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2024-03-28 23:14:01, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_000486               4288 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens aquaporin 2 (collecting duct) (AQP2), mRNA.
ACCESSION   NM_000486
VERSION     NM_000486.5  GI:209180415
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4288)
  AUTHORS   Bockenhauer,D. and Bichet,D.G.
  TITLE     Inherited secondary nephrogenic diabetes insipidus: concentrating
            on humans
  JOURNAL   Am. J. Physiol. Renal Physiol. 304 (8), F1037-F1042 (2013)
   PUBMED   23364801
  REMARK    GeneRIF: Investigations into primary inherited nephrogenic diabetes
            insipidus (NDI) have contributed enormously to our understanding of
            the mechanisms of urinary concentration and identified the
            vasopressin receptor AVPR2, as well as the water channel
            aquaporin-2.
            Review article
REFERENCE   2  (bases 1 to 4288)
  AUTHORS   Wu,H., Chen,L., Zhang,X., Zhou,Q., Li,J.M., Berger,S., Borok,Z.,
            Zhou,B., Xiao,Z., Yin,H., Liu,M., Wang,Y., Jin,J., Blackburn,M.R.,
            Xia,Y. and Zhang,W.
  TITLE     Aqp5 is a new transcriptional target of Dot1a and a regulator of
            Aqp2
  JOURNAL   PLoS ONE 8 (1), E53342 (2013)
   PUBMED   23326416
  REMARK    GeneRIF: upregulated Aqp5 may contribute to polyuria, possibly by
            impairing Aqp2 membrane localization, in Dot1l(AC) mice and in
            patients with diabetic nephropathy.
REFERENCE   3  (bases 1 to 4288)
  AUTHORS   Sasaki,S.
  TITLE     Aquaporin 2: from its discovery to molecular structure and medical
            implications
  JOURNAL   Mol. Aspects Med. 33 (5-6), 535-546 (2012)
   PUBMED   23078817
  REMARK    GeneRIF: AQP2 is greatly involved in many human abnormal water
            balance disorders. (Review)
            Review article
REFERENCE   4  (bases 1 to 4288)
  AUTHORS   Schenk,A.D., Werten,P.J., Scheuring,S., de Groot,B.L., Muller,S.A.,
            Stahlberg,H., Philippsen,A. and Engel,A.
  TITLE     The 4.5 A structure of human AQP2
  JOURNAL   J. Mol. Biol. 350 (2), 278-289 (2005)
   PUBMED   15922355
  REMARK    GeneRIF: crystallization of recombinantly expressed human AQP2 into
            two-dimensional protein-lipid arrays and their structural
            characterization by atomic force microscopy and electron
            crystallography
REFERENCE   5  (bases 1 to 4288)
  AUTHORS   Ma,T., Yang,B., Umenishi,F. and Verkman,A.S.
  TITLE     Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in
            a 27-kilobase segment at chromosome locus 12q13
  JOURNAL   Genomics 43 (3), 387-389 (1997)
   PUBMED   9268644
REFERENCE   6  (bases 1 to 4288)
  AUTHORS   Saito,F., Sasaki,S., Chepelinsky,A.B., Fushimi,K., Marumo,F. and
            Ikeuchi,T.
  TITLE     Human AQP2 and MIP genes, two members of the MIP family, map within
            chromosome band 12q13 on the basis of two-color FISH
  JOURNAL   Cytogenet. Cell Genet. 68 (1-2), 45-48 (1995)
   PUBMED   7525161
REFERENCE   7  (bases 1 to 4288)
  AUTHORS   van Lieburg,A.F., Verdijk,M.A., Knoers,V.V., van Essen,A.J.,
            Proesmans,W., Mallmann,R., Monnens,L.A., van Oost,B.A., van Os,C.H.
            and Deen,P.M.
  TITLE     Patients with autosomal nephrogenic diabetes insipidus homozygous
            for mutations in the aquaporin 2 water-channel gene
  JOURNAL   Am. J. Hum. Genet. 55 (4), 648-652 (1994)
   PUBMED   7524315
REFERENCE   8  (bases 1 to 4288)
  AUTHORS   Uchida,S., Sasaki,S., Fushimi,K. and Marumo,F.
  TITLE     Isolation of human aquaporin-CD gene
  JOURNAL   J. Biol. Chem. 269 (38), 23451-23455 (1994)
   PUBMED   7522228
REFERENCE   9  (bases 1 to 4288)
  AUTHORS   Sasaki,S., Fushimi,K., Saito,H., Saito,F., Uchida,S., Ishibashi,K.,
            Kuwahara,M., Ikeuchi,T., Inui,K., Nakajima,K. et al.
