Cloning of the cDNA for the human beta 1-adrenergic receptor JOURNAL Proc. Natl. Acad. Sci. U.S.A. 84 (22), 7920-7924 (1987) PUBMED 2825170 REFERENCE 10 (bases 1 to 2862) AUTHORS Stiles,G.L., Strasser,R.H., Lavin,T.N., Jones,L.R., Caron,M.G. and Lefkowitz,R.J. TITLE The cardiac beta-adrenergic receptor. Structural similarities of beta 1 and beta 2 receptor subtypes demonstrated by photoaffinity labeling JOURNAL J. Biol. Chem. 258 (13), 8443-8449 (1983) PUBMED 6305985 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL355543.13. This sequence is a reference standard in the RefSeqGene project. On Jul 14, 2006 this sequence version replaced gi:4557264. Summary: The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-2862 AL355543.13 35999-38860 FEATURES Location/Qualifiers source 1..2862 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="10" /map="10q25.3" gene 1..2862 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /note="adrenoceptor beta 1" /db_xref="GeneID:153" /db_xref="HGNC:285" /db_xref="HPRD:00181" /db_xref="MIM:109630" exon 1..2862 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /inference="alignment:Splign:1.39.8" STS 15..1627 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /db_xref="UniSTS:489671" CDS 87..1520 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /note="beta-1 adrenoceptor; beta-1 adrenoreceptor; adrenergic, beta-1-, receptor" /codon_start=1 /product="beta-1 adrenergic receptor" /protein_id="NP_000675.1" /db_xref="GI:4557265" /db_xref="CCDS:CCDS7586.1" /db_xref="GeneID:153" /db_xref="HGNC:285" /db_xref="HPRD:00181" /db_xref="MIM:109630" /translation="
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
" misc_feature 252..338 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P08588.2); transmembrane region" misc_feature 312..>602 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /note="Olfactory receptor; Region: 7tm_4; cl10458" /db_xref="CDD:209142" misc_feature 327..1217 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /note="7 transmembrane receptor (rhodopsin family); Region: 7tm_1; pfam00001" /db_xref="CDD:200918" misc_feature 366..446 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P08588.2); transmembrane region" misc_feature 483..548 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P08588.2); transmembrane region" misc_feature 603..674 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P08588.2); transmembrane region" misc_feature 738..782 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P08588.2); Region: Agonist and antagonist binding (By similarity)" misc_feature 753..830 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P08588.2); transmembrane region" misc_feature 1044..1133 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P08588.2); transmembrane region" misc_feature 1095..1118 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P08588.2); Region: Agonist and antagonist binding (By similarity)" misc_feature 1149..1217 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P08588.2); transmembrane region" misc_feature 1173..1187 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P08588.2); Region: Agonist and antagonist binding (By similarity)" misc_feature 1506..1517 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P08588.2); Region: PDZ-Binding" variation 163 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="t" /db_xref="dbSNP:34844626" variation 171 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="g" /db_xref="dbSNP:35720093" variation 176 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="g" /db_xref="dbSNP:34072930" variation 178 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="g" /db_xref="dbSNP:35230616" variation 191 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="t" /db_xref="dbSNP:35476499" variation 200 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="g" /db_xref="dbSNP:369867546" variation 203 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="t" /db_xref="dbSNP:371084372" variation 204 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="g" /db_xref="dbSNP:72556521" variation 205 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="c" /db_xref="dbSNP:375635406" variation 209 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="g" /db_xref="dbSNP:368596680" variation 212 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="g" /db_xref="dbSNP:34947712" variation 231 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="g" /db_xref="dbSNP:1801252" variation 293 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="g" /db_xref="dbSNP:116403933" variation 314 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="t" /db_xref="dbSNP:140442073" variation 318 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="t" /db_xref="dbSNP:373125312" STS 360..881 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /standard_name="Adrb1" /db_xref="UniSTS:256461" variation 377 