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2024-03-29 08:07:20, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_000602               3207 bp    mRNA    linear   PRI 08-JUL-2013
DEFINITION  Homo sapiens serpin peptidase inhibitor, clade E (nexin,
            plasminogen activator inhibitor type 1), member 1 (SERPINE1), mRNA.
ACCESSION   NM_000602
VERSION     NM_000602.4  GI:383286745
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3207)
  AUTHORS   Hagelgans,A., Menschikowski,M., Fuessel,S., Nacke,B., Arneth,B.M.,
            Wirth,M.P. and Siegert,G.
  TITLE     Deregulated expression of urokinase and its inhibitor type 1 in
            prostate cancer cells: role of epigenetic mechanisms
  JOURNAL   Exp. Mol. Pathol. 94 (3), 458-465 (2013)
   PUBMED   23541763
  REMARK    GeneRIF: PAI-1 and uPA expressions were changed in opposite
            directions in high invasive prostate cancer cell lines resulting in
            a strong decrease of PAI-1/uPA ratio.
REFERENCE   2  (bases 1 to 3207)
  AUTHORS   Lee,J.H., Kim,Y., Choi,J.W. and Kim,Y.S.
  TITLE     Clinicopathological significance of plasminogen activator
            inhibitor-1 promoter 4G/5G polymorphism in breast cancer: a
            meta-analysis
  JOURNAL   Arch. Med. Res. 44 (1), 39-45 (2013)
   PUBMED   23291383
  REMARK    GeneRIF: PAI-1 promoter 4G/5G polymorphism is associated with a
            relatively increased risk of breast cancer development and lymph
            node metastasis
REFERENCE   3  (bases 1 to 3207)
  AUTHORS   Reshetniak,T.M., Ostriakova,E.V., Patrusheva,N.L., Patrushev,L.I.,
            Aleksandrova,E.N., Seredavkina,N.V., Volkov,A.V. and Nasonov,E.L.
  TITLE     [Plasminogen activator inhibitor type 1 gene polymorphism and
            thromboses in patients with antiphospholipid syndrome]
  JOURNAL   Ter. Arkh. 85 (1), 76-84 (2013)
   PUBMED   23536951
  REMARK    GeneRIF: The prevalence of the PAI-1 5G/5G genotype in patients
            with APS and thrombosis was significantly lower than in those with
            SLE without APS or thrombosis.
REFERENCE   4  (bases 1 to 3207)
  AUTHORS   Halamkova,J., Kiss,I., Pavlovsky,Z., Tomasek,J., Jarkovsky,J.,
            Cech,Z., Bednarova,D., Tucek,S., Hanakova,L., Moulis,M.,
            Zavrelova,J., Man,M., Benda,P., Robek,O., Kala,Z. and Penka,M.
  TITLE     Clinical impact of PAI 1 4G/5G gene polymorphism in colorectal
            carcinoma patients
  JOURNAL   Neoplasma 60 (2), 151-159 (2013)
   PUBMED   23259783
  REMARK    GeneRIF: no relationship between polymorphisms of PAI 1 (-675
            4G/5G) in relation to stage, survival or tumor location.
REFERENCE   5  (bases 1 to 3207)
  AUTHORS   Zhong,Z.L. and Chen,S.
  TITLE     Plasma plasminogen activator inhibitor-1 is associated with
            end-stage proliferative diabetic retinopathy in the Northern
            Chinese Han population
  JOURNAL   Exp Diabetes Res 2012, 350852 (2012)
   PUBMED   23304115
  REMARK    GeneRIF: Higher plasma levels of PAI-1 were associated with
            end-stage proliferative diabetic retinopathy in the Northern
            Chinese Han population with type 2 diabetes mellitus.
REFERENCE   6  (bases 1 to 3207)
  AUTHORS   Fay,W.P., Shapiro,A.D., Shih,J.L., Schleef,R.R. and Ginsburg,D.
  TITLE     Brief report: complete deficiency of plasminogen-activator
            inhibitor type 1 due to a frame-shift mutation
  JOURNAL   N. Engl. J. Med. 327 (24), 1729-1733 (1992)
   PUBMED   1435917
REFERENCE   7  (bases 1 to 3207)
  AUTHORS   Koh,S.C., Wong,P.C., Yuen,R., Chua,S.E., Ng,B.L. and Ratnam,S.S.
