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2024-03-28 22:44:11, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_000435               8089 bp    mRNA    linear   PRI 15-JUL-2013
DEFINITION  Homo sapiens notch 3 (NOTCH3), mRNA.
ACCESSION   NM_000435
VERSION     NM_000435.2  GI:134244284
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8089)
  AUTHORS   Yamamoto,Y., Craggs,L.J., Watanabe,A., Booth,T., Attems,J.,
            Low,R.W., Oakley,A.E. and Kalaria,R.N.
  TITLE     Brain microvascular accumulation and distribution of the NOTCH3
            ectodomain and granular osmiophilic material in CADASIL
  JOURNAL   J. Neuropathol. Exp. Neurol. 72 (5), 416-431 (2013)
   PUBMED   23584202
  REMARK    GeneRIF: NOTCH3 fragments are major components of granular
            osmiophilic material deposits in brain samples from CADASIL
            patients.
REFERENCE   2  (bases 1 to 8089)
  AUTHORS   Ragno,M., Berbellini,A., Cacchio,G., Manca,A., Di Marzio,F.,
            Pianese,L., De Rosa,A., Silvestri,S., Scarcella,M. and De
            Michele,G.
  TITLE     Parkinsonism is a late, not rare, feature of CADASIL: a study on
            Italian patients carrying the R1006C mutation
  JOURNAL   Stroke 44 (4), 1147-1149 (2013)
   PUBMED   23412372
  REMARK    GeneRIF: Parkinsonism is a late, not rare, feature of CADASIL: a
            study on Italian patients carrying the R1006C mutation
REFERENCE   3  (bases 1 to 8089)
  AUTHORS   Viitanen,M., Sundstrom,E., Baumann,M., Poyhonen,M., Tikka,S. and
            Behbahani,H.
  TITLE     Experimental studies of mitochondrial function in CADASIL vascular
            smooth muscle cells
  JOURNAL   Exp. Cell Res. 319 (3), 134-143 (2013)
   PUBMED   23036509
  REMARK    GeneRIF: Cellular and mitochondrial function in vascular smooth
            muscle cell lines (VSMCs) established from CADASIL mutation
            carriers (R133C) and healthy controls.
REFERENCE   4  (bases 1 to 8089)
  AUTHORS   Mann,C.D., Bastianpillai,C., Neal,C.P., Masood,M.M., Jones,D.J.,
            Teichert,F., Singh,R., Karpova,E., Berry,D.P. and Manson,M.M.
  TITLE     Notch3 and HEY-1 as prognostic biomarkers in pancreatic
            adenocarcinoma
  JOURNAL   PLoS ONE 7 (12), E51119 (2012)
   PUBMED   23226563
  REMARK    GeneRIF: These data further support a central role for Notch
            signalling in pancreatic cancer and suggest that nuclear expression
            of Notch3 and its target gene, HEY-1, merit validation in biomarker
            panels for diagnosis, prognosis and treatment efficacy.
REFERENCE   5  (bases 1 to 8089)
  AUTHORS   Meng,H., Zhang,X., Yu,G., Lee,S.J., Chen,Y.E., Prudovsky,I. and
            Wang,M.M.
  TITLE     Biochemical characterization and cellular effects of CADASIL
            mutants of NOTCH3
  JOURNAL   PLoS ONE 7 (9), E44964 (2012)
   PUBMED   23028706
  REMARK    GeneRIF: CADASIL mutants of NOTCH3 complex with NOTCH1, 3, and 4,
            slow NOTCH3 clearance, and that overexpressed wild type and mutant
            NOTCH3 protein interfere with key NOTCH-mediated functions in
            smooth muscle cells
REFERENCE   6  (bases 1 to 8089)
  AUTHORS   Lewis,J.
  TITLE     Neurogenic genes and vertebrate neurogenesis
  JOURNAL   Curr. Opin. Neurobiol. 6 (1), 3-10 (1996)
   PUBMED   8794055
  REMARK    Review article
REFERENCE   7  (bases 1 to 8089)
  AUTHORS   Larsson,C., Lardelli,M., White,I. and Lendahl,U.
