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2024-03-29 01:11:31, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_000684               2862 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens adrenoceptor beta 1 (ADRB1), mRNA.
ACCESSION   NM_000684
VERSION     NM_000684.2  GI:110349783
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2862)
  AUTHORS   Meitzen,J., Perry,A.N., Westenbroek,C., Hedges,V.L., Becker,J.B.
            and Mermelstein,P.G.
  TITLE     Enhanced striatal beta1-adrenergic receptor expression following
            hormone loss in adulthood is programmed by both early sexual
            differentiation and puberty: a study of humans and rats
  JOURNAL   Endocrinology 154 (5), 1820-1831 (2013)
   PUBMED   23533220
  REMARK    GeneRIF: Up-regulation of beta1AR action was eliminated with
            17beta-estradiol addition to the media, directly implicating this
            hormone as a regulator of beta1AR expression.
REFERENCE   2  (bases 1 to 2862)
  AUTHORS   Cotarlan,V., Brofferio,A., Gerhard,G.S., Chu,X. and Shirani,J.
  TITLE     Impact of beta(1)- and beta(2)-adrenergic receptor gene single
            nucleotide polymorphisms on heart rate response to metoprolol prior
            to coronary computed tomographic angiography
  JOURNAL   Am. J. Cardiol. 111 (5), 661-666 (2013)
   PUBMED   23261005
  REMARK    GeneRIF: the selected SNPs of beta(1)-AR and beta(2)-AR genes
            influence HR response to metoprolol in patients who undergo
            coronary computed tomographic angiography.
REFERENCE   3  (bases 1 to 2862)
  AUTHORS   Moretti,S., Massi,D., Farini,V., Baroni,G., Parri,M., Innocenti,S.,
            Cecchi,R. and Chiarugi,P.
  TITLE     beta-adrenoceptors are upregulated in human melanoma and their
            activation releases pro-tumorigenic cytokines and metalloproteases
            in melanoma cell lines
  JOURNAL   Lab. Invest. 93 (3), 279-290 (2013)
   PUBMED   23318885
  REMARK    GeneRIF: beta-adrenoceptors are upregulated in human melanoma and
            their activation releases pro-tumorigenic cytokines and
            metalloproteases in melanoma cell lines.
REFERENCE   4  (bases 1 to 2862)
  AUTHORS   Aleong,R.G., Sauer,W.H., Robertson,A.D., Liggett,S.B. and
            Bristow,M.R.
  TITLE     Adrenergic receptor polymorphisms and prevention of ventricular
            arrhythmias with bucindolol in patients with chronic heart failure
  JOURNAL   Circ Arrhythm Electrophysiol 6 (1), 137-143 (2013)
   PUBMED   23275278
  REMARK    GeneRIF: Bucindolol prevents ventricular arrhythmias in subjects
            with heart failure and reduced left ventricular ejection fractions,
            and this effect is modulated by adrenergic beta(1) receptor
            polymorphisms.
