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2019-03-26 15:04:42, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_000376               4669 bp    mRNA    linear   PRI 15-JUL-2013
DEFINITION  Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor (VDR),
            transcript variant 1, mRNA.
ACCESSION   NM_000376
VERSION     NM_000376.2  GI:63054843
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4669)
  AUTHORS   Asano,L., Ito,I., Kuwabara,N., Waku,T., Yanagisawa,J., Miyachi,H.
            and Shimizu,T.
  TITLE     Structural basis for vitamin D receptor agonism by novel
            non-secosteroidal ligands
  JOURNAL   FEBS Lett. 587 (7), 957-963 (2013)
   PUBMED   23462137
  REMARK    GeneRIF: Data indicate that ligands changed the conformation of the
            vitamin D receptor (VDR), resulting in different hydrogen-bond
            networks depending on the potency of the ligand.
REFERENCE   2  (bases 1 to 4669)
  AUTHORS   Li,L., Wu,B., Liu,J.Y. and Yang,L.B.
  TITLE     Vitamin D receptor gene polymorphisms and type 2 diabetes: a
            meta-analysis
  JOURNAL   Arch. Med. Res. 44 (3), 235-241 (2013)
   PUBMED   23506721
  REMARK    GeneRIF: meta-analysis suggests that the FokI polymorphism of the
            VDR gene could be a risk factor for type 2 diabetes, especially in
            an Asian population
REFERENCE   3  (bases 1 to 4669)
  AUTHORS   Tiosano,D., Wildbaum,G., Gepstein,V., Verbitsky,O., Weisman,Y.,
            Karin,N. and Eztioni,A.
  TITLE     The role of vitamin D receptor in innate and adaptive immunity: a
            study in hereditary vitamin D-resistant rickets patients
  JOURNAL   J. Clin. Endocrinol. Metab. 98 (4), 1685-1693 (2013)
   PUBMED   23482605
  REMARK    GeneRIF: The role of vitamin D receptor in innate and adaptive
            immunity in vitamin D-resistant rickets.
REFERENCE   4  (bases 1 to 4669)
  AUTHORS   Chesney,R.W. and Han,X.
  TITLE     Differential regulation of TauT by calcitriol and retinoic acid via
            VDR/RXR in LLC-PK1 and MCF-7 cells
  JOURNAL   Adv. Exp. Med. Biol. 776, 291-305 (2013)
   PUBMED   23392891
  REMARK    GeneRIF: Expression of TauT is differentially regulated by Vitamin
            D(3) and retinoic acid via formation of VDR and RXR complexes in
            the nuclei in a cell type-dependent manner.
REFERENCE   5  (bases 1 to 4669)
  AUTHORS   Pervin,S., Hewison,M., Braga,M., Tran,L., Chun,R., Karam,A.,
            Chaudhuri,G., Norris,K. and Singh,R.
  TITLE     Down-regulation of vitamin D receptor in mammospheres: implications
            for vitamin D resistance in breast cancer and potential for
            combination therapy
  JOURNAL   PLoS ONE 8 (1), E53287 (2013)
   PUBMED   23341935
  REMARK    GeneRIF: Inhibition of VDR expression by siRNA led to a significant
            change in key epithelial mesenchymal transition-specific
            transcription factors and increased the ability of these cells to
            form mammospheres.
REFERENCE   6  (bases 1 to 4669)
  AUTHORS   Goto,H., Chen,K.S., Prahl,J.M. and DeLuca,H.F.
  TITLE     A single receptor identical with that from intestine/T47D cells
            mediates the action of 1,25-dihydroxyvitamin D-3 in HL-60 cells
  JOURNAL   Biochim. Biophys. Acta 1132 (1), 103-108 (1992)
   PUBMED   1324736
REFERENCE   7  (bases 1 to 4669)
  AUTHORS   Bugge,T.H., Pohl,J., Lonnoy,O. and Stunnenberg,H.G.
