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2019-03-23 03:04:18, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_000459               4817 bp    mRNA    linear   PRI 15-JUL-2013
DEFINITION  Homo sapiens TEK tyrosine kinase, endothelial (TEK), mRNA.
ACCESSION   NM_000459
VERSION     NM_000459.3  GI:183396798
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4817)
  AUTHORS   Yamakawa,D., Kidoya,H., Sakimoto,S., Jia,W., Naito,H. and
            Takakura,N.
  TITLE     Ligand-independent Tie2 dimers mediate kinase activity stimulated
            by high dose angiopoietin-1
  JOURNAL   J. Biol. Chem. 288 (18), 12469-12477 (2013)
   PUBMED   23504320
  REMARK    GeneRIF: ligand-independent dimerization of Tie2 is essential for a
            strong response upon stimulation with high dose Ang1.
REFERENCE   2  (bases 1 to 4817)
  AUTHORS   Scotti,L., Abramovich,D., Pascuali,N., de Zuniga,I., Oubina,A.,
            Kopcow,L., Lange,S., Owen,G., Tesone,M. and Parborell,F.
  TITLE     Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation
            syndrome (OHSS)
  JOURNAL   Mol. Cell. Endocrinol. 365 (2), 223-230 (2013)
   PUBMED   23123737
  REMARK    GeneRIF: The ANGPTs/Tie-2 system shows greater biological activity
            in both human and a rat model of ovarian hyperstimulation syndrome.
REFERENCE   3  (bases 1 to 4817)
  AUTHORS   Daly,C., Eichten,A., Castanaro,C., Pasnikowski,E., Adler,A.,
            Lalani,A.S., Papadopoulos,N., Kyle,A.H., Minchinton,A.I.,
            Yancopoulos,G.D. and Thurston,G.
  TITLE     Angiopoietin-2 functions as a Tie2 agonist in tumor models, where
            it limits the effects of VEGF inhibition
  JOURNAL   Cancer Res. 73 (1), 108-118 (2013)
   PUBMED   23149917
  REMARK    GeneRIF: our findings indicate that Ang2 plays a protective role in
            tumor endothelial cells by activating Tie2
REFERENCE   4  (bases 1 to 4817)
  AUTHORS   Lauc,G., Huffman,J.E., Pucic,M., Zgaga,L., Adamczyk,B., Muzinic,A.,
            Novokmet,M., Polasek,O., Gornik,O., Kristic,J., Keser,T.,
            Vitart,V., Scheijen,B., Uh,H.W., Molokhia,M., Patrick,A.L.,
            McKeigue,P., Kolcic,I., Lukic,I.K., Swann,O., van Leeuwen,F.N.,
            Ruhaak,L.R., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M.,
            de Craen,A.J., Deelder,A.M., Zeng,Q., Wang,W., Hastie,N.D.,
            Gyllensten,U., Wilson,J.F., Wuhrer,M., Wright,A.F., Rudd,P.M.,
            Hayward,C., Aulchenko,Y., Campbell,H. and Rudan,I.
  TITLE     Loci associated with N-glycosylation of human immunoglobulin G show
            pleiotropy with autoimmune diseases and haematological cancers
  JOURNAL   PLoS Genet. 9 (1), E1003225 (2013)
   PUBMED   23382691
REFERENCE   5  (bases 1 to 4817)
  AUTHORS   Cai,J., Ruan,Q., Chen,Z.J. and Han,S.
  TITLE     Connection of pericyte-angiopoietin-Tie-2 system in diabetic
            retinopathy: friend or foe?
  JOURNAL   Future Med Chem 4 (17), 2163-2176 (2012)
   PUBMED   23190105
  REMARK    GeneRIF: This article summarizes recent advances in pericyte study
            in conjunction with ANG1/ANG2-Tie-2 signaling and also discuss
            possible therapeutic strategies for diabetic retinopathy by
            targeting pericytes through manipulating ANG1/ANG2-Tie-2 signaling.
REFERENCE   6  (bases 1 to 4817)
  AUTHORS   Huang,L., Turck,C.W., Rao,P. and Peters,K.G.
