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2024-03-29 19:55:22, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_000411               6019 bp    mRNA    linear   PRI 20-APR-2013
DEFINITION  Homo sapiens holocarboxylase synthetase
            (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
            (HLCS), transcript variant 1, mRNA.
ACCESSION   NM_000411
VERSION     NM_000411.6  GI:338753395
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6019)
  AUTHORS   Esaki,S., Malkaram,S.A. and Zempleni,J.
  TITLE     Effects of single-nucleotide polymorphisms in the human
            holocarboxylase synthetase gene on enzyme catalysis
  JOURNAL   Eur. J. Hum. Genet. 20 (4), 428-433 (2012)
   PUBMED   22027809
  REMARK    GeneRIF: individuals with HLCS SNPs may benefit from supplemental
            biotin, yet to different extents depending on the genotype
REFERENCE   2  (bases 1 to 6019)
  AUTHORS   Bao,B., Wijeratne,S.S., Rodriguez-Melendez,R. and Zempleni,J.
  TITLE     Human holocarboxylase synthetase with a start site at methionine-58
            is the predominant nuclear variant of this protein and has
            catalytic activity
  JOURNAL   Biochem. Biophys. Res. Commun. 412 (1), 115-120 (2011)
   PUBMED   21802411
  REMARK    GeneRIF: HLCS methionine-58 is a functional translation start site
            in human cells.
REFERENCE   3  (bases 1 to 6019)
  AUTHORS   Bao,B., Pestinger,V., Hassan,Y.I., Borgstahl,G.E., Kolar,C. and
            Zempleni,J.
  TITLE     Holocarboxylase synthetase is a chromatin protein and interacts
            directly with histone H3 to mediate biotinylation of K9 and K18
  JOURNAL   J. Nutr. Biochem. 22 (5), 470-475 (2011)
   PUBMED   20688500
  REMARK    GeneRIF: Holocarboxylase synthetase interacts directly with histone
            H3, causing biotinylation of lysine K9 and K18.
REFERENCE   4  (bases 1 to 6019)
  AUTHORS   Bao,B., Rodriguez-Melendez,R., Wijeratne,S.S. and Zempleni,J.
  TITLE     Biotin regulates the expression of holocarboxylase synthetase in
            the miR-539 pathway in HEK-293 cells
  JOURNAL   J. Nutr. 140 (9), 1546-1551 (2010)
   PUBMED   20592104
  REMARK    GeneRIF: The results of this study suggest that miR-539 is among
            the factors sensing biotin and regulating holocarboxylase
            synthetase expression.
REFERENCE   5  (bases 1 to 6019)
  AUTHORS   Bailey,L.M., Wallace,J.C. and Polyak,S.W.
  TITLE     Holocarboxylase synthetase: correlation of protein localisation
            with biological function
  JOURNAL   Arch. Biochem. Biophys. 496 (1), 45-52 (2010)
   PUBMED   20153287
  REMARK    GeneRIF: the localisation of HCS and its isoforms
REFERENCE   6  (bases 1 to 6019)
  AUTHORS   Aoki,Y., Suzuki,Y., Sakamoto,O., Li,X., Takahashi,K., Ohtake,A.,
            Sakuta,R., Ohura,T., Miyabayashi,S. and Narisawa,K.
  TITLE     Molecular analysis of holocarboxylase synthetase deficiency: a
            missense mutation and a single base deletion are predominant in
            Japanese patients
  JOURNAL   Biochim. Biophys. Acta 1272 (3), 168-174 (1995)
   PUBMED   8541348
REFERENCE   7  (bases 1 to 6019)
  AUTHORS   Leon-Del-Rio,A., Leclerc,D., Akerman,B., Wakamatsu,N. and
            Gravel,R.A.
  TITLE     Isolation of a cDNA encoding human holocarboxylase synthetase by
            functional complementation of a biotin auxotroph of Escherichia
            coli
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (10), 4626-4630 (1995)
   PUBMED   7753853
REFERENCE   8  (bases 1 to 6019)
  AUTHORS   Suzuki,Y., Aoki,Y., Ishida,Y., Chiba,Y., Iwamatsu,A., Kishino,T.,
            Niikawa,N., Matsubara,Y. and Narisawa,K.
