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2018-11-22 03:19:53, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_000546               2591 bp    mRNA    linear   PRI 15-JUL-2013
DEFINITION  Homo sapiens tumor protein p53 (TP53), transcript variant 1, mRNA.
ACCESSION   NM_000546
VERSION     NM_000546.5  GI:371502114
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2591)
  AUTHORS   Marcel,V., Tran,P.L., Sagne,C., Martel-Planche,G., Vaslin,L.,
            Teulade-Fichou,M.P., Hall,J., Mergny,J.L., Hainaut,P. and Van
            Dyck,E.
  TITLE     G-quadruplex structures in TP53 intron 3: role in alternative
            splicing and in production of p53 mRNA isoforms
  JOURNAL   Carcinogenesis 32 (3), 271-278 (2011)
   PUBMED   21112961
REFERENCE   2  (bases 1 to 2591)
  AUTHORS   Marcel,V., Perrier,S., Aoubala,M., Ageorges,S., Groves,M.J.,
            Diot,A., Fernandes,K., Tauro,S. and Bourdon,J.C.
  TITLE     Delta160p53 is a novel N-terminal p53 isoform encoded by
            Delta133p53 transcript
  JOURNAL   FEBS Lett. 584 (21), 4463-4468 (2010)
   PUBMED   20937277
  REMARK    GeneRIF: Delta133p53 transcript generates two different p53
            isoforms, Delta133p53 and Delta160p53
REFERENCE   3  (bases 1 to 2591)
  AUTHORS   Anczukow,O., Ware,M.D., Buisson,M., Zetoune,A.B.,
            Stoppa-Lyonnet,D., Sinilnikova,O.M. and Mazoyer,S.
  TITLE     Does the nonsense-mediated mRNA decay mechanism prevent the
            synthesis of truncated BRCA1, CHK2, and p53 proteins?
  JOURNAL   Hum. Mutat. 29 (1), 65-73 (2008)
   PUBMED   17694537
  REMARK    GeneRIF: the p53 protein encoded by the 770delT allele is as
            abundant as the wild-type protein, as removal of the C-terminal p53
            domain leads to a stabilized mutant protein, whose abundance is
            markedly increased when NMD is inhibited.
REFERENCE   4  (bases 1 to 2591)
  AUTHORS   Bourdon,J.C.
  TITLE     p53 Family isoforms
  JOURNAL   Curr Pharm Biotechnol 8 (6), 332-336 (2007)
   PUBMED   18289041
  REMARK    Review article
REFERENCE   5  (bases 1 to 2591)
  AUTHORS   Candeias,M.M., Powell,D.J., Roubalova,E., Apcher,S., Bourougaa,K.,
            Vojtesek,B., Bruzzoni-Giovanelli,H. and Fahraeus,R.
  TITLE     Expression of p53 and p53/47 are controlled by alternative
            mechanisms of messenger RNA translation initiation
  JOURNAL   Oncogene 25 (52), 6936-6947 (2006)
   PUBMED   16983332
  REMARK    GeneRIF: harbouring alternative translation initiation sites, the
            p53 mRNA gives rise to different levels of the p53 isoforms which
            help to orchestrate the cell biological outcome of p53 activation
REFERENCE   6  (bases 1 to 2591)
  AUTHORS   Lamb,P. and Crawford,L.
  TITLE     Characterization of the human p53 gene
  JOURNAL   Mol. Cell. Biol. 6 (5), 1379-1385 (1986)
   PUBMED   2946935
REFERENCE   7  (bases 1 to 2591)
  AUTHORS   Isobe,M., Emanuel,B.S., Givol,D., Oren,M. and Croce,C.M.
  TITLE     Localization of gene for human p53 tumour antigen to band 17p13
  JOURNAL   Nature 320 (6057), 84-85 (1986)
   PUBMED   3456488
REFERENCE   8  (bases 1 to 2591)
  AUTHORS   Benchimol,S., Lamb,P., Crawford,L.V., Sheer,D., Shows,T.B.,
            Bruns,G.A. and Peacock,J.
  TITLE     Transformation associated p53 protein is encoded by a gene on human
            chromosome 17
  JOURNAL   Somat. Cell Mol. Genet. 11 (5), 505-510 (1985)
   PUBMED   2994241
REFERENCE   9  (bases 1 to 2591)
  AUTHORS   Harlow,E., Williamson,N.M., Ralston,R., Helfman,D.M. and Adams,T.E.
  TITLE     Molecular cloning and in vitro expression of a cDNA clone for human
            cellular tumor antigen p53
  JOURNAL   Mol. Cell. Biol. 5 (7), 1601-1610 (1985)
   PUBMED   3894933
REFERENCE   10 (bases 1 to 2591)
  AUTHORS   Zakut-Houri,R., Bienz-Tadmor,B., Givol,D. and Oren,M.