  TITLE     GRB2 and SH-PTP2: potentially important endothelial signaling
            molecules downstream of the TEK/TIE2 receptor tyrosine kinase
  JOURNAL   Oncogene 11 (10), 2097-2103 (1995)
   PUBMED   7478529
REFERENCE   7  (bases 1 to 4817)
  AUTHORS   Deans,J.P., Kalt,L., Ledbetter,J.A., Schieven,G.L., Bolen,J.B. and
            Johnson,P.
  TITLE     Association of 75/80-kDa phosphoproteins and the tyrosine kinases
            Lyn, Fyn, and Lck with the B cell molecule CD20. Evidence against
            involvement of the cytoplasmic regions of CD20
  JOURNAL   J. Biol. Chem. 270 (38), 22632-22638 (1995)
   PUBMED   7545683
REFERENCE   8  (bases 1 to 4817)
  AUTHORS   Gallione,C.J., Pasyk,K.A., Boon,L.M., Lennon,F., Johnson,D.W.,
            Helmbold,E.A., Markel,D.S., Vikkula,M., Mulliken,J.B., Warman,M.L.
            et al.
  TITLE     A gene for familial venous malformations maps to chromosome 9p in a
            second large kindred
  JOURNAL   J. Med. Genet. 32 (3), 197-199 (1995)
   PUBMED   7783168
REFERENCE   9  (bases 1 to 4817)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
REFERENCE   10 (bases 1 to 4817)
  AUTHORS   Partanen,J., Armstrong,E., Makela,T.P., Korhonen,J., Sandberg,M.,
            Renkonen,R., Knuutila,S., Huebner,K. and Alitalo,K.
  TITLE     A novel endothelial cell surface receptor tyrosine kinase with
            extracellular epidermal growth factor homology domains
  JOURNAL   Mol. Cell. Biol. 12 (4), 1698-1707 (1992)
   PUBMED   1312667
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC322431.1, DC324016.1,
            BC035514.1 and AB208796.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Apr 17, 2008 this sequence version replaced gi:88758595.
            
            Summary: The TEK receptor tyrosine kinase is expressed almost
            exclusively in endothelial cells in mice, rats, and humans. This
            receptor possesses a unique extracellular domain containing 2
            immunoglobulin-like loops separated by 3 epidermal growth
            factor-like repeats that are connected to 3 fibronectin type
            III-like repeats. The ligand for the receptor is angiopoietin-1.
            Defects in TEK are associated with inherited venous malformations;
            the TEK signaling pathway appears to be critical for endothelial
            cell-smooth muscle cell communication in venous morphogenesis. TEK
            is closely related to the TIE receptor tyrosine kinase. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035514.1, AB208796.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025082, ERS025083 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               DC322431.1         10-148
            140-648             DC324016.1         75-583
            649-2403            BC035514.1         332-2086
            2404-4758           AB208796.1         2090-4444
            4759-4817           BC035514.1         4442-4500
FEATURES             Location/Qualifiers
     source          1..4817
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21"
     gene            1..4817
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /note="TEK tyrosine kinase, endothelial"
                     /db_xref="GeneID:7010"
                     /db_xref="HGNC:11724"
                     /db_xref="MIM:600221"
     exon            1..494
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:1.39.8"
     variation       18
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149944814"
     variation       27
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375999077"
     variation       117
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147620532"
     variation       166..167
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:371499623"
     variation       167..168
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:72535318"
     variation       168..169
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace=""
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:3837240"
     variation       169
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199995407"
     variation       290
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188791221"
     variation       303
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142131414"
     variation       315
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145925243"
     misc_feature    341..343
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /note="upstream in-frame stop codon"
     variation       433
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370191539"
     CDS             443..3817
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /EC_number="2.7.10.1"
                     /note="angiopoietin-1 receptor; soluble TIE2 variant 1;
                     soluble TIE2 variant 2; hTIE2; p140 TEK; tyrosine-protein
                     kinase receptor TEK; tunica interna endothelial cell
                     kinase; tyrosine-protein kinase receptor TIE-2;
                     endothelial tyrosine kinase; tyrosine kinase with Ig and
                     EGF homology domains-2"
                     /codon_start=1
                     /product="angiopoietin-1 receptor precursor"
                     /protein_id="NP_000450.2"
                     /db_xref="GI:88758596"
                     /db_xref="CCDS:CCDS6519.1"
                     /db_xref="GeneID:7010"
                     /db_xref="HGNC:11724"
                     /db_xref="MIM:600221"
                     /translation="
MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNEACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMTPKIVDLPDHIEVNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTASIGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
"
     sig_peptide     443..496
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
