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2019-03-23 03:55:50, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_000593               2974 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens transporter 1, ATP-binding cassette, sub-family B
            (MDR/TAP) (TAP1), mRNA.
ACCESSION   NM_000593
VERSION     NM_000593.5  GI:53759115
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2974)
  AUTHORS   Xu,M., Li,L., Liu,Z., Jiao,Z., Xu,P., Kong,X., Huang,H. and
            Zhang,Y.
  TITLE     ABCB2 (TAP1) as the downstream target of SHH signaling enhances
            pancreatic ductal adenocarcinoma drug resistance
  JOURNAL   Cancer Lett. 333 (2), 152-158 (2013)
   PUBMED   23340176
  REMARK    GeneRIF: TAP1 is a downstream target gene of SHH signaling pathway
REFERENCE   2  (bases 1 to 2974)
  AUTHORS   El Hage,F., Durgeau,A. and Mami-Chouaib,F.
  TITLE     TAP expression level in tumor cells defines the nature and
            processing of MHC class I peptides for recognition by
            tumor-specific cytotoxic T lymphocytes
  JOURNAL   Ann. N. Y. Acad. Sci. 1283, 75-80 (2013)
   PUBMED   23302073
  REMARK    GeneRIF: Preprocalcitonin (ppCT16-25) human tumor epitope requires
            low TAP expression for efficient presentation.
            Review article
REFERENCE   3  (bases 1 to 2974)
  AUTHORS   Qiu,B., Huang,B., Wang,X., Liang,J., Feng,J., Chang,Y. and Li,D.
  TITLE     Association of TAP1 and TAP2 polymorphisms with the outcome of
            persistent HBV infection in a northeast Han Chinese population
  JOURNAL   Scand. J. Gastroenterol. 47 (11), 1368-1374 (2012)
   PUBMED   22989262
  REMARK    GeneRIF: The results suggest that TAP1 and TAP2 gene polymorphisms
            are associated with not only the susceptibility to hepatitis B
            virus infection, but also with inflammation progress, advanced
            fibrogenesis and cancer development.
REFERENCE   4  (bases 1 to 2974)
  AUTHORS   Chen,Q., Liu,Z. and Zhang,H.
  TITLE     [Relationship between rs1057141 and rs1135216 polymorphisms of TAP1
            gene and allergic rhinitis in Xinjiang Han people]
  JOURNAL   Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 26 (20), 917-920
            (2012)
   PUBMED   23272491
  REMARK    GeneRIF: There was no association of TAP1 * rs1057141, rs1135216
            gene G allele and allergic rhinitis in the Xinjiang Han people.
REFERENCE   5  (bases 1 to 2974)
  AUTHORS   Aikuer,G., Jiao,Z., Wu,X.C., Ma,J.Q., Abudla,A. and Hasim,A.
  TITLE     [Relationship between TAP gene promoter methylation and cervical
            lesions with HPV infection in Uyghur women]
  JOURNAL   Zhonghua Bing Li Xue Za Zhi 41 (7), 438-442 (2012)
   PUBMED   22932452
  REMARK    GeneRIF: TAP1 methylation is significantly associated with cervical
            HPV infection in Uyghur women.
REFERENCE   6  (bases 1 to 2974)
  AUTHORS   Beck,S., Kelly,A., Radley,E., Khurshid,F., Alderton,R.P. and
            Trowsdale,J.
  TITLE     DNA sequence analysis of 66 kb of the human MHC class II region
            encoding a cluster of genes for antigen processing
  JOURNAL   J. Mol. Biol. 228 (2), 433-441 (1992)
   PUBMED   1453454
REFERENCE   7  (bases 1 to 2974)
  AUTHORS   Colonna,M., Bresnahan,M., Bahram,S., Strominger,J.L. and Spies,T.
  TITLE     Allelic variants of the human putative peptide transporter involved
            in antigen processing
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89 (9), 3932-3936 (1992)
   PUBMED   1570316
REFERENCE   8  (bases 1 to 2974)
  AUTHORS   Bodmer,J.G., Marsh,S.G., Albert,E.D., Bodmer,W.F., Dupont,B.,
            Erlich,H.A., Mach,B., Mayr,W.R., Parham,P., Sasazuki,T. et al.
