GGRNA Home | Help | Advanced search

2024-03-29 15:36:48, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_000211               2977 bp    mRNA    linear   PRI 15-JUL-2013
DEFINITION  Homo sapiens integrin, beta 2 (complement component 3 receptor 3
            and 4 subunit) (ITGB2), transcript variant 1, mRNA.
ACCESSION   NM_000211
VERSION     NM_000211.3  GI:188595673
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2977)
  AUTHORS   Jerke,U., Rolle,S., Purfurst,B., Luft,F.C., Nauseef,W.M. and
            Kettritz,R.
  TITLE     beta2 integrin-mediated cell-cell contact transfers active
            myeloperoxidase from neutrophils to endothelial cells
  JOURNAL   J. Biol. Chem. 288 (18), 12910-12919 (2013)
   PUBMED   23532856
  REMARK    GeneRIF: EC uptake of soluble MPO, namely the cell
            contact-dependent, beta2 integrin-mediated transfer from
            neutrophils. The findings could be of therapeutic relevance in
            atherosclerosis and vasculitis.
REFERENCE   2  (bases 1 to 2977)
  AUTHORS   Reed,J.H., Jain,M., Lee,K., Kandimalla,E.R., Faridi,M.H.,
            Buyon,J.P., Gupta,V. and Clancy,R.M.
  TITLE     Complement receptor 3 influences toll-like receptor 7/8-dependent
            inflammation: implications for autoimmune diseases characterized by
            antibody reactivity to ribonucleoproteins
  JOURNAL   J. Biol. Chem. 288 (13), 9077-9083 (2013)
   PUBMED   23386618
  REMARK    GeneRIF: Complement receptor 3 influences toll-like receptor
            7/8-dependent inflammation
REFERENCE   3  (bases 1 to 2977)
  AUTHORS   Ding,W., Shimada,H., Li,L., Mittal,R., Zhang,X., Shudo,K., He,Q.,
            Prasadarao,N.V. and Wu,L.
  TITLE     Retinoid agonist Am80-enhanced neutrophil bactericidal activity
            arising from granulopoiesis in vitro and in a neutropenic mouse
            model
  JOURNAL   Blood 121 (6), 996-1007 (2013)
   PUBMED   23243275
  REMARK    GeneRIF: Studies suggest that Am80 promote bactericidal activities
            probably through coordinating the functional interaction of CD66
            with CD18 to enhance the development of neutrophil immunity during
            granulopoiesis.
REFERENCE   4  (bases 1 to 2977)
  AUTHORS   Reinholdt,J., Poulsen,K., Brinkmann,C.R., Hoffmann,S.V.,
            Stapulionis,R., Enghild,J.J., Jensen,U.B., Boesen,T. and
            Vorup-Jensen,T.
  TITLE     Monodisperse and LPS-free Aggregatibacter actinomycetemcomitans
            leukotoxin: interactions with human beta2 integrins and
            erythrocytes
  JOURNAL   Biochim. Biophys. Acta 1834 (2), 546-558 (2013)
   PUBMED   23234758
  REMARK    GeneRIF: Monodisperse and LPS-free Aggregatibacter
            actinomycetemcomitans leukotoxin: interactions with human beta2
            integrins and erythrocytes.
REFERENCE   5  (bases 1 to 2977)
  AUTHORS   Sarvari,M., Hrabovszky,E., Kallo,I., Solymosi,N., Liko,I.,
            Berchtold,N., Cotman,C. and Liposits,Z.
  TITLE     Menopause leads to elevated expression of macrophage-associated
            genes in the aging frontal cortex: rat and human studies identify
            strikingly similar changes
  JOURNAL   J Neuroinflammation 9, 264 (2012)
   PUBMED   23206327
  REMARK    GeneRIF: This study analysis revealed up-regulation of CD14, CD18,
            CD45, TLR2, TLR4, CD74, C1q, C3, CCL2, and down-regulation of CD36,
            CX3CR1, CX3CL1 and CD200 in postmenopausal women.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2977)
  AUTHORS   Corbi,A.L., Vara,A., Ursa,A., Garcia Rodriguez,M.C., Fontan,G. and
            Sanchez-Madrid,F.