  TITLE     Cloning, characterization, and chromosomal mapping of human
            aquaporin of collecting duct
  JOURNAL   J. Clin. Invest. 93 (3), 1250-1256 (1994)
   PUBMED   7510718
  REMARK    Erratum:[J Clin Invest 1994 Nov;94(5):following 216]
REFERENCE   10 (bases 1 to 4288)
  AUTHORS   Deen,P.M., Weghuis,D.O., Sinke,R.J., Geurts van Kessel,A.,
            Wieringa,B. and van Os,C.H.
  TITLE     Assignment of the human gene for the water channel of renal
            collecting duct Aquaporin 2 (AQP2) to chromosome 12 region
            q12-->q13
  JOURNAL   Cytogenet. Cell Genet. 66 (4), 260-262 (1994)
   PUBMED   7512890
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK225940.1, AI792401.1,
            BC042496.1 and AC025154.31.
            This sequence is a reference standard in the RefSeqGene project.
            On Oct 9, 2008 this sequence version replaced gi:186910297.
            
            Summary: This gene encodes a water channel protein located in the
            kidney collecting tubule. It belongs to the MIP/aquaporin family,
            some members of which are clustered together on chromosome 12q13.
            Mutations in this gene have been linked to autosomal dominant and
            recessive forms of nephrogenic diabetes insipidus. [provided by
            RefSeq, Oct 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042496.1, S73196.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025085 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-719               AK225940.1         1-719
            720-1066            AI792401.1         44-390
            1067-2467           BC042496.1         1062-2462
            2468-3908           AC025154.31        9560-11000
            3909-4288           BC042496.1         3904-4283
FEATURES             Location/Qualifiers
     source          1..4288
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q12-q13"
     gene            1..4288
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /note="aquaporin 2 (collecting duct)"
                     /db_xref="GeneID:359"
                     /db_xref="HGNC:634"
                     /db_xref="HPRD:00141"
                     /db_xref="MIM:107777"
     exon            1..450
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /inference="alignment:Splign:1.39.8"
     variation       16
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149553671"
     variation       25
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:143249649"
     variation       32
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:62620006"
     variation       40
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374778728"
     variation       43
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141361202"
     misc_feature    55..57
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /note="upstream in-frame stop codon"
     variation       75
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200777769"
     variation       81
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370614216"
     CDS             91..906
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /note="water-channel aquaporin 2; collecting duct water
                     channel protein; aquaporin-CD; AQP-2; ADH water channel;
                     water channel protein for renal collecting duct"
                     /codon_start=1
                     /product="aquaporin-2"
                     /protein_id="NP_000477.1"
                     /db_xref="GI:4502179"
                     /db_xref="CCDS:CCDS8792.1"
                     /db_xref="GeneID:359"
                     /db_xref="HGNC:634"
                     /db_xref="HPRD:00141"
                     /db_xref="MIM:107777"
                     /translation="
MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFPPAKSLSERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA
"
     misc_feature    121..756
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /note="Major intrinsic protein (MIP) superfamily. Members
                     of the MIP superfamily function as membrane channels that
                     selectively transport water, small neutral molecules, and
                     ions out of and between cells. The channel proteins share
                     a common fold: the N-terminal...; Region: MIP; cd00333"
                     /db_xref="CDD:29423"
     misc_feature    139..192
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P41181.1);
                     transmembrane region"
     misc_feature    211..267
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P41181.1);
                     transmembrane region"
     misc_feature    order(232..234,286..294,628..633,640..642,649..651)
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /note="amphipathic channel; other site"
                     /db_xref="CDD:29423"
     misc_feature    order(292..300,640..648)
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /note="Asn-Pro-Ala signature motifs; other site"
                     /db_xref="CDD:29423"
     misc_feature    292..300
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P41181.1);
                     Region: NPA 1"
     misc_feature    346..411
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P41181.1);
                     transmembrane region"
     misc_feature    472..534
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P41181.1);
                     transmembrane region"
     misc_feature    559..618
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P41181.1);
                     transmembrane region"
     misc_feature    640..648
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P41181.1);
                     Region: NPA 2"
     misc_feature    697..762
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P41181.1);
                     transmembrane region"
     misc_feature    856..858
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by PKA; propagated from
                     UniProtKB/Swiss-Prot (P41181.1); phosphorylation site"
     misc_feature    856..858
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     variation       101
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372883230"
     variation       104
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148006652"
     variation       117
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187754589"
     variation       122
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148085137"
     variation       129
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61733029"
     variation       141
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377296676"
     variation       153
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147136099"