     mat_peptide     497..3814
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /product="angiopoietin-1 receptor"
     misc_feature    509..796
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /note="Tie-2 Ig-like domain 1; Region: Ig_Tie2_1;
                     pfam10430"
                     /db_xref="CDD:118951"
     misc_feature    1097..1225
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /note="Laminin-type epidermal growth factor-like domai;
                     Region: EGF_Lam; smart00180"
                     /db_xref="CDD:197558"
     misc_feature    <1121..1198
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:28936"
     misc_feature    1373..1462
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cl09941"
                     /db_xref="CDD:209104"
     misc_feature    1550..1765
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /note="Immunoglobulin like; Region: IG_like; smart00410"
                     /db_xref="CDD:197708"
     misc_feature    1775..1996
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /note="Fibronectin type III domain; Region: fn3;
                     pfam00041"
                     /db_xref="CDD:200951"
     misc_feature    2105..2341
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:28945"
     misc_feature    order(2261..2263,2303..2305)
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /note="Interdomain contacts; other site"
                     /db_xref="CDD:28945"
     misc_feature    order(2306..2311,2315..2320)
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /note="Cytokine receptor motif; other site"
                     /db_xref="CDD:28945"
     misc_feature    2357..2635
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:28945"
     misc_feature    order(2357..2359,2552..2554,2597..2599)
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /note="Interdomain contacts; other site"
                     /db_xref="CDD:28945"
     misc_feature    order(2600..2605,2609..2614)
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /note="Cytokine receptor motif; other site"
                     /db_xref="CDD:28945"
     misc_feature    2687..2749
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02763.2);
                     transmembrane region"
     misc_feature    2888..3796
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Tie2; Region: PTKc_Tie2; cd05088"
                     /db_xref="CDD:133219"
     misc_feature    2912..3718
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /note="Protein kinase; unclassified specificity; Region:
                     STYKc; smart00221"
                     /db_xref="CDD:197583"
     misc_feature    order(2930..2944,2954..2956,2999..3001,3005..3007,
                     3056..3058,3068..3070,3077..3079,3098..3100,3146..3157,
                     3164..3169,3320..3322,3326..3328,3332..3334,3344..3349,
                     3353..3355,3380..3391,3431..3445,3470..3472,3572..3574)
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /note="active site"
                     /db_xref="CDD:133219"
     misc_feature    order(2930..2935,2939..2944,2954..2956,2999..3001,
                     3005..3007,3056..3058,3068..3070,3098..3100,3146..3157,
                     3164..3169,3344..3349,3353..3355,3386..3388)
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:133219"
     misc_feature    3020..3022
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (Q02763.2); phosphorylation site"
     misc_feature    3131..3133
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:02571"
     misc_feature    order(3332..3334,3344..3346,3431..3445,3470..3472,
                     3572..3574)
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:133219"
     misc_feature    3383..3451
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:133219"
     misc_feature    3416..3418
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (Q02763.2); phosphorylation site"
     misc_feature    3416..3418
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    3584..3586
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    3746..3748
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (Q02763.2); phosphorylation site"
     misc_feature    3746..3748
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:02571"
     misc_feature    3764..3766
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="dephosphorylation site; modified site"
                     /db_xref="HPRD:01470"
     misc_feature    3764..3766
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (Q02763.2); phosphorylation site"
     misc_feature    3764..3766
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    3797..3799
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     variation       454
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:146485295"
     variation       480
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201171013"
     variation       492
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:149096702"
     exon            495..806
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:1.39.8"
     variation       500
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202051322"
     variation       501
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143178677"
     variation       526
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138550182"
     variation       579
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200755526"
     variation       580
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:76223779"
     variation       593
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140406342"
     variation       630
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369048700"
     variation       635
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373772509"
     variation       654