REFERENCE   5  (bases 1 to 2862)
  AUTHORS   Horikoshi M, Yaghootkar H, Mook-Kanamori DO, Sovio U, Taal HR,
            Hennig BJ, Bradfield JP, St Pourcain B, Evans DM, Charoen P,
            Kaakinen M, Cousminer DL, Lehtimaki T, Kreiner-Moller E, Warrington
            NM, Bustamante M, Feenstra B, Berry DJ, Thiering E, Pfab T, Barton
            SJ, Shields BM, Kerkhof M, van Leeuwen EM, Fulford AJ, Kutalik Z,
            Zhao JH, den Hoed M, Mahajan A, Lindi V, Goh LK, Hottenga JJ, Wu Y,
            Raitakari OT, Harder MN, Meirhaeghe A, Ntalla I, Salem RM, Jameson
            KA, Zhou K, Monies DM, Lagou V, Kirin M, Heikkinen J, Adair LS,
            Alkuraya FS, Al-Odaib A, Amouyel P, Andersson EA, Bennett AJ,
            Blakemore AI, Buxton JL, Dallongeville J, Das S, de Geus EJ,
            Estivill X, Flexeder C, Froguel P, Geller F, Godfrey KM, Gottrand
            F, Groves CJ, Hansen T, Hirschhorn JN, Hofman A, Hollegaard MV,
            Hougaard DM, Hypponen E, Inskip HM, Isaacs A, Jorgensen T,
            Kanaka-Gantenbein C, Kemp JP, Kiess W, Kilpelainen TO, Klopp N,
            Knight BA, Kuzawa CW, McMahon G, Newnham JP, Niinikoski H, Oostra
            BA, Pedersen L, Postma DS, Ring SM, Rivadeneira F, Robertson NR,
            Sebert S, Simell O, Slowinski T, Tiesler CM, Tonjes A, Vaag A,
            Viikari JS, Vink JM, Vissing NH, Wareham NJ, Willemsen G, Witte DR,
            Zhang H, Zhao J, Wilson JF, Stumvoll M, Prentice AM, Meyer BF,
            Pearson ER, Boreham CA, Cooper C, Gillman MW, Dedoussis GV, Moreno
            LA, Pedersen O, Saarinen M, Mohlke KL, Boomsma DI, Saw SM, Lakka
            TA, Korner A, Loos RJ, Ong KK, Vollenweider P, van Duijn CM,
            Koppelman GH, Hattersley AT, Holloway JW, Hocher B, Heinrich J,
            Power C, Melbye M, Guxens M, Pennell CE, Bonnelykke K, Bisgaard H,
            Eriksson JG, Widen E, Hakonarson H, Uitterlinden AG, Pouta A,
            Lawlor DA, Smith GD, Frayling TM, McCarthy MI, Grant SF, Jaddoe VW,
            Jarvelin MR, Timpson NJ, Prokopenko I and Freathy RM.
  CONSRTM   Meta-Analyses of Glucose- and Insulin-related traits Consortium
            (MAGIC); Early Growth Genetics (EGG) Consortium
  TITLE     New loci associated with birth weight identify genetic links
            between intrauterine growth and adult height and metabolism
  JOURNAL   Nat. Genet. 45 (1), 76-82 (2013)
   PUBMED   23202124
REFERENCE   6  (bases 1 to 2862)
  AUTHORS   Yang-Feng,T.L., Xue,F.Y., Zhong,W.W., Cotecchia,S., Frielle,T.,
            Caron,M.G., Lefkowitz,R.J. and Francke,U.
  TITLE     Chromosomal organization of adrenergic receptor genes
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (4), 1516-1520 (1990)
   PUBMED   2154750
REFERENCE   7  (bases 1 to 2862)
  AUTHORS   Forse,R.A., Leibel,R. and Gagner,M.
  TITLE     The effect of Escherichia coli endotoxin on the adrenergic control
            of lipolysis in the human adipocyte
  JOURNAL   J. Surg. Res. 46 (1), 41-48 (1989)
   PUBMED   2536864
REFERENCE   8  (bases 1 to 2862)
  AUTHORS   Frielle,T., Kobilka,B., Lefkowitz,R.J. and Caron,M.G.
  TITLE     Human beta 1- and beta 2-adrenergic receptors: structurally and
            functionally related receptors derived from distinct genes
  JOURNAL   Trends Neurosci. 11 (7), 321-324 (1988)
   PUBMED   2465637
  REMARK    Review article
REFERENCE   9  (bases 1 to 2862)
  AUTHORS   Frielle,T., Collins,S., Daniel,K.W., Caron,M.G., Lefkowitz,R.J. and
            Kobilka,B.K.
  TITLE     Cloning of the cDNA for the human beta 1-adrenergic receptor
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 84 (22), 7920-7924 (1987)
   PUBMED   2825170
REFERENCE   10 (bases 1 to 2862)
  AUTHORS   Stiles,G.L., Strasser,R.H., Lavin,T.N., Jones,L.R., Caron,M.G. and
            Lefkowitz,R.J.