  TITLE     Human p53 cellular tumor antigen: cDNA sequence and expression in
            COS cells
  JOURNAL   EMBO J. 4 (5), 1251-1255 (1985)
   PUBMED   4006916
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA453049.1, X02469.1,
            AK223026.1 and DQ186650.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Jan 7, 2012 this sequence version replaced gi:187830767.
            
            Summary: This gene encodes a tumor suppressor protein containing
            transcriptional activation, DNA binding, and oligomerization
            domains. The encoded protein responds to diverse cellular stresses
            to regulate expression of target genes, thereby inducing cell cycle
            arrest, apoptosis, senescence, DNA repair, or changes in
            metabolism. Mutations in this gene are associated with a variety of
            human cancers, including hereditary cancers such as Li-Fraumeni
            syndrome. Alternative splicing of this gene and the use of
            alternate promoters result in multiple transcript variants and
            isoforms. Additional isoforms have also been shown to result from
            the use of alternate translation initiation codons (PMIDs:
            12032546, 20937277). [provided by RefSeq, Feb 2013].
            
            Transcript Variant: This variant (1) can initiate translation from
            two in-frame AUG start codons. The isoform represented in this
            variant (a, also known as p53alpha) results from translation
            initiation at the upstream start codon. Both variants 1 and 2
            encode isoform a, which is the longest isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ191317.1, DQ286964.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                DA453049.1         1-67
            68-1384             X02469.1           1-1317
            1385-2572           AK223026.1         478-1665
            2573-2591           DQ186650.1         2257-2275
FEATURES             Location/Qualifiers
     source          1..2591
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..2591
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /note="tumor protein p53"
                     /db_xref="GeneID:7157"
                     /db_xref="HGNC:11998"
                     /db_xref="MIM:191170"
     exon            1..174
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /inference="alignment:Splign:1.39.8"
     variation       92
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17884410"
     misc_feature    95..97
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /note="upstream in-frame stop codon"
     exon            175..276
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /inference="alignment:Splign:1.39.8"
     CDS             203..1384
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /note="isoform a is encoded by transcript variant 1;
                     cellular tumor antigen p53; phosphoprotein p53;
                     transformation-related protein 53; p53 tumor suppressor;
                     antigen NY-CO-13"
                     /codon_start=1
                     /product="cellular tumor antigen p53 isoform a"
                     /protein_id="NP_000537.3"
                     /db_xref="GI:120407068"
                     /db_xref="CCDS:CCDS11118.1"
                     /db_xref="GeneID:7157"
                     /db_xref="HGNC:11998"
                     /db_xref="MIM:191170"
                     /translation="
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
"
     misc_feature    203..451
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P04637.4);
                     Region: Interaction with HRMT1L2"
     misc_feature    203..334
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P04637.4);
                     Region: Transcription activation (acidic)"
     misc_feature    215..289
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /note="P53 transactivation motif; Region: P53_TAD;
                     pfam08563"
                     /db_xref="CDD:149567"
     misc_feature    218..220
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:02739"
     misc_feature    227..229
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by HIPK4; propagated from
                     UniProtKB/Swiss-Prot (P04637.4); phosphorylation site"
     misc_feature    227..229
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:02739"
     misc_feature    227..229
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:06347"
     misc_feature    245..247
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="dephosphorylation site; modified site"
                     /db_xref="HPRD:01146"
     misc_feature    245..247
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by CDK5, PRPK, AMPK, NUAK1 and ATM;
                     propagated from UniProtKB/Swiss-Prot (P04637.4);
                     phosphorylation site"
     misc_feature    245..247
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01496"
     misc_feature    245..247
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:02941"
     misc_feature    245..247
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:04356"
     misc_feature    245..247
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:06347"
     misc_feature    245..247
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:08369"
     misc_feature    245..247
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    251..277
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P04637.4);
                     Region: TADI"
     misc_feature    254..256
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="proteolytic cleavage site; modified site"
                     /db_xref="HPRD:00253"
     misc_feature    254..256
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by CK1, VRK1 and VRK2; propagated
                     from UniProtKB/Swiss-Prot (P04637.4); phosphorylation
                     site"
     misc_feature    254..256
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:02920"
     misc_feature    254..256
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:02941"
     misc_feature    254..256
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:03701"
     misc_feature    254..256
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:08369"
     misc_feature    254..256
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:00277"
     misc_feature    254..256
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:00278"
     misc_feature    260..262
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="proteolytic cleavage site; modified site"
                     /db_xref="HPRD:00253"
     misc_feature    260..262
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by CHEK2, CK1 and PLK3; propagated
                     from UniProtKB/Swiss-Prot (P04637.4); phosphorylation
                     site"
     misc_feature    260..262
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:02941"
     misc_feature    260..262
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:04222"