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144348052"
     variation       675
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146302981"
     variation       676
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:55892210"
     variation       762
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370256501"
     variation       788
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201999962"
     exon            807..917
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:1.39.8"
     STS             810..1251
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /standard_name="Tek"
                     /db_xref="UniSTS:144602"
     variation       831
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201071647"
     variation       856
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143058954"
     variation       885
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35969327"
     exon            918..1070
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:1.39.8"
     variation       952
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138265705"
     variation       1012
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149623302"
     variation       1060
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369561720"
     variation       1063
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:369286334"
     exon            1071..1202
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:1.39.8"
     variation       1107
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:144378392"
     variation       1119
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35814893"
     variation       1120
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149063993"
     variation       1125
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374382893"
     STS             1167..1244
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /standard_name="TEK"
                     /db_xref="UniSTS:513742"
     variation       1192
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:76324455"
     variation       1196
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367963556"
     exon            1203..1343
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:1.39.8"
     variation       1218
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138708761"
     variation       1251
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372307879"
     variation       1324
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:146169480"
     exon            1344..1472
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:1.39.8"
     variation       1357
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:371104063"
     variation       1372
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139143068"
     variation       1423
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:180827182"
     variation       1441
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:111637971"
     variation       1467
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373027386"
     exon            1473..1624
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:1.39.8"
     variation       1479
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:682632"
     variation       1482
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200235356"
     variation       1518
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372811397"
     variation       1546
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376994054"
     variation       1577
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368494167"
     variation       1588
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:146464819"
     variation       1606
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:371664404"
     variation       1614
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34032300"
     exon            1625..1769
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:1.39.8"
     variation       1682
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369394656"
     variation       1691
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:149712446"
     variation       1700
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149842646"
     variation       1735
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145574565"
     variation       1736
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:75365911"
     variation       1745
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:372461928"
     variation       1748
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148891712"
     variation       1755
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189543659"
     variation       1765
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199580378"
     exon            1770..1931
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:1.39.8"
     variation       1788
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149684174"
     variation       1796
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:45607336"
     variation       1799
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373235916"
     variation       1829
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200857533"
     variation       1878
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141586254"
     variation       1883
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147057883"
     variation       1885
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148120858"
     variation       1888
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370562453"
     variation       1898
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1334811"
     exon            1932..2066
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:1.39.8"
     variation       1949
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200574110"
