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2024-04-25 02:27:58, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_000129 3863 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens coagulation factor XIII, A1 polypeptide (F13A1), mRNA.
ACCESSION NM_000129
VERSION NM_000129.3 GI:119395708
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3863)
AUTHORS Smith,K.A., Pease,R.J., Avery,C.A., Brown,J.M., Adamson,P.J.,
Cooke,E.J., Neergaard-Petersen,S., Cordell,P.A., Ariens,R.A.,
Fishwick,C.W., Philippou,H. and Grant,P.J.
TITLE The activation peptide cleft exposed by thrombin cleavage of
FXIII-A(2) contains a recognition site for the fibrinogen alpha
chain
JOURNAL Blood 121 (11), 2117-2126 (2013)
PUBMED 23303819
REMARK GeneRIF: The activation peptide cleft exposed by thrombin cleavage
of FXIII-A(2) contains a recognition site for the fibrinogen alpha
chain.
REFERENCE 2 (bases 1 to 3863)
AUTHORS Richardson,V.R., Cordell,P., Standeven,K.F. and Carter,A.M.
TITLE Substrates of Factor XIII-A: roles in thrombosis and wound healing
JOURNAL Clin. Sci. 124 (3), 123-137 (2013)
PUBMED 23075332
REMARK GeneRIF: Studies indicate the importance of FXIII-A in thrombosis
and wound healing is emphasized in FXIII deficiency, which is
characterized by bleeding and abnormal wound healing.
Review article
REFERENCE 3 (bases 1 to 3863)
AUTHORS Williams FM, Carter AM, Hysi PG, Surdulescu G, Hodgkiss D, Soranzo
N, Traylor M, Bevan S, Dichgans M, Rothwell PM, Sudlow C, Farrall
M, Silander K, Kaunisto M, Wagner P, Saarela O, Kuulasmaa K,
Virtamo J, Salomaa V, Amouyel P, Arveiler D, Ferrieres J, Wiklund
PG, Ikram MA, Hofman A, Boncoraglio GB, Parati EA, Helgadottir A,
Gretarsdottir S, Thorsteinsdottir U, Thorleifsson G, Stefansson K,
Seshadri S, DeStefano A, Gschwendtner A, Psaty B, Longstreth W,
Mitchell BD, Cheng YC, Clarke R, Ferrario M, Bis JC, Levi C, Attia
J, Holliday EG, Scott RJ, Fornage M, Sharma P, Furie KL, Rosand J,
Nalls M, Meschia J, Mosely TH, Evans A, Palotie A, Markus HS, Grant
PJ and Spector TD.
CONSRTM EuroCLOT Investigators; Wellcome Trust Case Control Consortium 2;
MOnica Risk, Genetics, Archiving and Monograph; MetaStroke;
International Stroke Genetics Consortium
TITLE Ischemic stroke is associated with the ABO locus: the EuroCLOT
study
JOURNAL Ann. Neurol. 73 (1), 16-31 (2013)
PUBMED 23381943
REFERENCE 4 (bases 1 to 3863)
AUTHORS Kapusta,P., Wypasek,E., Natorska,J., Grudzien,G., Sobczyk,D.,
Sadowski,J. and Undas,A.
TITLE Factor XIII expression within aortic valves and its plasma activity
in patients with aortic stenosis: association with severity of
disease
JOURNAL Thromb. Haemost. 108 (6), 1172-1179 (2012)
PUBMED 23052999
REMARK GeneRIF: show abundant expression of FXIII-A at the mRNA and
protein levels within stenotic aortic valves, which is associated
with the severity of aortic stenosis
REFERENCE 5 (bases 1 to 3863)
AUTHORS Kopyta,I.A., Emich-Widera,E., Balcerzyk,A., Niemiec,P., Zak,I.,
Pilarska,E., Kacinski,M., Wendorff,J., Nowak,T., Iwanicki,T.,
Pienczk-Reclawowicz,K. and Palatynska,K.
TITLE Polymorphisms of genes encoding coagulation factors II, V, VII, and
XIII in relation to pediatric ischemic stroke: family-based and
case-control study
JOURNAL Neurologist 18 (5), 282-286 (2012)
PUBMED 22931734
REMARK GeneRIF: investigated possible association between the FII, FV,
FVII, and FXIII genes polymorphisms and pediatric ischemic stroke
(IS); analyzed polymorphisms were not significant determinants of
pediatric IS
REFERENCE 6 (bases 1 to 3863)
AUTHORS Board,P., Coggan,M. and Miloszewski,K.