     misc_feature    260..262
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:04356"
     misc_feature    260..262
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:06347"
     misc_feature    260..262
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:08369"
     misc_feature    269..271
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="proteolytic cleavage site; modified site"
     misc_feature    299..301
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by CDK5 and CDK7; propagated from
                     UniProtKB/Swiss-Prot (P04637.4); phosphorylation site"
     misc_feature    299..301
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:02941"
     misc_feature    299..301
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:05418"
     misc_feature    299..301
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:06347"
     misc_feature    299..301
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:00449"
     misc_feature    299..301
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:16016"
     misc_feature    299..301
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    311..313
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by MAPKAPK5; propagated from
                     UniProtKB/Swiss-Prot (P04637.4); phosphorylation site"
     misc_feature    311..313
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:02941"
     misc_feature    311..313
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:04356"
     misc_feature    311..313
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:06347"
     misc_feature    311..313
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:08369"
     misc_feature    311..313
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:09467"
     misc_feature    320..322
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /note="delta40p53alpha; Region: alternative start codon"
     misc_feature    338..340
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by CDK5, DYRK2, HIPK2 and PKC/PRKCG;
                     propagated from UniProtKB/Swiss-Prot (P04637.4);
                     phosphorylation site"
     misc_feature    338..340
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:06039"
     misc_feature    338..340
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:06347"
     misc_feature    344..370
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P04637.4);
                     Region: TADII"
     misc_feature    365..367
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="dephosphorylation site; modified site"
     misc_feature    365..367
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by TAF1 and GRK5; propagated from
                     UniProtKB/Swiss-Prot (P04637.4); phosphorylation site"
     misc_feature    365..367
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01496"
     misc_feature    398..532
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P04637.4);
                     Region: Interaction with WWOX"
     misc_feature    443..445
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:03100"
     misc_feature    443..445
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    497..499
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    500..1312
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P04637.4);
                     Region: Interaction with HIPK1 (By similarity)"
     misc_feature    527..1066
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /note="P53 DNA-binding domain; Region: P53; cd08367"
                     /db_xref="CDD:176262"
     misc_feature    539..910
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P04637.4);
                     Region: Required for interaction with FBXO42"
     misc_feature    548..1078
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P04637.4);
                     Region: Interaction with AXIN1 (By similarity)"
     misc_feature    560..562
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, by KAT6A; propagated from
                     UniProtKB/Swiss-Prot (P04637.4); acetylation site"
     misc_feature    560..562
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Interaction with DNA; propagated from
                     UniProtKB/Swiss-Prot (P04637.4); other site"
     misc_feature    665..667
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:00277"
     misc_feature    order(728..730,737..739,914..916,926..928)
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /note="zinc binding site [ion binding]; other site"
                     /db_xref="CDD:176262"
     misc_feature    order(731..739,743..745)
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /note="dimerization site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:176262"
     misc_feature    749..751
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by AURKB; propagated from
                     UniProtKB/Swiss-Prot (P04637.4); phosphorylation site"
     misc_feature    order(917..919,923..925,944..946,1019..1021,1025..1033,
                     1040..1042)
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:176262"
     misc_feature    923..946
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P04637.4);
                     Region: Interacts with the 53BP2 SH3 domain"
     misc_feature    968..1084
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P04637.4);
                     Region: Interaction with E4F1"
     misc_feature    1007..1009
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by AURKB; propagated from
                     UniProtKB/Swiss-Prot (P04637.4); phosphorylation site"
     misc_feature    1019..1042
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P04637.4);
                     Region: Interaction with DNA"
     misc_feature    1052..1054
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by AURKB; propagated from
                     UniProtKB/Swiss-Prot (P04637.4); phosphorylation site"
     misc_feature    1076..1078
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="acetylation site"
                     /db_xref="HPRD:04078"
     misc_feature    1100..1381
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P04637.4);
                     Region: Interaction with CARM1"
     misc_feature    1115..1165
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P04637.4);
                     Region: Bipartite nuclear localization signal"
     misc_feature    1115..1117
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P04637.4); acetylation site"
     misc_feature    1115..1117
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="acetylation site"
                     /db_xref="HPRD:04078"
     misc_feature    1145..1147
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="dephosphorylation site; modified site"
                     /db_xref="HPRD:04614"
     misc_feature    1145..1147
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="dephosphorylation site; modified site"
                     /db_xref="HPRD:04615"
     misc_feature    1145..1147
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by AURKA, CDK1 and CDK2; propagated
