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2024-04-25 10:31:25, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_000400 2568 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens excision repair cross-complementing rodent repair
deficiency, complementation group 2 (ERCC2), transcript variant 1,
mRNA.
ACCESSION NM_000400
VERSION NM_000400.3 GI:195947405
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2568)
AUTHORS Dong,Y., Zhuang,L. and Ma,W.
TITLE Comprehensive assessment of the association of ERCC2 Lys751Gln
polymorphism with susceptibility to cutaneous melanoma
JOURNAL Tumour Biol. 34 (2), 1155-1160 (2013)
PUBMED 23494240
REMARK GeneRIF: ERCC2 Lys751Gln polymorphism is associated with
susceptibility to cutaneous melanoma.
REFERENCE 2 (bases 1 to 2568)
AUTHORS Zhang,R.C. and Mou,S.H.
TITLE Polymorphisms of excision repair gene XPD Lys751Gln and hOGG1
Ser326Cys might not be associated with hepatocellular carcinoma
risk: a meta-analysis
JOURNAL Tumour Biol. 34 (2), 901-907 (2013)
PUBMED 23271362
REMARK GeneRIF: Polymorphisms of excision repair gene XPD Lys751Gln is not
associated with hepatocellular carcinoma risk.
REFERENCE 3 (bases 1 to 2568)
AUTHORS Abdulrahman,W., Iltis,I., Radu,L., Braun,C., Maglott-Roth,A.,
Giraudon,C., Egly,J.M. and Poterszman,A.
TITLE ARCH domain of XPD, an anchoring platform for CAK that conditions
TFIIH DNA repair and transcription activities
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 110 (8), E633-E642 (2013)
PUBMED 23382212
REMARK GeneRIF: results identify the ARCH domain of XPD as a platform for
the recruitment of CAK and as a molecular switch that might control
TFIIH composition and play a role in conversion of TFIIH from a
factor active in transcription to a factor involved in DNA repair
REFERENCE 4 (bases 1 to 2568)
AUTHORS Yang,L.M., Li,X.H. and Bao,C.F.
TITLE Glutathione S-transferase P1 and DNA polymorphisms influence
response to chemotherapy and prognosis of bone tumors
JOURNAL Asian Pac. J. Cancer Prev. 13 (11), 5883-5886 (2012)
PUBMED 23317281
REMARK GeneRIF: ERCC2 polymorphisms influence response to chemotherapy in
bone tumors
REFERENCE 5 (bases 1 to 2568)
AUTHORS Gan,Y., Li,X.R., Chen,D.J. and Wu,J.H.
TITLE Association between polymorphisms of XRCC1 Arg399Gln and XPD
Lys751Gln genes and prognosis of colorectal cancer in a Chinese
population
JOURNAL Asian Pac. J. Cancer Prev. 13 (11), 5721-5724 (2012)
PUBMED 23317245
REMARK GeneRIF: Polymorphisms of XPD Lys751Gln are associated with
colorectal cancer.
REFERENCE 6 (bases 1 to 2568)
AUTHORS Flejter,W.L., McDaniel,L.D., Johns,D., Friedberg,E.C. and
Schultz,R.A.
TITLE Correction of xeroderma pigmentosum complementation group D mutant
cell phenotypes by chromosome and gene transfer: involvement of the
human ERCC2 DNA repair gene
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (1), 261-265 (1992)
PUBMED 1729695
REFERENCE 7 (bases 1 to 2568)
AUTHORS Jacob,G.A., Luse,S.W. and Luse,D.S.
TITLE Abortive initiation is increased only for the weakest members of a
set of down mutants of the adenovirus 2 major late promoter
JOURNAL J. Biol. Chem. 266 (33), 22537-22544 (1991)
PUBMED 1939271
REFERENCE 8 (bases 1 to 2568)
AUTHORS Weber,C.A., Salazar,E.P., Stewart,S.A. and Thompson,L.H.
TITLE ERCC2: cDNA cloning and molecular characterization of a human
nucleotide excision repair gene with high homology to yeast RAD3
JOURNAL EMBO J. 9 (5), 1437-1447 (1990)
PUBMED 2184031
REFERENCE 9 (bases 1 to 2568)
AUTHORS Weber,C.A., Salazar,E.P., Stewart,S.A. and Thompson,L.H.