     variation       1989
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:150236410"
     variation       2007
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:138894008"
     variation       2008
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372395194"
     variation       2024
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:367917552"
     variation       2026
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371652913"
     variation       2038
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199871826"
     variation       2063
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201629688"
     exon            2067..2351
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:1.39.8"
     variation       2074
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368357438"
     variation       2105
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:67954416"
     variation       2122
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35357088"
     variation       2148
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:190513747"
     variation       2176
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146405482"
     variation       2202
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373551083"
     variation       2240
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:35030851"
     variation       2259
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:376770384"
     variation       2284
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142382870"
     variation       2311
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:55979986"
     variation       2342
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35378598"
     variation       2344
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:148629677"
     exon            2352..2651
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:1.39.8"
     variation       2404
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:639225"
     variation       2468
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56367117"
     variation       2488
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:112475919"
     variation       2494
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35818764"
     variation       2520
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141769154"
     variation       2536
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:45563539"
     variation       2612
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4631561"
     variation       2621
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373793318"
     exon            2652..2806
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:1.39.8"
     variation       2665
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147649992"
     variation       2666
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141520692"
     variation       2667
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:181093425"
     variation       2670
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:202131936"
     variation       2696
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:45510599"
     variation       2746
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370492416"
     variation       2747
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145334606"
     variation       2764
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:542913"
     variation       2777
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149152469"
     variation       2804
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:374265341"
     exon            2807..3017
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:1.39.8"
     variation       2807
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201024056"
     variation       2832
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143314314"
     variation       2896
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:55789591"
     variation       2965
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149452320"
     variation       2966
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147231791"
     variation       2967
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200750146"
     variation       2987
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:80338908"
     variation       2988
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376225163"
     variation       3015
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373458643"
     exon            3018..3128
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:1.39.8"
     variation       3083
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201842573"
     variation       3091
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375837222"
     exon            3129..3319
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:1.39.8"
     variation       3132
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:80338909"
     variation       3154
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148059950"
     variation       3157
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372316383"
     variation       3186
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:387906745"
     variation       3208
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145880361"
     variation       3215
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138463877"
     variation       3240
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199701926"
     variation       3241
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372897403"
     variation       3253
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:183991501"
     variation       3269
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143080429"
     variation       3274
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150499673"