                     from UniProtKB/Swiss-Prot (P04637.4); phosphorylation
                     site"
     misc_feature    1145..1147
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:00310"
     misc_feature    1145..1147
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:00449"
     misc_feature    1145..1147
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:16016"
     misc_feature    1145..1147
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1157..1282
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P04637.4);
                     Region: Interaction with HIPK2"
     misc_feature    1157..1279
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /note="P53 tetramerisation motif; Region: P53_tetramer;
                     pfam07710"
                     /db_xref="CDD:149007"
     misc_feature    1157..1159
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="ubiquitination site; modified site"
                     /db_xref="HPRD:04317"
     misc_feature    1160..1162
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="acetylation site"
                     /db_xref="HPRD:06780"
     misc_feature    1160..1162
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="ubiquitination site; modified site"
                     /db_xref="HPRD:04317"
     misc_feature    1160..1162
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="neddylation site; modified site"
                     /db_xref="HPRD:06985"
     misc_feature    1163..1165
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="ubiquitination site; modified site"
                     /db_xref="HPRD:04317"
     misc_feature    1163..1165
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="neddylation site; modified site"
                     /db_xref="HPRD:06985"
     misc_feature    1175..1270
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P04637.4);
                     Region: Oligomerization"
     misc_feature    1217..1252
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P04637.4);
                     Region: Nuclear export signal"
     misc_feature    1253..1255
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="ubiquitination site; modified site"
     misc_feature    1271..1273
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="ubiquitination site; modified site"
     misc_feature    1277..1291
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P04637.4);
                     Region: Interaction with USP7"
     misc_feature    1298..1300
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1304..1363
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P04637.4);
                     Region: Basic (repression of DNA-binding)"
     misc_feature    1310..1318
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P04637.4);
                     Region: [KR]-[STA]-K motif"
     misc_feature    1310..1312
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="acetylation site"
                     /db_xref="HPRD:04078"
     misc_feature    1310..1312
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6,N6-dimethyllysine, alternate; N6-methyllysine,
                     by SMYD2, alternate; propagated from UniProtKB/Swiss-Prot
                     (P04637.4); methylation site"
     misc_feature    1310..1312
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="methylation site"
                     /db_xref="HPRD:15406"
     misc_feature    1310..1312
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="ubiquitination site; modified site"
                     /db_xref="HPRD:01272"
     misc_feature    1310..1312
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="neddylation site; modified site"
                     /db_xref="HPRD:06985"
     misc_feature    1313..1315
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01498"
     misc_feature    1316..1318
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="acetylation site"
                     /db_xref="HPRD:04078"
     misc_feature    1316..1318
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-methyllysine, by SETD7; propagated from
                     UniProtKB/Swiss-Prot (P04637.4); methylation site"
     misc_feature    1316..1318
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="methylation site"
                     /db_xref="HPRD:16226"
     misc_feature    1316..1318
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="ubiquitination site; modified site"
                     /db_xref="HPRD:01272"
     misc_feature    1316..1318
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="neddylation site; modified site"
                     /db_xref="HPRD:06985"
     misc_feature    1319..1321
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate; propagated from
                     UniProtKB/Swiss-Prot (P04637.4); acetylation site"
     misc_feature    1319..1321
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="acetylation site"
                     /db_xref="HPRD:04078"
     misc_feature    1319..1321
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6,N6-dimethyllysine, by EHMT1 and EHMT2,
                     alternate; propagated from UniProtKB/Swiss-Prot
                     (P04637.4); methylation site"
     misc_feature    1319..1321
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="ubiquitination site; modified site"
                     /db_xref="HPRD:01272"
     misc_feature    1319..1321
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="deacetylation site; modified site"
                     /db_xref="HPRD:03143"
     misc_feature    1319..1321
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="neddylation site; modified site"
                     /db_xref="HPRD:06985"
     misc_feature    1334..1336
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01498"
     misc_feature    1343..1345
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P04637.4); acetylation site"
     misc_feature    1343..1345
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="acetylation site"
                     /db_xref="HPRD:04078"
     misc_feature    1343..1345
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="ubiquitination site; modified site"
                     /db_xref="HPRD:01272"
     misc_feature    1343..1345
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="neddylation site; modified site"
                     /db_xref="HPRD:06985"
     misc_feature    1346..1348
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, by KAT6A, alternate; propagated
                     from UniProtKB/Swiss-Prot (P04637.4); acetylation site"
     misc_feature    1346..1348
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="acetylation site"
                     /db_xref="HPRD:04078"
     misc_feature    1346..1348
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6,N6-dimethyllysine, alternate; N6-methyllysine,
                     by SETD8, alternate; propagated from UniProtKB/Swiss-Prot
                     (P04637.4); methylation site"
     misc_feature    1346..1348
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="deacylation site; modified site"