TITLE Identification of a point mutation in factor XIII A subunit
deficiency
JOURNAL Blood 80 (4), 937-941 (1992)
PUBMED 1353995
REFERENCE 7 (bases 1 to 3863)
AUTHORS Kamura,T., Okamura,T., Murakawa,M., Tsuda,H., Teshima,T.,
Shibuya,T., Harada,M. and Niho,Y.
TITLE Deficiency of coagulation factor XIII A subunit caused by the
dinucleotide deletion at the 5' end of exon III
JOURNAL J. Clin. Invest. 90 (2), 315-319 (1992)
PUBMED 1644910
REFERENCE 8 (bases 1 to 3863)
AUTHORS Harsfalvi,J., Fesus,L., Tarcsa,E., Laczko,J. and Loewy,A.G.
TITLE The presence of a covalently cross-linked matrix in human platelets
JOURNAL Biochim. Biophys. Acta 1073 (2), 268-274 (1991)
PUBMED 2009280
REFERENCE 9 (bases 1 to 3863)
AUTHORS Hilgenfeld,R., Liesum,A., Storm,R., Metzner,H.J. and Karges,H.E.
TITLE Crystallization of blood coagulation factor XIII by an automated
procedure
JOURNAL FEBS Lett. 265 (1-2), 110-112 (1990)
PUBMED 2365049
REFERENCE 10 (bases 1 to 3863)
AUTHORS Bishop,P.D., Teller,D.C., Smith,R.A., Lasser,G.W., Gilbert,T. and
Seale,R.L.
TITLE Expression, purification, and characterization of human factor XIII
in Saccharomyces cerevisiae
JOURNAL Biochemistry 29 (7), 1861-1869 (1990)
PUBMED 2184890
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BP251770.1, AB208852.1 and
AL157775.15.
This sequence is a reference standard in the RefSeqGene project.
On Dec 14, 2006 this sequence version replaced gi:9961355.
Summary: This gene encodes the coagulation factor XIII A subunit.
Coagulation factor XIII is the last zymogen to become activated in
the blood coagulation cascade. Plasma factor XIII is a
heterotetramer composed of 2 A subunits and 2 B subunits. The A
subunits have catalytic function, and the B subunits do not have
enzymatic activity and may serve as plasma carrier molecules.
Platelet factor XIII is comprised only of 2 A subunits, which are
identical to those of plasma origin. Upon cleavage of the
activation peptide by thrombin and in the presence of calcium ion,
the plasma factor XIII dissociates its B subunits and yields the
same active enzyme, factor XIIIa, as platelet factor XIII. This
enzyme acts as a transglutaminase to catalyze the formation of
gamma-glutamyl-epsilon-lysine crosslinking between fibrin
molecules, thus stabilizing the fibrin clot. It also crosslinks
alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of
fibrin. Factor XIII deficiency is classified into two categories:
type I deficiency, characterized by the lack of both the A and B
subunits; and type II deficiency, characterized by the lack of the
A subunit alone. These defects can result in a lifelong bleeding
tendency, defective wound healing, and habitual abortion. [provided
by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: M14539.1, M14354.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-583 BP251770.1 1-583
584-2447 AB208852.1 536-2399
2448-3863 AL157775.15 101907-103322 c
FEATURES Location/Qualifiers
source 1..3863
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6p25.3-p24.3"
gene 1..3863
/gene="F13A1"
/gene_synonym="F13A"
/note="coagulation factor XIII, A1 polypeptide"