     variation       154
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:104894336"
     variation       160
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200706192"
     variation       174
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373926562"
     variation       177
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:139709797"
     variation       231
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140262864"
     variation       252
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:143497314"
     variation       260
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:28931580"
     variation       262
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145685755"
     variation       270
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370848842"
     variation       279
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200279968"
     variation       280
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:104894326"
     variation       284
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147174725"
     variation       293
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:104894331"
     variation       294
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:57915981"
     variation       300
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139893949"
     variation       301
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149659001"
     variation       313
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:193922494"
     variation       314
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144443773"
     variation       322
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149823093"
     variation       366
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148785923"
     variation       389
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:104894338"
     variation       394
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201047682"
     variation       399
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11557014"
     variation       414
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143940351"
     variation       429
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144253988"
     variation       430
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370232864"
     variation       432
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35400945"
     variation       435
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:60629501"
     exon            451..615
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /inference="alignment:Splign:1.39.8"
     variation       451
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11169226"
     variation       464
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:104894333"
     variation       467
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:104894330"
     variation       468
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144891220"
     variation       480
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139064235"
     variation       483
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371158770"
     variation       513
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:151219353"
     variation       523
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373700329"
     variation       528
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143886391"
     variation       529
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:104894334"
     variation       536
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146384248"
     variation       537
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369985708"
     variation       545
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150344189"
     variation       548
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139771821"
     variation       549
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201617819"
     variation       550
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369214822"
     variation       561
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138000704"
     variation       591
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:426496"
     variation       613
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:104894335"
     exon            616..696
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /inference="alignment:Splign:1.39.8"
     variation       627
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199999215"
     variation       628
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:147039983"
     variation       633
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:104894337"
     variation       649
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:104894328"
     variation       650
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:193922495"
     variation       658
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:104894341"
     variation       669
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201812544"
     exon            697..4179
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /inference="alignment:Splign:1.39.8"
     variation       714
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201300211"
     variation       725
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142323499"
     variation       736
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:104894329"
     variation       737
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199422215"
     variation       741
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145940884"
     variation       765
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139738521"
     variation       792
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143104356"
     variation       819
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201761847"
     variation       825
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201195539"
     variation       841
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150666967"
     variation       848
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139913957"
     variation       853
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370879515"
     variation       862
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:104894332"
     variation       872
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376000406"
     variation       875
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:193922496"
     variation       875
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:104894339"
     variation       926
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:457487"
     variation       993