TITLE Molecular cloning and biological characterization of a human gene,
ERCC2, that corrects the nucleotide excision repair defect in CHO
UV5 cells
JOURNAL Mol. Cell. Biol. 8 (3), 1137-1146 (1988)
PUBMED 2835663
REFERENCE 10 (bases 1 to 2568)
AUTHORS Conaway,R.C. and Conaway,J.W.
TITLE ATP activates transcription initiation from promoters by RNA
polymerase II in a reversible step prior to RNA synthesis
JOURNAL J. Biol. Chem. 263 (6), 2962-2968 (1988)
PUBMED 2449431
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA409300.1, BC108255.1 and
CN388234.1.
This sequence is a reference standard in the RefSeqGene project.
On Aug 7, 2008 this sequence version replaced gi:40068510.
Summary: The nucleotide excision repair pathway is a mechanism to
repair damage to DNA. The protein encoded by this gene is involved
in transcription-coupled nucleotide excision repair and is an
integral member of the basal transcription factor BTF2/TFIIH
complex. The gene product has ATP-dependent DNA helicase activity
and belongs to the RAD3/XPD subfamily of helicases. Defects in this
gene can result in three different disorders, the cancer-prone
syndrome xeroderma pigmentosum complementation group D,
trichothiodystrophy, and Cockayne syndrome. Alternatively spliced
transcript variants encoding different isoforms have been found for
this gene. [provided by RefSeq, Aug 2008].
Transcript Variant: This variant (1) encodes the longer isoform
(1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC110523.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-37 DA409300.1 2-38
38-2365 BC108255.1 1-2328
2366-2568 CN388234.1 253-455
FEATURES Location/Qualifiers
source 1..2568
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19q13.3"
gene 1..2568
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/note="excision repair cross-complementing rodent repair
deficiency, complementation group 2"
/db_xref="GeneID:2068"
/db_xref="HGNC:3434"
/db_xref="HPRD:00530"
/db_xref="MIM:126340"
exon 1..52
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/inference="alignment:Splign:1.39.8"
STS 20..659
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/standard_name="GDB:364012"
/db_xref="UniSTS:156797"
CDS 48..2330
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/EC_number="3.6.4.12"
/note="isoform 1 is encoded by transcript variant 1;
xeroderma pigmentosum complementary group D; TFIIH basal
transcription factor complex helicase subunit; TFIIH basal
transcription factor complex helicase XPD subunit;
xeroderma pigmentosum group D-complementing protein; TFIIH
basal transcription factor complex 80 kDa subunit; CXPD;
BTF2 p80; TFIIH p80; TFIIH 80 kDa subunit; DNA excision
repair protein ERCC-2; DNA repair protein complementing
XP-D cells; basic transcription factor 2 80 kDa subunit"
/codon_start=1
/product="TFIIH basal transcription factor complex
helicase XPD subunit isoform 1"
/protein_id="NP_000391.1"
/db_xref="GI:15834617"
/db_xref="CCDS:CCDS33049.1"
/db_xref="GeneID:2068"
/db_xref="HGNC:3434"
/db_xref="HPRD:00530"
/db_xref="MIM:126340"
/translation="
MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLESEETLKRIEQIAQQL
"
misc_feature 66..2171
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/note="DNA repair helicase (rad3); Region: rad3;
TIGR00604"
/db_xref="CDD:161953"
misc_feature 261..815
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/note="DEAD_2; Region: DEAD_2; pfam06733"
/db_xref="CDD:191597"
misc_feature 747..758
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P18074.1);
Region: DEAH box"
misc_feature 849..1286
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/note="Protein of unknown function (DUF1227); Region:
DUF1227; pfam06777"
/db_xref="CDD:191608"
misc_feature 1359..1958
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P18074.1);
Region: Mediates interaction with MMS19"
misc_feature 1671..2105
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/note="helicase superfamily c-terminal domain; Region:
HELICc2; smart00491"
/db_xref="CDD:128767"
misc_feature 2091..2132
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P18074.1);
Region: Nuclear localization signal (Potential)"
exon 53..152
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/inference="alignment:Splign:1.39.8"
variation 119
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/replace="c"
/replace="t"
/db_xref="dbSNP:41549115"
exon 153..230