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="c" /db_xref="dbSNP:376293266" variation 401 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="g" /replace="t" /db_xref="dbSNP:7921133" variation 437 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="g" /db_xref="dbSNP:138330968" variation 461 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="g" /db_xref="dbSNP:141398460" variation 479 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="t" /db_xref="dbSNP:201111934" variation 490 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="g" /db_xref="dbSNP:373548972" variation 515 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="g" /db_xref="dbSNP:376207566" variation 520 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="g" /replace="t" /db_xref="dbSNP:145117867" variation 565 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="t" /db_xref="dbSNP:370777515" variation 610 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="g" /db_xref="dbSNP:138952486" variation 626 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="t" /db_xref="dbSNP:61729407" variation 741 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="g" /db_xref="dbSNP:373885952" variation 751 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="g" /db_xref="dbSNP:200385012" variation 815 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="g" /db_xref="dbSNP:147991732" variation 821 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="g" /db_xref="dbSNP:376035163" variation 823 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="g" /db_xref="dbSNP:375128225" variation 842 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="t" /db_xref="dbSNP:238742" variation 865 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="g" /db_xref="dbSNP:369955946" variation 890 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="g" /db_xref="dbSNP:2773468" variation 894 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="g" /db_xref="dbSNP:199698054" variation 908 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="g" /replace="t" /db_xref="dbSNP:376897657" variation 909 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="t" /db_xref="dbSNP:370424397" variation 1014 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="t" /db_xref="dbSNP:372579473" variation 1038 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="g" /replace="t" /db_xref="dbSNP:238741" variation 1057 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="t" /db_xref="dbSNP:622397" variation 1113 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="t" /db_xref="dbSNP:180897" variation 1142 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="c" /db_xref="dbSNP:189429" variation 1151 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="c" /db_xref="dbSNP:141633952" variation 1157 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="t" /db_xref="dbSNP:201721724" variation 1178 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="g" /db_xref="dbSNP:138212934" variation 1231 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="g" /db_xref="dbSNP:150497212" variation 1251 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="g" /db_xref="dbSNP:1801253" variation 1252 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="g" /replace="t" /db_xref="dbSNP:17875445" variation 1270 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="g" /db_xref="dbSNP:377602453" variation 1282 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="g" /db_xref="dbSNP:36052953" variation 1285 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="c" /db_xref="dbSNP:171170" variation 1299 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="t" /db_xref="dbSNP:35705839" variation 1329 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="g" /db_xref="dbSNP:371023749" variation 1394 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="g" /db_xref="dbSNP:365722" variation 1466 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="g" /replace="t" /db_xref="dbSNP:238740" variation 1528 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="c" /db_xref="dbSNP:75098615" variation 1538 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="g" /db_xref="dbSNP:372627850" variation 1575 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="g" /db_xref="dbSNP:171169" STS 1580..1682 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /standard_name="GDB:193846" /db_xref="UniSTS:155762" variation 1584 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="g" /replace="t" /db_xref="dbSNP:238739" variation 1592 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="c" /db_xref="dbSNP:367663132" STS 1596..1720 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /standard_name="RH68963" /db_xref="UniSTS:13016" variation 1723 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="g" /replace="t" /db_xref="dbSNP:79674809" variation 1724 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="g" /replace="t" /db_xref="dbSNP:78006160" variation 1733 