  TITLE     The human NOTCH1, 2, and 3 genes are located at chromosome
            positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of
            neoplasia-associated translocation
  JOURNAL   Genomics 24 (2), 253-258 (1994)
   PUBMED   7698746
REFERENCE   8  (bases 1 to 8089)
  AUTHORS   Sugaya,K., Fukagawa,T., Matsumoto,K., Mita,K., Takahashi,E.,
            Ando,A., Inoko,H. and Ikemura,T.
  TITLE     Three genes in the human MHC class III region near the junction
            with the class II: gene for receptor of advanced glycosylation end
            products, PBX2 homeobox gene and a notch homolog, human counterpart
            of mouse mammary tumor gene int-3
  JOURNAL   Genomics 23 (2), 408-419 (1994)
   PUBMED   7835890
REFERENCE   9  (bases 1 to 8089)
  AUTHORS   Tournier-Lasserve,E., Joutel,A., Melki,J., Weissenbach,J.,
            Lathrop,G.M., Chabriat,H., Mas,J.L., Cabanis,E.A., Baudrimont,M.,
            Maciazek,J. et al.
  TITLE     Cerebral autosomal dominant arteriopathy with subcortical infarcts
            and leukoencephalopathy maps to chromosome 19q12
  JOURNAL   Nat. Genet. 3 (3), 256-259 (1993)
   PUBMED   8485581
REFERENCE   10 (bases 1 to 8089)
  AUTHORS   Beleil,O.M., Mickey,M.R. and Terasaki,P.I.
  TITLE     Comparison of male and female kidney transplant survival rates
  JOURNAL   Transplantation 13 (5), 493-500 (1972)
   PUBMED   4557798
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U97669.1 and AC004663.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Mar 28, 2007 this sequence version replaced gi:4557798.
            
            Summary: This gene encodes the third discovered human homologue of
            the Drosophilia melanogaster type I membrane protein notch. In
            Drosophilia, notch interaction with its cell-bound ligands (delta,
            serrate) establishes an intercellular signalling pathway that plays
            a key role in neural development. Homologues of the notch-ligands
            have also been identified in human, but precise interactions
            between these ligands and the human notch homologues remains to be
            determined. Mutations in NOTCH3 have been identified as the
            underlying cause of cerebral autosomal dominant arteriopathy with
            subcortical infarcts and leukoencephalopathy (CADASIL). [provided
            by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because transcript sequence consistent with
            the reference genome assembly was not available for all regions of
            the RefSeq transcript. The extent of this transcript is supported
            by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U97669.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-681               U97669.1           3-683
            682-682             AC004663.1         35190-35190         c
            683-999             U97669.1           685-1001
            1000-1000           AC004663.1         34693-34693         c
            1001-2613           U97669.1           1003-2615
            2614-2614           AC004663.1         27480-27480         c
            2615-2817           U97669.1           2617-2819
            2818-2818           AC004663.1         24783-24783         c
            2819-4638           U97669.1           2821-4640
            4639-4639           AC004663.1         17398-17398         c
            4640-6513           U97669.1           4642-6515
            6514-7932           AC004663.1         2929-4347           c
            7933-8089           U97669.1           7935-8091
FEATURES             Location/Qualifiers
     source          1..8089
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2-p13.1"
     gene            1..8089
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="notch 3"
                     /db_xref="GeneID:4854"
                     /db_xref="HGNC:7883"
                     /db_xref="MIM:600276"
     exon            1..194
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     CDS             77..7042
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="neurogenic locus notch homolog protein 3; Notch