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/inference="alignment:Splign:1.39.8"
exon 231..293
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/inference="alignment:Splign:1.39.8"
exon 294..407
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/inference="alignment:Splign:1.39.8"
STS 371..1054
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/standard_name="GDB:364015"
/db_xref="UniSTS:156798"
exon 408..524
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/inference="alignment:Splign:1.39.8"
exon 525..641
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/inference="alignment:Splign:1.39.8"
exon 642..765
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/inference="alignment:Splign:1.39.8"
variation 644
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/replace="c"
/replace="g"
/db_xref="dbSNP:1799791"
variation 648
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/replace="c"
/replace="t"
/db_xref="dbSNP:1799792"
exon 766..862
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/inference="alignment:Splign:1.39.8"
exon 863..996
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/inference="alignment:Splign:1.39.8"
variation 981
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/replace="a"
/replace="g"
/db_xref="dbSNP:1799793"
STS 994..1634
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/standard_name="GDB:364018"
/db_xref="UniSTS:156799"
STS 994..1609
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/standard_name="GDB:364021"
/db_xref="UniSTS:156800"
exon 997..1165
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/inference="alignment:Splign:1.39.8"
exon 1166..1284
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/inference="alignment:Splign:1.39.8"
exon 1285..1354
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/inference="alignment:Splign:1.39.8"
exon 1355..1424
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/inference="alignment:Splign:1.39.8"
STS 1370..2366
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/standard_name="GDB:364025"
/db_xref="UniSTS:156801"
variation 1390
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/replace="c"
/replace="t"
/db_xref="dbSNP:41559922"
STS 1402..2366
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/standard_name="GDB:364029"
/db_xref="UniSTS:156802"
exon 1425..1526
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/inference="alignment:Splign:1.39.8"
exon 1527..1590
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/inference="alignment:Splign:1.39.8"
STS 1552..1667
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/standard_name="MARC_23995-23996:1029525921:1"
/db_xref="UniSTS:268821"
exon 1591..1712
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/inference="alignment:Splign:1.39.8"
exon 1713..1805
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/inference="alignment:Splign:1.39.8"
variation 1784
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/replace="c"
/replace="t"
/db_xref="dbSNP:3916876"
exon 1806..1878
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/inference="alignment:Splign:1.39.8"
exon 1879..1949
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/inference="alignment:Splign:1.39.8"
variation 1913
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/replace="c"
/replace="t"
/db_xref="dbSNP:16979773"
STS 1914..2236
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/standard_name="GDB:512988"
/db_xref="UniSTS:157537"
exon 1950..2093
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/inference="alignment:Splign:1.39.8"
exon 2094..2237
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/inference="alignment:Splign:1.39.8"
STS 2178..2313
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/standard_name="RH15967"
/db_xref="UniSTS:68429"
variation 2180
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/replace="c"
/replace="t"
/db_xref="dbSNP:1052555"
exon 2238..2568
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/inference="alignment:Splign:1.39.8"
STS 2350..2489
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/standard_name="RH80858"
/db_xref="UniSTS:83698"
polyA_site 2372
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
variation 2400
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/replace="c"
/replace="t"
/db_xref="dbSNP:3916889"
variation 2449
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/replace=""
/replace="c"
/db_xref="dbSNP:3916890"
variation 2501
/gene="ERCC2"