  TITLE     The cardiac beta-adrenergic receptor. Structural similarities of
            beta 1 and beta 2 receptor subtypes demonstrated by photoaffinity
            labeling
  JOURNAL   J. Biol. Chem. 258 (13), 8443-8449 (1983)
   PUBMED   6305985
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355543.13.
            This sequence is a reference standard in the RefSeqGene project.
            On Jul 14, 2006 this sequence version replaced gi:4557264.
            
            Summary: The adrenergic receptors (subtypes alpha 1, alpha 2, beta
            1, and beta 2) are a prototypic family of guanine nucleotide
            binding regulatory protein-coupled receptors that mediate the
            physiological effects of the hormone epinephrine and the
            neurotransmitter norepinephrine. Specific polymorphisms in this
            gene have been shown to affect the resting heart rate and can be
            involved in heart failure. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2862              AL355543.13        35999-38860
FEATURES             Location/Qualifiers
     source          1..2862
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.3"
     gene            1..2862
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /note="adrenoceptor beta 1"
                     /db_xref="GeneID:153"
                     /db_xref="HGNC:285"
                     /db_xref="HPRD:00181"
                     /db_xref="MIM:109630"
     exon            1..2862
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /inference="alignment:Splign:1.39.8"
     STS             15..1627
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /db_xref="UniSTS:489671"
     CDS             87..1520
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /note="beta-1 adrenoceptor; beta-1 adrenoreceptor;
                     adrenergic, beta-1-, receptor"
                     /codon_start=1
                     /product="beta-1 adrenergic receptor"
                     /protein_id="NP_000675.1"
                     /db_xref="GI:4557265"
                     /db_xref="CCDS:CCDS7586.1"
                     /db_xref="GeneID:153"
                     /db_xref="HGNC:285"
                     /db_xref="HPRD:00181"
                     /db_xref="MIM:109630"
                     /translation="
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
"
     misc_feature    252..338
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P08588.2);
                     transmembrane region"
     misc_feature    312..>602
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /note="Olfactory receptor; Region: 7tm_4; cl10458"
                     /db_xref="CDD:209142"
     misc_feature    327..1217
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /note="7 transmembrane receptor (rhodopsin family);
                     Region: 7tm_1; pfam00001"
                     /db_xref="CDD:200918"
     misc_feature    366..446
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P08588.2);
                     transmembrane region"
     misc_feature    483..548
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P08588.2);
                     transmembrane region"
     misc_feature    603..674
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P08588.2);
                     transmembrane region"
     misc_feature    738..782
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P08588.2);
                     Region: Agonist and antagonist binding (By similarity)"
     misc_feature    753..830
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P08588.2);
                     transmembrane region"
     misc_feature    1044..1133
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P08588.2);
                     transmembrane region"
     misc_feature    1095..1118
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P08588.2);
                     Region: Agonist and antagonist binding (By similarity)"
     misc_feature    1149..1217
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P08588.2);
                     transmembrane region"
     misc_feature    1173..1187
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P08588.2);
                     Region: Agonist and antagonist binding (By similarity)"
     misc_feature    1506..1517
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P08588.2);
                     Region: PDZ-Binding"
     variation       163
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34844626"
     variation       171
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35720093"
     variation       176
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34072930"
     variation       178
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35230616"
     variation       191
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35476499"
     variation       200
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369867546"
     variation       203
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371084372"
     variation       204
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:72556521"
     variation       205
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375635406"
     variation       209