  TITLE     Concentration of plasminogen activators and inhibitor in the human
            endometrium at different phases of the menstrual cycle
  JOURNAL   J. Reprod. Fertil. 96 (2), 407-413 (1992)
   PUBMED   1339823
REFERENCE   8  (bases 1 to 3207)
  AUTHORS   Hagege,J., Peraldi,M.N., Rondeau,E., Adida,C., Delarue,F.,
            Medcalf,R., Schleuning,W.D. and Sraer,J.D.
  TITLE     Plasminogen activator inhibitor-1 deposition in the extracellular
            matrix of cultured human mesangial cells
  JOURNAL   Am. J. Pathol. 141 (1), 117-128 (1992)
   PUBMED   1632457
REFERENCE   9  (bases 1 to 3207)
  AUTHORS   Mottonen,J., Strand,A., Symersky,J., Sweet,R.M., Danley,D.E.,
            Geoghegan,K.F., Gerard,R.D. and Goldsmith,E.J.
  TITLE     Structural basis of latency in plasminogen activator inhibitor-1
  JOURNAL   Nature 355 (6357), 270-273 (1992)
   PUBMED   1731226
REFERENCE   10 (bases 1 to 3207)
  AUTHORS   Ehrlich,H.J., Gebbink,R.K., Keijer,J., Linders,M., Preissner,K.T.
            and Pannekoek,H.
  TITLE     Alteration of serpin specificity by a protein cofactor. Vitronectin
            endows plasminogen activator inhibitor 1 with thrombin inhibitory
            properties
  JOURNAL   J. Biol. Chem. 265 (22), 13029-13035 (1990)
   PUBMED   1695900
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN309001.1, BC010860.1,
            M16006.1 and AI752990.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Apr 5, 2012 this sequence version replaced gi:259155304.
            
            Summary: This gene encodes a member of the serine proteinase
            inhibitor (serpin) superfamily. This member is the principal
            inhibitor of tissue plasminogen activator (tPA) and urokinase
            (uPA), and hence is an inhibitor of fibrinolysis. Defects in this
            gene are the cause of plasminogen activator inhibitor-1 deficiency
            (PAI-1 deficiency), and high concentrations of the gene product are
            associated with thrombophilia. Alternatively spliced transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Sep 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M16006.1, BC010860.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                CN309001.1         2-36
            36-1726             BC010860.1         1-1691
            1727-2371           M16006.1           1645-2289
            2372-2949           M16006.1           2299-2876
            2950-3207           AI752990.1         1-258               c
FEATURES             Location/Qualifiers
     source          1..3207
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..3207
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /note="serpin peptidase inhibitor, clade E (nexin,
                     plasminogen activator inhibitor type 1), member 1"
                     /db_xref="GeneID:5054"
                     /db_xref="HGNC:8583"
                     /db_xref="HPRD:01418"
                     /db_xref="MIM:173360"
     exon            1..156
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /inference="alignment:Splign:1.39.8"
     variation       4
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2227634"
     variation       66
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367883271"
     variation       89
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2227635"
     variation       120
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112880101"
     variation       125
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:13306844"
     variation       138
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:36228265"
     exon            157..428
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /inference="alignment:Splign:1.39.8"
     CDS             158..1366
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /note="serine (or cysteine) proteinase inhibitor, clade E
                     (nexin, plasminogen activator inhibitor type 1), member 1;
                     endothelial plasminogen activator inhibitor; serpin E1"
                     /codon_start=1
                     /product="plasminogen activator inhibitor 1 precursor"
                     /protein_id="NP_000593.1"
                     /db_xref="GI:10835159"
                     /db_xref="CCDS:CCDS5711.1"
                     /db_xref="GeneID:5054"
                     /db_xref="HGNC:8583"
                     /db_xref="HPRD:01418"
                     /db_xref="MIM:173360"
                     /translation="
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
"
     sig_peptide     158..226
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     mat_peptide     227..1363
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /product="Plasminogen activator inhibitor 1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05121.1)"
     misc_feature    230..1363
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /note="Plasminogen activator inhibitor-1_like. Plasminogen
                     activator inhibitor-1 (PAI-1) is the primary, fast-acting
                     inhibitor of plasminogen activators. It is often bound to
                     vitronectin, an abundant component of the extracellular
                     matrix in many tissues; Region: PAI-1_nexin-1; cd02051"
                     /db_xref="CDD:29126"
     misc_feature    851..853
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="glycosylation site"
     misc_feature    1019..1021
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="glycosylation site"
     misc_feature    1220..1297
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /note="reactive center loop; other site"
                     /db_xref="CDD:29126"
     misc_feature    1235..1237
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="proteolytic cleavage site; modified site"
                     /db_xref="HPRD:01703"