                     homolog 3"
                     /codon_start=1
                     /product="neurogenic locus notch homolog protein 3
                     precursor"
                     /protein_id="NP_000426.2"
                     /db_xref="GI:134244285"
                     /db_xref="CCDS:CCDS12326.1"
                     /db_xref="GeneID:4854"
                     /db_xref="HGNC:7883"
                     /db_xref="MIM:600276"
                     /translation="
MGPGARGRRRRRRPMSPPPPPPPVRALPLLLLLAGPGAAAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGCNTEECGWDGLDCASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDAHGQAMVFPYHRPSPGSEPRARRELAPEVIGSVVMLEIDNRLCLQSPENDHCFPDAQSAADYLGALSAVERLDFPYPLRDVRGEPLEPPEPSVPLLPLLVAGAVLLLVILVLGVMVARRKREHSTLWFPEGFSLHKDVASGHKGRREPVGQDALGMKNMAKGESLMGEVATDWMDTECPEAKRLKVEEPGMGAEEAVDCRQWTQHHLVAADIRVAPAMALTPPQGDADADGMDVNVRGPDGFTPLMLASFCGGALEPMPTEEDEADDTSASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQPSGPRSPPGPHGLGPLLCPPGAFLPGLKAAQSGSKKSRRPPGKAGLGPQGPRGRGKKLTLACPGPLADSSVTLSPVDSLDSPRPFGGPPASPGGFPLEGPYAAATATAVSLAQLGGPGRAGLGRQPPGGCVLSLGLLNPVAVPLDWARLPPPAPPGPSFLLPLAPGPQLLNPGTPVSPQERPPPYLAVPGHGEEYPAAGAHSSPPKARFLRVPSEHPYLTPSPESPEHWASPSPPSLSDWSESTPSPATATGAMATTTGALPAQPLPLSVPSSLAQAQTQLGPQPEVTPKRQVLA
"
     sig_peptide     77..193
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     misc_feature    548..661
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:28936"
     misc_feature    order(548..550,557..559,602..604)
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:28936"
     misc_feature    782..892
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:28936"
     misc_feature    order(782..784,791..793,833..835)
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:28936"
     misc_feature    896..1009
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:28936"
     misc_feature    order(896..898,905..907,953..955)
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:28936"
     misc_feature    1016..>1105
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cl09941"
                     /db_xref="CDD:209104"
     misc_feature    1247..1363
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:28936"
     misc_feature    order(1247..1249,1256..1258,1304..1306)
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:28936"
     misc_feature    1367..1477
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:28936"
     misc_feature    order(1367..1369,1376..1378,1418..1420)
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:28936"
     misc_feature    1481..1591
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:28936"
     misc_feature    order(1481..1483,1490..1492,1532..1534)
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:28936"
     misc_feature    1595..1705
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:28936"
     misc_feature    order(1595..1597,1604..1606,1646..1648)
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:28936"
     misc_feature    1709..1816
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:28936"
     misc_feature    order(1709..1711,1718..1720,1757..1759)
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:28936"
     misc_feature    1823..1930
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:28936"
     misc_feature    order(1829..1831,1871..1873)
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:28936"
     misc_feature    2504..2617
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:28936"
     misc_feature    order(2504..2506,2513..2515,2558..2560)
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:28936"
     misc_feature    2621..2728
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:28936"
     misc_feature    order(2621..2623,2630..2632,2672..2674)
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:28936"
     misc_feature    2735..2842
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:28936"
     misc_feature    order(2735..2737,2744..2746,2783..2785)
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:28936"
     misc_feature    2861..2956