     variation       3280
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:45505400"
     variation       3283
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:56154987"
     variation       3291
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376285577"
     variation       3310
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113493000"
     exon            3320..3433
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:1.39.8"
     variation       3409
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149269841"
     variation       3418
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3737188"
     variation       3431
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200011475"
     variation       3433
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370591821"
     exon            3434..3504
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:1.39.8"
     variation       3463
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368457184"
     exon            3505..3545
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:1.39.8"
     variation       3532
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56133834"
     exon            3546..3642
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:1.39.8"
     variation       3556
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:145261015"
     variation       3562
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147198662"
     variation       3565
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2273719"
     variation       3593
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2273718"
     variation       3595
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:377362798"
     variation       3601
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201502264"
     variation       3622
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369172187"
     variation       3628
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:55702716"
     exon            3643..3742
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:1.39.8"
     variation       3661
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149296103"
     variation       3715
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:144527376"
     variation       3733
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:377406447"
     exon            3743..4759
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:1.39.8"
     variation       3748
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151035628"
     variation       3751
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199954698"
     variation       3757
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148842789"
     variation       3790..3791
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:34067938"
     variation       3810
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369356295"
     variation       3822
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112801403"
     variation       3825
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147570838"
     variation       3832
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141937008"
     variation       3857
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372823330"
     variation       3869
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:117748450"
     variation       3875
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1051728"
     variation       3985
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372214778"
     variation       4023
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:45521836"
     variation       4060
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190522156"
     variation       4131
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:7037246"
     variation       4134
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:183136289"
     variation       4198
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:10967789"
     variation       4251
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1051729"
     variation       4262
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:188713985"
     variation       4284
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:41272849"
     variation       4301
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:192476871"
     STS             4333..4657
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /standard_name="SHGC-12831"
                     /db_xref="UniSTS:78903"
     variation       4333..4334
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace=""
                     /replace="tc"
                     /db_xref="dbSNP:139215084"
     variation       4361
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1049"
     variation       4372
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182565061"
     variation       4373
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:857"
     variation       4396
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138916876"
     STS             4416..4609
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /standard_name="G10657"
                     /db_xref="UniSTS:38250"
     STS             4419..4596
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /standard_name="RH68989"
                     /db_xref="UniSTS:23344"
     variation       4534
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:41272851"
     variation       4605..4606
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace=""
                     /replace="at"
                     /db_xref="dbSNP:140755654"
     variation       4635
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141265339"
     variation       4705
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150338418"
     polyA_signal    4732..4737
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