  TITLE     Nomenclature for factors of the HLA system, 1991. WHO Nomenclature
            Committee for factors of the HLA system
  JOURNAL   Tissue Antigens 39 (4), 161-173 (1992)
   PUBMED   1529427
  REMARK    Erratum:[Tissue Antigens. 1992 Nov;40(5):229-43. PMID: 1362295]
REFERENCE   9  (bases 1 to 2974)
  AUTHORS   Kelly,A., Powis,S.H., Kerr,L.A., Mockridge,I., Elliott,T.,
            Bastin,J., Uchanska-Ziegler,B., Ziegler,A., Trowsdale,J. and
            Townsend,A.
  TITLE     Assembly and function of the two ABC transporter proteins encoded
            in the human major histocompatibility complex
  JOURNAL   Nature 355 (6361), 641-644 (1992)
   PUBMED   1538751
REFERENCE   10 (bases 1 to 2974)
  AUTHORS   Bahram,S., Arnold,D., Bresnahan,M., Strominger,J.L. and Spies,T.
  TITLE     Two putative subunits of a peptide pump encoded in the human major
            histocompatibility complex class II region
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 88 (22), 10094-10098 (1991)
   PUBMED   1946428
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC014081.2.
            This sequence is a reference standard in the RefSeqGene project.
            On Oct 4, 2004 this sequence version replaced gi:24797159.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the MDR/TAP subfamily. Members
            of the MDR/TAP subfamily are involved in multidrug resistance. The
            protein encoded by this gene is involved in the pumping of degraded
            cytosolic peptides across the endoplasmic reticulum into the
            membrane-bound compartment where class I molecules assemble.
            Mutations in this gene may be associated with ankylosing
            spondylitis, insulin-dependent diabetes mellitus, and celiac
            disease. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014081.2, X57522.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2974              BC014081.2         1-2974
FEATURES             Location/Qualifiers
     source          1..2974
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.3"
     gene            1..2974
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /note="transporter 1, ATP-binding cassette, sub-family B
                     (MDR/TAP)"
                     /db_xref="GeneID:6890"
                     /db_xref="HGNC:43"
                     /db_xref="HPRD:01359"
                     /db_xref="MIM:170260"
     exon            1..933
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:1.39.8"
     variation       21
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:36229528"
     variation       40
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:3216794"
     misc_feature    153..155
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /note="upstream in-frame stop codon"
     CDS             156..2582
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /note="transporter, ATP-binding cassette, major
                     histocompatibility complex, 1; ABC transporter, MHC 1;
                     peptide supply factor 1; ATP-binding cassette, sub-family
                     B (MDR/TAP), member 2; transporter associated with antigen
                     processing; peptide transporter PSF1; peptide transporter
                     TAP1; really interesting new gene 4 protein; ATP-binding
                     cassette sub-family B member 2; peptide transporter
                     involved in antigen processing 1"
                     /codon_start=1
                     /product="antigen peptide transporter 1"
                     /protein_id="NP_000584.2"
                     /db_xref="GI:9665248"
                     /db_xref="CCDS:CCDS4758.1"
                     /db_xref="GeneID:6890"
                     /db_xref="HGNC:43"
                     /db_xref="HPRD:01359"
                     /db_xref="MIM:170260"
                     /translation="
MAELLASAGSACSWDFPRAPPSFPPPAASRGGLGGTRSFRPHRGAESPRPGRDRDGVRVPMASSRCPAPRGCRCLPGASLAWLGTVLLLLADWVLLRTALPRIFSLLVPTALPLLRVWAVGLSRWAVLWLGACGVLRATVGSKSENAGAQGWLAALKPLAAALGLALPGLALFRELISWGAPGSADSTRLLHWGSHPTAFVVSYAAALPAAALWHKLGSLWVPGGQGGSGNPVRRLLGCLGSETRRLSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSADTFTRNLTLMSILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMVQAPADAPE
"
     misc_feature    381..443
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03518.2);
                     transmembrane region"
     misc_feature    456..2555
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /note="Conjugate Transporter-2 (CT2) Family protein;
                     Region: 3a01208; TIGR00958"
                     /db_xref="CDD:162132"
     misc_feature    495..563
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03518.2);
                     transmembrane region"
     misc_feature    612..674
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03518.2);
                     transmembrane region"
     misc_feature    735..797
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03518.2);
                     transmembrane region"
     misc_feature    894..956
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03518.2);
                     transmembrane region"
     misc_feature    936..1709
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /note="ABC transporter transmembrane region; Region:
                     ABC_membrane; pfam00664"
                     /db_xref="CDD:201380"
     misc_feature    1017..1079
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03518.2);
                     transmembrane region"
     misc_feature    1230..1292
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03518.2);
                     transmembrane region"
     misc_feature    1320..1382
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03518.2);
                     transmembrane region"
     misc_feature    1458..1595
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03518.2);
                     Region: Involved in peptide-binding site"
     misc_feature    1590..1652
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03518.2);
                     transmembrane region"
     misc_feature    1665..1727
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03518.2);
                     transmembrane region"
     misc_feature    1692..1796
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03518.2);
                     Region: Involved in peptide-binding site"
     misc_feature    1809..2495
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /note="TAP, the Transporter Associated with Antigen
                     Processing; TAP is essential for peptide delivery from the
                     cytosol into the lumen of the endoplasmic reticulum (ER),
                     where these peptides are loaded on major
                     histocompatibility complex (MHC) I molecules; Region:
                     ABCC_TAP; cd03248"
                     /db_xref="CDD:73007"
     misc_feature    1947..1970
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /note="Walker A/P-loop; other site"
                     /db_xref="CDD:73007"
     misc_feature    order(1956..1961,1965..1973,2091..2093,2334..2339,
                     2436..2438)
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:73007"
     misc_feature    2082..2093
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /note="Q-loop/lid; other site"
                     /db_xref="CDD:73007"
     misc_feature    2262..2291
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /note="ABC transporter signature motif; other site"
                     /db_xref="CDD:73007"
     misc_feature    2322..2339
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /note="Walker B; other site"
                     /db_xref="CDD:73007"
     misc_feature    2346..2357
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /note="D-loop; other site"
                     /db_xref="CDD:73007"
     misc_feature    2424..2444
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /note="H-loop/switch region; other site"
                     /db_xref="CDD:73007"
     variation       302
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2071536"
     variation       547
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41540013"
     STS             569..856
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /standard_name="PMC115886P1"
                     /db_xref="UniSTS:270304"
     variation       578
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41545912"
     variation       663
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2228108"
     variation       923
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2228109"
     exon            934..1048
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:1.39.8"
     variation       934
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:41555220"
     STS             963..1429
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /standard_name="GDB:365643"
                     /db_xref="UniSTS:156808"
     exon            1049..1179
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:1.39.8"
     variation       1065
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:36229525"
     variation       1097
