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2024-04-18 17:12:40, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_000593 2974 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens transporter 1, ATP-binding cassette, sub-family B
(MDR/TAP) (TAP1), mRNA.
ACCESSION NM_000593
VERSION NM_000593.5 GI:53759115
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2974)
AUTHORS Xu,M., Li,L., Liu,Z., Jiao,Z., Xu,P., Kong,X., Huang,H. and
Zhang,Y.
TITLE ABCB2 (TAP1) as the downstream target of SHH signaling enhances
pancreatic ductal adenocarcinoma drug resistance
JOURNAL Cancer Lett. 333 (2), 152-158 (2013)
PUBMED 23340176
REMARK GeneRIF: TAP1 is a downstream target gene of SHH signaling pathway
REFERENCE 2 (bases 1 to 2974)
AUTHORS El Hage,F., Durgeau,A. and Mami-Chouaib,F.
TITLE TAP expression level in tumor cells defines the nature and
processing of MHC class I peptides for recognition by
tumor-specific cytotoxic T lymphocytes
JOURNAL Ann. N. Y. Acad. Sci. 1283, 75-80 (2013)
PUBMED 23302073
REMARK GeneRIF: Preprocalcitonin (ppCT16-25) human tumor epitope requires
low TAP expression for efficient presentation.
Review article
REFERENCE 3 (bases 1 to 2974)
AUTHORS Qiu,B., Huang,B., Wang,X., Liang,J., Feng,J., Chang,Y. and Li,D.
TITLE Association of TAP1 and TAP2 polymorphisms with the outcome of
persistent HBV infection in a northeast Han Chinese population
JOURNAL Scand. J. Gastroenterol. 47 (11), 1368-1374 (2012)
PUBMED 22989262
REMARK GeneRIF: The results suggest that TAP1 and TAP2 gene polymorphisms
are associated with not only the susceptibility to hepatitis B
virus infection, but also with inflammation progress, advanced
fibrogenesis and cancer development.
REFERENCE 4 (bases 1 to 2974)
AUTHORS Chen,Q., Liu,Z. and Zhang,H.
TITLE [Relationship between rs1057141 and rs1135216 polymorphisms of TAP1
gene and allergic rhinitis in Xinjiang Han people]
JOURNAL Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 26 (20), 917-920
(2012)
PUBMED 23272491
REMARK GeneRIF: There was no association of TAP1 * rs1057141, rs1135216
gene G allele and allergic rhinitis in the Xinjiang Han people.
REFERENCE 5 (bases 1 to 2974)
AUTHORS Aikuer,G., Jiao,Z., Wu,X.C., Ma,J.Q., Abudla,A. and Hasim,A.
TITLE [Relationship between TAP gene promoter methylation and cervical
lesions with HPV infection in Uyghur women]
JOURNAL Zhonghua Bing Li Xue Za Zhi 41 (7), 438-442 (2012)
PUBMED 22932452
REMARK GeneRIF: TAP1 methylation is significantly associated with cervical
HPV infection in Uyghur women.
REFERENCE 6 (bases 1 to 2974)
AUTHORS Beck,S., Kelly,A., Radley,E., Khurshid,F., Alderton,R.P. and
Trowsdale,J.
TITLE DNA sequence analysis of 66 kb of the human MHC class II region
encoding a cluster of genes for antigen processing
JOURNAL J. Mol. Biol. 228 (2), 433-441 (1992)
PUBMED 1453454
REFERENCE 7 (bases 1 to 2974)
AUTHORS Colonna,M., Bresnahan,M., Bahram,S., Strominger,J.L. and Spies,T.
TITLE Allelic variants of the human putative peptide transporter involved
in antigen processing
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (9), 3932-3936 (1992)
PUBMED 1570316
REFERENCE 8 (bases 1 to 2974)
AUTHORS Bodmer,J.G., Marsh,S.G., Albert,E.D., Bodmer,W.F., Dupont,B.,
Erlich,H.A., Mach,B., Mayr,W.R., Parham,P., Sasazuki,T. et al.