     variation       4739
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:9987817"
     polyA_site      4759
                     /gene="TEK"
                     /gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
ORIGIN      
agtttcccgcctatgagaggatacccctattgtttctgaaaatgctgaccgggacccacacttccaacaaaaattcctctgcccctacagcagcagcaaaagcagcagcagaagcaacagcaacagataagtgttttgatgaattgcgagatggatagggcttgagtgcccccagccctgctgataccaaatgcctttaagatacagcctttcccatcctaatctacaaaggaaacaggaaaaaggaacttaaaactccctgtgctcagacagaaatgagactgttacagcctgcttctgtgctgttccttcttgcctctaacttgtaaacaagacgtagtaggacgatgctaatggaaagtcacaaaccgctgggtttttgaaaggatccttgggacctcatgcacatttgtggaaactggatggagagatttggggaagcatggactctttagccagcttagttctctgtggagtcagcttgctcctttctggaactgtggaaggtgccatggacttgatcttgatcaattccctacctcttgtatctgatgctgaaacatctctcacctgcattgcctctgggtggcgcccccatgagcccatcaccataggaagggactttgaagccttaatgaaccagcaccaggatccgctggaagttactcaagatgtgaccagagaatgggctaaaaaagttgtttggaagagagaaaaggctagtaagatcaatggtgcttatttctgtgaagggcgagttcgaggagaggcaatcaggatacgaaccatgaagatgcgtcaacaagcttccttcctaccagctactttaactatgactgtggacaagggagataacgtgaacatatctttcaaaaaggtattgattaaagaagaagatgcagtgatttacaaaaatggttccttcatccattcagtgccccggcatgaagtacctgatattctagaagtacacctgcctcatgctcagccccaggatgctggagtgtactcggccaggtatataggaggaaacctcttcacctcggccttcaccaggctgatagtccggagatgtgaagcccagaagtggggacctgaatgcaaccatctctgtactgcttgtatgaacaatggtgtctgccatgaagatactggagaatgcatttgccctcctgggtttatgggaaggacgtgtgagaaggcttgtgaactgcacacgtttggcagaacttgtaaagaaaggtgcagtggacaagagggatgcaagtcttatgtgttctgtctccctgacccctatgggtgttcctgtgccacaggctggaagggtctgcagtgcaatgaagcatgccaccctggtttttacgggccagattgtaagcttaggtgcagctgcaacaatggggagatgtgtgatcgcttccaaggatgtctctgctctccaggatggcaggggctccagtgtgagagagaaggcataccgaggatgaccccaaagatagtggatttgccagatcatatagaagtaaacagtggtaaatttaatcccatttgcaaagcttctggctggccgctacctactaatgaagaaatgaccctggtgaagccggatgggacagtgctccatccaaaagactttaaccatacggatcatttctcagtagccatattcaccatccaccggatcctcccccctgactcaggagtttgggtctgcagtgtgaacacagtggctgggatggtggaaaagcccttcaacatttctgttaaagttcttccaaagcccctgaatgccccaaacgtgattgacactggacataactttgctgtcatcaacatcagctctgagccttactttggggatggaccaatcaaatccaagaagcttctatacaaacccgttaatcactatgaggcttggcaacatattcaagtgacaaatgagattgttacactcaactatttggaacctcggacagaatatgaactctgtgtgcaactggtccgtcgtggagagggtggggaagggcatcctggacctgtgagacgcttcacaacagcttctatcggactccctcctccaagaggtctaaatctcctgcctaaaagtcagaccactctaaatttgacctggcaaccaatatttccaagctcggaagatgacttttatgttgaagtggagagaaggtctgtgcaaaaaagtgatcagcagaatattaaagttccaggcaacttgacttcggtgctacttaacaacttacatcccagggagcagtacgtggtccgagctagagtcaacaccaaggcccagggggaatggagtgaagatctcactgcttggacccttagtgacattcttcctcctcaaccagaaaacatcaagatttccaacattacacactcctcagctgtgatttcttggacaatattggatggctattctatttcttctattactatccgttacaaggttcaaggcaagaatgaagaccagcacgttgatgtgaagataaagaatgccaccatcactcagtatcagctcaagggcctagagcctgaaacagcataccaggtggacatttttgcagagaacaacatagggtcaagcaacccagccttttctcatgaactggtgaccctcccagaatctcaagcaccagcggacctcggaggggggaagatgctgcttatagccatccttggctctgctggaatgacctgcctgactgtgctgttggcctttctgatcatattgcaattgaagagggcaaatgtgcaaaggagaatggcccaagccttccaaaacgtgagggaagaaccagctgtgcagttcaactcagggactctggccctaaacaggaaggtcaaaaacaacccagatcctacaatttatccagtgcttgactggaatgacatcaaatttcaagatgtgattggggagggcaattttggccaagttcttaaggcgcgcatcaagaaggatgggttacggatggatgctgccatcaaaagaatgaaagaatatgcctccaaagatgatcacagggactttgcaggagaactggaagttctttgtaaacttggacaccatccaaacatcatcaatctcttaggagcatgtgaacatcgaggctacttgtacctggccattgagtacgcgccccatggaaaccttctggacttccttcgcaagagccgtgtgctggagacggacccagcatttgccattgccaatagcaccgcgtccacactgtcctcccagcagctccttcacttcgctgccgacgtggcccggggcatggactacttgagccaaaaacagtttatccacagggatctggctgccagaaacattttagttggtgaaaactatgtggcaaaaatagcagattttggattgtcccgaggtcaagaggtgtatgtgaaaaagacaatgggaaggctcccagtgcgctggatggccatcgagtcactgaattacagtgtgtacacaaccaacagtgatgtatggtcctatggtgtgttactatgggagattgttagcttaggaggcacaccctactgcgggatgacttgtgcagaactctacgagaagctgccccagggctacagactggagaagcccctgaactgtgatgatgaggtgtatgatctaatgagacaatgctggcgggagaagccttatgagaggccatcatttgcccagatattggtgtccttaaacagaatgttagaggagcgaaagacctacgtgaataccacgctttatgagaagtttacttatgcaggaattgactgttctgctgaagaagcggcctaggacagaacatctgtataccctctgtttccctttcactggcatgggagacccttgacacctgctgagaaaacatgcctctgccaaaggatgtgatatataagtgtacatatgtgctgtacacctgggaccttcaccactgtagatcccatgcatggatctatgtagtatgctctgactctaataggactgtatatactgttttaagaatgggctgaaatcagaatgcctgtttgtggtttcatatgcaataatatatttttttaaaaatgtggacttcataggaaggcgtgagtacaattagtataatgcataactcattgttgtcctagatattttgatatttacctttatgttgaatgctattaaatgttttcctgtgtcaaagtaaaatattgttaataaacctaacaatgaccctgatagtacaggttaagtgagagaactatatgaattctaacaagtcataggttaatatttaagacactgaaaaatctaagtgatataaatcagattcttctctctcaattttatccctcacctgtagcagccagtcccgtttcatttagtcatgtgaccactctgtcttgtgtttccacagcctgcaagtcagtccaggatgctaacatctaaaaatagacttaaatctcattgcttacaagcctaagaatctttagagaagtatacataagtttaggataaaataatgggattttcttttcttttctctggtaatattgacttgtatattttaagaaataacagaaagcctgggtgacatttgggagacatgtgacatttatatattgaattaatatccctacatgtattgcacattgtaaaaagttttagttttgatgagttgtgagtttaccttgtatactgtaggcacactttgcactgatatatcatgagtgaataaatgtcttgcctactcacgtctcaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:7010 -> Molecular function: GO:0004672 [protein kinase activity] evidence: TAS
            GeneID:7010 -> Molecular function: GO:0004713 [protein tyrosine kinase activity] evidence: IDA
            GeneID:7010 -> Molecular function: GO:0004713 [protein tyrosine kinase activity] evidence: TAS
            GeneID:7010 -> Molecular function: GO:0004714 [transmembrane receptor protein tyrosine kinase activity] evidence: IEA
            GeneID:7010 -> Molecular function: GO:0004872 [receptor activity] evidence: TAS
            GeneID:7010 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:7010 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:7010 -> Biological process: GO:0001525 [angiogenesis] evidence: ISS
            GeneID:7010 -> Biological process: GO:0001934 [positive regulation of protein phosphorylation] evidence: IDA