                     /db_xref="HPRD:08381"
     misc_feature    1346..1348
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="deacetylation site; modified site"
                     /db_xref="HPRD:03143"
     misc_feature    1346..1348
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="neddylation site; modified site"
                     /db_xref="HPRD:06985"
     misc_feature    1358..1360
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="ubiquitination site; modified site"
     misc_feature    1358..1360
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="ubiquitination site; modified site"
                     /db_xref="HPRD:01272"
     misc_feature    1358..1360
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="neddylation site; modified site"
                     /db_xref="HPRD:06985"
     misc_feature    1376..1378
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by CK2, CDK2 and NUAK1; propagated
                     from UniProtKB/Swiss-Prot (P04637.4); phosphorylation
                     site"
     misc_feature    1376..1378
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01468"
     misc_feature    1376..1378
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:02619"
     misc_feature    1376..1378
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:00277"
     misc_feature    1376..1378
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:00310"
     misc_feature    1376..1378
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:16016"
     variation       265
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1800369"
     exon            277..298
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /inference="alignment:Splign:1.39.8"
     exon            299..577
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /inference="alignment:Splign:1.39.8"
     variation       304
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11575998"
     STS             305..503
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /standard_name="GDB:177814"
                     /db_xref="UniSTS:154969"
     variation       310
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1800370"
     STS             319..577
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /standard_name="GDB:177797"
                     /db_xref="UniSTS:154963"
     variation       341
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1800371"
     variation       531
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11540654"
     exon            578..761
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /inference="alignment:Splign:1.39.8"
     variation       661
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:72661116"
     STS             680..754
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /standard_name="PMC340938P3"
                     /db_xref="UniSTS:273171"
     variation       752
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:72661117"
     exon            762..874
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /inference="alignment:Splign:1.39.8"
     variation       841
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1800372"
     variation       851
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35163653"
     variation       868
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:72661118"
     exon            875..984
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /inference="alignment:Splign:1.39.8"
     STS             955..1153
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /standard_name="PMC310707P2"
                     /db_xref="UniSTS:272633"
     STS             959..1033
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /standard_name="GDB:190076"
                     /db_xref="UniSTS:155620"
     exon            985..1121
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /inference="alignment:Splign:1.39.8"
     variation       989
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:72661119"
     variation       1105
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:72661120"
     exon            1122..1195
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /inference="alignment:Splign:1.39.8"
     variation       1195
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11575996"
     exon            1196..1302
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /inference="alignment:Splign:1.39.8"
     variation       1217
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17882252"
     variation       1281
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:35993958"
     variation       1298
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:17881470"
     exon            1303..2591
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /inference="alignment:Splign:1.39.8"
     variation       1421
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1042526"
     STS             1454..1570
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /standard_name="D17S1678"
                     /db_xref="UniSTS:82485"
     variation       1489
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35919705"
     variation       1698
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34486624"
     variation       1712
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17881366"
     variation       1875
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:916131"
     variation       1898
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:916132"
     STS             1911..2057
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /standard_name="D17S1506E"
                     /db_xref="UniSTS:151711"
     variation       1918..1919
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1811095"
     variation       1954
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace=""
                     /replace="gt"
                     /db_xref="dbSNP:17886358"
     variation       1997
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:17879353"
     variation       2018..2019
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1794291"
     variation       2018
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1042535"
     variation       2138
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199729221"
     variation       2210
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17884306"
     variation       2239
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17884586"
     variation       2270
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35659787"
     variation       2440..2441
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1794292"
     STS             2446..2522
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /standard_name="WI-20715"
                     /db_xref="UniSTS:59997"
     polyA_signal    2555..2560
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
     variation       2559
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:78378222"
     polyA_site      2572
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /note="The 3' most polyA site has not been determined."