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:28936"
     misc_feature    3326..3436
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:28936"
     misc_feature    order(3326..3328,3335..3337,3377..3379)
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:28936"
     misc_feature    3440..3550
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:28936"
     misc_feature    order(3440..3442,3449..3451,3491..3493)
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:28936"
     misc_feature    3587..3685
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:28936"
     misc_feature    4232..4327
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Domain found in Notch and Lin-12; Region: NL;
                     smart00004"
                     /db_xref="CDD:197463"
     misc_feature    4235..4357
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UM47.2);
                     Region: LNR 1"
     misc_feature    4337..4450
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Domain found in Notch and Lin-12; Region: NL;
                     smart00004"
                     /db_xref="CDD:197463"
     misc_feature    4358..4450
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UM47.2);
                     Region: LNR 2"
     misc_feature    4475..4591
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UM47.2);
                     Region: LNR 3"
     misc_feature    4487..4576
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="LNR domain; Region: Notch; pfam00066"
                     /db_xref="CDD:200970"
     misc_feature    4589..4756
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="NOTCH protein; Region: NOD; pfam06816"
                     /db_xref="CDD:191614"
     misc_feature    4787..4792
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="Cleavage, by furin-like protease (By similarity);
                     propagated from UniProtKB/Swiss-Prot (Q9UM47.2); cleavage
                     site"
     misc_feature    4802..4966
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="NOTCH protein; Region: NODP; pfam07684"
                     /db_xref="CDD:191811"
     misc_feature    4958..4960
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="proteolytic cleavage site; modified site"
     misc_feature    5006..5068
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UM47.2);
                     transmembrane region"
     misc_feature    5057..5059
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="proteolytic cleavage site; modified site"
     misc_feature    <5411..5854
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="ankyrin repeats;  ankyrin repeats mediate
                     protein-protein interactions in very diverse families of
                     proteins. The number of ANK repeats in a protein can range
                     from 2 to over 20 (ankyrins, for example). ANK repeats may
                     occur in combinations with other...; Region: ANK; cd00204"
                     /db_xref="CDD:29261"
     misc_feature    5588..5677
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UM47.2);
                     Region: ANK 1"
     misc_feature    5672..6052
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="ankyrin repeats;  ankyrin repeats mediate
                     protein-protein interactions in very diverse families of
                     proteins. The number of ANK repeats in a protein can range
                     from 2 to over 20 (ankyrins, for example). ANK repeats may
                     occur in combinations with other...; Region: ANK; cd00204"
                     /db_xref="CDD:29261"
     misc_feature    5672..5815
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Ankyrin repeats (many copies); Region: Ank_5;
                     pfam13857"
                     /db_xref="CDD:206028"
     misc_feature    5687..5779
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UM47.2);
                     Region: ANK 2"
     misc_feature    5789..5878
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UM47.2);
                     Region: ANK 3"
     misc_feature    5804..6082