/db_xref="GeneID:2162"
/db_xref="HGNC:3531"
/db_xref="MIM:134570"
exon 1..105
/gene="F13A1"
/gene_synonym="F13A"
/inference="alignment:Splign:1.39.8"
misc_feature 4..6
/gene="F13A1"
/gene_synonym="F13A"
/note="upstream in-frame stop codon"
variation 91
/gene="F13A1"
/gene_synonym="F13A"
/replace="c"
/replace="g"
/db_xref="dbSNP:3024311"
exon 106..253
/gene="F13A1"
/gene_synonym="F13A"
/inference="alignment:Splign:1.39.8"
CDS 124..2322
/gene="F13A1"
/gene_synonym="F13A"
/EC_number="2.3.2.13"
/note="TGase; fibrin stabilizing factor, A subunit; FSF, A
subunit; fibrinoligase; transglutaminase. plasma;
protein-glutamine gamma-glutamyltransferase A chain;
coagulation factor XIII, A polypeptide; factor XIIIa;
bA525O21.1 (coagulation factor XIII, A1 polypeptide);
coagulation factor XIIIa; transglutaminase A chain"
/codon_start=1
/product="coagulation factor XIII A chain precursor"
/protein_id="NP_000120.2"
/db_xref="GI:119395709"
/db_xref="CCDS:CCDS4496.1"
/db_xref="GeneID:2162"
/db_xref="HGNC:3531"
/db_xref="MIM:134570"
/translation="
MSETSRTAFGGRRAVPPNNSNAAEDDLPTVELQGVVPRGVNLQEFLNVTSVHLFKERWDTNKVDHHTDKYENNKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVIGRYPQENKGTYIPVPIVSELQSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRMYVAVWTPYGVLRTSRNPETDTYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRSWSYGQFEDGILDTCLYVMDRAQMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNIYAYGVPPSAWTGSVDILLEYRSSENPVRYGQCWVFAGVFNTFLRCLGIPARIVTNYFSAHDNDANLQMDIFLEEDGNVNSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAIKHGHVCFQFDAPFVFAEVNSDLIYITAKKDGTHVVENVDATHIGKLIVTKQIGGDGMMDITDTYKFQEGQEEERLALETALMYGAKKPLNTEGVMKSRSNVDMDFEVENAVLGKDFKLSITFRNNSHNRYTITAYLSANITFYTGVPKAEFKKETFDVTLEPLSFKKEAVLIQAGEYMGQLLEQASLHFFVTARINETRDVLAKQKSTVLTIPEIIIKVRGTQVVGSDMTVTVEFTNPLKETLRNVWVHLDGPGVTRPMKKMFREIRPNSTVQWEEVCRPWVSGHRKLIASMSSDSLRHVYGELDVQIQRRPSM
"
sig_peptide 124..237
/gene="F13A1"
/gene_synonym="F13A"
misc_feature 127..237
/gene="F13A1"
/gene_synonym="F13A"
/note="activation peptide; Region: propeptide"
misc_feature 127..129
/gene="F13A1"
/gene_synonym="F13A"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylserine; propagated from
UniProtKB/Swiss-Prot (P00488.4); acetylation site"
misc_feature 235..240
/gene="F13A1"
/gene_synonym="F13A"
/experiment="experimental evidence, no additional details
recorded"
/note="Cleavage, by thrombin, to produce active factor
XIII-A; propagated from UniProtKB/Swiss-Prot (P00488.4);
cleavage site"
mat_peptide 238..2319
/gene="F13A1"
/gene_synonym="F13A"
/product="coagulation factor XIII A chain"
misc_feature 259..624
/gene="F13A1"
/gene_synonym="F13A"
/note="Transglutaminase family; Region: Transglut_N;
pfam00868"
/db_xref="CDD:201479"
misc_feature <973..1347
/gene="F13A1"
/gene_synonym="F13A"
/note="Transglutaminase-like enzymes, putative cysteine
proteases [Amino acid transport and metabolism]; Region:
COG1305"
/db_xref="CDD:31496"
misc_feature 1048..1323
/gene="F13A1"
/gene_synonym="F13A"
/note="Transglutaminase/protease-like homologues; Region:
TGc; smart00460"
/db_xref="CDD:128736"
misc_feature 1684..1989