  TITLE     Isolation and characterization of mutations in the human
            holocarboxylase synthetase cDNA
  JOURNAL   Nat. Genet. 8 (2), 122-128 (1994)
   PUBMED   7842009
REFERENCE   9  (bases 1 to 6019)
  AUTHORS   Chiba,Y., Suzuki,Y., Aoki,Y., Ishida,Y. and Narisawa,K.
  TITLE     Purification and properties of bovine liver holocarboxylase
            synthetase
  JOURNAL   Arch. Biochem. Biophys. 313 (1), 8-14 (1994)
   PUBMED   8053691
REFERENCE   10 (bases 1 to 6019)
  AUTHORS   Narisawa,K., Arai,N., Igarashi,Y., Satoh,T., Tada,K. and Hirooka,Y.
  TITLE     Clinical and biochemical findings on a child with multiple
            biotin-responsive carboxylase deficiencies
  JOURNAL   J. Inherit. Metab. Dis. 5 (2), 67-68 (1982)
   PUBMED   6133032
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA334377.1, D23672.2, D87328.1
            and AP000697.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Jun 28, 2011 this sequence version replaced gi:274327273.
            
            Summary: This gene encodes an enzyme that catalyzes the binding of
            biotin to carboxylases and histones. The protein plays an important
            role in gluconeogenesis, fatty acid synthesis and branched chain
            amino acid catabolism. Defects in this gene are the cause of
            holocarboxylase synthetase deficiency. Multiple alternatively
            spliced variants, encoding the same protein, have been
            identified.[provided by RefSeq, Jun 2011].
            
            Transcript Variant: This variant (1) is the shortest transcript.
            Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D23672.2, BC060787.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025084 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DA334377.1         1-9
            10-2976             D23672.2           1-2967
            2977-5387           D87328.1           3728-6138
            5388-6019           AP000697.1         124311-124942       c
FEATURES             Location/Qualifiers
     source          1..6019
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.13"
     gene            1..6019
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /note="holocarboxylase synthetase
                     (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing))
                     ligase)"
                     /db_xref="GeneID:3141"
                     /db_xref="HGNC:4976"
                     /db_xref="HPRD:08360"
                     /db_xref="MIM:609018"
     exon            1..88
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /inference="alignment:Splign:1.39.8"
     exon            89..223
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /inference="alignment:Splign:1.39.8"
     exon            224..369
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    358..360
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /note="upstream in-frame stop codon"
     exon            370..532
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /inference="alignment:Splign:1.39.8"
     CDS             481..2661
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /EC_number="6.3.4.10"
                     /EC_number="6.3.4.11"
                     /EC_number="6.3.4.15"
                     /EC_number="6.3.4.9"
                     /note="holocarboxylase synthetase
                     (biotin-(proprionyl-Coenzyme A-carboxylase
                     (ATP-hydrolysing)) ligase); biotin apo-protein ligase;
                     biotin--[methylmalonyl-CoA-carboxytransferase] ligase;