     misc_feature    1247..1249
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="proteolytic cleavage site; modified site"
                     /db_xref="HPRD:01703"
     misc_feature    1262..1267
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Reactive bond; propagated from UniProtKB/Swiss-Prot
                     (P05121.1); other site"
     misc_feature    1292..1294
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="proteolytic cleavage site; modified site"
                     /db_xref="HPRD:01006"
     variation       200
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:6092"
     variation       206
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:6090"
     variation       210
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370185023"
     variation       231
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2227647"
     variation       248
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141347752"
     variation       319
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373294605"
     variation       337
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376485687"
     variation       349
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370646624"
     variation       374
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374379570"
     variation       397
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:367935516"
     variation       413
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370298461"
     exon            429..662
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /inference="alignment:Splign:1.39.8"
     variation       448
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:145084838"
     variation       452
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144953342"
     variation       474
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61731296"
     variation       493
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3177930"
     STS             495..661
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /standard_name="RH48262"
                     /db_xref="UniSTS:12396"
     variation       504
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373286742"
     variation       505
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149070955"
     variation       513
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143027028"
     variation       514
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:6091"
     variation       520
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377652063"
     variation       528
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199790102"
     variation       541..542
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:11416893"
     variation       542
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371649267"
     variation       556
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140708600"
     variation       578
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377193732"
     variation       579
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145904727"
     variation       610
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181510325"
     variation       613
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200318916"
     variation       616
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138393809"
     variation       626
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375620822"
     variation       630
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370663207"
     variation       651
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:78007052"
     exon            663..857
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /inference="alignment:Splign:1.39.8"
     variation       666
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200926782"
     variation       681
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142959808"
     variation       683
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372569598"
     variation       694
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376407844"
     variation       710
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371179958"
     variation       712
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201293550"
     variation       742
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150630227"
     variation       743
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373629815"
     variation       767
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138796302"
     variation       777
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149389532"
     variation       783
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2227669"
     variation       785
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139905333"
     variation       805
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2227670"
     variation       807
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147436426"
     variation       826
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139626071"
     variation       852
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147003064"
     variation       857
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376831061"
     exon            858..1056
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /inference="alignment:Splign:1.39.8"
     variation       870
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201327802"
     variation       874
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150996863"
     variation       882
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140766181"
     variation       885
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:13306846"
     variation       913
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200763116"
     variation       921
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2227685"