ORIGIN      
gatgggattggggttttcccctcccatgtgctcaagactggcgctaaaagttttgagcttctcaaaagtctagagccaccgtccagggagcaggtagctgctgggctccggggacactttgcgttcgggctgggagcgtgctttccacgacggtgacacgcttccctggattggcagccagactgccttccgggtcactgccatggaggagccgcagtcagatcctagcgtcgagccccctctgagtcaggaaacattttcagacctatggaaactacttcctgaaaacaacgttctgtcccccttgccgtcccaagcaatggatgatttgatgctgtccccggacgatattgaacaatggttcactgaagacccaggtccagatgaagctcccagaatgccagaggctgctccccccgtggcccctgcaccagcagctcctacaccggcggcccctgcaccagccccctcctggcccctgtcatcttctgtcccttcccagaaaacctaccagggcagctacggtttccgtctgggcttcttgcattctgggacagccaagtctgtgacttgcacgtactcccctgccctcaacaagatgttttgccaactggccaagacctgccctgtgcagctgtgggttgattccacacccccgcccggcacccgcgtccgcgccatggccatctacaagcagtcacagcacatgacggaggttgtgaggcgctgcccccaccatgagcgctgctcagatagcgatggtctggcccctcctcagcatcttatccgagtggaaggaaatttgcgtgtggagtatttggatgacagaaacacttttcgacatagtgtggtggtgccctatgagccgcctgaggttggctctgactgtaccaccatccactacaactacatgtgtaacagttcctgcatgggcggcatgaaccggaggcccatcctcaccatcatcacactggaagactccagtggtaatctactgggacggaacagctttgaggtgcgtgtttgtgcctgtcctgggagagaccggcgcacagaggaagagaatctccgcaagaaaggggagcctcaccacgagctgcccccagggagcactaagcgagcactgcccaacaacaccagctcctctccccagccaaagaagaaaccactggatggagaatatttcacccttcagatccgtgggcgtgagcgcttcgagatgttccgagagctgaatgaggccttggaactcaaggatgcccaggctgggaaggagccaggggggagcagggctcactccagccacctgaagtccaaaaagggtcagtctacctcccgccataaaaaactcatgttcaagacagaagggcctgactcagactgacattctccacttcttgttccccactgacagcctcccacccccatctctccctcccctgccattttgggttttgggtctttgaacccttgcttgcaataggtgtgcgtcagaagcacccaggacttccatttgctttgtcccggggctccactgaacaagttggcctgcactggtgttttgttgtggggaggaggatggggagtaggacataccagcttagattttaaggtttttactgtgagggatgtttgggagatgtaagaaatgttcttgcagttaagggttagtttacaatcagccacattctaggtaggggcccacttcaccgtactaaccagggaagctgtccctcactgttgaattttctctaacttcaaggcccatatctgtgaaatgctggcatttgcacctacctcacagagtgcattgtgagggttaatgaaataatgtacatctggccttgaaaccaccttttattacatggggtctagaacttgacccccttgagggtgcttgttccctctccctgttggtcggtgggttggtagtttctacagttgggcagctggttaggtagagggagttgtcaagtctctgctggcccagccaaaccctgtctgacaacctcttggtgaaccttagtacctaaaaggaaatctcaccccatcccacaccctggaggatttcatctcttgtatatgatgatctggatccaccaagacttgttttatgctcagggtcaatttcttttttcttttttttttttttttttctttttctttgagactgggtctcgctttgttgcccaggctggagtggagtggcgtgatcttggcttactgcagcctttgcctccccggctcgagcagtcctgcctcagcctccggagtagctgggaccacaggttcatgccaccatggccagccaacttttgcatgttttgtagagatggggtctcacagtgttgcccaggctggtctcaaactcctgggctcaggcgatccacctgtctcagcctcccagagtgctgggattacaattgtgagccaccacgtccagctggaagggtcaacatcttttacattctgcaagcacatctgcattttcaccccacccttcccctccttctccctttttatatcccatttttatatcgatctcttattttacaataaaactttgctgccacctgtgtgtctgaggggtg
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:7157 -> Molecular function: GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] evidence: IEA
            GeneID:7157 -> Molecular function: GO:0001085 [RNA polymerase II transcription factor binding] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] evidence: IDA
            GeneID:7157 -> Molecular function: GO:0002020 [protease binding] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0002039 [p53 binding] evidence: IBA
            GeneID:7157 -> Molecular function: GO:0003677 [DNA binding] evidence: IMP
            GeneID:7157 -> Molecular function: GO:0003682 [chromatin binding] evidence: IDA
            GeneID:7157 -> Molecular function: GO:0003684 [damaged DNA binding] evidence: IBA
            GeneID:7157 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IDA
            GeneID:7157 -> Molecular function: GO:0005507 [copper ion binding] evidence: IDA
            GeneID:7157 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0005524 [ATP binding] evidence: IDA
            GeneID:7157 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0008270 [zinc ion binding] evidence: TAS
            GeneID:7157 -> Molecular function: GO:0019899 [enzyme binding] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0030971 [receptor tyrosine kinase binding] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0031625 [ubiquitin protein ligase binding] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0035033 [histone deacetylase regulator activity] evidence: IEA
            GeneID:7157 -> Molecular function: GO:0035035 [histone acetyltransferase binding] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0044212 [transcription regulatory region DNA binding] evidence: IDA
            GeneID:7157 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0047485 [protein N-terminus binding] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0051087 [chaperone binding] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0051721 [protein phosphatase 2A binding] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0097371 [MDM2/MDM4 family protein binding] evidence: IEA
            GeneID:7157 -> Biological process: GO:0000060 [protein import into nucleus, translocation] evidence: IEA
            GeneID:7157 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IBA
            GeneID:7157 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:7157 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: ISS
            GeneID:7157 -> Biological process: GO:0000733 [DNA strand renaturation] evidence: IDA
            GeneID:7157 -> Biological process: GO:0001701 [in utero embryonic development] evidence: IEA