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Ankyrin repeats (3 copies); Region: Ank_2;
                     pfam12796"
                     /db_xref="CDD:205076"
     misc_feature    5888..5977
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UM47.2);
                     Region: ANK 4"
     misc_feature    5987..6076
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UM47.2);
                     Region: ANK 5"
     misc_feature    6707..6880
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /note="Domain of unknown function (DUF3454); Region:
                     DUF3454; pfam11936"
                     /db_xref="CDD:152371"
     exon            195..273
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     exon            274..416
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     exon            417..755
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     variation       682
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1043994"
     exon            756..878
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     exon            879..1112
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     variation       1000
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1043995"
     exon            1113..1268
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     exon            1269..1454
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     exon            1455..1568
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     exon            1569..1682
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     variation       1570
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142762020"
     variation       1576
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146055867"
     exon            1683..1916
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     variation       1748
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:75068032"
     variation       1801
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:79926127"
     exon            1917..2027
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     exon            2028..2220
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     exon            2221..2372
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     exon            2373..2486
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     exon            2487..2642
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     variation       2614
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1043996"
     exon            2643..2868
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     variation       2818
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1043997"
     exon            2869..3070
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     variation       3017
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143695196"
     exon            3071..3218
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     variation       3159
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:146829488"
     exon            3219..3403
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     exon            3404..3536
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     variation       3448
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140642726"
     exon            3537..3794
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     STS             3786..3910
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /standard_name="SHGC-57293"
                     /db_xref="UniSTS:52587"
     exon            3795..3913
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     exon            3914..4479
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     variation       4120
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:78926093"
     variation       4393
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:76555145"
     exon            4480..4812
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     variation       4639
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1044006"
     exon            4813..4967