                     biotin--[methylcrotonoyl-CoA-carboxylase] ligase;
                     biotin--[acetyl-CoA-carboxylase] ligase"
                     /codon_start=1
                     /product="biotin--protein ligase"
                     /protein_id="NP_000402.3"
                     /db_xref="GI:46255045"
                     /db_xref="CCDS:CCDS13647.1"
                     /db_xref="GeneID:3141"
                     /db_xref="HGNC:4976"
                     /db_xref="HPRD:08360"
                     /db_xref="MIM:609018"
                     /translation="
MEDRLHMDNGLVPQKIVSVHLQDSTLKEVKDQVSNKQAQILEPKPEPSLEIKPEQDGMEHVGRDDPKALGEEPKQRRGSASGSEPAGDSDRGGGPVEHYHLHLSSCHECLELENSTIESVKFASAENIPDLPYDYSSSLESVADETSPEREGRRVNLTGKAPNILLYVGSDSQEALGRFHEVRSVLADCVDIDSYILYHLLEDSALRDPWTDNCLLLVIATRESIPEDLYQKFMAYLSQGGKVLGLSSSFTFGGFQVTSKGALHKTVQNLVFSKADQSEVKLSVLSSGCRYQEGPVRLSPGRLQGHLENEDKDRMIVHVPFGTRGGEAVLCQVHLELPPSSNIVQTPEDFNLLKSSNFRRYEVLREILTTLGLSCDMKQVPALTPLYLLSAAEEIRDPLMQWLGKHVDSEGEIKSGQLSLRFVSSYVSEVEITPSCIPVVTNMEAFSSEHFNLEIYRQNLQTKQLGKVILFAEVTPTTMRLLDGLMFQTPQEMGLIVIAARQTEGKGRGGNVWLSPVGCALSTLLISIPLRSQLGQRIPFVQHLMSVAVVEAVRSIPEYQDINLRVKWPNDIYYSDLMKIGGVLVNSTLMGETFYILIGCGFNVTNSNPTICINDLITEYNKQHKAELKPLRADYLIARVVTVLEKLIKEFQDKGPNSVLPLYYRYWVHSGQQVHLGSAEGPKVSIVGLDDSGFLQVHQEGGEVVTVHPDGNSFDMLRNLILPKRR
"
     misc_feature    919..921
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P50747.1); phosphorylation site"
     misc_feature    1084..1860
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /note="Type 1 glutamine amidotransferase (GATase1)-like
                     domain; Region: GAT_1; cl00020"
                     /db_xref="CDD:206787"
     misc_feature    1891..2628
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /note="Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme
                     metabolism]; Region: BirA; COG0340"
                     /db_xref="CDD:30688"
     misc_feature    1954..2289
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /note="Biotin/lipoate A/B protein ligase family; Region:
                     BPL_LplA_LipB; pfam03099"
                     /db_xref="CDD:202534"
     misc_feature    2485..2628
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /note="Biotin protein ligase C terminal domain; Region:
                     BPL_C; pfam02237"
                     /db_xref="CDD:111161"
     exon            533..1476
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /inference="alignment:Splign:1.39.8"
     variation       765
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2230182"
     variation       1314
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1065758"
     exon            1477..1659
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /inference="alignment:Splign:1.39.8"
     variation       1533
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1065759"
     exon            1660..1931
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /inference="alignment:Splign:1.39.8"
     exon            1932..1999
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /inference="alignment:Splign:1.39.8"
     exon            2000..2160
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /inference="alignment:Splign:1.39.8"
     exon            2161..2275
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /inference="alignment:Splign:1.39.8"
     exon            2276..2489
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /inference="alignment:Splign:1.39.8"
     exon            2490..6019
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /inference="alignment:Splign:1.39.8"