  TITLE     RXR alpha, a promiscuous partner of retinoic acid and thyroid
            hormone receptors
  JOURNAL   EMBO J. 11 (4), 1409-1418 (1992)
   PUBMED   1314167
REFERENCE   8  (bases 1 to 4669)
  AUTHORS   Szpirer,J., Szpirer,C., Riviere,M., Levan,G., Marynen,P.,
            Cassiman,J.J., Wiese,R. and DeLuca,H.F.
  TITLE     The Sp1 transcription factor gene (SP1) and the
            1,25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized on
            human chromosome arm 12q and rat chromosome 7
  JOURNAL   Genomics 11 (1), 168-173 (1991)
   PUBMED   1662663
REFERENCE   9  (bases 1 to 4669)
  AUTHORS   Saijo,T., Ito,M., Takeda,E., Huq,A.H., Naito,E., Yokota,I.,
            Sone,T., Pike,J.W. and Kuroda,Y.
  TITLE     A unique mutation in the vitamin D receptor gene in three Japanese
            patients with vitamin D-dependent rickets type II: utility of
            single-strand conformation polymorphism analysis for heterozygous
            carrier detection
  JOURNAL   Am. J. Hum. Genet. 49 (3), 668-673 (1991)
   PUBMED   1652893
REFERENCE   10 (bases 1 to 4669)
  AUTHORS   Yu,X.P., Mocharla,H., Hustmyer,F.G. and Manolagas,S.C.
  TITLE     Vitamin D receptor expression in human lymphocytes. Signal
            requirements and characterization by western blots and DNA
            sequencing
  JOURNAL   J. Biol. Chem. 266 (12), 7588-7595 (1991)
   PUBMED   1850412
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC121338.6, CF138099.1,
            BC060832.1, AC004466.1, J03258.1, BM908433.1 and BQ002808.1.
            On May 5, 2005 this sequence version replaced gi:4507882.
            
            Summary: This gene encodes the nuclear hormone receptor for vitamin
            D3. This receptor also functions as a receptor for the secondary
            bile acid lithocholic acid. The receptor belongs to the family of
            trans-acting transcriptional regulatory factors and shows sequence
            similarity to the steroid and thyroid hormone receptors. Downstream
            targets of this nuclear hormone receptor are principally involved
            in mineral metabolism though the receptor regulates a variety of
            other metabolic pathways, such as those involved in the immune
            response and cancer. Mutations in this gene are associated with
            type II vitamin D-resistant rickets. A single nucleotide
            polymorphism in the initiation codon results in an alternate
            translation start site three codons downstream. Alternative
            splicing results in multiple transcript variants encoding different
            proteins. [provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (1) differs in the 5' UTR and
            coding sequence compared to variant 3. The resulting isoform (VDRA)
            is shorter at the N-terminus compared to isoform VDRB1. Variants 1
            and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J03258.1, AK225844.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC121338.6         15879-15894         c
            17-158              CF138099.1         7-148
            159-3422            BC060832.1         522-3785
            3423-3423           AC004466.1         48367-48367
            3424-3546           BC060832.1         3787-3909
            3547-3566           J03258.1           3499-3518
            3567-3854           J03258.1           3520-3807
            3855-3906           J03258.1           3809-3860
            3907-3978           J03258.1           3862-3933
            3979-4403           BM908433.1         185-609
            4404-4615           J03258.1           4356-4567
            4616-4650           J03258.1           4569-4603
            4651-4669           BQ002808.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..4669
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.11"
     gene            1..4669
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /note="vitamin D (1,25- dihydroxyvitamin D3) receptor"
                     /db_xref="GeneID:7421"
                     /db_xref="HGNC:12679"
                     /db_xref="HPRD:03463"
                     /db_xref="MIM:601769"
     exon            1..77
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /inference="alignment:Splign:1.39.8"
     variation       29
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11574011"
     exon            78..158