TITLE Nomenclature for factors of the HLA system, 1991. WHO Nomenclature
Committee for factors of the HLA system
JOURNAL Tissue Antigens 39 (4), 161-173 (1992)
PUBMED 1529427
REMARK Erratum:[Tissue Antigens. 1992 Nov;40(5):229-43. PMID: 1362295]
REFERENCE 9 (bases 1 to 2974)
AUTHORS Kelly,A., Powis,S.H., Kerr,L.A., Mockridge,I., Elliott,T.,
Bastin,J., Uchanska-Ziegler,B., Ziegler,A., Trowsdale,J. and
Townsend,A.
TITLE Assembly and function of the two ABC transporter proteins encoded
in the human major histocompatibility complex
JOURNAL Nature 355 (6361), 641-644 (1992)
PUBMED 1538751
REFERENCE 10 (bases 1 to 2974)
AUTHORS Bahram,S., Arnold,D., Bresnahan,M., Strominger,J.L. and Spies,T.
TITLE Two putative subunits of a peptide pump encoded in the human major
histocompatibility complex class II region
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88 (22), 10094-10098 (1991)
PUBMED 1946428
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC014081.2.
This sequence is a reference standard in the RefSeqGene project.
On Oct 4, 2004 this sequence version replaced gi:24797159.
Summary: The membrane-associated protein encoded by this gene is a
member of the superfamily of ATP-binding cassette (ABC)
transporters. ABC proteins transport various molecules across
extra- and intra-cellular membranes. ABC genes are divided into
seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
White). This protein is a member of the MDR/TAP subfamily. Members
of the MDR/TAP subfamily are involved in multidrug resistance. The
protein encoded by this gene is involved in the pumping of degraded
cytosolic peptides across the endoplasmic reticulum into the
membrane-bound compartment where class I molecules assemble.
Mutations in this gene may be associated with ankylosing
spondylitis, insulin-dependent diabetes mellitus, and celiac
disease. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC014081.2, X57522.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-2974 BC014081.2 1-2974
FEATURES Location/Qualifiers
source 1..2974
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6p21.3"
gene 1..2974
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/note="transporter 1, ATP-binding cassette, sub-family B
(MDR/TAP)"
/db_xref="GeneID:6890"
/db_xref="HGNC:43"
/db_xref="HPRD:01359"
/db_xref="MIM:170260"
exon 1..933
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/inference="alignment:Splign:1.39.8"
variation 21
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/replace="a"
/replace="t"
/db_xref="dbSNP:36229528"
variation 40
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/replace=""
/replace="c"
/db_xref="dbSNP:3216794"
misc_feature 153..155
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/note="upstream in-frame stop codon"
CDS 156..2582
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/note="transporter, ATP-binding cassette, major
histocompatibility complex, 1; ABC transporter, MHC 1;
peptide supply factor 1; ATP-binding cassette, sub-family
B (MDR/TAP), member 2; transporter associated with antigen
processing; peptide transporter PSF1; peptide transporter
TAP1; really interesting new gene 4 protein; ATP-binding
cassette sub-family B member 2; peptide transporter
involved in antigen processing 1"
/codon_start=1
/product="antigen peptide transporter 1"
/protein_id="NP_000584.2"
/db_xref="GI:9665248"
/db_xref="CCDS:CCDS4758.1"
/db_xref="GeneID:6890"
/db_xref="HGNC:43"
/db_xref="HPRD:01359"
/db_xref="MIM:170260"
/translation="
MAELLASAGSACSWDFPRAPPSFPPPAASRGGLGGTRSFRPHRGAESPRPGRDRDGVRVPMASSRCPAPRGCRCLPGASLAWLGTVLLLLADWVLLRTALPRIFSLLVPTALPLLRVWAVGLSRWAVLWLGACGVLRATVGSKSENAGAQGWLAALKPLAAALGLALPGLALFRELISWGAPGSADSTRLLHWGSHPTAFVVSYAAALPAAALWHKLGSLWVPGGQGGSGNPVRRLLGCLGSETRRLSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSADTFTRNLTLMSILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMVQAPADAPE
"
misc_feature 381..443
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q03518.2);
transmembrane region"
misc_feature 456..2555
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/note="Conjugate Transporter-2 (CT2) Family protein;
Region: 3a01208; TIGR00958"
/db_xref="CDD:162132"
misc_feature 495..563
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q03518.2);
transmembrane region"
misc_feature 612..674
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q03518.2);