            GeneID:7010 -> Biological process: GO:0001934 [positive regulation of protein phosphorylation] evidence: IMP
            GeneID:7010 -> Biological process: GO:0001935 [endothelial cell proliferation] evidence: ISS
            GeneID:7010 -> Biological process: GO:0001938 [positive regulation of endothelial cell proliferation] evidence: TAS
            GeneID:7010 -> Biological process: GO:0002040 [sprouting angiogenesis] evidence: IMP
            GeneID:7010 -> Biological process: GO:0007160 [cell-matrix adhesion] evidence: IEA
            GeneID:7010 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
            GeneID:7010 -> Biological process: GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] evidence: IDA
            GeneID:7010 -> Biological process: GO:0007267 [cell-cell signaling] evidence: TAS
            GeneID:7010 -> Biological process: GO:0007507 [heart development] evidence: ISS
            GeneID:7010 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
            GeneID:7010 -> Biological process: GO:0010595 [positive regulation of endothelial cell migration] evidence: IDA
            GeneID:7010 -> Biological process: GO:0010595 [positive regulation of endothelial cell migration] evidence: IMP
            GeneID:7010 -> Biological process: GO:0010740 [positive regulation of intracellular protein kinase cascade] evidence: IMP
            GeneID:7010 -> Biological process: GO:0014068 [positive regulation of phosphatidylinositol 3-kinase cascade] evidence: IMP
            GeneID:7010 -> Biological process: GO:0016337 [cell-cell adhesion] evidence: IEA
            GeneID:7010 -> Biological process: GO:0016525 [negative regulation of angiogenesis] evidence: IMP
            GeneID:7010 -> Biological process: GO:0018108 [peptidyl-tyrosine phosphorylation] evidence: IDA
            GeneID:7010 -> Biological process: GO:0032878 [regulation of establishment or maintenance of cell polarity] evidence: IMP
            GeneID:7010 -> Biological process: GO:0033138 [positive regulation of peptidyl-serine phosphorylation] evidence: IEA
            GeneID:7010 -> Biological process: GO:0034446 [substrate adhesion-dependent cell spreading] evidence: IMP
            GeneID:7010 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
            GeneID:7010 -> Biological process: GO:0043114 [regulation of vascular permeability] evidence: TAS
            GeneID:7010 -> Biological process: GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] evidence: IMP
            GeneID:7010 -> Biological process: GO:0045766 [positive regulation of angiogenesis] evidence: IDA
            GeneID:7010 -> Biological process: GO:0045766 [positive regulation of angiogenesis] evidence: IMP
            GeneID:7010 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA
            GeneID:7010 -> Biological process: GO:0048014 [Tie signaling pathway] evidence: IDA
            GeneID:7010 -> Biological process: GO:0050728 [negative regulation of inflammatory response] evidence: TAS
            GeneID:7010 -> Biological process: GO:0050900 [leukocyte migration] evidence: TAS
            GeneID:7010 -> Biological process: GO:0051259 [protein oligomerization] evidence: IDA
            GeneID:7010 -> Biological process: GO:0051894 [positive regulation of focal adhesion assembly] evidence: IMP
            GeneID:7010 -> Biological process: GO:0051897 [positive regulation of protein kinase B signaling cascade] evidence: IDA
            GeneID:7010 -> Biological process: GO:0051897 [positive regulation of protein kinase B signaling cascade] evidence: IMP
            GeneID:7010 -> Biological process: GO:0060216 [definitive hemopoiesis] evidence: TAS
            GeneID:7010 -> Biological process: GO:0060347 [heart trabecula formation] evidence: ISS
            GeneID:7010 -> Biological process: GO:0070374 [positive regulation of ERK1 and ERK2 cascade] evidence: IDA
            GeneID:7010 -> Biological process: GO:0070374 [positive regulation of ERK1 and ERK2 cascade] evidence: IMP
            GeneID:7010 -> Biological process: GO:2000251 [positive regulation of actin cytoskeleton reorganization] evidence: IMP
            GeneID:7010 -> Biological process: GO:2000351 [regulation of endothelial cell apoptotic process] evidence: TAS
            GeneID:7010 -> Biological process: GO:2000352 [negative regulation of endothelial cell apoptotic process] evidence: ISS
            GeneID:7010 -> Cellular component: GO:0001725 [stress fiber] evidence: IDA
            GeneID:7010 -> Cellular component: GO:0005576 [extracellular region] evidence: IEA
            GeneID:7010 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
            GeneID:7010 -> Cellular component: GO:0005884 [actin filament] evidence: IDA
            GeneID:7010 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
            GeneID:7010 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: IDA
            GeneID:7010 -> Cellular component: GO:0005902 [microvillus] evidence: IDA
            GeneID:7010 -> Cellular component: GO:0005911 [cell-cell junction] evidence: IDA
            GeneID:7010 -> Cellular component: GO:0005925 [focal adhesion] evidence: IEA
            GeneID:7010 -> Cellular component: GO:0009925 [basal plasma membrane] evidence: IDA
            GeneID:7010 -> Cellular component: GO:0009986 [cell surface] evidence: IDA
            GeneID:7010 -> Cellular component: GO:0016323 [basolateral plasma membrane] evidence: IDA
            GeneID:7010 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: IDA
            GeneID:7010 -> Cellular component: GO:0045121 [membrane raft] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_000450 -> EC 2.7.10.1

by @meso_cacase at DBCLS
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