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /inference="alignment:Splign:1.39.8"
     exon            159..306
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /inference="alignment:Splign:1.39.8"
     CDS             161..1444
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /note="isoform VDRA is encoded by transcript variant 1;
                     vitamin D3 receptor; vitamin D nuclear receptor variant 1;
                     1,25-dihydroxyvitamin D3 receptor; nuclear receptor
                     subfamily 1 group I member 1"
                     /codon_start=1
                     /product="vitamin D3 receptor isoform VDRA"
                     /protein_id="NP_000367.1"
                     /db_xref="GI:4507883"
                     /db_xref="CCDS:CCDS8757.1"
                     /db_xref="GeneID:7421"
                     /db_xref="HGNC:12679"
                     /db_xref="HPRD:03463"
                     /db_xref="MIM:601769"
                     /translation="
MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGNEIS
"
     misc_feature    170..172
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /note="Region: alternate start codon"
     misc_feature    206..526
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /note="DNA-binding domain of vitamin D receptors (VDR) is
                     composed of two C4-type zinc fingers; Region: NR_DBD_VDR;
                     cd06955"
                     /db_xref="CDD:143513"
     misc_feature    order(230..232,239..241,281..283,290..292,338..340,
                     356..358,386..388,395..397)
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /note="zinc binding site [ion binding]; other site"
                     /db_xref="CDD:143513"
     misc_feature    order(260..268,284..289,293..295,305..310,377..382,
                     398..400,440..445,458..460)
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143513"
     misc_feature    order(341..346,383..385,434..439)
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:143513"
     misc_feature    449..733
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P11473.1);
                     Region: Hinge"
     misc_feature    530..>637
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /note="The ligand binding domain of nuclear receptors, a
                     family of ligand-activated transcription regulators;
                     Region: NR_LBD; cl11397"
                     /db_xref="CDD:209301"
     misc_feature    734..1441
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P11473.1);
                     Region: Ligand-binding"
     misc_feature    782..784
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:00277"
     misc_feature    827..1438
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /note="The ligand binding domain of vitamin D receptors, a
                     member of the nuclear receptor superfamily; Region:
                     NR_LBD_VDR; cd06933"
                     /db_xref="CDD:132731"
     misc_feature    order(839..841,848..850,857..862,869..871,971..973,
                     980..985,992..994,1016..1018,1022..1024,1058..1060,
                     1067..1069,1073..1075,1349..1351,1361..1363,1370..1372)
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:132731"
     misc_feature    839..871
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P11473.1);
                     Region: Vitamin D3 binding"
     misc_feature    order(884..886,896..898,914..916,929..931,935..940,
                     950..952,1406..1411,1418..1423,1433..1438)
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /note="coactivator recognition site [polypeptide binding];
                     other site"
                     /db_xref="CDD:132731"
     misc_feature    971..994
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P11473.1);
                     Region: Vitamin D3 binding"
     variation       162
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2228570"
     variation       217
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2228572"
     exon            307..437
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /inference="alignment:Splign:1.39.8"
     exon            438..622
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /inference="alignment:Splign:1.39.8"
     variation       604
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2229828"
     exon            623..743