  TITLE     Molecular basis for a severe case of leukocyte adhesion deficiency
  JOURNAL   Eur. J. Immunol. 22 (7), 1877-1881 (1992)
   PUBMED   1352501
REFERENCE   7  (bases 1 to 2977)
  AUTHORS   Matsuura,S., Kishi,F., Tsukahara,M., Nunoi,H., Matsuda,I.,
            Kobayashi,K. and Kajii,T.
  TITLE     Leukocyte adhesion deficiency: identification of novel mutations in
            two Japanese patients with a severe form
  JOURNAL   Biochem. Biophys. Res. Commun. 184 (3), 1460-1467 (1992)
   PUBMED   1590804
REFERENCE   8  (bases 1 to 2977)
  AUTHORS   Back,A.L., Kwok,W.W. and Hickstein,D.D.
  TITLE     Identification of two molecular defects in a child with leukocyte
            adherence deficiency
  JOURNAL   J. Biol. Chem. 267 (8), 5482-5487 (1992)
   PUBMED   1347532
REFERENCE   9  (bases 1 to 2977)
  AUTHORS   Nelson,C., Rabb,H. and Arnaout,M.A.
  TITLE     Genetic cause of leukocyte adhesion molecule deficiency. Abnormal
            splicing and a missense mutation in a conserved region of CD18
            impair cell surface expression of beta 2 integrins
  JOURNAL   J. Biol. Chem. 267 (5), 3351-3357 (1992)
   PUBMED   1346613
REFERENCE   10 (bases 1 to 2977)
  AUTHORS   Petersen,M.B., Slaugenhaupt,S.A., Lewis,J.G., Warren,A.C.,
            Chakravarti,A. and Antonarakis,S.E.
  TITLE     A genetic linkage map of 27 markers on human chromosome 21
  JOURNAL   Genomics 9 (3), 407-419 (1991)
   PUBMED   1674496
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA200537.1, AK128344.1,
            BC005861.2, AL773603.1 and M15395.1.
            This sequence is a reference standard in the RefSeqGene project.
            On May 21, 2008 this sequence version replaced gi:89191864.
            
            Summary: The product of this gene belongs to the integrin beta
            chain family of proteins. Integrins are integral cell-surface
            proteins composed of an alpha chain and a beta chain. This gene
            encodes the integrin beta chain beta 2. A given chain may combine
            with multiple partners resulting in different integrins. For
            example, beta 2 combines with the alpha L chain to form the
            integrin LFA-1, and combines with the alpha M chain to form the
            integrin Mac-1. Integrins are known to participate in cell adhesion
            as well as cell-surface mediated signalling. Defects in this gene
            are the cause of leukocyte adhesion deficiency type I (LAD1). Two
            transcript variants encoding the same protein have been identified
            for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222505.1, M15395.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               DA200537.1         221-371
            152-380             AK128344.1         1-229
            381-1294            BC005861.2         192-1105
            1295-1295           AL773603.1         91061-91061         c
            1296-1555           AK128344.1         1121-1380
            1556-2614           M15395.1           1395-2453
            2615-2665           M15395.1           2455-2505
            2666-2977           BC005861.2         2477-2788
FEATURES             Location/Qualifiers
     source          1..2977
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..2977
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /note="integrin, beta 2 (complement component 3 receptor 3
                     and 4 subunit)"
                     /db_xref="GeneID:3689"
                     /db_xref="HGNC:6155"
                     /db_xref="MIM:600065"
     exon            1..230
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    96..98
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /note="upstream in-frame stop codon"
     variation       123
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2070947"
     variation       211
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1140646"
     exon            231..291
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:1.39.8"
     CDS             234..2543
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /note="integrin beta-2; cell surface adhesion glycoprotein
                     LFA-1/CR3/P150,959 beta subunit precursor);
                     leukocyte-associated antigens CD18/11A, CD18/11B,
                     CD18/11C; complement receptor C3 beta-subunit; leukocyte
                     cell adhesion molecule CD18; integrin beta chain, beta 2;
                     complement receptor C3 subunit beta; cell surface adhesion