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="" /replace="t" /db_xref="dbSNP:35435446" variation 1734 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="t" /db_xref="dbSNP:11196607" variation 1744 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="t" /db_xref="dbSNP:377360766" variation 1748..1754 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="" /replace="cttcttc" /db_xref="dbSNP:376858529" variation 1754 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="t" /db_xref="dbSNP:113352788" variation 1764 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="" /replace="ttttt" /db_xref="dbSNP:10536225" variation 1776 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="" /replace="ttttt" /db_xref="dbSNP:61645383" variation 1777 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="t" /db_xref="dbSNP:74383431" variation 1784 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="g" /replace="t" /db_xref="dbSNP:71484919" variation 1823 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="t" /db_xref="dbSNP:190324624" variation 1864 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="c" /db_xref="dbSNP:143711992" variation 1919 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="g" /db_xref="dbSNP:182255881" variation 1928 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="t" /db_xref="dbSNP:17875477" variation 1998 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="g" /replace="t" /db_xref="dbSNP:1047284" variation 2103..2104 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="" /replace="a" /db_xref="dbSNP:200145649" variation 2112 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="t" /db_xref="dbSNP:79955839" variation 2129 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="g" /db_xref="dbSNP:370624279" STS 2149..2410 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /standard_name="STS-U29690" /db_xref="UniSTS:13348" variation 2218 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="g" /replace="t" /db_xref="dbSNP:3177559" variation 2423 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="" /replace="aaacaa" /db_xref="dbSNP:71719350" variation 2426 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="g" /replace="t" /db_xref="dbSNP:2210096" variation 2427..2428 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="" /replace="a" /replace="c" /db_xref="dbSNP:17875446" variation 2436 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="t" /db_xref="dbSNP:199866231" variation 2686 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="c" /replace="g" /db_xref="dbSNP:187312072" variation 2693 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" /replace="a" /replace="t" /db_xref="dbSNP:17875447" polyA_signal 2837..2842 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" polyA_site 2862 /gene="ADRB1" /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR" ORIGIN
gcaccacgccgcccgggcttctggggtgttccccaaccacggcccagccctgccacaccccccgcccccggcctccgcagctcggcatgggcgcgggggtgctcgtcctgggcgcctccgagcccggtaacctgtcgtcggccgcaccgctccccgacggcgcggccaccgcggcgcggctgctggtgcccgcgtcgccgcccgcctcgttgctgcctcccgccagcgaaagccccgagccgctgtctcagcagtggacagcgggcatgggtctgctgatggcgctcatcgtgctgctcatcgtggcgggcaatgtgctggtgatcgtggccatcgccaagacgccgcggctgcagacgctcaccaacctcttcatcatgtccctggccagcgccgacctggtcatggggctgctggtggtgccgttcggggccaccatcgtggtgtggggccgctgggagtacggctccttcttctgcgagctgtggacctcagtggacgtgctgtgcgtgacggccagcatcgagaccctgtgtgtcattgccctggaccgctacctcgccatcacctcgcccttccgctaccagagcctgctgacgcgcgcgcgggcgcggggcctcgtgtgcaccgtgtgggccatctcggccctggtgtccttcctgcccatcctcatgcactggtggcgggcggagagcgacgaggcgcgccgctgctacaacgaccccaagtgctgcgacttcgtcaccaaccgggcctacgccatcgcctcgtccgtagtctccttctacgtgcccctgtgcatcatggccttcgtgtacctgcgggtgttccgcgaggcccagaagcaggtgaagaagatcgacagctgcgagcgccgtttcctcggcggcccagcgcggccgccctcgccctcgccctcgcccgtccccgcgcccgcgccgccgcccggacccccgcgccccgccgccgccgccgccaccgccccgctggccaacgggcgtgcgggtaagcggcggccctcgcgcctcgtggccctgcgcgagcagaaggcgctcaagacgctgggcatcatcatgggcgtcttcacgctctgctggctgcccttcttcctggccaacgtggtgaaggccttccaccgcgagctggtgcccgaccgcctcttcgtcttcttcaactggctgggctacgccaactcggccttcaaccccatcatctactgccgcagccccgacttccgcaaggccttccagggactgctctgctgcgcgcgcagggctgcccgccggcgccacgcgacccacggagaccggccgcgcgcctcgggctgtctggcccggcccggacccccgccatcgcccggggccgcctcggacgacgacgacgacgatgtcgtcggggccacgccgcccgcgcgcctgctggagccctgggccggctgcaacggcggggcggcggcggacagcgactcgagcctggacgagccgtgccgccccggcttcgcctcggaatccaaggtgtagggcccggcgcggggcgcggactccgggcacggcttcccaggggaacgaggagatctgtgtttacttaagaccgatagcaggtgaactcgaagcccacaatcctcgtctgaatcatccgaggcaaagagaaaagccacggaccgttgcacaaaaaggaaagtttgggaagggatgggagagtggcttgctgatgttccttgttgttttttttttcttttcttttctttcttcttcttttttttttttttttttttttctgtttgtggtccggccttcttttgtgtgtgcgtgtgatgcatctttagatttttttcccccaccaggtggtttttgacactctctgagaggaccggagtggaagatgggtgggttaggggaagggagaagcattaggaggggattaaaatcgatcatcgtggctcccatccctttcccgggaacaggaacacactaccagccagagagaggagaatgacagtttgtcaagacatatttccttttgctttccagagaaatttcattttaatttctaagtaatgatttctgctgttatgaaagcaaagagaaaggatggaggcaaaataaaaaaaaatcacgtttcaagaaatgttaagctcttcttggaacaagccccaccttgctttccttgtgtagggcaaacccgctgtcccccgcgcgcctgggtggtcaggctgagggatttctacctcacactgtgcatttgcacagcagatagaaagacttgtttatattaaacagcttatttatgtatcaatattagttggaaggaccaggcgcagagcctctctctgtgacatgtgactctgtcaattgaagacaggacattaaaagagagcgagagagagaaacagttcagattactgcacatgtggataaaaacaaaaacaaaaaaaaggagtggttcaaaatgccatttttgcacagtgttaggaattacaaaatccacagaagatgttacttgcacaaaaagaaattaaatattttttaaagggagaggggctgggcagatcttaaataaaattcaaactctacttctgttgtctagtatgttattgagctaatgattcattgggaaaatacctttttatactcctttatcatggtactgtaactgtatccatattataaatataattatcttaaggattttttatttttttttatgtccaagtgcccacgtgaatttgctggtgaaagttagcacttgtgtgtaaattctacttcctcttgtgtgttttaccaagtatttatactctggtgcaactaactactgtgtgaggaattggtccatgtgcaataaataccaatgaagcacaatcaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:153 -> Molecular function: GO:0004939 [beta-adrenergic receptor activity] evidence: TAS GeneID:153 -> Molecular function: GO:0004940 [beta1-adrenergic receptor activity] evidence: IEA GeneID:153 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:153 -> Molecular function: GO:0008144 [drug binding] evidence: IEA GeneID:153 -> Molecular function: GO:0030165 [PDZ domain binding] evidence: IPI GeneID:153 -> Molecular function: GO:0031694 [alpha-2A adrenergic receptor binding] evidence: IPI GeneID:153 -> Molecular function: GO:0035240 [dopamine binding] evidence: IEA GeneID:153 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IPI GeneID:153 -> Molecular function: GO:0051379 [epinephrine binding] evidence: IEA GeneID:153 -> Molecular function: GO:0051380 [norepinephrine binding] evidence: IEA GeneID:153 -> Biological process: GO:0001996 [positive regulation of heart rate by epinephrine-norepinephrine] evidence: IEA GeneID:153 -> Biological process: GO:0002024 [diet induced thermogenesis] evidence: IEA GeneID:153 -> Biological process: GO:0002025 [vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure] evidence: IEA GeneID:153 -> Biological process: GO:0003061 [positive regulation of the force of heart contraction by norepinephrine] evidence: IEA GeneID:153 -> Biological process: GO:0003084 [positive regulation of systemic arterial blood pressure] evidence: IEA GeneID:153 -> Biological process: GO:0005980 [glycogen catabolic process] evidence: IEA GeneID:153 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA GeneID:153 -> Biological process: GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] evidence: IEA GeneID:153 -> Biological process: GO:0007190 [activation of adenylate cyclase activity] evidence: TAS GeneID:153 -> Biological process: GO:0007266 [Rho protein signal transduction] evidence: IEA GeneID:153 -> Biological process: GO:0007568 [aging] evidence: IEA GeneID:153 -> Biological process: GO:0007613 [memory] evidence: IEA GeneID:153 -> Biological process: GO:0009409 [response to cold] evidence: IEA GeneID:153 -> Biological process: GO:0019233 [sensory perception of pain] evidence: IEA GeneID:153 -> Biological process: GO:0030819 [positive regulation of cAMP biosynthetic process] evidence: IDA GeneID:153 -> Biological process: GO:0031649 [heat generation] evidence: IEA GeneID:153 -> Biological process: GO:0033365 [protein localization to organelle] evidence: IEA GeneID:153 -> Biological process: GO:0035811 [negative regulation of urine volume] evidence: IEA GeneID:153 -> Biological process: GO:0040015 [negative regulation of multicellular organism growth] evidence: IEA GeneID:153 -> Biological process: GO:0042060 [wound healing] evidence: IEA GeneID:153 -> Biological process: GO:0042596 [fear response] evidence: IEA GeneID:153 -> Biological process: GO:0045986 [negative regulation of smooth muscle contraction] evidence: IEA GeneID:153 -> Biological process: GO:0046878 [positive regulation of saliva secretion] evidence: IEA GeneID:153 -> Biological process: GO:0050873 [brown fat cell differentiation] evidence: IEA GeneID:153 -> Biological process: GO:0051924 [regulation of calcium ion transport] evidence: IEA GeneID:153 -> Biological process: GO:0055088 [lipid homeostasis] evidence: IEA GeneID:153 -> Biological process: GO:0060080 [regulation of inhibitory postsynaptic membrane potential] evidence: IEA GeneID:153 -> Biological process: GO:0061051 [positive regulation of cell growth involved in cardiac muscle cell development] evidence: IEA GeneID:153 -> Biological process: GO:0086004 [regulation of cardiac muscle cell contraction] evidence: IEA GeneID:153 -> Biological process: GO:2001259 [positive regulation of cation channel activity] evidence: IEA GeneID:153 -> Cellular component: GO:0005634 [nucleus] evidence: IEA GeneID:153 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA GeneID:153 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA GeneID:153 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS GeneID:153 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
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