/gene_synonym="COFS2; EM9; TTD; XPD"
/replace="c"
/replace="g"
/db_xref="dbSNP:3916891"
ORIGIN
ttcatgagggaggcgggtcgaccccgctgcacagtccggccggcgccatgaagctcaacgtggacgggctcctggtctacttcccgtacgactacatctaccccgagcagttctcctacatgcgggagctcaaacgcacgctggacgccaagggtcatggagtcctggagatgccctcaggcaccgggaagacagtatccctgttggccctgatcatggcataccagagagcatatccgctggaggtgaccaaactcatctactgctcaagaactgtgccagagattgagaaggtgattgaagagcttcgaaagttgctcaacttctatgagaagcaggagggcgagaagctgccgtttctgggactggctctgagctcccgcaaaaacttgtgtattcaccctgaggtgacacccctgcgctttgggaaggacgtcgatgggaaatgccacagcctcacagcctcctatgtgcgggcgcagtaccagcatgacaccagcctgccccactgccgattctatgaggaatttgatgcccatgggcgtgaggtgcccctccccgctggcatctacaacctggatgacctgaaggccctggggcggcgccagggctggtgcccatacttccttgctcgatactcaatcctgcatgccaatgtggtggtttatagctaccactacctcctggaccccaagattgcagacctggtgtccaaggaactggcccgcaaggccgtcgtggtcttcgacgaggcccacaacattgacaacgtctgcatcgactccatgagcgtcaacctcacccgccggacccttgaccggtgccagggcaacctggagaccctgcagaagacggtgctcaggatcaaagagacagacgagcagcgcctgcgggacgagtaccggcgtctggtggaggggctgcgggaggccagcgccgcccgggagacggacgcccacctggccaaccccgtgctgcccgacgaagtgctgcaggaggcagtgcctggctccatccgcacggccgagcatttcctgggcttcctgaggcggctgctggagtacgtgaagtggcggctgcgtgtgcagcatgtggtgcaggagagcccgcccgccttcctgagcggcctggcccagcgcgtgtgcatccagcgcaagcccctcagattctgtgctgaacgcctccggtccctgctgcatactctggagatcaccgaccttgctgacttctccccgctcaccctccttgctaactttgccacccttgtcagcacctacgccaaaggcttcaccatcatcatcgagccctttgacgacagaaccccgaccattgccaaccccatcctgcacttcagctgcatggacgcctcgctggccatcaaacccgtatttgagcgtttccagtctgtcatcatcacatctgggacactgtccccgctggacatctaccccaagatcctggacttccaccccgtcaccatggcaaccttcaccatgacgctggcacgggtctgcctctgccctatgatcatcggccgtggcaatgaccaggtggccatcagctccaaatttgagacccgggaggatattgctgtgatccggaactatgggaacctcctgctggagatgtccgctgtggtccctgatggcatcgtggccttcttcaccagctaccagtacatggagagcaccgtggcctcctggtatgagcaggggatccttgagaacatccagaggaacaagctgctctttattgagacccaggatggtgccgaaaccagtgtcgccctggagaagtaccaggaggcctgcgagaatggccgcggggccatcctgctgtcagtggcccggggcaaagtgtccgagggaatcgactttgtgcaccactacgggcgggccgtcatcatgtttggcgtcccctacgtctacacacagagccgcattctcaaggcgcggctggaatacctgcgggaccagttccagattcgtgagaatgactttcttaccttcgatgccatgcgccacgcggcccagtgtgtgggtcgggccatcaggggcaagacggactacggcctcatggtctttgccgacaagcggtttgcccgtggggacaagcgggggaagctgccccgctggatccaggagcacctcacagatgccaacctcaacctgaccgtggacgagggtgtccaggtggccaagtacttcctgcggcagatggcacagcccttccaccgggaggatcagctgggcctgtccctgctcagcctggagcagctagaatcagaggagacgctgaagaggatagagcagattgctcagcagctctgagtggggcgggtggggccataaacggttcctggtgactcctgagtcttgcctggccctggttcccagcggcggtggtgctagaaggtcttatgaagtcaggtgacatttctcactgtcacgtccacagcctttaatcgcaggagaaggcagctatccaccaggtacccagaggcaagggggggccaggagatgatagaccccctctcaccccaccagcccatccctcctgcactgttcc
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:2068 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:2068 -> Molecular function: GO:0004003 [ATP-dependent DNA helicase activity] evidence: IEA
GeneID:2068 -> Molecular function: GO:0004672 [protein kinase activity] evidence: IDA
GeneID:2068 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:2068 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:2068 -> Molecular function: GO:0008022 [protein C-terminus binding] evidence: IPI
GeneID:2068 -> Molecular function: GO:0008094 [DNA-dependent ATPase activity] evidence: IDA
GeneID:2068 -> Molecular function: GO:0008094 [DNA-dependent ATPase activity] evidence: TAS
GeneID:2068 -> Molecular function: GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity] evidence: IDA
GeneID:2068 -> Molecular function: GO:0043139 [5'-3' DNA helicase activity] evidence: IDA
GeneID:2068 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:2068 -> Molecular function: GO:0047485 [protein N-terminus binding] evidence: IPI
GeneID:2068 -> Molecular function: GO:0051539 [4 iron, 4 sulfur cluster binding] evidence: IEA
GeneID:2068 -> Biological process: GO:0000075 [cell cycle checkpoint] evidence: IMP
GeneID:2068 -> Biological process: GO:0000718 [nucleotide-excision repair, DNA damage removal] evidence: TAS
GeneID:2068 -> Biological process: GO:0001666 [response to hypoxia] evidence: IEA
GeneID:2068 -> Biological process: GO:0001701 [in utero embryonic development] evidence: IEA
GeneID:2068 -> Biological process: GO:0006281 [DNA repair] evidence: TAS
GeneID:2068 -> Biological process: GO:0006283 [transcription-coupled nucleotide-excision repair] evidence: IDA
GeneID:2068 -> Biological process: GO:0006283 [transcription-coupled nucleotide-excision repair] evidence: TAS