            GeneID:7157 -> Biological process: GO:0001756 [somitogenesis] evidence: IEA
            GeneID:7157 -> Biological process: GO:0001836 [release of cytochrome c from mitochondria] evidence: IEA
            GeneID:7157 -> Biological process: GO:0002309 [T cell proliferation involved in immune response] evidence: IEA
            GeneID:7157 -> Biological process: GO:0002326 [B cell lineage commitment] evidence: IEA
            GeneID:7157 -> Biological process: GO:0002360 [T cell lineage commitment] evidence: IEA
            GeneID:7157 -> Biological process: GO:0002931 [response to ischemia] evidence: IEA
            GeneID:7157 -> Biological process: GO:0006284 [base-excision repair] evidence: TAS
            GeneID:7157 -> Biological process: GO:0006289 [nucleotide-excision repair] evidence: IMP
            GeneID:7157 -> Biological process: GO:0006302 [double-strand break repair] evidence: IEA
            GeneID:7157 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IDA
            GeneID:7157 -> Biological process: GO:0006461 [protein complex assembly] evidence: IDA
            GeneID:7157 -> Biological process: GO:0006917 [induction of apoptosis] evidence: IEA
            GeneID:7157 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: IDA
            GeneID:7157 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS
            GeneID:7157 -> Biological process: GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] evidence: IMP
            GeneID:7157 -> Biological process: GO:0006983 [ER overload response] evidence: IDA
            GeneID:7157 -> Biological process: GO:0007050 [cell cycle arrest] evidence: IDA
            GeneID:7157 -> Biological process: GO:0007050 [cell cycle arrest] evidence: IMP
            GeneID:7157 -> Biological process: GO:0007179 [transforming growth factor beta receptor signaling pathway] evidence: IEA
            GeneID:7157 -> Biological process: GO:0007265 [Ras protein signal transduction] evidence: IEP
            GeneID:7157 -> Biological process: GO:0007275 [multicellular organismal development] evidence: IMP
            GeneID:7157 -> Biological process: GO:0007369 [gastrulation] evidence: IEA
            GeneID:7157 -> Biological process: GO:0007406 [negative regulation of neuroblast proliferation] evidence: IEA
            GeneID:7157 -> Biological process: GO:0007417 [central nervous system development] evidence: IEA
            GeneID:7157 -> Biological process: GO:0007569 [cell aging] evidence: IMP
            GeneID:7157 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
            GeneID:7157 -> Biological process: GO:0008104 [protein localization] evidence: IDA
            GeneID:7157 -> Biological process: GO:0008156 [negative regulation of DNA replication] evidence: IEA
            GeneID:7157 -> Biological process: GO:0008283 [cell proliferation] evidence: TAS
            GeneID:7157 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: ISS
            GeneID:7157 -> Biological process: GO:0008340 [determination of adult lifespan] evidence: ISS
            GeneID:7157 -> Biological process: GO:0009303 [rRNA transcription] evidence: IEA
            GeneID:7157 -> Biological process: GO:0009651 [response to salt stress] evidence: IEA
            GeneID:7157 -> Biological process: GO:0010165 [response to X-ray] evidence: IBA
            GeneID:7157 -> Biological process: GO:0010332 [response to gamma radiation] evidence: IMP
            GeneID:7157 -> Biological process: GO:0010666 [positive regulation of cardiac muscle cell apoptotic process] evidence: IEA
            GeneID:7157 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
            GeneID:7157 -> Biological process: GO:0030154 [cell differentiation] evidence: TAS
            GeneID:7157 -> Biological process: GO:0030308 [negative regulation of cell growth] evidence: IMP
            GeneID:7157 -> Biological process: GO:0030330 [DNA damage response, signal transduction by p53 class mediator] evidence: IDA
            GeneID:7157 -> Biological process: GO:0030330 [DNA damage response, signal transduction by p53 class mediator] evidence: IMP
            GeneID:7157 -> Biological process: GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] evidence: IEA
            GeneID:7157 -> Biological process: GO:0031065 [positive regulation of histone deacetylation] evidence: IBA
            GeneID:7157 -> Biological process: GO:0031497 [chromatin assembly] evidence: IDA
            GeneID:7157 -> Biological process: GO:0031571 [mitotic G1 DNA damage checkpoint] evidence: IMP
            GeneID:7157 -> Biological process: GO:0032461 [positive regulation of protein oligomerization] evidence: IDA
            GeneID:7157 -> Biological process: GO:0033077 [T cell differentiation in thymus] evidence: IEA
            GeneID:7157 -> Biological process: GO:0034103 [regulation of tissue remodeling] evidence: IEA
            GeneID:7157 -> Biological process: GO:0034613 [cellular protein localization] evidence: IDA
            GeneID:7157 -> Biological process: GO:0034644 [cellular response to UV] evidence: IBA
            GeneID:7157 -> Biological process: GO:0035264 [multicellular organism growth] evidence: IEA
            GeneID:7157 -> Biological process: GO:0035690 [cellular response to drug] evidence: IEP