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     exon            4968..5190
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     variation       4990
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149222385"
     exon            5191..5275
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     variation       5205
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143411026"
     exon            5276..5438
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     exon            5439..5743
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     exon            5744..5891
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     exon            5892..5989
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     exon            5990..8071
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /inference="alignment:Splign:1.39.8"
     variation       6107
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142007575"
     variation       6174
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145859816"
     variation       6318
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:141231747"
     variation       6514
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1044008"
     variation       6744
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1044009"
     STS             7055..7292
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /standard_name="PMC122602P1"
                     /db_xref="UniSTS:270400"
     variation       7651
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1804976"
     variation       7710
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1044055"
     STS             7783..7943
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /standard_name="G62127"
                     /db_xref="UniSTS:139187"
     STS             7828..7942
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /standard_name="D19S1009"
                     /db_xref="UniSTS:20959"
     variation       7850
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1044116"
     variation       7879
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12082"
     variation       7932
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1044123"
     polyA_signal    8049..8054
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
     polyA_site      8071
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CASIL; IMF2"
ORIGIN      
gcggcgcggaggctggcccgggacgcgcccggagcccagggaaggagggaggaggggagggtcgcggccggccgccatggggccgggggcccgtggccgccgccgccgccgtcgcccgatgtcgccgccaccgccaccgccacccgtgcgggcgctgcccctgctgctgctgctagcggggccgggggctgcagcccccccttgcctggacggaagcccgtgtgcaaatggaggtcgttgcacccagctgccctcccgggaggctgcctgcctgtgcccgcctggctgggtgggtgagcggtgtcagctggaggacccctgtcactcaggcccctgtgctggccgtggtgtctgccagagttcagtggtggctggcaccgcccgattctcatgccggtgcccccgtggcttccgaggccctgactgctccctgccagatccctgcctcagcagcccttgtgcccacggtgcccgctgctcagtggggcccgatggacgcttcctctgctcctgcccacctggctaccagggccgcagctgccgaagcgacgtggatgagtgccgggtgggtgagccctgccgccatggtggcacctgcctcaacacacctggctccttccgctgccagtgtccagctggctacacagggccactatgtgagaaccccgcggtgccctgtgcaccctcaccatgccgtaacgggggcacctgcaggcagagtggcgacctcacttacgactgtgcctgtcttcctgggtttgagggtcagaattgtgaagtgaacgtggacgactgtccaggacaccgatgtctcaatggggggacatgcgtggatggcgtcaacacctataactgccagtgccctcctgagtggacaggccagttctgcacggaggacgtggatgagtgtcagctgcagcccaacgcctgccacaatgggggtacctgcttcaacacgctgggtggccacagctgcgtgtgtgtcaatggctggacaggcgagagctgcagtcagaatatcgatgactgtgccacagccgtgtgcttccatggggccacctgccatgaccgcgtggcttctttctactgtgcctgccccatgggcaagactggcctcctgtgtcacctggatgacgcctgtgtcagcaacccctgccacgaggatgctatctgtgacacaaatccggtgaacggccgggccatttgcacctgtcctcccggcttcacgggtggggcatgtgaccaggatgtggacgagtgctctatcggcgccaacccctgcgagcacttgggcaggtgcgtgaacacgcagggctccttcctgtgccagtgcggtcgtggctacactggacctcgctgtgagaccgatgtcaacgagtgtctgtcggggccctgccgaaaccaggccacgtgcctcgaccgcataggccagttcacctgtatctgtatggcaggcttcacaggaacctattgcgaggtggacattgacgagtgtcagagtagcccctgtgtcaacggtggggtctgcaaggaccgagtcaatggcttcagctgcacctgcccctcgggcttcagcggctccacgtgtcagctggacgtggacgaatgcgccagcacgccctgcaggaatggcgccaaatgcgtggaccagcccgatggctacgagtgccgctgtgccgagggctttgagggcacgctgtgtgatcgcaacgtggacgactgctcccctgacccatgccaccatggtcgctgcgtggatggcatcgccagcttctcatgtgcctgtgctcctggctacacgggcacacgctgcgagagccaggtggacgaatgccgcagccagccctgccgccatggcggcaaatgcctagacctggtggacaagtacctctgccgctgcccttctgggaccacaggtgtgaactgcgaagtgaacattgacgactgtgccagcaacccctgcacctttggagtctgccgtgatggcatcaaccgctacgactgtgtctgccaacctggcttcacagggcccctttgtaacgtggagatcaatgagtgtgcttccagcccatgcggcgagggaggttcctgtgtggatggggaaaatggcttccgctgcctctgcccgcctggctccttgcccccactctgcctccccccgagccatccctgtgcccatgagccctgcagtcacggcatctgctatgatgcacctggcgggttccgctgtgtgtgtgagcctggctggagtggcccccgctgcagccagagcctggcccgagacgcctgtgagtcccagccgtgcagggccggtgggacatgcagcagcgatggaatgggtttccactgcacctgcccgcctggtgtccagggacgtcagtgtgaactcctctccccctgcaccccgaacccctgtgagcatgggggccgctgcgagtctgcccctggccagctgcctgtctgctcctgcccccagggctggcaaggcccacgatgccagcaggatgtggacgagtgtgctggccccgcaccctgtggccctcatggtatctgcaccaacctggcagggagtttcagctgcacctgccatggagggtacactggcccttcctgcgatcaggacatcaatgactgtgaccccaacccatgcctgaacggtggctcgtgccaagacggcgtgggctccttttcctgctcctgcctccctggtttcgccggcccacgatgcgcccgcgatgtggatgagtgcctgagcaacccctgcggcccgggcacctgtaccgaccacgtggcctccttcacctgcacctgcccgccaggctacggaggcttccactgcgaacaggacctgcccgactgcagccccagctcctgcttcaatggcgggacctgtgtggacggcgtgaactcgttcagctgcctgtgccgtcccggctacacaggagcccactgccaacatgaggcagacccctgcctctcgcggccctgcctacacgggggcgtctgcagcgccgcccaccctggcttccgctgcacctgcctcgagagcttcacgggcccgcagtgccagacgctggtggattggtgcagccgccagccttgtcaaaacgggggtcgctgcgtccagactggggcctattgcctttgtccccctggatggagcggacgcctctgtgacatccgaagcttgccctgcagggaggccgcagcccagatcggggtgcggctggagcagctgtgtcaggcgggtgggcagtgtgtggatgaagacagctcccactactgcgtgtgcccagagggccgtactggtagccactgtgagcaggaggtggacccctgcttggcccagccctgccagcatggggggacctgccgtggctatatggggggctacatgtgtgagtgtcttcctggctacaatggtgataactgtgaggacgacgtggacgagtgtgcctcccagccctgccagcacgggggttcatgcattgacctcgtggcccgctatctctgctcctgtcccccaggaacgctgggggtgctctgcgagattaatgaggatgactgcggcccaggcccaccgctggactcagggccccggtgcctacacaatggcacctgcgtggacctggtgggtggtttccgctgcacctgtcccccaggatacactggtttgcgctgcgaggcagacatcaatgagtgtcgctcaggtgcctgccacgcggcacacacccgggactgcctgcaggacccaggcggaggtttccgttgcctttgtcatgctggcttctcaggtcctcgctgtcagactgtcctgtctccctgcgagtcccagccatgccagcatggaggccagtgccgtcctagcccgggtcctgggggtgggctgaccttcacctgtcactgtgcccagccgttctggggtccgcgttgcgagcgggtggcgcgctcctgccgggagctgcagtgcccggtgggcgtcccatgccagcagacgccccgcgggccgcgctgcgcctgccccccagggttgtcgggaccctcctgccgcagcttcccggggtcgccgccgggggccagcaacgccagctgcgcggccgccccctgtctccacgggggctcctgccgccccgcgccgctcgcgcccttcttccgctgcgcttgcgcgcagggctggaccgggccgcgctgcgaggcgcccgccgcggcacccgaggtctcggaggagccgcggtgcccgcgcgccgcctgccaggccaagcgcggggaccagcgctgcgaccgcgagtgcaacagcccaggctgcggctgggacggcggcgactgctcgctgagcgtgggcgacccctggcggcaatgcgaggcgctgcagtgctggcgcctcttcaacaacagccgctgcgaccccgcctgcagctcgcccgcctgcctctacgacaacttcgactgccacgccggtggccgcgagcgcacttgcaacccggtgtacgagaagtactgcgccgaccactttgccgacggccgctgcgaccagggctgcaacacggaggagtgcggctgggatgggctggattgtgccagcgaggtgccggccctgctggcccgcggcgtgctggtgctcacagtgctgctgccgccagaggagctactgcgttccagcgccgactttctgcagcggctcagcgccatcctgcgcacctcgctgcgcttccgcctggacgcgcacggccaggccatggtcttcccttaccaccggcctagtcctggctccgaaccccgggcccgtcgggagctggcccccgaggtgatcggctcggtagtaatgctggagattgacaaccggctctgcctgcagtcgcctgagaatgatcactgcttccccgatgcccagagcgccgctgactacctgggagcgttgtcagcggtggagcgcctggacttcccgtacccactgcgggacgtgcggggggagccgctggagcctccagaacccagcgtcccgctgctgccactgctagtggcgggcgctgtcttgctgctggtcattctcgtcctgggtgtcatggtggcccggcgcaagcgcgagcacagcaccctctggttccctgagggcttctcactgcacaaggacgtggcctctggtcacaagggccggcgggaacccgtgggccaggacgcgctgggcatgaagaacatggccaagggtgagagcctgatgggggaggtggccacagactggatggacacagagtgcccagaggccaagcggctaaaggtagaggagccaggcatgggggctgaggaggctgtggattgccgtcagtggactcaacaccatctggttgctgctgacatccgcgtggcaccagccatggcactgacaccaccacagggcgacgcagatgctgatggcatggatgtcaatgtgcgtggcccagatggcttcaccccgctaatgctggcttccttctgtgggggggctctggagccaatgccaactgaagaggatgaggcagatgacacatcagctagcatcatctccgacctgatctgccagggggctcagcttggggcacggactgaccgtactggcgagactgctttgcacctggctgcccgttatgcccgtgctgatgcagccaagcggctgctggatgctggggcagacaccaatgcccaggaccactcaggccgcactcccctgcacacagctgtcacagccgatgcccagggtgtcttccagattctcatccgaaaccgctctacagacttggatgcccgcatggcagatggctcaacggcactgatcctggcggcccgcctggcagtagagggcatggtggaagagctcatcgccagccatgctgatgtcaatgctgtggatgagcttgggaaatcagccttacactgggctgcggctgtgaacaacgtggaagccactttggccctgctcaaaaatggagccaataaggacatgcaggatagcaaggaggagacccccctattcctggccgcccgcgagggcagctatgaggctgccaagctgctgttggaccactttgccaaccgtgagatcaccgaccacctggacaggctgccgcgggacgtagcccaggagagactgcaccaggacatcgtgcgcttgctggatcaacccagtgggccccgcagcccccccggtccccacggcctggggcctctgctctgtcctccaggggccttcctccctggcctcaaagcggcacagtcggggtccaagaagagcaggaggccccccgggaaggcggggctggggccgcaggggccccgggggcggggcaagaagctgacgctggcctgcccgggccccctggctgacagctcggtcacgctgtcgcccgtggactcgctggactccccgcggcctttcggtgggccccctgcttcccctggtggcttcccccttgaggggccctatgcagctgccactgccactgcagtgtctctggcacagcttggtggcccaggccgggcgggtctagggcgccagccccctggaggatgtgtactcagcctgggcctgctgaaccctgtggctgtgcccctcgattgggcccggctgcccccacctgcccctccaggcccctcgttcctgctgccactggcgccgggaccccagctgctcaacccagggacccccgtctccccgcaggagcggcccccgccttacctggcagtcccaggacatggcgaggagtacccggcggctggggcacacagcagccccccaaaggcccgcttcctgcgggttcccagtgagcacccttacctgaccccatcccccgaatcccctgagcactgggccagcccctcacctccctccctctcagactggtccgaatccacgcctagcccagccactgccactggggccatggccaccaccactggggcactgcctgcccagccacttcccttgtctgttcccagctcccttgctcaggcccagacccagctggggccccagccggaagttacccccaagaggcaagtgttggcctgagacgctcgtcagttcttagatcttgggggcctaaagagacccccgtcctgcctcctttctttctctgtctcttccttccttttagtctttttcatcctcttctctttccaccaaccctcctgcatccttgccttgcagcgtgaccgagataggtcatcagcccagggcttcagtcttcctttatttataatgggtgggggctaccacccaccctctcagtcttgtgaagagtctgggacctccttcttccccacttctctcttccctcattcctttctctctccttctggcctctcatttccttacactctgacatgaatgaattattattatttttatttttctttttttttttacattttgtatagaaacaaattcatttaaacaaacttattattattattttttacaaaatatatatatggagatgctccctccccctgtgaaccccccagtgcccccgtggggctgagtctgtgggcccattcggccaagctggattctgtgtacctagtacacaggcatgactgggatcccgtgtaccgagtacacgacccaggtatgtaccaagtaggcacccttgggcgcacccactggggccaggggtcgggggagtgttgggagcctcctccccaccccacctccctcacttcactgcattccagatgggacatgttccatagccttgctggggaagggcccactgccaactccctctgccccagccccacccttggccatctccctttgggaactagggggctgctggtgggaaatgggagccagggcagatgtatgcattcctttgtgtccctgtaaatgtgggactacaagaagaggagctgcctgagtggtactttctcttcctggtaatcctctggcccagcctcatggcagaatagaggtatttttaggctatttttgtaatatggcttctggtcaaaatccctgtgtagctgaattcccaagccctgcattgtacagccccccactcccctcaccacctaataaaggaatagttaacactcaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:4854 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IEA
            GeneID:4854 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:4854 -> Molecular function: GO:0019899 [enzyme binding] evidence: IEA
            GeneID:4854 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
            GeneID:4854 -> Biological process: GO:0006367 [transcription initiation from RNA polymerase II promoter] evidence: TAS
            GeneID:4854 -> Biological process: GO:0007219 [Notch signaling pathway] evidence: TAS
            GeneID:4854 -> Biological process: GO:0007220 [Notch receptor processing] evidence: TAS
            GeneID:4854 -> Biological process: GO:0010467 [gene expression] evidence: TAS
            GeneID:4854 -> Biological process: GO:0030900 [forebrain development] evidence: IEA
            GeneID:4854 -> Biological process: GO:0045665 [negative regulation of neuron differentiation] evidence: IEA
            GeneID:4854 -> Biological process: GO:0048661 [positive regulation of smooth muscle cell proliferation] evidence: IEA
            GeneID:4854 -> Biological process: GO:0048663 [neuron fate commitment] evidence: IEA
            GeneID:4854 -> Biological process: GO:0072104 [glomerular capillary formation] evidence: IEA
            GeneID:4854 -> Cellular component: GO:0000139 [Golgi membrane] evidence: TAS
            GeneID:4854 -> Cellular component: GO:0005576 [extracellular region] evidence: TAS
            GeneID:4854 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:4854 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: TAS
            GeneID:4854 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:4854 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
            GeneID:4854 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA

by @meso_cacase at DBCLS
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