GeneID:2068 -> Biological process: GO:0006289 [nucleotide-excision repair] evidence: IGI
GeneID:2068 -> Biological process: GO:0006289 [nucleotide-excision repair] evidence: NAS
GeneID:2068 -> Biological process: GO:0006289 [nucleotide-excision repair] evidence: TAS
GeneID:2068 -> Biological process: GO:0006360 [transcription from RNA polymerase I promoter] evidence: TAS
GeneID:2068 -> Biological process: GO:0006361 [transcription initiation from RNA polymerase I promoter] evidence: TAS
GeneID:2068 -> Biological process: GO:0006362 [transcription elongation from RNA polymerase I promoter] evidence: TAS
GeneID:2068 -> Biological process: GO:0006363 [termination of RNA polymerase I transcription] evidence: TAS
GeneID:2068 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: IDA
GeneID:2068 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: TAS
GeneID:2068 -> Biological process: GO:0006367 [transcription initiation from RNA polymerase II promoter] evidence: TAS
GeneID:2068 -> Biological process: GO:0006368 [transcription elongation from RNA polymerase II promoter] evidence: TAS
GeneID:2068 -> Biological process: GO:0006370 [7-methylguanosine mRNA capping] evidence: TAS
GeneID:2068 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
GeneID:2068 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:2068 -> Biological process: GO:0006917 [induction of apoptosis] evidence: IMP
GeneID:2068 -> Biological process: GO:0006979 [response to oxidative stress] evidence: IMP
GeneID:2068 -> Biological process: GO:0007059 [chromosome segregation] evidence: IMP
GeneID:2068 -> Biological process: GO:0007568 [aging] evidence: IEA
GeneID:2068 -> Biological process: GO:0008283 [cell proliferation] evidence: IEA
GeneID:2068 -> Biological process: GO:0009650 [UV protection] evidence: IGI
GeneID:2068 -> Biological process: GO:0009791 [post-embryonic development] evidence: IEA
GeneID:2068 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:2068 -> Biological process: GO:0016032 [viral process] evidence: TAS
GeneID:2068 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
GeneID:2068 -> Biological process: GO:0021510 [spinal cord development] evidence: IEA
GeneID:2068 -> Biological process: GO:0030198 [extracellular matrix organization] evidence: IEA
GeneID:2068 -> Biological process: GO:0030282 [bone mineralization] evidence: IEA
GeneID:2068 -> Biological process: GO:0032289 [central nervous system myelin formation] evidence: IEA
GeneID:2068 -> Biological process: GO:0033683 [nucleotide-excision repair, DNA incision] evidence: IMP
GeneID:2068 -> Biological process: GO:0035264 [multicellular organism growth] evidence: IEA
GeneID:2068 -> Biological process: GO:0035315 [hair cell differentiation] evidence: IMP
GeneID:2068 -> Biological process: GO:0040016 [embryonic cleavage] evidence: IEA
GeneID:2068 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IEA
GeneID:2068 -> Biological process: GO:0043249 [erythrocyte maturation] evidence: IEA
GeneID:2068 -> Biological process: GO:0043388 [positive regulation of DNA binding] evidence: IEA
GeneID:2068 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:2068 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IDA
GeneID:2068 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA
GeneID:2068 -> Biological process: GO:0048820 [hair follicle maturation] evidence: IEA
GeneID:2068 -> Biological process: GO:0050434 [positive regulation of viral transcription] evidence: TAS
GeneID:2068 -> Biological process: GO:0060218 [hematopoietic stem cell differentiation] evidence: IEA
GeneID:2068 -> Cellular component: GO:0000441 [SSL2-core TFIIH complex] evidence: IEA
GeneID:2068 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:2068 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:2068 -> Cellular component: GO:0005675 [holo TFIIH complex] evidence: IDA
GeneID:2068 -> Cellular component: GO:0005675 [holo TFIIH complex] evidence: TAS
GeneID:2068 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:2068 -> Cellular component: GO:0005819 [spindle] evidence: IDA
GeneID:2068 -> Cellular component: GO:0019907 [cyclin-dependent protein kinase activating kinase holoenzyme complex] evidence: IDA
GeneID:2068 -> Cellular component: GO:0071817 [MMXD complex] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_000391 -> EC 3.6.4.12
by
@meso_cacase at
DBCLS
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