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368596680"
     variation       212
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34947712"
     variation       231
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1801252"
     variation       293
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116403933"
     variation       314
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140442073"
     variation       318
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373125312"
     STS             360..881
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /standard_name="Adrb1"
                     /db_xref="UniSTS:256461"
     variation       377
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376293266"
     variation       401
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:7921133"
     variation       437
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:138330968"
     variation       461
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141398460"
     variation       479
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201111934"
     variation       490
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373548972"
     variation       515
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376207566"
     variation       520
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:145117867"
     variation       565
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:370777515"
     variation       610
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:138952486"
     variation       626
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61729407"
     variation       741
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373885952"
     variation       751
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200385012"
     variation       815
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147991732"
     variation       821
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376035163"
     variation       823
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375128225"
     variation       842
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:238742"
     variation       865
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369955946"
     variation       890
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2773468"
     variation       894
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199698054"
     variation       908
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376897657"
     variation       909
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370424397"
     variation       1014
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372579473"
     variation       1038
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:238741"
     variation       1057
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:622397"
     variation       1113
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:180897"
     variation       1142
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:189429"
     variation       1151
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:141633952"
     variation       1157
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201721724"
     variation       1178
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:138212934"
     variation       1231
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150497212"
     variation       1251
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1801253"
     variation       1252
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:17875445"
     variation       1270
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377602453"
     variation       1282
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:36052953"
     variation       1285
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:171170"
     variation       1299
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35705839"
     variation       1329
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371023749"
     variation       1394
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:365722"
     variation       1466
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:238740"
     variation       1528
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:75098615"
     variation       1538
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372627850"
     variation       1575
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:171169"
     STS             1580..1682
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /standard_name="GDB:193846"
                     /db_xref="UniSTS:155762"
     variation       1584
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:238739"
     variation       1592
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:367663132"
     STS             1596..1720
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /standard_name="RH68963"
                     /db_xref="UniSTS:13016"
     variation       1723
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:79674809"
     variation       1724
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:78006160"
     variation       1733