/gene="F13A1"
/gene_synonym="F13A"
/note="Transglutaminase family, C-terminal ig like domain;
Region: Transglut_C; pfam00927"
/db_xref="CDD:201509"
misc_feature 2020..2304
/gene="F13A1"
/gene_synonym="F13A"
/note="Transglutaminase family, C-terminal ig like domain;
Region: Transglut_C; pfam00927"
/db_xref="CDD:201509"
variation 241
/gene="F13A1"
/gene_synonym="F13A"
/replace="a"
/replace="g"
/db_xref="dbSNP:3024472"
exon 254..442
/gene="F13A1"
/gene_synonym="F13A"
/inference="alignment:Splign:1.39.8"
variation 388
/gene="F13A1"
/gene_synonym="F13A"
/replace="c"
/replace="t"
/db_xref="dbSNP:1050777"
exon 443..694
/gene="F13A1"
/gene_synonym="F13A"
/inference="alignment:Splign:1.39.8"
exon 695..813
/gene="F13A1"
/gene_synonym="F13A"
/inference="alignment:Splign:1.39.8"
variation 737
/gene="F13A1"
/gene_synonym="F13A"
/replace="a"
/replace="t"
/db_xref="dbSNP:3024477"
exon 814..921
/gene="F13A1"
/gene_synonym="F13A"
/inference="alignment:Splign:1.39.8"
exon 922..1096
/gene="F13A1"
/gene_synonym="F13A"
/inference="alignment:Splign:1.39.8"
exon 1097..1235
/gene="F13A1"
/gene_synonym="F13A"
/inference="alignment:Splign:1.39.8"
variation 1119
/gene="F13A1"
/gene_synonym="F13A"
/replace="a"
/replace="c"
/db_xref="dbSNP:5981"
variation 1175
/gene="F13A1"
/gene_synonym="F13A"
/replace="a"
/replace="t"
/db_xref="dbSNP:2230848"
exon 1236..1339
/gene="F13A1"
/gene_synonym="F13A"
/inference="alignment:Splign:1.39.8"
exon 1340..1428
/gene="F13A1"
/gene_synonym="F13A"
/inference="alignment:Splign:1.39.8"
exon 1429..1582
/gene="F13A1"
/gene_synonym="F13A"
/inference="alignment:Splign:1.39.8"
variation 1542
/gene="F13A1"
/gene_synonym="F13A"
/replace="c"
/replace="t"
/db_xref="dbSNP:3024438"
exon 1583..1870
/gene="F13A1"
/gene_synonym="F13A"
/inference="alignment:Splign:1.39.8"
variation 1775
/gene="F13A1"
/gene_synonym="F13A"
/replace="c"
/replace="t"
/db_xref="dbSNP:5984"
variation 1817
/gene="F13A1"
/gene_synonym="F13A"
/replace="c"
/replace="t"
/db_xref="dbSNP:5982"
variation 1827
/gene="F13A1"
/gene_synonym="F13A"
/replace="a"
/replace="g"
/db_xref="dbSNP:5986"
exon 1871..2031
/gene="F13A1"
/gene_synonym="F13A"
/inference="alignment:Splign:1.39.8"
variation 1889
/gene="F13A1"
/gene_synonym="F13A"
/replace="a"
/replace="t"
/db_xref="dbSNP:5983"
exon 2032..2168
/gene="F13A1"
/gene_synonym="F13A"
/inference="alignment:Splign:1.39.8"
variation 2074
/gene="F13A1"
/gene_synonym="F13A"
/replace="a"
/replace="g"
/db_xref="dbSNP:5987"
variation 2077
/gene="F13A1"
/gene_synonym="F13A"
/replace="c"
/replace="g"
/db_xref="dbSNP:5988"
exon 2169..3863
/gene="F13A1"
/gene_synonym="F13A"
/inference="alignment:Splign:1.39.8"
variation 2292
/gene="F13A1"
/gene_synonym="F13A"
/replace="c"
/replace="t"
/db_xref="dbSNP:5989"
STS 2335..2440
/gene="F13A1"
/gene_synonym="F13A"
/standard_name="RH36374"
/db_xref="UniSTS:47734"
variation 2411
/gene="F13A1"
/gene_synonym="F13A"
/replace="a"
/replace="g"
/db_xref="dbSNP:3024462"
variation 2434
/gene="F13A1"
/gene_synonym="F13A"
/replace="g"
/replace="t"
/db_xref="dbSNP:3024463"
variation 2448
/gene="F13A1"
/gene_synonym="F13A"