transmembrane region"
misc_feature 735..797
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q03518.2);
transmembrane region"
misc_feature 894..956
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q03518.2);
transmembrane region"
misc_feature 936..1709
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/note="ABC transporter transmembrane region; Region:
ABC_membrane; pfam00664"
/db_xref="CDD:201380"
misc_feature 1017..1079
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q03518.2);
transmembrane region"
misc_feature 1230..1292
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q03518.2);
transmembrane region"
misc_feature 1320..1382
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q03518.2);
transmembrane region"
misc_feature 1458..1595
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q03518.2);
Region: Involved in peptide-binding site"
misc_feature 1590..1652
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q03518.2);
transmembrane region"
misc_feature 1665..1727
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q03518.2);
transmembrane region"
misc_feature 1692..1796
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q03518.2);
Region: Involved in peptide-binding site"
misc_feature 1809..2495
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/note="TAP, the Transporter Associated with Antigen
Processing; TAP is essential for peptide delivery from the
cytosol into the lumen of the endoplasmic reticulum (ER),
where these peptides are loaded on major
histocompatibility complex (MHC) I molecules; Region:
ABCC_TAP; cd03248"
/db_xref="CDD:73007"
misc_feature 1947..1970
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/note="Walker A/P-loop; other site"
/db_xref="CDD:73007"
misc_feature order(1956..1961,1965..1973,2091..2093,2334..2339,
2436..2438)
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:73007"
misc_feature 2082..2093
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/note="Q-loop/lid; other site"
/db_xref="CDD:73007"
misc_feature 2262..2291
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/note="ABC transporter signature motif; other site"
/db_xref="CDD:73007"
misc_feature 2322..2339
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/note="Walker B; other site"
/db_xref="CDD:73007"
misc_feature 2346..2357
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/note="D-loop; other site"
/db_xref="CDD:73007"
misc_feature 2424..2444
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/note="H-loop/switch region; other site"
/db_xref="CDD:73007"
variation 302
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/replace="a"
/replace="g"
/db_xref="dbSNP:2071536"
variation 547
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/replace="c"
/replace="t"
/db_xref="dbSNP:41540013"
STS 569..856
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/standard_name="PMC115886P1"
/db_xref="UniSTS:270304"
variation 578
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/replace="c"
/replace="t"
/db_xref="dbSNP:41545912"
variation 663
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/replace="c"
/replace="g"
/db_xref="dbSNP:2228108"
variation 923
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/replace="c"
/replace="g"
/db_xref="dbSNP:2228109"
exon 934..1048
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/inference="alignment:Splign:1.39.8"
variation 934
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/replace=""
/replace="g"
/db_xref="dbSNP:41555220"
STS 963..1429
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/standard_name="GDB:365643"
/db_xref="UniSTS:156808"
exon 1049..1179
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/inference="alignment:Splign:1.39.8"
variation 1065
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/replace="g"
/replace="t"
/db_xref="dbSNP:36229525"
variation 1097
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/replace="a"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:41549617"
exon 1180..1385
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/inference="alignment:Splign:1.39.8"
variation 1192
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:2228111"
exon 1386..1583
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/inference="alignment:Splign:1.39.8"
variation 1444