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /inference="alignment:Splign:1.39.8"
     exon            744..915
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /inference="alignment:Splign:1.39.8"
     variation       848
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11574090"
     exon            916..1067
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /inference="alignment:Splign:1.39.8"
     STS             930..1037
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /standard_name="VDR"
                     /db_xref="UniSTS:503993"
     exon            1068..1184
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /inference="alignment:Splign:1.39.8"
     variation       1069
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12721365"
     exon            1185..4653
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /inference="alignment:Splign:1.39.8"
     variation       1210
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4987032"
     variation       1216
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:731236"
     variation       1245
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11574115"
     variation       1366
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2229829"
     STS             1384..1965
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /standard_name="VDRU1"
                     /db_xref="UniSTS:463500"
     variation       1628
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11574116"
     variation       1666
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11574117"
     variation       1853
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11574118"
     STS             1878..2489
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /standard_name="VDRU2"
                     /db_xref="UniSTS:463501"
     variation       1881
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11574119"
     variation       1972
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11574120"
     variation       2045
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11574121"
     variation       2092
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11574122"
     variation       2133
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11574123"
     variation       2192
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11574124"
     variation       2237
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11574125"
     variation       2238
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11574126"
     variation       2336
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11574127"
     STS             2398..3022
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /standard_name="VDRU3"
                     /db_xref="UniSTS:463502"
     STS             2622..2764
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /standard_name="WI-17447"
                     /db_xref="UniSTS:55150"
     variation       2623..2624
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:201007499"
     variation       2623
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:11574128"
     variation       2670
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11574129"
     variation       2693..2694
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace=""
                     /replace="ccagc"
                     /db_xref="dbSNP:11574130"
     variation       2763
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11574131"
     variation       2921
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11574132"
     STS             2947..3535
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /standard_name="VDRU4"
                     /db_xref="UniSTS:463503"
     variation       2964
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:11574133"
     variation       3110
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11574134"
     variation       3285
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:12088"
     variation       3309
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11540149"
     variation       3350
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:9729"
     variation       3467
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11574135"
     STS             3470..4124
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /standard_name="VDRU5"
                     /db_xref="UniSTS:463504"
     STS             3470..3868