     variation       958
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61749911"
     variation       967
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:113010194"
     variation       973
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199561546"
     variation       980
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:149701969"
     variation       1023
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140246744"
     exon            1057..1157
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /inference="alignment:Splign:1.39.8"
     variation       1067
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377501438"
     variation       1117
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:145850643"
     variation       1146
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192692662"
     variation       1155
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369508275"
     exon            1158..1244
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /inference="alignment:Splign:1.39.8"
     variation       1177
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201351580"
     variation       1179
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371573254"
     variation       1185
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138483939"
     variation       1205
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376197859"
     variation       1225
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368895147"
     variation       1231
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375309788"
     exon            1245..1328
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /inference="alignment:Splign:1.39.8"
     variation       1266
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:52795188"
     variation       1286
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141469348"
     variation       1297
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199603787"
     exon            1329..3190
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /inference="alignment:Splign:1.39.8"
     variation       1366
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:149110965"
     variation       1367
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368514992"
     variation       1386
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200019259"
     variation       1392
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370173813"
     variation       1399..1400
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:34950159"
     variation       1413
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186042546"
     variation       1458
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:374893237"
     variation       1489
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2227695"
     variation       1533
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2227696"
     variation       1546
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41334349"
     variation       1671
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2227697"
     variation       1727
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11178"
     variation       1735
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:13306842"
     variation       1791
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148235544"
     variation       1797
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:188845456"
     variation       1806
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:58167134"
     variation       1821
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146323865"
     variation       1854
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:13306843"
     variation       1895
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11553533"
     variation       1904
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11553532"
     variation       1983
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:186133446"
     variation       2016
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200688827"
     variation       2027
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138333231"
     variation       2051
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1050766"
     variation       2056
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:7241"
     variation       2063
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:15196"
     variation       2088
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:7242"
     variation       2111
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2227698"
     variation       2118
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:374321581"
     variation       2197
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2854229"
     variation       2200
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2854230"
     polyA_site      2227
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
     variation       2258
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1050813"
     variation       2287..2288
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:35674524"
     variation       2354..2355
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace=""
                     /replace="cgcgcccc"
                     /replace="cgcgccccc"
                     /db_xref="dbSNP:2227699"
     variation       2354
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:62483759"
     variation       2355..2356
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace=""
                     /replace="ggggcgcg"
                     /db_xref="dbSNP:111774460"
     variation       2362..2363
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace=""
                     /replace="cccgcgccc"
                     /db_xref="dbSNP:72325242"
     variation       2363..2364
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace=""