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/replace="c"
/replace="t"
/db_xref="dbSNP:2127679"
variation 1445
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/replace="a"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:41558420"
exon 1584..1712
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/inference="alignment:Splign:1.39.8"
variation 1590
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/replace="g"
/replace="t"
/db_xref="dbSNP:2228110"
variation 1707
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:41550019"
exon 1713..1901
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/inference="alignment:Splign:1.39.8"
STS 1843..2066
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/standard_name="BARC0051"
/db_xref="UniSTS:255331"
variation 1882
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/replace="c"
/replace="t"
/db_xref="dbSNP:2228106"
variation 1887
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/replace="a"
/replace="g"
/db_xref="dbSNP:41561219"
exon 1902..2075
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/inference="alignment:Splign:1.39.8"
exon 2076..2238
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/inference="alignment:Splign:1.39.8"
STS 2176..2820
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/standard_name="GDB:362795"
/db_xref="UniSTS:156766"
exon 2239..2375
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/inference="alignment:Splign:1.39.8"
variation 2262
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/replace="c"
/replace="t"
/db_xref="dbSNP:41559815"
variation 2278
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/replace="a"
/replace="g"
/db_xref="dbSNP:1057149"
variation 2318
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/replace="a"
/replace="g"
/db_xref="dbSNP:41551515"
exon 2376..2952
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/inference="alignment:Splign:1.39.8"
STS 2605..2840
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/standard_name="D6S2042"
/db_xref="UniSTS:21567"
variation 2659
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/replace="g"
/replace="t"
/db_xref="dbSNP:1057373"
STS 2718..2917
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/standard_name="RH70842"
/db_xref="UniSTS:4353"
variation 2724
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/replace="c"
/replace="t"
/db_xref="dbSNP:3198005"
variation 2777
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/replace="c"
/replace="g"
/db_xref="dbSNP:8842"
STS 2788..2917
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
/standard_name="RH69680"
/db_xref="UniSTS:35689"
polyA_signal 2933..2938
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
polyA_site 2952
/gene="TAP1"
/gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
RING4; TAP1*0102N; TAP1N"
ORIGIN
gtgtgcgtgatggagaaaattgggcaccagggctgctcccgagattctcagatctgatttccacgcttgctaccaaaatagtctgggcaggccacttttggaagtaggcgttatctagtgagcaggcggccgctttcgatttcgctttcccctaaatggctgagcttctcgccagcgcaggatcagcctgttcctgggactttccgagagccccgccctcgttccctcccccagccgccagtaggggaggactcggcggtacccggagcttcaggccccaccggggcgcggagagtcccaggcccggccgggaccgggacggcgtccgagtgccaatggctagctctaggtgtcccgctccccgcgggtgccgctgcctccccggagcttctctcgcatggctggggacagtactgctacttctcgccgactgggtgctgctccggaccgcgctgccccgcatattctccctgctggtgcccaccgcgctgccactgctccgggtctgggcggtgggcctgagccgctgggccgtgctctggctgggggcctgcggggtcctcagggcaacggttggctccaagagcgaaaacgcaggtgcccagggctggctggctgctttgaagccattagctgcggcactgggcttggccctgccgggacttgccttgttccgagagctgatctcatggggagcccccgggtccgcggatagcaccaggctactgcactggggaagtcaccctaccgccttcgttgtcagttatgcagcggcactgcccgcagcagccctgtggcacaaactcgggagcctctgggtgcccggcggtcagggcggctctggaaaccctgtgcgtcggcttctaggctgcctgggctcggagacgcgccgcctctcgctgttcctggtcctggtggtcctctcctctcttggggagatggccattccattctttacgggccgcctcactgactggattctacaagatggctcagccgataccttcactcgaaacttaactctcatgtccattctcaccatagccagtgcagtgctggagttcgtgggtgacgggatctataacaacaccatgggccacgtgcacagccacttgcagggagaggtgtttggggctgtcctgcgccaggagacggagtttttccaacagaaccagacaggtaacatcatgtctcgggtaacagaggacacgtccaccctgagtgattctctgagtgagaatctgagcttatttctgtggtacctggtgcgaggcctatgtctcttggggatcatgctctggggatcagtgtccctcaccatggtcaccctgatcaccctgcctctgcttttccttctgcccaagaaggtgggaaaatggtaccagttgctggaagtgcaggtgcgggaatctctggcaaagtccagccaggtggccattgaggctctgtcggccatgcctacagttcgaagctttgccaacgaggagggcgaagcccagaagtttagggaaaagctgcaagaaataaagacactcaaccagaaggaggctgtggcctatgcagtcaactcctggaccactagtatttcaggtatgctgctgaaagtgggaatcctctacattggtgggcagctggtgaccagtggggctgtaagcagtgggaaccttgtcacatttgttctctaccagatgcagttcacccaggctgtggaggtactgctctccatctaccccagagtacagaaggctgtgggctcctcagagaaaatatttgagtacctggaccgcacccctcgctgcccacccagtggtctgttgactcccttacacttggagggccttgtccagttccaagatgtctcctttgcctacccaaaccgcccagatgtcttagtgctacaggggctgacattcaccctacgccctggcgaggtgacggcgctggtgggacccaatgggtctgggaagagcacagtggctgccctgctgcagaatctgtaccagcccaccgggggacagctgctgttggatgggaagccccttccccaatatgagcaccgctacctgcacaggcaggtggctgcagtgggacaagagccacaggtatttggaagaagtcttcaagaaaatattgcctatggcctgacccagaagccaactatggaggaaatcacagctgctgcagtaaagtctggggcccatagtttcatctctggactccctcagggctatgacacagaggtagacgaggctgggagccagctgtcagggggtcagcgacaggcagtggcgttggcccgagcattgatccggaaaccgtgtgtacttatcctggatgatgccaccagtgccctggatgcaaacagccagttacaggtggagcagctcctgtacgaaagccctgagcggtactcccgctcagtgcttctcatcacccagcacctcagcctggtggagcaggctgaccacatcctctttctggaaggaggcgctatccgggaggggggaacccaccagcagctcatggagaaaaaggggtgctactgggccatggtgcaggctcctgcagatgctccagaatgaaagccttctcagacctgcgcactccatctccctcccttttcttctctctgtggtggagaaccacagctgcagagtaggcagctgcctccaggatgagttacttgaaatttgccttgagtgtgttacctcctttccaagctcctcgtgataatgcagacttcctggagtacaaacacaggatttgtaattccttactgtaacggagtttagagccagggctgatgctttggtgtggccagcactctgaaactgagaaatgttcagaatgtacggaaagatgatcagctattttcaacataactgaaggcatatgctggcccataaacaccctgtaggttcttgatatttataataaaattggtgttttgtaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6890 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:6890 -> Molecular function: GO:0005524 [ATP binding] evidence: IDA
GeneID:6890 -> Molecular function: GO:0015197 [peptide transporter activity] evidence: IGI
GeneID:6890 -> Molecular function: GO:0015197 [peptide transporter activity] evidence: IMP
GeneID:6890 -> Molecular function: GO:0015421 [oligopeptide-transporting ATPase activity] evidence: IBA
GeneID:6890 -> Molecular function: GO:0042288 [MHC class I protein binding] evidence: IBA
GeneID:6890 -> Molecular function: GO:0042605 [peptide antigen binding] evidence: IBA
GeneID:6890 -> Molecular function: GO:0042605 [peptide antigen binding] evidence: NAS
GeneID:6890 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: ISS
GeneID:6890 -> Molecular function: GO:0043531 [ADP binding] evidence: IDA
GeneID:6890 -> Molecular function: GO:0046978 [TAP1 binding] evidence: IBA
GeneID:6890 -> Molecular function: GO:0046978 [TAP1 binding] evidence: ISS
GeneID:6890 -> Molecular function: GO:0046979 [TAP2 binding] evidence: IBA
GeneID:6890 -> Molecular function: GO:0046979 [TAP2 binding] evidence: IPI
GeneID:6890 -> Molecular function: GO:0046980 [tapasin binding] evidence: IBA
GeneID:6890 -> Biological process: GO:0001916 [positive regulation of T cell mediated cytotoxicity] evidence: IBA
GeneID:6890 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS
GeneID:6890 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS
GeneID:6890 -> Biological process: GO:0006952 [defense response] evidence: IEA
GeneID:6890 -> Biological process: GO:0015833 [peptide transport] evidence: IBA
GeneID:6890 -> Biological process: GO:0015833 [peptide transport] evidence: IMP
GeneID:6890 -> Biological process: GO:0019060 [intracellular transport of viral proteins in host cell] evidence: IMP
GeneID:6890 -> Biological process: GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I] evidence: IMP
GeneID:6890 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS
GeneID:6890 -> Biological process: GO:0046967 [cytosol to ER transport] evidence: IMP
GeneID:6890 -> Biological process: GO:0055085 [transmembrane transport] evidence: IBA
GeneID:6890 -> Cellular component: GO:0005743 [mitochondrial inner membrane] evidence: IRD
GeneID:6890 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: TAS
GeneID:6890 -> Cellular component: GO:0005829 [cytosol] evidence: NAS
GeneID:6890 -> Cellular component: GO:0005886 [plasma membrane] evidence: IBA
GeneID:6890 -> Cellular component: GO:0016021 [integral to membrane] evidence: IDA
GeneID:6890 -> Cellular component: GO:0030176 [integral to endoplasmic reticulum membrane] evidence: IDA
GeneID:6890 -> Cellular component: GO:0042825 [TAP complex] evidence: IBA
GeneID:6890 -> Cellular component: GO:0042825 [TAP complex] evidence: IDA
by
@meso_cacase at
DBCLS
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