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:35435446"
     variation       1734
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11196607"
     variation       1744
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377360766"
     variation       1748..1754
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace=""
                     /replace="cttcttc"
                     /db_xref="dbSNP:376858529"
     variation       1754
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113352788"
     variation       1764
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace=""
                     /replace="ttttt"
                     /db_xref="dbSNP:10536225"
     variation       1776
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace=""
                     /replace="ttttt"
                     /db_xref="dbSNP:61645383"
     variation       1777
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:74383431"
     variation       1784
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:71484919"
     variation       1823
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190324624"
     variation       1864
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:143711992"
     variation       1919
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182255881"
     variation       1928
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17875477"
     variation       1998
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1047284"
     variation       2103..2104
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:200145649"
     variation       2112
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:79955839"
     variation       2129
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370624279"
     STS             2149..2410
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /standard_name="STS-U29690"
                     /db_xref="UniSTS:13348"
     variation       2218
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3177559"
     variation       2423
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace=""
                     /replace="aaacaa"
                     /db_xref="dbSNP:71719350"
     variation       2426
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2210096"
     variation       2427..2428
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace=""
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:17875446"
     variation       2436
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199866231"
     variation       2686
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:187312072"
     variation       2693
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:17875447"
     polyA_signal    2837..2842
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
     polyA_site      2862
                     /gene="ADRB1"
                     /gene_synonym="ADRB1R; B1AR; BETA1AR; RHR"
ORIGIN      
gcaccacgccgcccgggcttctggggtgttccccaaccacggcccagccctgccacaccccccgcccccggcctccgcagctcggcatgggcgcgggggtgctcgtcctgggcgcctccgagcccggtaacctgtcgtcggccgcaccgctccccgacggcgcggccaccgcggcgcggctgctggtgcccgcgtcgccgcccgcctcgttgctgcctcccgccagcgaaagccccgagccgctgtctcagcagtggacagcgggcatgggtctgctgatggcgctcatcgtgctgctcatcgtggcgggcaatgtgctggtgatcgtggccatcgccaagacgccgcggctgcagacgctcaccaacctcttcatcatgtccctggccagcgccgacctggtcatggggctgctggtggtgccgttcggggccaccatcgtggtgtggggccgctgggagtacggctccttcttctgcgagctgtggacctcagtggacgtgctgtgcgtgacggccagcatcgagaccctgtgtgtcattgccctggaccgctacctcgccatcacctcgcccttccgctaccagagcctgctgacgcgcgcgcgggcgcggggcctcgtgtgcaccgtgtgggccatctcggccctggtgtccttcctgcccatcctcatgcactggtggcgggcggagagcgacgaggcgcgccgctgctacaacgaccccaagtgctgcgacttcgtcaccaaccgggcctacgccatcgcctcgtccgtagtctccttctacgtgcccctgtgcatcatggccttcgtgtacctgcgggtgttccgcgaggcccagaagcaggtgaagaagatcgacagctgcgagcgccgtttcctcggcggcccagcgcggccgccctcgccctcgccctcgcccgtccccgcgcccgcgccgccgcccggacccccgcgccccgccgccgccgccgccaccgccccgctggccaacgggcgtgcgggtaagcggcggccctcgcgcctcgtggccctgcgcgagcagaaggcgctcaagacgctgggcatcatcatgggcgtcttcacgctctgctggctgcccttcttcctggccaacgtggtgaaggccttccaccgcgagctggtgcccgaccgcctcttcgtcttcttcaactggctgggctacgccaactcggccttcaaccccatcatctactgccgcagccccgacttccgcaaggccttccagggactgctctgctgcgcgcgcagggctgcccgccggcgccacgcgacccacggagaccggccgcgcgcctcgggctgtctggcccggcccggacccccgccatcgcccggggccgcctcggacgacgacgacgacgatgtcgtcggggccacgccgcccgcgcgcctgctggagccctgggccggctgcaacggcggggcggcggcggacagcgactcgagcctggacgagccgtgccgccccggcttcgcctcggaatccaaggtgtagggcccggcgcggggcgcggactccgggcacggcttcccaggggaacgaggagatctgtgtttacttaagaccgatagcaggtgaactcgaagcccacaatcctcgtctgaatcatccgaggcaaagagaaaagccacggaccgttgcacaaaaaggaaagtttgggaagggatgggagagtggcttgctgatgttccttgttgttttttttttcttttcttttctttcttcttcttttttttttttttttttttttctgtttgtggtccggccttcttttgtgtgtgcgtgtgatgcatctttagatttttttcccccaccaggtggtttttgacactctctgagaggaccggagtggaagatgggtgggttaggggaagggagaagcattaggaggggattaaaatcgatcatcgtggctcccatccctttcccgggaacaggaacacactaccagccagagagaggagaatgacagtttgtcaagacatatttccttttgctttccagagaaatttcattttaatttctaagtaatgatttctgctgttatgaaagcaaagagaaaggatggaggcaaaataaaaaaaaatcacgtttcaagaaatgttaagctcttcttggaacaagccccaccttgctttccttgtgtagggcaaacccgctgtcccccgcgcgcctgggtggtcaggctgagggatttctacctcacactgtgcatttgcacagcagatagaaagacttgtttatattaaacagcttatttatgtatcaatattagttggaaggaccaggcgcagagcctctctctgtgacatgtgactctgtcaattgaagacaggacattaaaagagagcgagagagagaaacagttcagattactgcacatgtggataaaaacaaaaacaaaaaaaaggagtggttcaaaatgccatttttgcacagtgttaggaattacaaaatccacagaagatgttacttgcacaaaaagaaattaaatattttttaaagggagaggggctgggcagatcttaaataaaattcaaactctacttctgttgtctagtatgttattgagctaatgattcattgggaaaatacctttttatactcctttatcatggtactgtaactgtatccatattataaatataattatcttaaggattttttatttttttttatgtccaagtgcccacgtgaatttgctggtgaaagttagcacttgtgtgtaaattctacttcctcttgtgtgttttaccaagtatttatactctggtgcaactaactactgtgtgaggaattggtccatgtgcaataaataccaatgaagcacaatcaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:153 -> Molecular function: GO:0004939 [beta-adrenergic receptor activity] evidence: TAS