                     /replace="ccgcgcccc"
                     /replace="gcgcccc"
                     /db_xref="dbSNP:71685432"
     variation       2366..2367
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace=""
                     /replace="cgccccccg"
                     /db_xref="dbSNP:71722834"
     variation       2371..2372
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace=""
                     /replace="ccgcgcccc"
                     /db_xref="dbSNP:41423845"
     variation       2372..2373
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace=""
                     /replace="ccg"
                     /replace="ccgcgcccc"
                     /db_xref="dbSNP:67258334"
     variation       2372
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201434513"
     variation       2386
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:13230881"
     variation       2413
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:368475944"
     variation       2440
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:367757456"
     variation       2552
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2227714"
     variation       2596
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1801003"
     variation       2630..2631
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:2227715"
     variation       2640
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:78314587"
     variation       2661
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372017980"
     variation       2724
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2227700"
     variation       2754
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:71557295"
     variation       2815
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2227716"
     variation       2827
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191126376"
     variation       2887
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:180692432"
     STS             2900..3056
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /standard_name="G10517"
                     /db_xref="UniSTS:77302"
     STS             2950..3081
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /standard_name="STS-D29544"
                     /db_xref="UniSTS:35580"
     variation       2983
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186602438"
     variation       2998..2999
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:71720076"
     variation       2999..3000
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace=""
                     /replace="tttc"
                     /db_xref="dbSNP:139055667"
     variation       3011
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11553535"
     variation       3016
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191350469"
     variation       3103
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1050955"
     variation       3149
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:2227701"
     polyA_signal    3151..3156
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
     variation       3153
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182671641"
     polyA_signal    3160..3165
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
     variation       3168
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187612187"
     polyA_site      3171
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
     polyA_site      3190
                     /gene="SERPINE1"
                     /gene_synonym="PAI; PAI-1; PAI1; PLANH1"
ORIGIN      
ggcccacagaggagcacagctgtgtttggctgcagggccaagagcgctgtcaagaagacccacacgcccccctccagcagctgaattcctgcagctcagcagccgccgccagagcaggacgaaccgccaatcgcaaggcacctctgagaacttcaggatgcagatgtctccagccctcacctgcctagtcctgggcctggcccttgtctttggtgaagggtctgctgtgcaccatcccccatcctacgtggcccacctggcctcagacttcggggtgagggtgtttcagcaggtggcgcaggcctccaaggaccgcaacgtggttttctcaccctatggggtggcctcggtgttggccatgctccagctgacaacaggaggagaaacccagcagcagattcaagcagctatgggattcaagattgatgacaagggcatggcccccgccctccggcatctgtacaaggagctcatggggccatggaacaaggatgagatcagcaccacagacgcgatcttcgtccagcgggatctgaagctggtccagggcttcatgccccacttcttcaggctgttccggagcacggtcaagcaagtggacttttcagaggtggagagagccagattcatcatcaatgactgggtgaagacacacacaaaaggtatgatcagcaacttgcttgggaaaggagccgtggaccagctgacacggctggtgctggtgaatgccctctacttcaacggccagtggaagactcccttccccgactccagcacccaccgccgcctcttccacaaatcagacggcagcactgtctctgtgcccatgatggctcagaccaacaagttcaactatactgagttcaccacgcccgatggccattactacgacatcctggaactgccctaccacggggacaccctcagcatgttcattgctgccccttatgaaaaagaggtgcctctctctgccctcaccaacattctgagtgcccagctcatcagccactggaaaggcaacatgaccaggctgccccgcctcctggttctgcccaagttctccctggagactgaagtcgacctcaggaagcccctagagaacctgggaatgaccgacatgttcagacagtttcaggctgacttcacgagtctttcagaccaagagcctctccacgtcgcgcaggcgctgcagaaagtgaagatcgaggtgaacgagagtggcacggtggcctcctcatccacagctgtcatagtctcagcccgcatggcccccgaggagatcatcatggacagacccttcctctttgtggtccggcacaaccccacaggaacagtccttttcatgggccaagtgatggaaccctgaccctggggaaagacgccttcatctgggacaaaactggagatgcatcgggaaagaagaaactccgaagaaaagaattttagtgttaatgactctttctgaaggaagagaagacatttgccttttgttaaaagatggtaaaccagatctgtctccaagaccttggcctctccttggaggacctttaggtcaaactccctagtctccacctgagaccctgggagagaagtttgaagcacaactcccttaaggtctccaaaccagacggtgacgcctgcgggaccatctggggcacctgcttccacccgtctctctgcccactcgggtctgcagacctggttcccactgaggccctttgcaggatggaactacggggcttacaggagcttttgtgtgcctggtagaaactatttctgttccagtcacattgccatcactcttgtactgcctgccaccgcggaggaggctggtgacaggccaaaggccagtggaagaaacaccctttcatctcagagtccactgtggcactggccacccctccccagtacaggggtgctgcaggtggcagagtgaatgtcccccatcatgtggcccaactctcctggcctggccatctccctccccagaaacagtgtgcatgggttattttggagtgtaggtgacttgtttactcattgaagcagatttctgcttccttttatttttataggaatagaggaagaaatgtcagatgcgtgcccagctcttcaccccccaatctcttggtggggaggggtgtacctaaatatttatcatatccttgcccttgagtgcttgttagagagaaagagaactactaaggaaaataatattatttaaactcgctcctagtgtttctttgtggtctgtgtcaccgtatctcaggaagtccagccacttgactggcacacacccctccggacatccagcgtgacggagcccacactgccaccttgtggccgcctgagaccctcgcgccccccgcgcccctctttttccccttgatggaaattgaccatacaatttcatcctccttcaggggatcaaaaggacggagtggggggacagagactcagatgaggacagagtggtttccaatgtgttcaatagatttaggagcagaaatgcaaggggctgcatgacctaccaggacagaactttccccaattacagggtgactcacagccgcattggtgactcacttcaatgtgtcatttccggctgctgtgtgtgagcagtggacacgtgaggggggggtgggtgagagagacaggcagctcggattcaactaccttagataatatttctgaaaacctaccagccagagggtagggcacaaagatggatgtaatgcactttgggaggccaaggcgggaggattgcttgagcccaggagttcaagaccagcctgggcaacataccaagacccccgtctctttaaaaatatatatattttaaatatacttaaatatatatttctaatatctttaaatatatatatatattttaaagaccaatttatgggagaattgcacacagatgtgaaatgaatgtaatctaatagaagcctaatcagcccaccatgttctccactgaaaaatcctctttctttggggtttttctttctttcttttttgattttgcactggacggtgacgtcagccatgtacaggatccacaggggtggtgtcaaatgctattgaaattgtgttgaattgtatgctttttcacttttgataaataaacatgtaaaaatgtttcaaaaaaataataaaataaataaatacgaagaatatgtcaggacagtcaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5054 -> Molecular function: GO:0002020 [protease binding] evidence: IPI
            GeneID:5054 -> Molecular function: GO:0004867 [serine-type endopeptidase inhibitor activity] evidence: IDA
            GeneID:5054 -> Molecular function: GO:0005102 [receptor binding] evidence: IPI
            GeneID:5054 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5054 -> Biological process: GO:0001300 [chronological cell aging] evidence: IEP
            GeneID:5054 -> Biological process: GO:0001525 [angiogenesis] evidence: IEP
            GeneID:5054 -> Biological process: GO:0002576 [platelet degranulation] evidence: TAS
            GeneID:5054 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: TAS
            GeneID:5054 -> Biological process: GO:0006367 [transcription initiation from RNA polymerase II promoter] evidence: TAS
            GeneID:5054 -> Biological process: GO:0007179 [transforming growth factor beta receptor signaling pathway] evidence: TAS
            GeneID:5054 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
            GeneID:5054 -> Biological process: GO:0010467 [gene expression] evidence: TAS
            GeneID:5054 -> Biological process: GO:0010469 [regulation of receptor activity] evidence: IDA
            GeneID:5054 -> Biological process: GO:0010757 [negative regulation of plasminogen activation] evidence: IDA
            GeneID:5054 -> Biological process: GO:0010757 [negative regulation of plasminogen activation] evidence: IMP
            GeneID:5054 -> Biological process: GO:0010951 [negative regulation of endopeptidase activity] evidence: IDA
            GeneID:5054 -> Biological process: GO:0014912 [negative regulation of smooth muscle cell migration] evidence: IDA
            GeneID:5054 -> Biological process: GO:0030168 [platelet activation] evidence: TAS
            GeneID:5054 -> Biological process: GO:0030194 [positive regulation of blood coagulation] evidence: IMP
            GeneID:5054 -> Biological process: GO:0030195 [negative regulation of blood coagulation] evidence: IC
            GeneID:5054 -> Biological process: GO:0030198 [extracellular matrix organization] evidence: TAS
            GeneID:5054 -> Biological process: GO:0030336 [negative regulation of cell migration] evidence: IDA
            GeneID:5054 -> Biological process: GO:0032757 [positive regulation of interleukin-8 production] evidence: IMP
            GeneID:5054 -> Biological process: GO:0033629 [negative regulation of cell adhesion mediated by integrin] evidence: IDA
            GeneID:5054 -> Biological process: GO:0035491 [positive regulation of leukotriene production involved in inflammatory response] evidence: IMP
            GeneID:5054 -> Biological process: GO:0042127 [regulation of cell proliferation] evidence: IEA
            GeneID:5054 -> Biological process: GO:0042730 [fibrinolysis] evidence: TAS
            GeneID:5054 -> Biological process: GO:0045766 [positive regulation of angiogenesis] evidence: IMP
            GeneID:5054 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: TAS
            GeneID:5054 -> Biological process: GO:0048260 [positive regulation of receptor-mediated endocytosis] evidence: IDA
            GeneID:5054 -> Biological process: GO:0050729 [positive regulation of inflammatory response] evidence: IGI
            GeneID:5054 -> Biological process: GO:0050829 [defense response to Gram-negative bacterium] evidence: IGI
            GeneID:5054 -> Biological process: GO:0051918 [negative regulation of fibrinolysis] evidence: IDA
            GeneID:5054 -> Biological process: GO:0061044 [negative regulation of vascular wound healing] evidence: IGI
            GeneID:5054 -> Biological process: GO:0061045 [negative regulation of wound healing] evidence: IC
            GeneID:5054 -> Biological process: GO:0071222 [cellular response to lipopolysaccharide] evidence: IMP
            GeneID:5054 -> Biological process: GO:0090026 [positive regulation of monocyte chemotaxis] evidence: IMP
            GeneID:5054 -> Biological process: GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] evidence: IMP
            GeneID:5054 -> Biological process: GO:2000098 [negative regulation of smooth muscle cell-matrix adhesion] evidence: IDA
            GeneID:5054 -> Biological process: GO:2000352 [negative regulation of endothelial cell apoptotic process] evidence: IMP
            GeneID:5054 -> Cellular component: GO:0005576 [extracellular region] evidence: IDA
            GeneID:5054 -> Cellular component: GO:0005576 [extracellular region] evidence: TAS
            GeneID:5054 -> Cellular component: GO:0005615 [extracellular space] evidence: IDA
            GeneID:5054 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
            GeneID:5054 -> Cellular component: GO:0031012 [extracellular matrix] evidence: IDA
            GeneID:5054 -> Cellular component: GO:0031093 [platelet alpha granule lumen] evidence: TAS

by @meso_cacase at DBCLS
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