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:145741662"
     variation       1027
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:75528468"
     variation       1132
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145323624"
     variation       1146
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1047224"
     variation       1156
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373992535"
     variation       1157
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:35872356"
     variation       1158
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114099597"
     variation       1176
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368208178"
     variation       1187
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:142263071"
     STS             1214..1383
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /standard_name="STS-D31846"
                     /db_xref="UniSTS:41469"
     variation       1223
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:143209925"
     variation       1227
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:151189685"
     variation       1265..1266
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:34335497"
     variation       1275
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140262155"
     variation       1277
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:35146277"
     variation       1280
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:467323"
     variation       1292
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:137959340"
     variation       1298
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:35190790"
     variation       1319
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:35104166"
     variation       1330
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56160615"
     variation       1331
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149425435"
     variation       1379
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:185701115"
     variation       1436
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:74091160"
     variation       1447
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144600878"
     variation       1457
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375057124"
     polyA_signal    1458..1463
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
     variation       1466
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138553011"
     variation       1471
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:143040820"
     polyA_site      1478
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
     variation       1494
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144410593"
     variation       1545
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148800696"
     variation       1607
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190748197"
     variation       1610
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141505727"
     variation       1666
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369989916"
     variation       1779
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150878207"
     variation       1785
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139933330"
     variation       1789
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374844138"
     variation       1793
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145489632"
     variation       1807
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:147666604"
     variation       1813
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:60887132"
     variation       1814
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149776268"
     variation       1817
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145603433"
     variation       1882
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372756747"
     variation       1907
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148904180"
     variation       1929
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143529505"
     variation       1952
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:146499105"
     variation       1993
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186839162"
     variation       2124
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376984675"
     variation       2134
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:77904078"
     variation       2285
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144704751"
     variation       2291
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:138521926"
     variation       2301
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140054228"
     variation       2313
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:150302183"
     variation       2314
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:138918672"
     variation       2330
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:149432877"
     variation       2372
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:144781042"
     variation       2448
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138508276"
     variation       2452
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143902080"
     variation       2468
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:296766"
     variation       2531..2532
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:34780794"
     variation       2544
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:140840803"
     variation       2557
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:142248293"
     variation       2565
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:150827515"
     variation       2570
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139195477"
     variation       2575
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:149970166"
     variation       2590
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:10875989"
     variation       2636
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:141050726"
     variation       2663
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74091162"
     variation       2678
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:146686241"
     variation       2684
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148850890"
     variation       2753
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113705802"
     variation       2779
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147991678"
     variation       2849
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140601595"
     variation       2852
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144000063"
     variation       2923