                     glycoproteins LFA-1/CR3/p150,95 subunit beta"
                     /codon_start=1
                     /product="integrin beta-2 precursor"
                     /protein_id="NP_000202.2"
                     /db_xref="GI:89191865"
                     /db_xref="CCDS:CCDS13716.1"
                     /db_xref="GeneID:3689"
                     /db_xref="HGNC:6155"
                     /db_xref="MIM:600065"
                     /translation="
MLGLRPPLLALVGLLSLGCVLSQECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSIRCDTRPQLLMRGCAADDIMDPTSLAETQEDHNGGQKQLSPQKVTLYLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFVNTHPDKLRNPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKRSNEFDYPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSEDSSNVVQLIKNAYNKLSSRVFLDHNALPDTLKVTYDSFCSNGVTHRNQPRGDCDGVQINVPITFQVKVTATECIQEQSFVIRALGFTDIVTVQVLPQCECRCRDQSRDRSLCHGKGFLECGICRCDTGYIGKNCECQTQGRSSQELEGSCRKDNNSIICSGLGDCVCGQCLCHTSDVPGKLIYGQYCECDTINCERYNGQVCGGPGRGLCFCGKCRCHPGFEGSACQCERTTEGCLNPRRVECSGRGRCRCNVCECHSGYQLPLCQECPGCPSPCGKYISCAECLKFEKGPFGKNCSAACPGLQLSNNPVKGRTCKERDSEGCWVAYTLEQQDGMDRYLIYVDESRECVAGPNIAAIVGGTVAGIVLIGILLLVIWKALIHLSDLREYRRFEKEKLKSQWNNDNPLFKSATTTVMNPKFAES
"
     sig_peptide     234..299
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     mat_peptide     300..2540
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /product="integrin beta-2"
     misc_feature    300..302
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05107.2);
                     other site"
     misc_feature    327..1574
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /note="Integrin, beta chain; Region: Integrin_beta;
                     pfam00362"
                     /db_xref="CDD:201181"
     misc_feature    1422..1430
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05107.2);
                     Region: Cell attachment site (Potential)"
     misc_feature    1578..2084
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05107.2);
                     Region: Cysteine-rich tandem repeats"
     misc_feature    2097..2333
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /note="Integrin beta tail domain; Region: Integrin_B_tail;
                     pfam07965"
                     /db_xref="CDD:149183"
     misc_feature    2334..2402
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05107.2);
                     transmembrane region"
     misc_feature    2403..2537
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /note="Integrin beta cytoplasmic domain; Region:
                     Integrin_b_cyt; pfam08725"
                     /db_xref="CDD:149701"
     misc_feature    2466..2468
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by PKC; propagated from
                     UniProtKB/Swiss-Prot (P05107.2); phosphorylation site"
     misc_feature    2466..2468
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01499"
     misc_feature    2466..2468
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01501"
     misc_feature    2499..2501
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05107.2); phosphorylation site"
     misc_feature    2499..2501
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01501"
     misc_feature    2505..2507
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by PKC, in vitro; propagated from
                     UniProtKB/Swiss-Prot (P05107.2); phosphorylation site"
     misc_feature    2505..2507
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01498"
     misc_feature    2505..2507
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01499"
     misc_feature    2505..2507
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01501"
     misc_feature    2505..2507
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:05669"
     misc_feature    2511..2513
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by PKC/PRKCA, in vitro;
                     propagated from UniProtKB/Swiss-Prot (P05107.2);
                     phosphorylation site"
     misc_feature    2511..2513
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01498"
     variation       264
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:5030667"
     exon            292..380
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:1.39.8"
     variation       350
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35903905"
     STS             374..508
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /standard_name="RH93593"
                     /db_xref="UniSTS:92737"
     exon            381..561
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:1.39.8"