            GeneID:7157 -> Biological process: GO:0042149 [cellular response to glucose starvation] evidence: IDA
            GeneID:7157 -> Biological process: GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] evidence: IDA
            GeneID:7157 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: IDA
            GeneID:7157 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IDA
            GeneID:7157 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IDA
            GeneID:7157 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IEA
            GeneID:7157 -> Biological process: GO:0043525 [positive regulation of neuron apoptotic process] evidence: IBA
            GeneID:7157 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: ISS
            GeneID:7157 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IDA
            GeneID:7157 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IMP
            GeneID:7157 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:7157 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IGI
            GeneID:7157 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IMP
            GeneID:7157 -> Biological process: GO:0046677 [response to antibiotic] evidence: IEP
            GeneID:7157 -> Biological process: GO:0046902 [regulation of mitochondrial membrane permeability] evidence: TAS
            GeneID:7157 -> Biological process: GO:0048147 [negative regulation of fibroblast proliferation] evidence: IMP
            GeneID:7157 -> Biological process: GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] evidence: ISS
            GeneID:7157 -> Biological process: GO:0051097 [negative regulation of helicase activity] evidence: TAS
            GeneID:7157 -> Biological process: GO:0051262 [protein tetramerization] evidence: TAS
            GeneID:7157 -> Biological process: GO:0051402 [neuron apoptotic process] evidence: IEA
            GeneID:7157 -> Biological process: GO:0070245 [positive regulation of thymocyte apoptotic process] evidence: ISS
            GeneID:7157 -> Biological process: GO:0071158 [positive regulation of cell cycle arrest] evidence: IMP
            GeneID:7157 -> Biological process: GO:0071456 [cellular response to hypoxia] evidence: IEP
            GeneID:7157 -> Biological process: GO:0071479 [cellular response to ionizing radiation] evidence: IMP
            GeneID:7157 -> Biological process: GO:0071850 [mitotic cell cycle arrest] evidence: IEA
            GeneID:7157 -> Biological process: GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] evidence: IMP
            GeneID:7157 -> Biological process: GO:0090200 [positive regulation of release of cytochrome c from mitochondria] evidence: IDA
            GeneID:7157 -> Biological process: GO:0090343 [positive regulation of cell aging] evidence: IEA
            GeneID:7157 -> Biological process: GO:0090399 [replicative senescence] evidence: IMP
            GeneID:7157 -> Biological process: GO:0090403 [oxidative stress-induced premature senescence] evidence: IMP
            GeneID:7157 -> Biological process: GO:0097193 [intrinsic apoptotic signaling pathway] evidence: TAS
            GeneID:7157 -> Biological process: GO:0097252 [oligodendrocyte apoptotic process] evidence: IDA
            GeneID:7157 -> Biological process: GO:1901525 [negative regulation of macromitophagy] evidence: IEA
            GeneID:7157 -> Biological process: GO:2000378 [negative regulation of reactive oxygen species metabolic process] evidence: IEA
            GeneID:7157 -> Biological process: GO:2000379 [positive regulation of reactive oxygen species metabolic process] evidence: IMP
            GeneID:7157 -> Biological process: GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway] evidence: IMP
            GeneID:7157 -> Cellular component: GO:0000785 [chromatin] evidence: IBA
            GeneID:7157 -> Cellular component: GO:0000790 [nuclear chromatin] evidence: IDA
            GeneID:7157 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:7157 -> Cellular component: GO:0005654 [nucleoplasm] evidence: IDA
            GeneID:7157 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:7157 -> Cellular component: GO:0005657 [replication fork] evidence: IBA
            GeneID:7157 -> Cellular component: GO:0005669 [transcription factor TFIID complex] evidence: IDA
            GeneID:7157 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
            GeneID:7157 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:7157 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA
            GeneID:7157 -> Cellular component: GO:0005759 [mitochondrial matrix] evidence: IEA
            GeneID:7157 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IEA
            GeneID:7157 -> Cellular component: GO:0005829 [cytosol] evidence: IBA
            GeneID:7157 -> Cellular component: GO:0005829 [cytosol] evidence: IDA
            GeneID:7157 -> Cellular component: GO:0016363 [nuclear matrix] evidence: IDA
            GeneID:7157 -> Cellular component: GO:0016604 [nuclear body] evidence: IDA
            GeneID:7157 -> Cellular component: GO:0016605 [PML body] evidence: IDA
            GeneID:7157 -> Cellular component: GO:0043234 [protein complex] evidence: IDA

by @meso_cacase at DBCLS
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