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:41549617"
     exon            1180..1385
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:1.39.8"
     variation       1192
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2228111"
     exon            1386..1583
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:1.39.8"
     variation       1444
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2127679"
     variation       1445
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:41558420"
     exon            1584..1712
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:1.39.8"
     variation       1590
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2228110"
     variation       1707
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:41550019"
     exon            1713..1901
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:1.39.8"
     STS             1843..2066
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /standard_name="BARC0051"
                     /db_xref="UniSTS:255331"
     variation       1882
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2228106"
     variation       1887
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41561219"
     exon            1902..2075
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:1.39.8"
     exon            2076..2238
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:1.39.8"
     STS             2176..2820
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /standard_name="GDB:362795"
                     /db_xref="UniSTS:156766"
     exon            2239..2375
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:1.39.8"
     variation       2262
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41559815"
     variation       2278
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1057149"
     variation       2318
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41551515"
     exon            2376..2952
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:1.39.8"
     STS             2605..2840
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /standard_name="D6S2042"
                     /db_xref="UniSTS:21567"
     variation       2659
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1057373"
     STS             2718..2917
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /standard_name="RH70842"
                     /db_xref="UniSTS:4353"
     variation       2724
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3198005"
     variation       2777
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:8842"
     STS             2788..2917
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
                     /standard_name="RH69680"
                     /db_xref="UniSTS:35689"
     polyA_signal    2933..2938
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
     polyA_site      2952
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1;
                     RING4; TAP1*0102N; TAP1N"
ORIGIN      
gtgtgcgtgatggagaaaattgggcaccagggctgctcccgagattctcagatctgatttccacgcttgctaccaaaatagtctgggcaggccacttttggaagtaggcgttatctagtgagcaggcggccgctttcgatttcgctttcccctaaatggctgagcttctcgccagcgcaggatcagcctgttcctgggactttccgagagccccgccctcgttccctcccccagccgccagtaggggaggactcggcggtacccggagcttcaggccccaccggggcgcggagagtcccaggcccggccgggaccgggacggcgtccgagtgccaatggctagctctaggtgtcccgctccccgcgggtgccgctgcctccccggagcttctctcgcatggctggggacagtactgctacttctcgccgactgggtgctgctccggaccgcgctgccccgcatattctccctgctggtgcccaccgcgctgccactgctccgggtctgggcggtgggcctgagccgctgggccgtgctctggctgggggcctgcggggtcctcagggcaacggttggctccaagagcgaaaacgcaggtgcccagggctggctggctgctttgaagccattagctgcggcactgggcttggccctgccgggacttgccttgttccgagagctgatctcatggggagcccccgggtccgcggatagcaccaggctactgcactggggaagtcaccctaccgccttcgttgtcagttatgcagcggcactgcccgcagcagccctgtggcacaaactcgggagcctctgggtgcccggcggtcagggcggctctggaaaccctgtgcgtcggcttctaggctgcctgggctcggagacgcgccgcctctcgctgttcctggtcctggtggtcctctcctctcttggggagatggccattccattctttacgggccgcctcactgactggattctacaagatggctcagccgataccttcactcgaaacttaactctcatgtccattctcaccatagccagtgcagtgctggagttcgtgggtgacgggatctataacaacaccatgggccacgtgcacagccacttgcagggagaggtgtttggggctgtcctgcgccaggagacggagtttttccaacagaaccagacaggtaacatcatgtctcgggtaacagaggacacgtccaccctgagtgattctctgagtgagaatctgagcttatttctgtggtacctggtgcgaggcctatgtctcttggggatcatgctctggggatcagtgtccctcaccatggtcaccctgatcaccctgcctctgcttttccttctgcccaagaaggtgggaaaatggtaccagttgctggaagtgcaggtgcgggaatctctggcaaagtccagccaggtggccattgaggctctgtcggccatgcctacagttcgaagctttgccaacgaggagggcgaagcccagaagtttagggaaaagctgcaagaaataaagacactcaaccagaaggaggctgtggcctatgcagtcaactcctggaccactagtatttcaggtatgctgctgaaagtgggaatcctctacattggtgggcagctggtgaccagtggggctgtaagcagtgggaaccttgtcacatttgttctctaccagatgcagttcacccaggctgtggaggtactgctctccatctaccccagagtacagaaggctgtgggctcctcagagaaaatatttgagtacctggaccgcacccctcgctgcccacccagtggtctgttgactcccttacacttggagggccttgtccagttccaagatgtctcctttgcctacccaaaccgcccagatgtcttagtgctacaggggctgacattcaccctacgccctggcgaggtgacggcgctggtgggacccaatgggtctgggaagagcacagtggctgccctgctgcagaatctgtaccagcccaccgggggacagctgctgttggatgggaagccccttccccaatatgagcaccgctacctgcacaggcaggtggctgcagtgggacaagagccacaggtatttggaagaagtcttcaagaaaatattgcctatggcctgacccagaagccaactatggaggaaatcacagctgctgcagtaaagtctggggcccatagtttcatctctggactccctcagggctatgacacagaggtagacgaggctgggagccagctgtcagggggtcagcgacaggcagtggcgttggcccgagcattgatccggaaaccgtgtgtacttatcctggatgatgccaccagtgccctggatgcaaacagccagttacaggtggagcagctcctgtacgaaagccctgagcggtactcccgctcagtgcttctcatcacccagcacctcagcctggtggagcaggctgaccacatcctctttctggaaggaggcgctatccgggaggggggaacccaccagcagctcatggagaaaaaggggtgctactgggccatggtgcaggctcctgcagatgctccagaatgaaagccttctcagacctgcgcactccatctccctcccttttcttctctctgtggtggagaaccacagctgcagagtaggcagctgcctccaggatgagttacttgaaatttgccttgagtgtgttacctcctttccaagctcctcgtgataatgcagacttcctggagtacaaacacaggatttgtaattccttactgtaacggagtttagagccagggctgatgctttggtgtggccagcactctgaaactgagaaatgttcagaatgtacggaaagatgatcagctattttcaacataactgaaggcatatgctggcccataaacaccctgtaggttcttgatatttataataaaattggtgttttgtaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:6890 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:6890 -> Molecular function: GO:0005524 [ATP binding] evidence: IDA
            GeneID:6890 -> Molecular function: GO:0015197 [peptide transporter activity] evidence: IGI
            GeneID:6890 -> Molecular function: GO:0015197 [peptide transporter activity] evidence: IMP
            GeneID:6890 -> Molecular function: GO:0015421 [oligopeptide-transporting ATPase activity] evidence: IBA
            GeneID:6890 -> Molecular function: GO:0042288 [MHC class I protein binding] evidence: IBA
            GeneID:6890 -> Molecular function: GO:0042605 [peptide antigen binding] evidence: IBA
            GeneID:6890 -> Molecular function: GO:0042605 [peptide antigen binding] evidence: NAS
            GeneID:6890 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: ISS
            GeneID:6890 -> Molecular function: GO:0043531 [ADP binding] evidence: IDA
            GeneID:6890 -> Molecular function: GO:0046978 [TAP1 binding] evidence: IBA
            GeneID:6890 -> Molecular function: GO:0046978 [TAP1 binding] evidence: ISS
            GeneID:6890 -> Molecular function: GO:0046979 [TAP2 binding] evidence: IBA
            GeneID:6890 -> Molecular function: GO:0046979 [TAP2 binding] evidence: IPI
            GeneID:6890 -> Molecular function: GO:0046980 [tapasin binding] evidence: IBA
            GeneID:6890 -> Biological process: GO:0001916 [positive regulation of T cell mediated cytotoxicity] evidence: IBA
            GeneID:6890 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS
            GeneID:6890 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS
            GeneID:6890 -> Biological process: GO:0006952 [defense response] evidence: IEA
            GeneID:6890 -> Biological process: GO:0015833 [peptide transport] evidence: IBA
            GeneID:6890 -> Biological process: GO:0015833 [peptide transport] evidence: IMP
            GeneID:6890 -> Biological process: GO:0019060 [intracellular transport of viral proteins in host cell] evidence: IMP
            GeneID:6890 -> Biological process: GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I] evidence: IMP
            GeneID:6890 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS
            GeneID:6890 -> Biological process: GO:0046967 [cytosol to ER transport] evidence: IMP
            GeneID:6890 -> Biological process: GO:0055085 [transmembrane transport] evidence: IBA
            GeneID:6890 -> Cellular component: GO:0005743 [mitochondrial inner membrane] evidence: IRD
            GeneID:6890 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: TAS
            GeneID:6890 -> Cellular component: GO:0005829 [cytosol] evidence: NAS
            GeneID:6890 -> Cellular component: GO:0005886 [plasma membrane] evidence: IBA
            GeneID:6890 -> Cellular component: GO:0016021 [integral to membrane] evidence: IDA
            GeneID:6890 -> Cellular component: GO:0030176 [integral to endoplasmic reticulum membrane] evidence: IDA
            GeneID:6890 -> Cellular component: GO:0042825 [TAP complex] evidence: IBA
            GeneID:6890 -> Cellular component: GO:0042825 [TAP complex] evidence: IDA

by @meso_cacase at DBCLS
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