     STS             2613..2726
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /standard_name="SHGC-52086"
                     /db_xref="UniSTS:22825"
     STS             2698..2972
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /standard_name="SHGC-12620"
                     /db_xref="UniSTS:31493"
     STS             2992..3116
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /standard_name="WI-15188"
                     /db_xref="UniSTS:77963"
     STS             3846..4084
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /standard_name="SHGC-53043"
                     /db_xref="UniSTS:6445"
     variation       3849
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3191054"
     variation       4265
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1050706"
     variation       4267
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1050707"
     polyA_signal    4837..4842
                     /gene="HLCS"
                     /gene_synonym="HCS"
     STS             4848..5007
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /standard_name="SHGC-87611"
                     /db_xref="UniSTS:81190"
     polyA_site      4857
                     /gene="HLCS"
                     /gene_synonym="HCS"
     STS             5000..5186
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /standard_name="SHGC-52136"
                     /db_xref="UniSTS:55079"
     variation       5283
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:14407"
     STS             5598..5726
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /standard_name="SHGC-87607"
                     /db_xref="UniSTS:51963"
     polyA_signal    5693..5698
                     /gene="HLCS"
                     /gene_synonym="HCS"
     polyA_site      5715
                     /gene="HLCS"
                     /gene_synonym="HCS"
ORIGIN      
aggcgggccacgagagggcgcagcgcggcgcggcagggattcgcgggcgaccacccggcgcaggagcggccgcgtttcggcctcagaatccattgaagacttgaacaagtgggccctatttcttgtgtctccttttatacttgaagcagaacacatagcatttgtgacggagagcatttgggtacaaagtgagaatttacagagatcatcctcttcagaaacagttcggtttttgcccactagggatgatgtggtttctcatgaggttacttgctctaaaggactttatattttggaaccataagagcacccttgtggcccaggcactttatggatgatcccttttagtgctcccagtaaccttccaagattgtcaagtggtcagactgttgtttgccattagcttgcagacctggggatccttatcggctaattgctgaagcaagtgtggacaacttcagcaagctgggggtggcgttcatggaagatagactccacatggataatggactggtaccccaaaagattgtgtcggtgcacttgcaggactccactctgaaggaagttaaggatcaggtctcaaacaagcaagcccagatcctagagccgaagcctgaaccttctcttgagattaagcctgagcaggacggtatggagcatgttggcagagatgacccaaaggctcttggtgaagaacccaaacaaaggagaggcagtgcctctgggagtgagcctgctggggacagtgacaggggagggggccccgttgagcattatcacctccatctgtctagttgccacgagtgtctggaacttgagaacagcaccattgagtcagtcaagtttgcgtctgccgagaacattccagaccttccctacgattatagcagcagtttggagagtgttgctgatgagacctcccccgaaagagaagggaggagagtcaacctcacgggaaaggcacccaacatcctcctctatgtgggctccgactcccaggaagccctcggccggttccacgaggtccggtctgtgctggccgactgtgtggacattgacagttatattctctaccacctgctggaggacagtgctctcagagacccgtggacggacaactgtctgctgttggtcattgctaccagggagtccattcccgaagacctgtaccagaagttcatggcctatctttctcagggagggaaggtgttgggcctgtcttcatccttcacctttggtggctttcaggtgacaagcaagggtgcactgcacaagacagtccagaacttggttttctccaaggctgaccagagcgaggtgaagctcagcgtcttgagcagtggctgcaggtaccaggaaggccccgtccggctcagccccggcaggctccagggccacctggagaatgaggacaaggacaggatgattgtgcatgtgccttttggaactcgcgggggagaagctgttctttgccaggtgcacttagaactacctcccagctccaacatagtgcaaactccagaagattttaacttgctcaagtcaagcaattttagaagatacgaagtccttagagagattctgacaacccttggcctcagctgtgacatgaaacaagttcctgccttaactcctctttacttgctgtcagctgcggaggaaatcagggatcctcttatgcagtggcttgggaaacatgtggactccgagggagaaataaaatccggccagctctctcttagatttgtttcatcctacgtgtctgaagtagaaataaccccatcttgtatacctgtggtgaccaacatggaggccttctcatcagaacatttcaacttagagatctatcgccaaaatctgcagaccaagcagttggggaaagtaattttgtttgccgaagtgacccccacaacgatgcgtctcctggatgggctgatgtttcagacaccgcaggaaatgggcttaatagtgatcgcggcccggcagaccgagggcaaaggacggggagggaatgtgtggctgagccctgtgggatgtgctctttctactctgctcatctccattccactgagatcccagctgggacagaggatcccgtttgtccagcatctgatgtccgtggctgtcgtggaagcagtgaggtccattcccgagtatcaggatatcaacttacgagtgaagtggcccaacgatatttattacagtgacctcatgaagatcggcggagttctggttaactcaacactcatgggagaaacattttatatacttattggctgtggatttaatgtgactaacagtaaccctaccatctgcatcaacgacctcatcacagaatacaataaacaacacaaggcagaactgaagcccttaagagccgattatctcatcgccagagtcgtgactgtgctggagaaactgatcaaagagtttcaggacaaagggcccaacagcgtccttcccctttattaccgatactgggtccacagtggtcagcaagtccatctgggcagcgcagagggaccaaaggtgtccatcgttggcctggacgattctggcttcctccaggttcaccaggagggcggcgaggttgtgactgtgcacccggacggcaactccttcgacatgctgagaaacctcatcctccccaaacggcggtaatgccgggcgtccccgagacgcggctgcctgtccgtgcccatgcatctggaaatctaatttagagttgtaggtgaattttcttttcctccaattcatttgttaagtctttgttctttttctgtgtttctgtttgtttttaggtttgttttgttgtcgttttctttggtgtttgaagaggctctgggatagatggttaagaagtagaaaatttagtttagggaaagccctcccacaggtgggaaattgctctcccctctgtggcttggacttacgtttattgtcaaggggagtttttacatggaaatgacaatgggaaaattcagatattttcttagtagtgcagacctttacccctagtctatgaaaaaacaaaccaaaatatgctcttgcgcccaggccagtggtgagttagaggtatgctatcactgtttgtaagcatctggggaggtactgaactgtaagaacatgcttggacacttagtcattgttctgtgtttttattaatgaagaaaagggaagacagacttccaagagttactgtccacccggtggtgtggccccatagcgaagtctaaatgcctgtagagatagagctagctggtgtggttgcagtgaccttgtagaggaaatcagttcattactttgacatcattcagtgagctctcctttcctaaggaagtttaaatgtccttagttagggactgactttcttaagtaagtttaaatttactacatattgtgaagagacaggatcaagttcagaatccttaaatgtctgattaggcatcacttggatgaggaggtgggcgatttggctctgacagctggagatgaaggcacactcataccacatacaagggaggatttggagcttttaagccagtttcagatttactctgaaatgtggagcattcctgcaagactgtgcagctcacggaatatagaagacatggcattttactcagaagtcataagtttttgcccccctcatttacctcgtattaccaagaaagaaaatgttatcgatactaaacaccatcagttcagagggaggatgtgtgtgtgtgcccgcatatgtgtgtgcgtgcgtgtgtgcgcacatagctttaaaagaagacattcaaaatttgatgtgctacaagcctcatgaaagaacaaaagaaatgaagccttttgatatgcattcgctattcccagatgtacgccatgccttttccatgtccctcctatctctgttgaacttatgaatcatactcattacttttcagctttttaaaaggccaatttttgtccagttttctctcttccagtcccagctgaaattagtggaaagaaagtttgatggagctttcagctttgaacaaaatcccttcattgtaaactagcaccatctttatccaggtcttacccagtcaggctaattccagaaacttgtggtttttagtatagtctgtctacctttagccaggcacaggacagccctatgaaaaaatacccaatatatattttttggaaatgaaacattaaaagaacttaaaaagtaatttttggaaatgaggcttcaattagaattatttttctcaaaaaacaaacaaacaaaaaacacaaaaaaaaccactcttctccaaatgcccaagccttctttcaaaattagttagaaacttaagtaaaatacaagtccacaccatccccaaattacaaaatggacttacccttgagagggcatctgcagaatatcatcagggacaaagatctcgaggctaacgatgtaggtttcatttctcagactttgtaatataaggcaagccctctctcagagctgccatcatcactttttgaatttctttgggggttatttaatgaaaaacatgctatgttttgttttaagctgaagtcctattctggacactctgctttgggaaaaaatgttatcatttaatttcctttctgcaaattaaaactaatgaagtgtggccttgtcaaaggctatggagatgttccgggcatactgctgtgctctgtgctttccagcaggcgctcctccctcacgcaggagactcagttgtcctgagagagatgaagcagccttgaagcagatgctgcgttttccataaacctgattttgcctcacatgaaccaaagactctcaaaactccgcttctatagaattagctgaataaaggcattttactgatagctgttcgtgttagcgaaacctgtctacctgctatagcacactctccgatttgggccatttatgcaccccgcaacctgggatctcaaggagctttaaagtcttaatgggaacttggcattttcctgatgatctttaaaatgtggtcactaaactcaggattggcgtgtgcttttagaacactggagtagcccttgttttagaggctgtgcattgagtatcgaccgtattttgtaaaaggcaagatatcctcccttccaggctggtaacgggtttcaaggggactcttgaggaagtgccccctaaaatagaacacagcaataactgggcttcctgtccccacccccaccccagcagtgctctctggcactgggaactctgctagggagtggtggaagtaggaaggatttgtgtgcaaaggaaaatcgtggttgagtttcactgcagcaggctgacgttgcctgatgtgagagcaagtggccgactggggtgcgggtgcacaggtcgggggagcacaggccacagagcgcagcctctgggggtcccccaaggcacagcatatacagcatggtcgccccttgccctggagtctgggaacaaagagaggagccagcctccccgcactgcttcagatggaaaagggaggcagggtgggcttccgttctccagatctgtttgctcttaacaggcagaacatgggagaatccttattcctggttaatcactatgcatatttgaaataaaagaaagcgtaagcctctgcaattttaacttctcaaaggatgtctctgaaaagaatcactttaaaccaatgcctataaaaagcaagtctaccaaaataaactaagactttctatgtggtttgggctccctcttatttttacaagtttcatttttaaaagtaggcaactactttgggttacagtatttttattcatatttaaacatttttacaaaataaataaagtgttttacatagtaaggaatatgtacgtatttccaagtattaagaagccaagtgtttttttttttgacgtattattgacaaatgtattcagcgccatacacaagagaaatattattactccaaagaacgaaagttaacaaaactccaaagcaaaaacccttttaatggaggtgagaaataaatttaatgtaacaaca
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:3141 -> Molecular function: GO:0004077 [biotin-[acetyl-CoA-carboxylase] ligase activity] evidence: IEA
            GeneID:3141 -> Molecular function: GO:0004078 [biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity] evidence: IEA
            GeneID:3141 -> Molecular function: GO:0004079 [biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity] evidence: IEA
            GeneID:3141 -> Molecular function: GO:0004080 [biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity] evidence: IDA
            GeneID:3141 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:3141 -> Molecular function: GO:0009374 [biotin binding] evidence: IDA
            GeneID:3141 -> Molecular function: GO:0018271 [biotin-protein ligase activity] evidence: IDA
            GeneID:3141 -> Molecular function: GO:0018271 [biotin-protein ligase activity] evidence: IMP
            GeneID:3141 -> Molecular function: GO:0019899 [enzyme binding] evidence: IPI
            GeneID:3141 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IEA
            GeneID:3141 -> Biological process: GO:0006766 [vitamin metabolic process] evidence: TAS
            GeneID:3141 -> Biological process: GO:0006767 [water-soluble vitamin metabolic process] evidence: TAS
            GeneID:3141 -> Biological process: GO:0006768 [biotin metabolic process] evidence: TAS
            GeneID:3141 -> Biological process: GO:0008283 [cell proliferation] evidence: IMP
            GeneID:3141 -> Biological process: GO:0009305 [protein biotinylation] evidence: IDA
            GeneID:3141 -> Biological process: GO:0016570 [histone modification] evidence: IDA
            GeneID:3141 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
            GeneID:3141 -> Biological process: GO:0070781 [response to biotin] evidence: IDA
            GeneID:3141 -> Biological process: GO:0071110 [histone biotinylation] evidence: IDA
            GeneID:3141 -> Cellular component: GO:0000785 [chromatin] evidence: IDA
            GeneID:3141 -> Cellular component: GO:0005652 [nuclear lamina] evidence: IDA
            GeneID:3141 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:3141 -> Cellular component: GO:0005739 [mitochondrion] evidence: IEA
            GeneID:3141 -> Cellular component: GO:0005829 [cytosol] evidence: IDA
            GeneID:3141 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:3141 -> Cellular component: GO:0016363 [nuclear matrix] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_000402 -> EC 6.3.4.10
            NP_000402 -> EC 6.3.4.11
            NP_000402 -> EC 6.3.4.15
            NP_000402 -> EC 6.3.4.9

by @meso_cacase at DBCLS
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