/replace="c"
/replace="t"
/db_xref="dbSNP:1050782"
variation 2482
/gene="F13A1"
/gene_synonym="F13A"
/replace="a"
/replace="g"
/db_xref="dbSNP:1050783"
variation 2543
/gene="F13A1"
/gene_synonym="F13A"
/replace="a"
/replace="g"
/db_xref="dbSNP:3024464"
variation 2765
/gene="F13A1"
/gene_synonym="F13A"
/replace="a"
/replace="g"
/db_xref="dbSNP:3024486"
variation 2907
/gene="F13A1"
/gene_synonym="F13A"
/replace="a"
/replace="t"
/db_xref="dbSNP:3024465"
STS 3035..3328
/gene="F13A1"
/gene_synonym="F13A"
/standard_name="WI-18963"
/db_xref="UniSTS:42725"
STS 3046..3372
/gene="F13A1"
/gene_synonym="F13A"
/standard_name="D6S1421"
/db_xref="UniSTS:10661"
variation 3065
/gene="F13A1"
/gene_synonym="F13A"
/replace="a"
/replace="g"
/db_xref="dbSNP:12862"
variation 3317
/gene="F13A1"
/gene_synonym="F13A"
/replace="g"
/replace="t"
/db_xref="dbSNP:3024466"
variation 3367
/gene="F13A1"
/gene_synonym="F13A"
/replace="c"
/replace="g"
/db_xref="dbSNP:3024487"
variation 3389
/gene="F13A1"
/gene_synonym="F13A"
/replace="c"
/replace="t"
/db_xref="dbSNP:11511"
STS 3451..3659
/gene="F13A1"
/gene_synonym="F13A"
/standard_name="RH17664"
/db_xref="UniSTS:4673"
variation 3575
/gene="F13A1"
/gene_synonym="F13A"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:1803604"
variation 3710
/gene="F13A1"
/gene_synonym="F13A"
/replace="c"
/replace="t"
/db_xref="dbSNP:14901"
polyA_signal 3837..3842
/gene="F13A1"
/gene_synonym="F13A"
polyA_site 3863
/gene="F13A1"
/gene_synonym="F13A"
ORIGIN
atttaagagccaactgtcttgtctttcccgagtccgtttgaggaagtccccgaggcgcacagagcaagcccacgcgagggcacctctggaggggagcgcctgcaggaccttgtaaagtcaaaaatgtcagaaacttccaggaccgcctttggaggcagaagagcagttccacccaataactctaatgcagcggaagatgacctgcccacagtggagcttcagggcgtggtgccccggggcgtcaacctgcaagagtttcttaatgtcacgagcgttcacctgttcaaggagagatgggacactaacaaggtggaccaccacactgacaagtatgaaaacaacaagctgattgtccgcagagggcagtctttctatgtgcagattgacttcagtcgtccatatgaccccagaagggatctcttcagggtggaatacgtcattggtcgctacccacaggagaacaagggaacctacatcccagtgcctatagtctcagagttacaaagtggaaagtggggggccaagattgtcatgagagaggacaggtctgtgcggctgtccatccagtcttcccccaaatgtattgtggggaaattccgcatgtatgttgctgtctggactccctatggcgtacttcgaaccagtcgaaacccagaaacagacacgtacattctcttcaatccttggtgtgaagatgatgctgtgtatctggacaatgagaaagaaagagaagagtatgtcctgaatgacatcggggtaattttttatggagaggtcaatgacatcaagaccagaagctggagctatggtcagtttgaagatggcatcctggacacttgcctgtatgtgatggacagagcacaaatggacctctctggaagagggaatcccatcaaagtcagccgtgtggggtctgcaatggtgaatgccaaagatgacgaaggtgtcctcgttggatcctgggacaatatctatgcctatggcgtccccccatcggcctggactggaagcgttgacattctattggaataccggagctctgagaatccagtccggtatggccaatgctgggtttttgctggtgtctttaacacatttttacgatgccttggaataccagcaagaattgttaccaattatttctctgcccatgataatgatgccaatttgcaaatggacatcttcctggaagaagatgggaacgtgaattccaaactcaccaaggattcagtgtggaactaccactgctggaatgaagcatggatgacaaggcctgaccttcctgttggatttggaggctggcaagctgtggacagcaccccccaggaaaatagcgatggcatgtatcggtgtggccccgcctcggttcaagccatcaagcacggccatgtctgcttccaatttgatgcaccttttgtttttgcagaggtcaacagcgacctcatttacattacagctaagaaagatggcactcatgtggtggaaaatgtggatgccacccacattgggaaattaattgtgaccaaacaaattggaggagatggcatgatggatattactgatacttacaaattccaagaaggtcaagaagaagagagattggccctagaaactgccctgatgtacggagctaaaaagcccctcaacacagaaggtgtcatgaaatcaaggtccaacgttgacatggactttgaagtggaaaatgctgtgctgggaaaagacttcaagctctccatcaccttccggaacaacagccacaaccgttacaccatcacagcttatctctcagccaacatcaccttctacaccggggtcccgaaggcagaattcaagaaggagacgttcgacgtgacgctggagcccttgtccttcaagaaagaggcggtgctgatccaagccggcgagtacatgggtcagctgctggaacaagcgtccctgcacttctttgtcacagctcgcatcaatgagaccagggatgttctggccaagcaaaagtccaccgtgctaaccatccctgagatcatcatcaaggtccgtggcactcaggtagttggttctgacatgactgtgacagttgagtttaccaatcctttaaaagaaaccctgcgaaatgtctgggtacacctggatggtcctggagtaacaagaccaatgaagaagatgttccgtgaaatccggcccaactccaccgtgcagtgggaagaagtgtgccggccctgggtctctgggcatcggaagctgatagccagcatgagcagtgactccctgagacatgtgtatggcgagctggacgtgcagattcaaagacgaccttccatgtgaatgcacaggaagctgagatgaaccctggcatttggcctcttgtagtcttggctaaggaaattctaacgcaaaaatagctcttgctttgacttaggtgtgaagacccagacaggactgcagagggctccagagtggagatcccacatatttcaaaaacatgcttttccaaacccaggctattcggcaaggaagttagtttttaatctctccaccttccaaagagtgctaagcattagctttaattaagctctcatagctcataagagtaacagtcatcatttatcatcacaaatggctacatctccaaatatcagtgggctctcttaccagggagatttgctcaatacctggcctcatttaaaacaagacttcagattccccactcagccttttgggaataatagcacatgatttgggctctagaattccagtcccctttctcggggtcaggttctaccctccatgtgagaatatttttcccaggactagagcacaacataatttttatttttggcaaagccagaaaaagatctttcattttgcacctgcagccaagcaaatgcctgccaaattttagatttaccttgttagaagaggtggccccatattaacaaattgcatttgtgggaaacttaaccacctacaaggagataagaaagcaggtgcaacactcaagtctattgaataatgtagttttgtgatgcattttatagaatgtgtcacactgtggcctgatcagcaggagccaatatcccttactttaaccctttctgggatgcaatactaggaagtaaagtgaagaatttatctctttagttagtgattatatttcacccatctctcaggaatcatctcctttgcagaatgatgcaggttcaggtcccctttcagagatataataagcccaacaagttgaagaagctggcggatctagtgaccagatatatagaaggactgcagccactgattctctcttgtccttcacatcacccatgttgagacctcagcttggcactcaggtgctgaagggtaatatggactcagccttgcaaatagccagtgctagttctgacccaaccacagaggatgctgacatcatttgtattatgttccaaggctactacagagaaggctgcctgctatgtatttgcaaggctgatttatggtcagaatttccctctgatatgtctagggtgtgatttaggtcagtagactgtgattcttagcaaaaaatgaacagtgataagtatactgggggcaaaatcagaatggaatgctctggtctatataaccacatttctaagcctttgagactgttcctgagccttcagcactaacctatgagggtgagctggtcccctctatatatacatcatacttaactttactaagtaatctcacagcatttgccaagtctcccaatatccaattttaaaatgaaatgcattttgctagacagttaaactggcttaacttagtatattattattaattacaatgtaatagaagcttaaaataaagttaaactgattatatttgca
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:2162 -> Molecular function: GO:0003810 [protein-glutamine gamma-glutamyltransferase activity] evidence: TAS
GeneID:2162 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:2162 -> Biological process: GO:0002576 [platelet degranulation] evidence: TAS
GeneID:2162 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
GeneID:2162 -> Biological process: GO:0018149 [peptide cross-linking] evidence: IEA
GeneID:2162 -> Biological process: GO:0030168 [platelet activation] evidence: TAS
GeneID:2162 -> Cellular component: GO:0005576 [extracellular region] evidence: TAS
GeneID:2162 -> Cellular component: GO:0031093 [platelet alpha granule lumen] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_000120 -> EC 2.3.2.13
by
@meso_cacase at
DBCLS
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