     exon            562..732
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:1.39.8"
     exon            733..974
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:1.39.8"
     exon            975..1130
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:1.39.8"
     variation       1052
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2230528"
     variation       1082
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35013643"
     exon            1131..1226
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:1.39.8"
     variation       1139
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35370671"
     exon            1227..1316
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:1.39.8"
     exon            1317..1457
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:1.39.8"
     variation       1334
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2230529"
     exon            1458..1645
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:1.39.8"
     STS             1485..1631
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /standard_name="GDB:373059"
                     /db_xref="UniSTS:156893"
     variation       1556
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:235326"
     variation       1558..1561
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /replace=""
                     /replace="ttcc"
                     /db_xref="dbSNP:34737082"
     exon            1646..1890
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:1.39.8"
     STS             1647..1878
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /standard_name="PMC129056P1"
                     /db_xref="UniSTS:270585"
     variation       1775
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2230530"
     exon            1891..2110
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:1.39.8"
     STS             1891..2110
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /standard_name="PMC129056P2"
                     /db_xref="UniSTS:270586"
     exon            2111..2313
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:1.39.8"
     variation       2121
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2230531"
     exon            2314..2480
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:1.39.8"
     exon            2481..2958
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:1.39.8"
     STS             2516..2740
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /standard_name="STS-M15395"
                     /db_xref="UniSTS:28058"
     STS             2523..2847
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /standard_name="G60035"
                     /db_xref="UniSTS:137301"
     STS             2544..2886
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /standard_name="GDB:185175"
                     /db_xref="UniSTS:155430"
     STS             2614..2817
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /standard_name="G44333"
                     /db_xref="UniSTS:95120"
     STS             2616..2829
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /standard_name="GDB:181564"
                     /db_xref="UniSTS:155290"
     variation       2665
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:684"
     variation       2714
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:6570"
     variation       2811
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1063594"
     polyA_signal    2927..2932
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
     polyA_site      2958
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
ORIGIN      
gggccgctctctgacatcagagctgctgtagagcggagaggggcaggggtgaagggccacggtggtgcaacccaccacttcctccaaggaggagctgagaggaacaggaagtgtcaggactttacgacccgcgcctccagctgaggtttctagacgtgacccagggcagactggtagcaaagcccccacgcccagccaggagcaccgccgaggactccagcacaccgagggacatgctgggcctgcgccccccactgctcgccctggtggggctgctctccctcgggtgcgtcctctctcaggagtgcacgaagttcaaggtcagcagctgccgggaatgcatcgagtcggggcccggctgcacctggtgccagaagctgaacttcacagggccgggggatcctgactccattcgctgcgacacccggccacagctgctcatgaggggctgtgcggctgacgacatcatggaccccacaagcctcgctgaaacccaggaagaccacaatgggggccagaagcagctgtccccacaaaaagtgacgctttacctgcgaccaggccaggcagcagcgttcaacgtgaccttccggcgggccaagggctaccccatcgacctgtactatctgatggacctctcctactccatgcttgatgacctcaggaatgtcaagaagctaggtggcgacctgctccgggccctcaacgagatcaccgagtccggccgcattggcttcgggtccttcgtggacaagaccgtgctgccgttcgtgaacacgcaccctgataagctgcgaaacccatgccccaacaaggagaaagagtgccagcccccgtttgccttcaggcacgtgctgaagctgaccaacaactccaaccagtttcagaccgaggtcgggaagcagctgatttccggaaacctggatgcacccgagggtgggctggacgccatgatgcaggtcgccgcctgcccggaggaaatcggctggcgcaacgtcacgcggctgctggtgtttgccactgatgacggcttccatttcgcgggcgacgggaagctgggcgccatcctgacccccaacgacggccgctgtcacctggaggacaacttgtacaagaggagcaacgaattcgactacccatcggtgggccagctggcgcacaagctggctgaaaacaacatccagcccatcttcgcggtgaccagtaggatggtgaagacctacgagaaactcaccgagatcatccccaagtcagccgtgggggagctgtctgaggactccagcaatgtggtccaactcattaagaatgcttacaataaactctcctccagggtcttcctggatcacaacgccctccccgacaccctgaaagtcacctacgactccttctgcagcaatggagtgacgcacaggaaccagcccagaggtgactgtgatggcgtgcagatcaatgtcccgatcaccttccaggtgaaggtcacggccacagagtgcatccaggagcagtcgtttgtcatccgggcgctgggcttcacggacatagtgaccgtgcaggttcttccccagtgtgagtgccggtgccgggaccagagcagagaccgcagcctctgccatggcaagggcttcttggagtgcggcatctgcaggtgtgacactggctacattgggaaaaactgtgagtgccagacacagggccggagcagccaggagctggaaggaagctgccggaaggacaacaactccatcatctgctcagggctgggggactgtgtctgcgggcagtgcctgtgccacaccagcgacgtccccggcaagctgatatacgggcagtactgcgagtgtgacaccatcaactgtgagcgctacaacggccaggtctgcggcggcccggggagggggctctgcttctgcgggaagtgccgctgccacccgggctttgagggctcagcgtgccagtgcgagaggaccactgagggctgcctgaacccgcggcgtgttgagtgtagtggtcgtggccggtgccgctgcaacgtatgcgagtgccattcaggctaccagctgcctctgtgccaggagtgccccggctgcccctcaccctgtggcaagtacatctcctgcgccgagtgcctgaagttcgaaaagggcccctttgggaagaactgcagcgcggcgtgtccgggcctgcagctgtcgaacaaccccgtgaagggcaggacctgcaaggagagggactcagagggctgctgggtggcctacacgctggagcagcaggacgggatggaccgctacctcatctatgtggatgagagccgagagtgtgtggcaggccccaacatcgccgccatcgtcgggggcaccgtggcaggcatcgtgctgatcggcattctcctgctggtcatctggaaggctctgatccacctgagcgacctccgggagtacaggcgctttgagaaggagaagctcaagtcccagtggaacaatgataatccccttttcaagagcgccaccacgacggtcatgaaccccaagtttgctgagagttaggagcacttggtgaagacaaggccgtcaggacccaccatgtctgccccatcacgcggccgagacatggcttgccacagctcttgaggatgtcaccaattaaccagaaatccagttattttccgccctcaaaatgacagccatggccggccgggtgcttctgggggctcgtcggggggacagctccactctgactggcacagtctttgcatggagacttgaggagggagggcttgaggttggtgaggttaggtgcgtgtttcctgtgcaagtcaggacatcagtctgattaaaggtggtgccaatttatttacatttaaacttgtcagggtataaaatgacatcccattaattatattgttaatcaatcacgtgtatagaaaaaaaataaaacttcaatacaggctgtccatggaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:3689 -> Molecular function: GO:0001948 [glycoprotein binding] evidence: IPI
            GeneID:3689 -> Molecular function: GO:0004872 [receptor activity] evidence: IEA
            GeneID:3689 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IPI
            GeneID:3689 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
            GeneID:3689 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS
            GeneID:3689 -> Biological process: GO:0006915 [apoptotic process] evidence: NAS
            GeneID:3689 -> Biological process: GO:0006954 [inflammatory response] evidence: NAS
            GeneID:3689 -> Biological process: GO:0007155 [cell adhesion] evidence: TAS
            GeneID:3689 -> Biological process: GO:0007159 [leukocyte cell-cell adhesion] evidence: IDA
            GeneID:3689 -> Biological process: GO:0007160 [cell-matrix adhesion] evidence: IEA
            GeneID:3689 -> Biological process: GO:0007229 [integrin-mediated signaling pathway] evidence: NAS
            GeneID:3689 -> Biological process: GO:0007267 [cell-cell signaling] evidence: NAS
            GeneID:3689 -> Biological process: GO:0007275 [multicellular organismal development] evidence: IEA
            GeneID:3689 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
            GeneID:3689 -> Biological process: GO:0008360 [regulation of cell shape] evidence: NAS
            GeneID:3689 -> Biological process: GO:0030593 [neutrophil chemotaxis] evidence: IDA
            GeneID:3689 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS
            GeneID:3689 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:3689 -> Biological process: GO:0045123 [cellular extravasation] evidence: IEA
            GeneID:3689 -> Biological process: GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] evidence: IDA
            GeneID:3689 -> Biological process: GO:0050776 [regulation of immune response] evidence: TAS
            GeneID:3689 -> Biological process: GO:0050798 [activated T cell proliferation] evidence: IEA
            GeneID:3689 -> Biological process: GO:0050900 [leukocyte migration] evidence: TAS
            GeneID:3689 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
            GeneID:3689 -> Cellular component: GO:0008305 [integrin complex] evidence: NAS
            GeneID:3689 -> Cellular component: GO:0009986 [cell surface] evidence: IEA
            GeneID:3689 -> Cellular component: GO:0045121 [membrane raft] evidence: IEA

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.