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /standard_name="VDRU5-PoA"
                     /db_xref="UniSTS:463505"
     variation       3581
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12721386"
     variation       3587
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:2853562"
     variation       3670
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11574136"
     variation       3900
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11574137"
     variation       4037
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11168263"
     variation       4235
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2853563"
     variation       4271
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11574138"
     STS             4373..4545
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /standard_name="RH17584"
                     /db_xref="UniSTS:5822"
     variation       4418
                     /gene="VDR"
                     /gene_synonym="NR1I1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:11574139"
     polyA_signal    4631..4636
                     /gene="VDR"
                     /gene_synonym="NR1I1"
     polyA_site      4653
                     /gene="VDR"
                     /gene_synonym="NR1I1"
ORIGIN      
ctgcttgtcaaaaggcggcagcggagccgtgtgcgccgggagcgcggaacagcttgtccacccgccggccggaccagaagcctttgggtctgaagtgtctgtgagacctcacagaagagcacccctgggctccacttacctgccccctgctccttcagggatggaggcaatggcggccagcacttccctgcctgaccctggagactttgaccggaacgtgccccggatctgtggggtgtgtggagaccgagccactggctttcacttcaatgctatgacctgtgaaggctgcaaaggcttcttcaggcgaagcatgaagcggaaggcactattcacctgccccttcaacggggactgccgcatcaccaaggacaaccgacgccactgccaggcctgccggctcaaacgctgtgtggacatcggcatgatgaaggagttcattctgacagatgaggaagtgcagaggaagcgggagatgatcctgaagcggaaggaggaggaggccttgaaggacagtctgcggcccaagctgtctgaggagcagcagcgcatcattgccatactgctggacgcccaccataagacctacgaccccacctactccgacttctgccagttccggcctccagttcgtgtgaatgatggtggagggagccatccttccaggcccaactccagacacactcccagcttctctggggactcctcctcctcctgctcagatcactgtatcacctcttcagacatgatggactcgtccagcttctccaatctggatctgagtgaagaagattcagatgacccttctgtgaccctagagctgtcccagctctccatgctgccccacctggctgacctggtcagttacagcatccaaaaggtcattggctttgctaagatgataccaggattcagagacctcacctctgaggaccagatcgtactgctgaagtcaagtgccattgaggtcatcatgttgcgctccaatgagtccttcaccatggacgacatgtcctggacctgtggcaaccaagactacaagtaccgcgtcagtgacgtgaccaaagccggacacagcctggagctgattgagcccctcatcaagttccaggtgggactgaagaagctgaacttgcatgaggaggagcatgtcctgctcatggccatctgcatcgtctccccagatcgtcctggggtgcaggacgccgcgctgattgaggccatccaggaccgcctgtccaacacactgcagacgtacatccgctgccgccacccgcccccgggcagccacctgctctatgccaagatgatccagaagctagccgacctgcgcagcctcaatgaggagcactccaagcagtaccgctgcctctccttccagcctgagtgcagcatgaagctaacgccccttgtgctcgaagtgtttggcaatgagatctcctgactaggacagcctgtggcggtgcctgggtggggctgctcctccagggccacgtgccaggcccggggctggcggctactcagcagccctcctcaccccgtctggggttcagcccctcctctgccacctcccctatccacccagcccattctctctcctgtccaacctaacccctttcctgcgggcttttccccggtcccttgagacctcagccatgaggagttgctgtttgtttgacaaagaaacccaagtgggggcagagggcagaggctggaggcagggccttgcccagagatgcctccaccgctgcctaagtggctgctgactgatgttgagggaacagacaggagaaatgcatccattcctcagggacagagacacctgcacctccccccactgcaggccccgcttgtccagcgcctagtggggtctccctctcctgcctactcacgataaataatcggcccacagctcccaccccacccccttcagtgcccaccaacatcccattgccctggttatattctcacgggcagtagctgtggtgaggtgggttttcttcccatcactggagcaccaggcacgaacccacctgctgagagacccaaggaggaaaaacagacaaaaacagcctcacagaagaatatgacagctgtccctgtcaccaagctcacagttcctcgccctgggtctaaggggttggttgaggtggaagccctccttccacggatccatgtagcaggactgaattgtccccagtttgcagaaaagcacctgccgacctcgtcctccccctgccagtgccttacctcctgcccaggagagccagccctccctgtcctcctcggatcaccgagagtagccgagagcctgctcccccaccccctccccaggggagagggtctggagaagcagtgagccgcatcttctccatctggcagggtgggatggaggagaagaattttcagaccccagcggctgagtcatgatctccctgccgcctcaatgtggttgcaaggccgctgttcacccacagggctaagagctagcgctgccgcaccccagagtgtgggaagggagagcggggcagtctcgggtggctagtcagagagagtgtttgggggttccgtgatgtagggtaaggtgccttcttattctcactccaccacccaaaagtcaaaaggtgcctgtgaggcaggggcggagtgatacaacttcaagtgcatgctctctgcagccagcccagcccagctggtgggaagcgtctgtccgtttactccaaggtggggtctttgtgagagtgagctgtaggtgtgcgggaccggtacagaaaggcgttcttcgaggtggatcacagaggcttcttcagatcagtgcttgagtttggggaatgcggccgcattccctgagtcaccaggaatgttaaagtcagtgggaacgtgactgccccaactcctggaagctgtgtccttgcacctgcatccgtagttccctgaaaacccagagaggaatcagacttcacactgcaagagccttggtgtccacctggccccatgtctctcagaattcttcaggtggaaaaacatctgaaagccacgttccttactgcagaatagcatatatatcgcttaatcttaaatttattagatatgagttgttttcagactcagactccatttgtattatagtctaatatacagggtagcaggtaccactgatttggagatatttatggggggagaacttacattgtgaaacttctgtacattaattattattgctgttgttattttacaagggtctagggagagacccttgtttgattttagctgcagaacgtattggtccagcttgctcttcagtgggagaaaacacttgtaagttgctaaacgagtcaatcccctcattcaggaaaactgacagaggagggcgtgactcacccaagcatatataactagctagaagtgggccaggacaggcccggcgcggtggctcacgcctgtaatcccagcagtttgggaggtcgaggtaggtggatcacctgaggtcgggagttcgagaccaacctgaccaacatggagaaaccctgtctctattaaaaatacaaaaaaaaaaaaaaaaaaaatagccgggcatggtggcgcaagcctgtaatcccagctactcaggaggctgaggcagaagaattgaacccaggaggtggaggttgcagtgagctgagatcgtgccgttactctccaacctggacaacaagagcgaaactccgtcttagaagtggaccaggacaggaccagattttggagtcatggtccggtgtccttttcactacaccatgtttgagctcagacccccactctcattccccaggtggctgacccagtccctgggggaagccctggatttcagaaagagcaagtctggatctgggaccctttccttccttccctggcttgtaactccaccaacccatcagaaggagaaggaaggagactcacctctgcctcaatgtgaatcagaccctaccccaccacgatgtggccctggcctgctgggctctccacctcagccttggataatgctgttgcctcatctataacatgcatttgtctttgtaatgtcaccaccttcccagctctccctctggccctgccttcttcggggaactcctggaaatatcagttactcagccctgggccccaccacctaggccactcctccaaaggaagtctaggagctgggaggaaaagaaaagaggggaaaatgagtttttatggggctgaacggggagaaaaggtcatcatcgattctactttagaatgagagtgtgaaatagacatttgtaaatgtaaaacttttaaggtatatcattataactgaaggagaaggtgccccaaaatgcaagattttccacaagattcccagagacaggaaaatcctctggctggctaactggaagcatgtaggagaatccaagcgaggtcaacagagaaggcaggaatgtgtggcagatttagtgaaagctagagatatggcagcgaaaggatgtaaacagtgcctgctgaatgatttccaaagagaaaaaaagtttgccagaagtttgtcaagtcaaccaatgtagaaagctttgcttatggtaataaaaatggctcatacttatatagcacttactttgttgcaagtactgctgtaaataaatgctttatgcaaaccaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:7421 -> Molecular function: GO:0003677 [DNA binding] evidence: IDA
            GeneID:7421 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IDA
            GeneID:7421 -> Molecular function: GO:0003707 [steroid hormone receptor activity] evidence: IEA
            GeneID:7421 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:7421 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
            GeneID:7421 -> Molecular function: GO:0008434 [calcitriol receptor activity] evidence: IDA
            GeneID:7421 -> Molecular function: GO:0038186 [lithocholic acid receptor activity] evidence: IDA
            GeneID:7421 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:7421 -> Molecular function: GO:0046965 [retinoid X receptor binding] evidence: IPI
            GeneID:7421 -> Molecular function: GO:0070644 [vitamin D response element binding] evidence: IDA
            GeneID:7421 -> Molecular function: GO:1902098 [calcitriol binding] evidence: IDA
            GeneID:7421 -> Molecular function: GO:1902121 [lithocholic acid binding] evidence: IDA
            GeneID:7421 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:7421 -> Biological process: GO:0000902 [cell morphogenesis] evidence: IMP
            GeneID:7421 -> Biological process: GO:0006367 [transcription initiation from RNA polymerase II promoter] evidence: TAS
            GeneID:7421 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
            GeneID:7421 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IDA
            GeneID:7421 -> Biological process: GO:0010467 [gene expression] evidence: TAS
            GeneID:7421 -> Biological process: GO:0010628 [positive regulation of gene expression] evidence: IMP
            GeneID:7421 -> Biological process: GO:0010839 [negative regulation of keratinocyte proliferation] evidence: IMP
            GeneID:7421 -> Biological process: GO:0010980 [positive regulation of vitamin D 24-hydroxylase activity] evidence: IDA
            GeneID:7421 -> Biological process: GO:0038183 [bile acid signaling pathway] evidence: IDA
            GeneID:7421 -> Biological process: GO:0045618 [positive regulation of keratinocyte differentiation] evidence: IMP
            GeneID:7421 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
            GeneID:7421 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IMP
            GeneID:7421 -> Biological process: GO:0046697 [decidualization] evidence: IEP
            GeneID:7421 -> Biological process: GO:0060558 [regulation of calcidiol 1-monooxygenase activity] evidence: ISS
            GeneID:7421 -> Biological process: GO:0070561 [vitamin D receptor signaling pathway] evidence: IDA
            GeneID:7421 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:7421 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS

by @meso_cacase at DBCLS
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