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147121391"
     variation       2953
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138464500"
     variation       2975..2976
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:146460961"
     variation       3007
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:77661963"
     variation       3036
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:147299953"
     variation       3046
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:139100177"
     variation       3090
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:149388266"
     variation       3138
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:142286713"
     variation       3156
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:296767"
     variation       3179
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:142678894"
     variation       3182
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:146020668"
     variation       3185
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139981875"
     variation       3195..3198
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace=""
                     /replace="tctc"
                     /db_xref="dbSNP:34614799"
     variation       3198..3201
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace=""
                     /replace="ctct"
                     /db_xref="dbSNP:72283122"
     variation       3198
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201471282"
     variation       3206
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146727766"
     variation       3217
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192037751"
     variation       3258
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149742362"
     variation       3265
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140184713"
     variation       3285
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149916875"
     variation       3390
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:145588525"
     variation       3401
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:296768"
     variation       3448
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:149042011"
     variation       3519
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376235969"
     variation       3521
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148876709"
     variation       3528
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145783831"
     variation       3537
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147733377"
     variation       3621
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:142648983"
     variation       3631
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1077520"
     variation       3701
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1077521"
     variation       3742
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141457763"
     variation       3744
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113903023"
     variation       3747
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138229213"
     variation       3778
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:142738661"
     variation       3785
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:146060042"
     variation       3786
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:139949172"
     variation       3822
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141894535"
     variation       3832
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187623325"
     variation       3865
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2336709"
     variation       3870
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147698325"
     variation       3878..3879
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:34704996"
     variation       3889
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146241781"
     variation       3908
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2878771"
     variation       3930
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142554418"
     variation       3994
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150948503"
     variation       3999
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371072705"
     variation       4010
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116924705"
     variation       4074
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2878772"
     variation       4095
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147782490"
     variation       4109
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142636775"
     variation       4153
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142405052"
     polyA_signal    4157..4162
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
     variation       4176
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146912406"
     polyA_site      4179
                     /gene="AQP2"
                     /gene_synonym="AQP-CD; WCH-CD"
ORIGIN      
cttgagaaagagagcgatagagtgcgagagcgagtgcccggagcatcctggccctgagacagctgggccagccccgcagggctctgcagcatgtgggagctccgctccatagccttctccagggctgtgttcgcagagttcctggccacactcctcttcgtcttctttggcctcggctctgccctcaactggccacaggccctgccctctgtgctacagattgccatggcgtttggcttgggtattggcaccctggtacaggctctgggccacataagcggggcccacatcaaccctgccgtgactgtggcctgcctggtgggctgccacgtctccgttctccgagccgccttctacgtggctgcccagctgctgggggctgtggccggagccgctctgctccatgagatcacgccagcagacatccgcggggacctggctgtcaatgctctcagcaacagcacgacggctggccaggcggtgactgtggagctcttcctgacactgcagctggtgctctgcatcttcgcctccaccgatgagcgccgcggagagaacccgggcacccctgctctctccataggcttctccgtggccctgggccacctccttgggatccattacaccggctgctctatgaatcctgcccgctccctggctccagctgtcgtcactggcaaatttgatgaccactgggtcttctggatcggacccctggtgggcgccatcctgggctccctcctctacaactacgtgctgtttccgccagccaagagcctgtcggagcgcctggcagtgctgaagggcctggagccggacaccgattgggaggagcgcgaggtgcgacggcggcagtcggtggagctgcactcgccgcagagcctgccacggggtaccaaggcctgagggccgccagcggcctctaaggccccgacggacgcttgtgaggcccgaggcagaagggcccaccccgtccctcctctcccgcaggtctgaagttggccccccagcgcagagtagctgcttcctggacgtgcgcgcccaggccagtgctgtgagcaggcggggaggaggctgccggagggagccctgagcctggcaggtcccctgccctgaggctgtgagcagctagtggtggcttctccagcctttttcagggaactgggaacttaggggactgagctggggagggaggcaggtgggtggtaagagggaaactctggagagcctgcacccaggtactgagtggggagtgtacagacccctgccttgggggttccgggaatgatgcaactggttttactagtgtgcaagtgtgttcatccccaagttctcttttgtcctcacatgcagagttgtgcatgcccctgagtgtgaacaggtttgcctacgttggtgcaagtgtgcatggctggggacttctcacttccccttgcaccccttcctccccaacctgcaataaatccgcttctcctgcagtggatgagtgtgggtgccagtcctcctcaggagaaggggaagggaaggaggccactttgagagggctgaagggagggccttgatttccagccgcaatctggctcctcctggaaaatttcccccacctgcagcgctgggccccaaggcttgccaagactcattgctggaggtagagaggtgtcaaccagagaacagctcccctagacatggcctctggaaaaaggaaatctttggtggccaaagatttcctttctgtggtgagggagaacctctccaaagaggaagcaggcatatgagtgcgcacgccttcacgtgtgtgtatgctgtgtgtgcccgggacccccgtctccaggggtgccccagacccagagattagcctcccacttcggcgcagaaaacaaaagccctttgtgggacccgggcctttgtcttgggtgaggggagatttgcacctagacacttcttgaaaggagacactcagtttcacaagtgagccctcttgcccagcacacacctatggctggctgggcaaggcgctcaggcatgcaaccatgggcaccaggcaatacccatccatcacccatctcactctccccagtcctcaggcagcagcttttccaccccaggaatctctgttccttctctgtctgcctctccacagcccgtgatcccctgcttctggctcctaccactggacagtcattgtggatagagcagcctgctgctctcaggaccagagaagggaaatgacttctccaggcagaggcagatctgagtctagaacccaggcttctaaatttctaggccagtactactgctctcaaaagagattaactgggattaagtgagatgacgcatgtaaagatgctgtgtaaactgtaattcttaataccattatcacgcattactagaatcatttcattatttctgcttcctgggggaaggatgcagaaggagtctgatgctcaacatcccttacctcctttcgttgatggccaaagcaaaggagagtcctgggagcccacaagatccaggcagaaggagatgggtttggggctggccccatcctggcccagcctcttaacctcttcttaccctgaatgtgtgccctatcttttctcccacctccttcctcctaccacccagccctatccattctctccttccctctccagcctgctgtataagtaacatgtgggtcataccttgaacccccctccgcccccatgctctctgtggcctccatgccttcaagacttctgtctgtatctatctcacactgcaccaagcacccactgtgcaccaggcactaagtctctagcctctttctcccttctgctcccatccaagaaagacagtgtataaggaacatctctgtaattgtgtcccctctcatctatgctctttcctgtcttccttgaccaaagctctctttgaggtccaaaaaaggctgccctgggccatatgtgctatggagaggactctcccaaacccccaatagctagtgacagccacttggcctcactaccagaagaagggtggagtcagaaaccaaagtgacctccagagctgtcctcctggcacctgagtgtccttgctctagaggttcaaaggcagcaaggcagtgagctatgagcccagcatggatgtgtctcaggcacctcatccccaccccacctcaccccaacaaactcctctagaagaagccaagaatttctctctatgtctgtttcactttttggattgcatctccccaaaaactaaatgtgaaatccctaccatttctagcctctattgcccagattggagtcagaggtcaaaaaaggattccaagtgatggaactccaggggtggagggaaattggcagttcctggcatctcttgtgtaccagctgctgtgctgggtgccttgcatgcacggacttatctgatcttcctcaaacttcagataggttagggaaggacaaaggcccccagccatgaagggttttgctatttccaaagcttccccttatcgtcccctgtgattatctcccaaccccgtgacaaaggtagagcaaatattgttcttcccattttacagattcagaaaccaaggctaagggactggtctaaagtctcacaggtagtatatggtggagccaacacttgaactcagacctttttacacaaaatcccatgatttttccactgagacaaatcctaggctcctgggaggccctggcagaagccagaacacatggctgggcctttccagcccaacccactgtcttgcagtggacggagagccttggcgagggcagcagggtagagaggacaaagaatgtggggctggtttctgccctttaagagcacccggtcagtcagagaacagagatcacacacaccaaaccagacagaggcagggcagcatggagacaggtagacagacctccaggtccctaagctggggacagagaaggttctgagctgtcccatactcccactttgtgccaaatgactttgcacctgcaaatggtgcttcaatgtcgttttgtatctttaagctgtgatgttgtatatatacaatgcctcccagctagactgtaagccctttggggacaagggctgcttccagttcttggatggcgttctcctatctaccttccttcaactgctctgcatataataagcactcaataaatgctcatttgccaataaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:359 -> Molecular function: GO:0003779 [actin binding] evidence: IEA
            GeneID:359 -> Molecular function: GO:0005372 [water transmembrane transporter activity] evidence: IDA
            GeneID:359 -> Molecular function: GO:0015168 [glycerol transmembrane transporter activity] evidence: IDA
            GeneID:359 -> Molecular function: GO:0015250 [water channel activity] evidence: EXP
            GeneID:359 -> Molecular function: GO:0030165 [PDZ domain binding] evidence: IEA
            GeneID:359 -> Biological process: GO:0003097 [renal water transport] evidence: IEA
            GeneID:359 -> Biological process: GO:0006833 [water transport] evidence: IDA
            GeneID:359 -> Biological process: GO:0006833 [water transport] evidence: TAS
            GeneID:359 -> Biological process: GO:0006884 [cell volume homeostasis] evidence: IEA
            GeneID:359 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:359 -> Biological process: GO:0006972 [hyperosmotic response] evidence: IEA
            GeneID:359 -> Biological process: GO:0007565 [female pregnancy] evidence: IEA
            GeneID:359 -> Biological process: GO:0007568 [aging] evidence: IEA
            GeneID:359 -> Biological process: GO:0007588 [excretion] evidence: TAS
            GeneID:359 -> Biological process: GO:0009651 [response to salt stress] evidence: IEA
            GeneID:359 -> Biological process: GO:0010226 [response to lithium ion] evidence: IEA
            GeneID:359 -> Biological process: GO:0015793 [glycerol transport] evidence: IDA
            GeneID:359 -> Biological process: GO:0030042 [actin filament depolymerization] evidence: IEA
            GeneID:359 -> Biological process: GO:0032496 [response to lipopolysaccharide] evidence: IEA
            GeneID:359 -> Biological process: GO:0033762 [response to glucagon stimulus] evidence: IEA
            GeneID:359 -> Biological process: GO:0042594 [response to starvation] evidence: IEA
            GeneID:359 -> Biological process: GO:0042631 [cellular response to water deprivation] evidence: IEA
            GeneID:359 -> Biological process: GO:0051592 [response to calcium ion] evidence: IEA
            GeneID:359 -> Biological process: GO:0051928 [positive regulation of calcium ion transport] evidence: IEA
            GeneID:359 -> Biological process: GO:0055085 [transmembrane transport] evidence: TAS
            GeneID:359 -> Biological process: GO:0071280 [cellular response to copper ion] evidence: IDA
            GeneID:359 -> Biological process: GO:0071288 [cellular response to mercury ion] evidence: IDA
            GeneID:359 -> Biological process: GO:0072205 [metanephric collecting duct development] evidence: IEA
            GeneID:359 -> Cellular component: GO:0005764 [lysosome] evidence: IEA
            GeneID:359 -> Cellular component: GO:0005769 [early endosome] evidence: IEA
            GeneID:359 -> Cellular component: GO:0005791 [rough endoplasmic reticulum] evidence: IEA
            GeneID:359 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IEA
            GeneID:359 -> Cellular component: GO:0005802 [trans-Golgi network] evidence: IEA
            GeneID:359 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
            GeneID:359 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
            GeneID:359 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
            GeneID:359 -> Cellular component: GO:0016323 [basolateral plasma membrane] evidence: IEA
            GeneID:359 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: IDA
            GeneID:359 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: ISS
            GeneID:359 -> Cellular component: GO:0030136 [clathrin-coated vesicle] evidence: IEA
            GeneID:359 -> Cellular component: GO:0030658 [transport vesicle membrane] evidence: TAS
            GeneID:359 -> Cellular component: GO:0043234 [protein complex] evidence: IEA
            GeneID:359 -> Cellular component: GO:0055037 [recycling endosome] evidence: IEA
            GeneID:359 -> Cellular component: GO:0070382 [exocytic vesicle] evidence: IEA

by @meso_cacase at DBCLS
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