            GeneID:153 -> Molecular function: GO:0004940 [beta1-adrenergic receptor activity] evidence: IEA
            GeneID:153 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:153 -> Molecular function: GO:0008144 [drug binding] evidence: IEA
            GeneID:153 -> Molecular function: GO:0030165 [PDZ domain binding] evidence: IPI
            GeneID:153 -> Molecular function: GO:0031694 [alpha-2A adrenergic receptor binding] evidence: IPI
            GeneID:153 -> Molecular function: GO:0035240 [dopamine binding] evidence: IEA
            GeneID:153 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IPI
            GeneID:153 -> Molecular function: GO:0051379 [epinephrine binding] evidence: IEA
            GeneID:153 -> Molecular function: GO:0051380 [norepinephrine binding] evidence: IEA
            GeneID:153 -> Biological process: GO:0001996 [positive regulation of heart rate by epinephrine-norepinephrine] evidence: IEA
            GeneID:153 -> Biological process: GO:0002024 [diet induced thermogenesis] evidence: IEA
            GeneID:153 -> Biological process: GO:0002025 [vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure] evidence: IEA
            GeneID:153 -> Biological process: GO:0003061 [positive regulation of the force of heart contraction by norepinephrine] evidence: IEA
            GeneID:153 -> Biological process: GO:0003084 [positive regulation of systemic arterial blood pressure] evidence: IEA
            GeneID:153 -> Biological process: GO:0005980 [glycogen catabolic process] evidence: IEA
            GeneID:153 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:153 -> Biological process: GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] evidence: IEA
            GeneID:153 -> Biological process: GO:0007190 [activation of adenylate cyclase activity] evidence: TAS
            GeneID:153 -> Biological process: GO:0007266 [Rho protein signal transduction] evidence: IEA
            GeneID:153 -> Biological process: GO:0007568 [aging] evidence: IEA
            GeneID:153 -> Biological process: GO:0007613 [memory] evidence: IEA
            GeneID:153 -> Biological process: GO:0009409 [response to cold] evidence: IEA
            GeneID:153 -> Biological process: GO:0019233 [sensory perception of pain] evidence: IEA
            GeneID:153 -> Biological process: GO:0030819 [positive regulation of cAMP biosynthetic process] evidence: IDA
            GeneID:153 -> Biological process: GO:0031649 [heat generation] evidence: IEA
            GeneID:153 -> Biological process: GO:0033365 [protein localization to organelle] evidence: IEA
            GeneID:153 -> Biological process: GO:0035811 [negative regulation of urine volume] evidence: IEA
            GeneID:153 -> Biological process: GO:0040015 [negative regulation of multicellular organism growth] evidence: IEA
            GeneID:153 -> Biological process: GO:0042060 [wound healing] evidence: IEA
            GeneID:153 -> Biological process: GO:0042596 [fear response] evidence: IEA
            GeneID:153 -> Biological process: GO:0045986 [negative regulation of smooth muscle contraction] evidence: IEA
            GeneID:153 -> Biological process: GO:0046878 [positive regulation of saliva secretion] evidence: IEA
            GeneID:153 -> Biological process: GO:0050873 [brown fat cell differentiation] evidence: IEA
            GeneID:153 -> Biological process: GO:0051924 [regulation of calcium ion transport] evidence: IEA
            GeneID:153 -> Biological process: GO:0055088 [lipid homeostasis] evidence: IEA
            GeneID:153 -> Biological process: GO:0060080 [regulation of inhibitory postsynaptic membrane potential] evidence: IEA
            GeneID:153 -> Biological process: GO:0061051 [positive regulation of cell growth involved in cardiac muscle cell development] evidence: IEA
            GeneID:153 -> Biological process: GO:0086004 [regulation of cardiac muscle cell contraction] evidence: IEA
            GeneID:153 -> Biological process: GO:2001259 [positive regulation of cation channel activity] evidence: IEA
            GeneID:153 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
            GeneID:153 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
            GeneID:153 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
            GeneID:153 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
            GeneID:153 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS

by @meso_cacase at DBCLS
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